Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
2801 |
EN300-116092_2
|
|
CCS(=O)(=O)NCCCOC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.4
|
7.3
± 0.3
|
2802 |
EN300-263153_4
|
|
Cn1cc(nn1)C(=O)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.4
|
7.3
± 0.3
|
2803 |
EN300-185398_2
|
|
CC(C(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(F)F)O |
−10.0
± 0.2
|
7.3
± 0.2
|
2804 |
EN300-248888_1
|
|
CC(C=C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.0
± 0.2
|
7.3
± 0.2
|
2805 |
EN300-94900_1
|
|
CS(=O)(=O)Cc1nc(on1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2806 |
EN300-181938_2
|
|
CC(CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C=C)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2807 |
EN300-148421_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CCOC5)O |
−10.0
± 0.5
|
7.3
± 0.4
|
2808 |
EN300-6481960_2
|
|
Cn1c(c2c(n1)CCOC2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.0
± 0.5
|
7.3
± 0.3
|
2809 |
EN300-59285_2
|
|
CC(C)(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.0
± 0.2
|
7.3
± 0.2
|
2810 |
EN300-71022_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCN(CC5)CCO |
−10.0
± 0.4
|
7.3
± 0.3
|
2811 |
EN300-55744_3
|
|
CCCCC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−10.0
± 0.4
|
7.3
± 0.3
|
2812 |
EN300-1696058_1
|
|
CC(=O)OCCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.3
|
7.3
± 0.2
|
2813 |
EN300-02015_4
|
|
COCCNC(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.4
|
7.3
± 0.3
|
2814 |
EN300-295515_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)O |
−10.0
± 0.2
|
7.3
± 0.2
|
2815 |
EN300-3143295_3
|
|
Cn1cnnc1[C@@H]2CC[C@@H]2C(=O)NCC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.0
± 0.3
|
7.3
± 0.3
|
2816 |
EN300-1067786_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCNC(=O)C56CC6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2817 |
EN300-1073320_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(C5(CCC5)O)O |
−10.0
± 0.2
|
7.3
± 0.2
|
2818 |
EN300-184355_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(C(=O)N)O |
−10.0
± 0.4
|
7.3
± 0.3
|
2819 |
EN300-98099_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc(cs5)S(=O)(=O)N |
−10.0
± 0.3
|
7.3
± 0.2
|
2820 |
EN300-148421_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCOC5)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2821 |
EN300-1644723_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5C6C5COCC6 |
−10.0
± 0.1
|
7.3
± 0.1
|
2822 |
EN300-124374_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(cn5)S(=O)(=O)N |
−10.0
± 0.3
|
7.3
± 0.2
|
2823 |
EN300-1703015_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(=O)Nc5[nH]ccn5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2824 |
EN300-55109_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCC5CO |
−10.0
± 0.2
|
7.3
± 0.2
|
2825 |
EN300-716207_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)C(CO)(F)F |
−10.0
± 0.2
|
7.3
± 0.2
|
2826 |
EN300-23221_3
|
|
CC(C)NC(=O)CNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.4
|
7.3
± 0.3
|
2827 |
EN300-718785_3
|
|
CCN1C(CCC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.4
|
7.3
± 0.3
|
2828 |
EN300-817777_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC[C@H]6[C@@]5(C6)C(=O)N |
−10.0
± 0.3
|
7.3
± 0.2
|
2829 |
EN300-7355737_4
|
|
Cn1cc(c(n1)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)N |
−10.0
± 0.4
|
7.3
± 0.3
|
2830 |
EN300-16772_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCCO |
−10.0
± 0.3
|
7.3
± 0.2
|
2831 |
EN300-261056_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(cn5)c6ncccn6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2832 |
EN300-01527_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCC5CCCO5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2833 |
EN300-101443_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(COC5)O |
−10.0
± 0.2
|
7.3
± 0.1
|
2834 |
EN300-54837_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5C(=O)CCCC5=O |
−10.0
± 0.4
|
7.3
± 0.3
|
2835 |
EN300-35612_1
|
|
CN(CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)COC |
−10.0
± 0.3
|
7.3
± 0.2
|
2836 |
EN300-367351_1
|
|
Cn1c(cnn1)C2(CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2837 |
EN300-1588613_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCN6C5COCC6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2838 |
EN300-1273016_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCc6n5ncn6 |
−10.0
± 0.2
|
7.3
± 0.2
|
2839 |
EN300-195743_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H](CCO)CO |
−10.0
± 0.3
|
7.3
± 0.2
|
2840 |
EN300-1588613_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCN6C5COCC6 |
−10.0
± 0.4
|
7.3
± 0.3
|
2841 |
EN300-2008102_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5CN6CC(O5)CCC6=O |
−10.0
± 0.4
|
7.3
± 0.3
|
2842 |
EN300-315963_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cc5cnoc5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2843 |
EN300-67302_1
|
|
Cc1c(c(n[nH]1)C(=O)N)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2844 |
EN300-28262_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc6n5ncn6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2845 |
EN300-51801_3
|
|
CCCC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−10.0
± 0.3
|
7.3
± 0.3
|
2846 |
EN300-7355835_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCn6c(c(cn6)O)C5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2847 |
EN300-6491697_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCc5cccc(=O)[nH]5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2848 |
EN300-72211_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(C5CC5)O |
−10.0
± 0.4
|
7.3
± 0.3
|
2849 |
EN300-7435482_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C6(C5)CCOCC6)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2850 |
