Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
2701 |
EN300-108507_1
|
|
COC1CN(CCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.2
|
7.3
± 0.2
|
2702 |
EN300-244744_3
|
|
Cn1ncc(n1)CCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.3
± 0.2
|
2703 |
EN300-30458_4
|
|
CN1CCC(CC1=O)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.4
|
7.3
± 0.3
|
2704 |
EN300-13252_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCCCNC(=O)N |
−10.1
± 0.4
|
7.3
± 0.3
|
2705 |
EN300-181492_4
|
|
C=CC(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.1
± 0.2
|
7.3
± 0.2
|
2706 |
EN300-255086_2
|
|
CN(C)CCn1cc(cn1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.3
± 0.2
|
2707 |
EN300-3710141_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CCCO5)C#N |
−10.1
± 0.3
|
7.3
± 0.2
|
2708 |
EN300-194172_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)CC(=O)N |
−10.1
± 0.3
|
7.3
± 0.2
|
2709 |
EN300-76382_3
|
|
CCNC(=O)NC(C)(C)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.5
|
7.3
± 0.3
|
2710 |
EN300-331593_1
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)CC(=O)N[C@H]5C[C@H](C5)CO)cc1 |
−10.1
± 0.3
|
7.3
± 0.2
|
2711 |
EN300-1700143_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)c6ncon6 |
−10.1
± 0.3
|
7.3
± 0.2
|
2712 |
EN300-31998_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c[nH]nn5 |
−10.1
± 0.2
|
7.3
± 0.2
|
2713 |
EN300-42269_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnns5 |
−10.1
± 0.3
|
7.3
± 0.2
|
2714 |
EN300-37077_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5ccn[nH]5 |
−10.1
± 0.3
|
7.3
± 0.2
|
2715 |
EN300-02015_2
|
|
COCCNC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.4
|
7.3
± 0.3
|
2716 |
EN300-6486576_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5nnc(o5)N6CCOCC6 |
−10.1
± 0.3
|
7.3
± 0.2
|
2717 |
EN300-134204_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCc5[nH]nnn5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2718 |
EN300-122319_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c(=O)[nH]c(=O)[nH]n5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2719 |
EN300-7352736_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5C[C@@H]([C@@H](CO5)O)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2720 |
EN300-252260_1
|
|
COc1cc(cnn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2721 |
EN300-128715_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC(=O)NCC(F)(F)F |
−10.0
± 0.3
|
7.3
± 0.2
|
2722 |
EN300-97300_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC5F |
−10.0
± 0.1
|
7.32
± 0.08
|
2723 |
EN300-365791_1
|
|
C[C@H](C1CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2724 |
EN300-2008102_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5CN6CC(O5)CCC6=O |
−10.0
± 0.2
|
7.3
± 0.2
|
2725 |
EN300-1270299_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(cn5)CO |
−10.0
± 0.3
|
7.3
± 0.2
|
2726 |
EN300-368758_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)CC6CCCO6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2727 |
EN300-316216_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCCn5cncn5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2728 |
EN300-1600517_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(CO)F |
−10.0
± 0.3
|
7.3
± 0.2
|
2729 |
EN300-261859_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c(=O)[nH]sn5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2730 |
EN300-110423_2
|
|
Cc1c(c(=O)[nH]o1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2731 |
EN300-257945_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5[C@H]6[C@@H]5COC6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2732 |
EN300-7351945_2
|
|
CC1(CC(CNC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−10.0
± 0.2
|
7.3
± 0.2
|
2733 |
EN300-125379_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOCC56CCOC6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2734 |
EN300-297144_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC(CCO)CO |
−10.0
± 0.2
|
7.3
± 0.2
|
2735 |
EN300-96001_1
|
|
CC(C)(C)[C@@H](C(=O)N)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.3
|
7.3
± 0.2
|
2736 |
EN300-187385_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCc5ccc(=O)[nH]c5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2737 |
EN300-171752_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCOC5 |
−10.0
± 0.2
|
7.3
± 0.1
|
2738 |
EN300-31845_1
|
|
COCCN1CC(CC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2739 |
EN300-73967_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCS(=O)(=O)CC5)C#N |
−10.0
± 0.3
|
7.3
± 0.2
|
2740 |
EN300-6503702_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C56CCC(C5)S(=O)(=O)CC6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2741 |
EN300-16582_3
|
|
CC(C)C(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−10.0
± 0.3
|
7.3
± 0.2
|
2742 |
EN300-233951_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCC(C5)O |
−10.0
± 0.2
|
7.3
± 0.2
|
2743 |
EN300-86282_1
|
|
C[C@@H](CO)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.3
|
7.3
± 0.2
|
2744 |
EN300-109535_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5CC(=O)OC5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2745 |
EN300-7457160_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5=NOC(C5)CC6(COC6)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2746 |
EN300-104088_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)OCCO |
−10.0
± 0.4
|
7.3
± 0.3
|
2747 |
EN300-6746890_1
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)NC(=O)[C@H]5C[C@@](C5)(F)CO)cc1 |
−10.0
± 0.3
|
7.3
± 0.2
|
2748 |
EN300-7370063_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)CO |
−10.0
± 0.2
|
7.3
± 0.1
|
2749 |
EN300-304695_3
|
|
CN1CCCCC(C1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2750 |
EN300-6501360_3
|
|
CN(C)C(=O)NCC(COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.0
± 0.4
|
7.3
± 0.3
|
2751 |
EN300-44873_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCN5CCCS5(=O)=O |
−10.0
± 0.6
|
7.3
± 0.5
|
2752 |
EN300-7456641_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6c(nn5)CCOC6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2753 |
EN300-141809_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC56CCS(=O)(=O)CC6 |
−10.0
± 0.2
|
7.3
± 0.2
|
2754 |
EN300-1178209_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCc5c[nH]nn5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2755 |
EN300-68875_3
|
|
CNS(=O)(=O)CCCOCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.3
|
7.3
± 0.2
|
2756 |
EN300-253443_3
|
|
CCCN1CC(CC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2757 |
EN300-7355737_3
|
|
Cn1cc(c(n1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)N |
−10.0
± 0.3
|
7.3
± 0.2
|
2758 |
EN300-18561_1
|
|
CC(=O)NCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.3
|
7.3
± 0.2
|
2759 |
EN300-113507_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(=O)N |
−10.0
± 0.3
|
7.3
± 0.2
|
2760 |
EN300-36123_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6[C@H](C5)[C@H]6CO |
−10.0
± 0.3
|
7.3
± 0.2
|
2761 |
EN300-08705_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCNC(=O)C5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2762 |
EN300-7459545_2
|
|
CN(C)CC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C(F)(F)F)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2763 |
EN300-78368_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCCCC5)NC(=O)N |
−10.0
± 0.4
|
7.3
± 0.3
|
2764 |
EN300-30572_3
|
|
CS(=O)(=O)NCCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.7
|
7.3
± 0.5
|
2765 |
EN300-6745712_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6(CC5)CNC(=O)N6 |
−10.0
± 0.4
|
7.3
± 0.3
|
2766 |
EN300-113112_1
|
|
Cn1cnnc1CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2767 |
EN300-182725_1
|
|
CC(C(C)S(=O)(=O)C)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.2
|
7.3
± 0.1
|
2768 |
EN300-1653482_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCn6c(nnn6)C5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2769 |
EN300-1588753_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)(c6cnn[nH]6)O |
−10.0
± 0.4
|
7.3
± 0.3
|
2770 |
EN300-1629199_3
|
|
Cc1c(c(nn1C)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)N |
−10.0
± 0.4
|
7.3
± 0.3
|
2771 |
EN300-114526_2
|
|
Cc1c(c(n[nH]1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2772 |
EN300-113564_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc6n5ncc6C(=O)N |
−10.0
± 0.3
|
7.3
± 0.2
|
2773 |
EN300-321789_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]6C[C@@H]5CO6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2774 |
EN300-188582_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC[C@@H](C5)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2775 |
EN300-7435581_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5=NO[C@H]6[C@@H]5COC6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2776 |
EN300-135530_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cccnc5C(=O)N |
−10.0
± 0.4
|
7.3
± 0.3
|
2777 |
EN300-6764450_2
|
|
CNC(=O)N1CCC(CC1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2778 |
EN300-28106_2
|
|
CC(C(=O)N1CCN(CC1)C(=O)C)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.3
|
2779 |
EN300-00271_3
|
|
CC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−10.0
± 0.2
|
7.3
± 0.2
|
2780 |
EN300-196160_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)(c6[nH]nnn6)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2781 |
EN300-6482296_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5COC6C5COC6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2782 |
EN300-6489145_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCNS(=O)(=O)CC5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2783 |
EN300-1299691_1
|
|
CC(C)OCC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−10.0
± 0.2
|
7.3
± 0.2
|
2784 |
EN300-1387145_3
|
|
CS(=O)(=O)C1CCCC1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2785 |
EN300-104029_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6C(C5)C(=O)NC6=O |
−10.0
± 0.3
|
7.3
± 0.2
|
2786 |
EN300-21009_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCCO5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2787 |
EN300-84186_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC(CO)CO |
−10.0
± 0.4
|
7.3
± 0.3
|
2788 |
EN300-75342_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5ccnc5 |
−10.0
± 0.2
|
7.3
± 0.1
|
2789 |
EN300-6492197_1
|
|
CNC(=O)[C@H]1CCCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2790 |
EN300-04492_4
|
|
COCCCNC(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.4
|
7.3
± 0.3
|
2791 |
EN300-36938_1
|
|
Cc1cc(no1)NC(=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2792 |
EN300-115421_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)c5c(cccn5)O |
−10.0
± 0.3
|
7.3
± 0.3
|
2793 |
EN300-81038_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(C5)COC6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2794 |
EN300-60314_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CCC[C@H]5O |
−10.0
± 0.2
|
7.3
± 0.1
|
2795 |
JOH-SUS-a69c159d-2
|
|
c1ccc2c(c1)c(cnc2F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−10.01
± 0.05
|
7.29
± 0.03
|
2796 |
EN300-119126_4
|
|
Cc1[nH]c(nn1)CC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.4
|
7.3
± 0.3
|
2797 |
EN300-343433_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCc5c[nH]c(=O)nc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2798 |
EDJ-MED-e4b030d8-11
|
|
C[C@H]1COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−10.01
± 0.06
|
7.29
± 0.04
|
2799 |
EN300-6494158_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5CC(CO5)CO |
−10.0
± 0.2
|
7.3
± 0.1
|
2800 |
EN300-219330_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCN5CCOCC5=O |
−10.0
± 0.3
|
7.3
± 0.2
|