EN300-50657_2
|
|
Cc1nc(on1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2851 |
EN300-29617_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c(=O)n6c(n5)CCCCC6 |
−10.0
± 0.4
|
7.3
± 0.3
|
2852 |
EN300-366278_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(=O)NCC56COC6 |
−10.0
± 0.2
|
7.3
± 0.2
|
2853 |
EN300-122847_2
|
|
Cn1ccc(n1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2854 |
EN300-97699_1
|
|
CC(CS(=O)(=O)C)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.3
|
7.3
± 0.2
|
2855 |
EN300-245061_1
|
|
Cc1c(cn(n1)C)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2856 |
EN300-7431365_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6n(c5)CCCNC6=O |
−10.0
± 0.3
|
7.3
± 0.2
|
2857 |
EN300-399072_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@@H]5CO |
−10.0
± 0.3
|
7.3
± 0.2
|
2858 |
EN300-204936_4
|
|
Cn1c(cnn1)C(=O)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2859 |
EN300-96933_1
|
|
CC(C)c1nnnn1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2860 |
EN300-125884_1
|
|
CC[C@H](CO)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.4
|
7.3
± 0.3
|
2861 |
EN300-138676_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N(CC(=O)N)CC(F)(F)F |
−10.0
± 0.2
|
7.3
± 0.2
|
2862 |
EN300-6472558_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCn6c(nnc6CCO)C5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2863 |
EN300-1654606_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5C[C@@H]5F |
−10.0
± 0.1
|
7.27
± 0.10
|
2864 |
EN300-637424_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)[C@@H]6COC[C@H]6O |
−10.0
± 0.4
|
7.3
± 0.3
|
2865 |
EN300-85849_3
|
|
CC(C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NS(=O)(=O)C |
−10.0
± 0.3
|
7.3
± 0.2
|
2866 |
EN300-155498_1
|
|
CC(=C)[C@H](CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2867 |
EN300-304135_2
|
|
CCC1(CCNC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.4
|
7.3
± 0.3
|
2868 |
EN300-36495_1
|
|
CCOC(=O)NCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.3
|
7.3
± 0.2
|
2869 |
EN300-224665_2
|
|
CC1(CN(CCOC1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−10.0
± 0.2
|
7.3
± 0.2
|
2870 |
EN300-152418_3
|
|
Cn1cncc1CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2871 |
DAR-DIA-0d514e7d-1
|
|
C[C@H]1COc2c(cc(cc2OC)Cl)[C@@H]1C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.1
|
7.27
± 0.09
|
2872 |
EN300-172020_3
|
|
Cn1cc(cn1)CC(C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.0
± 0.4
|
7.3
± 0.3
|
2873 |
EN300-73582_3
|
|
CCS(=O)(=O)NCCOCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.5
|
7.3
± 0.4
|
2874 |
EN300-113234_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CC(=O)OC5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2875 |
EN300-133915_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5csc(=O)[nH]5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2876 |
EN300-312618_1
|
|
Cn1cc(n(c1=O)C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2877 |
EN300-29220_1
|
|
Cc1c(n[nH]c(=O)c1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−10.0
± 0.3
|
7.3
± 0.2
|
2878 |
EN300-3044054_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCC(=O)N5C6CC6 |
−10.0
± 0.2
|
7.3
± 0.2
|
2879 |
EN300-54922_2
|
|
CS(=O)(=O)N1CCCC(C1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2880 |
EN300-10397_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)N |
−10.0
± 0.2
|
7.3
± 0.2
|
2881 |
EN300-254883_4
|
|
Cc1c(non1)CC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2882 |
EN300-130825_1
|
|
CN1[C@@H](CCC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2883 |
EN300-30480_2
|
|
Cn1ccc(cc1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2884 |
EN300-23214_1
|
|
CCCNC(=O)C(C)NC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.3
|
7.3
± 0.2
|
2885 |
EN300-1644703_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CC5)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2886 |
EN300-1266218_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6c([nH]n5)nc[nH]c6=O |
−10.0
± 0.2
|
7.3
± 0.2
|
2887 |
EN300-19507_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(F)F |
−10.0
± 0.1
|
7.3
± 0.1
|
2888 |
EN300-18561_4
|
|
CC(=O)NCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.3
|
7.3
± 0.2
|
2889 |
EN300-178876_2
|
|
CC1(CCCNC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2890 |
EN300-2007627_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(CC(C5)CO)CO |
−10.0
± 0.5
|
7.3
± 0.4
|
2891 |
EN300-103219_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CC(=O)N5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2892 |
EN300-1387172_1
|
|
CNC(=O)OC1CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2893 |
EN300-7426383_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c6c(ccn5)[nH]nn6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2894 |
EN300-216063_1
|
|
CN(C)C(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.1
|
7.26
± 0.09
|
2895 |
EN300-114112_1
|
|
CC(C)(CNC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)NC |
−10.0
± 0.3
|
7.3
± 0.2
|
2896 |
EN300-6473108_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6cccnn6n5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2897 |
EN300-7537194_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccn6cnnc6c5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2898 |
EN300-209068_1
|
|
C[C@H](CN(C)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.0
± 0.2
|
7.3
± 0.2
|
2899 |
EN300-6736890_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5COC[C@@H]5n6ccnc6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2900 |
EN300-179352_1
|
|
CNC(=O)C(CNC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.0
± 0.3
|
7.3
± 0.2
|