Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
2501 |
EN300-100765_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN6C(C5)CNC6=O |
−10.2
± 0.4
|
7.4
± 0.3
|
2502 |
EN300-6766359_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@H]6C[C@H]6C(=O)N5 |
−10.2
± 0.2
|
7.4
± 0.2
|
2503 |
EN300-6766760_4
|
|
CCn1cnnc1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.2
± 0.3
|
7.4
± 0.2
|
2504 |
EN300-34491_1
|
|
CNC(=O)CN(C)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.2
± 0.2
|
7.4
± 0.1
|
2505 |
EN300-65853_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)c5ccc(cc5)C#N |
−10.2
± 0.3
|
7.4
± 0.2
|
2506 |
EN300-129455_4
|
|
CCNC(=O)CC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.2
± 0.3
|
7.4
± 0.2
|
2507 |
EN300-211422_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC5 |
−10.2
± 0.2
|
7.4
± 0.1
|
2508 |
EN300-188217_4
|
|
CC(C)(CS(=O)(=O)C)C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.2
± 0.3
|
7.4
± 0.2
|
2509 |
EN300-104395_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5CCCO5 |
−10.2
± 0.3
|
7.4
± 0.2
|
2510 |
EN300-248888_3
|
|
CC(C=C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.2
± 0.3
|
7.4
± 0.2
|
2511 |
EN300-192482_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H]5[C@H]6[C@@H]5COC6 |
−10.2
± 0.2
|
7.4
± 0.2
|
2512 |
EN300-30480_1
|
|
Cn1ccc(cc1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.2
± 0.2
|
7.4
± 0.2
|
2513 |
EN300-50228_1
|
|
c1ccc(cc1)C(=O)NC(CO)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.2
± 0.3
|
7.4
± 0.2
|
2514 |
EN300-743350_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC6(C5)CCNC6=O |
−10.2
± 0.3
|
7.4
± 0.2
|
2515 |
EN300-72730_4
|
|
CC(C#N)C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.2
± 0.3
|
7.4
± 0.2
|
2516 |
EN300-299215_2
|
|
C[C@H]1[C@H](OCCO1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.2
± 0.3
|
7.4
± 0.2
|
2517 |
EN300-1705754_2
|
|
CC1(CS(=O)(=O)C1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.2
± 0.2
|
7.4
± 0.2
|
2518 |
EN300-722418_1
|
|
CC(CN(CC(C)O)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.2
± 0.3
|
7.4
± 0.2
|
2519 |
EN300-2803713_1
|
|
CC(C)[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NS(=O)(=O)N |
−10.2
± 0.4
|
7.4
± 0.3
|
2520 |
EN300-48886_2
|
|
CC(=O)NC1CCCN(C1)C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.2
± 0.3
|
7.4
± 0.2
|
2521 |
EN300-05512_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NC5CCS(=O)(=O)C5 |
−10.2
± 0.4
|
7.4
± 0.3
|
2522 |
EN300-91905_4
|
|
C[C@@H](C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.2
± 0.3
|
7.4
± 0.2
|
2523 |
EN300-68889_3
|
|
CCNC(=O)CCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.2
± 0.3
|
7.4
± 0.2
|
2524 |
EN300-259251_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCn6c(c(cn6)CO)C5 |
−10.2
± 0.3
|
7.4
± 0.2
|
2525 |
EN300-91401_1
|
|
CC1CCNC(=O)C1NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.2
± 0.2
|
7.4
± 0.2
|
2526 |
EN300-160143_1
|
|
CN1CCCN(CC1=O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.2
|
7.4
± 0.1
|
2527 |
EN300-71560_1
|
|
COC(=O)NCCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.3
|
7.4
± 0.2
|
2528 |
EN300-315792_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)COCC(F)F |
−10.1
± 0.3
|
7.4
± 0.2
|
2529 |
EN300-66494_4
|
|
CNC(=O)NCCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.4
|
7.4
± 0.3
|
2530 |
EN300-39151_1
|
|
Cc1ccc(c(=O)[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
2531 |
EN300-126389_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5COC(=O)N5 |
−10.1
± 0.2
|
7.4
± 0.2
|
2532 |
EN300-126127_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(C6CC6)O |
−10.1
± 0.3
|
7.4
± 0.2
|
2533 |
EN300-159953_1
|
|
CN(C1CCN2CCOC1C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.1
± 0.4
|
7.4
± 0.3
|
2534 |
EN300-1587691_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCNC(=O)C5CCO |
−10.1
± 0.3
|
7.4
± 0.2
|
2535 |
EN300-317085_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@@H](C5)F)O |
−10.1
± 0.2
|
7.4
± 0.2
|
2536 |
EN300-219496_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCN(C5)S(=O)(=O)N |
−10.1
± 0.2
|
7.4
± 0.2
|
2537 |
EN300-23318_2
|
|
CC(C(=O)NC1CCS(=O)(=O)C1)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
2538 |
EN300-24014_1
|
|
CS(=O)(=O)N1CCCCC1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
2539 |
EN300-6759512_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)[C@@H]6COC[C@@H]6F |
−10.1
± 0.3
|
7.4
± 0.2
|
2540 |
EN300-158272_3
|
|
CC(=O)N1C[C@H](C[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−10.1
± 0.4
|
7.4
± 0.3
|
2541 |
EN300-1273248_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5COC[C@@H]5n6ccnn6 |
−10.1
± 0.3
|
7.4
± 0.2
|
2542 |
EN300-05620_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCNC(=O)N |
−10.1
± 0.3
|
7.4
± 0.2
|
2543 |
EN300-172640_2
|
|
CC1C(NC(=O)O1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.2
|
7.4
± 0.1
|
2544 |
EN300-154332_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC5CO |
−10.1
± 0.2
|
7.4
± 0.1
|
2545 |
EN300-123398_1
|
|
CCOC(=O)C(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)F |
−10.1
± 0.2
|
7.4
± 0.1
|
2546 |
EN300-1600517_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(CO)F |
−10.1
± 0.3
|
7.4
± 0.2
|
2547 |
EN300-2855057_1
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)N5CCOCC5 |
−10.1
± 0.2
|
7.4
± 0.2
|
2548 |
EN300-246248_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5CCNC5=O |
−10.1
± 0.3
|
7.4
± 0.2
|
2549 |
EN300-1725538_3
|
|
Cn1cc(nc1)CC(C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.1
± 0.2
|
7.4
± 0.2
|
2550 |
EN300-2666482_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cncc(n5)n6ccnc6 |
−10.1
± 0.3
|
7.4
± 0.2
|
2551 |
EN300-1179673_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5cccc(c5)C(=O)N |
−10.1
± 0.4
|
7.4
± 0.3
|
2552 |
EN300-7443668_1
|
|
CN1C(=O)NCC12CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.1
± 0.3
|
7.4
± 0.2
|
2553 |
EN300-5638430_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5CS(=O)(=O)C5 |
−10.1
± 0.4
|
7.4
± 0.3
|
2554 |
EN300-98648_1
|
|
CN1CCC(C1=O)O[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.2
|
7.4
± 0.1
|
2555 |
EN300-107493_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCNC(=O)C5 |
−10.1
± 0.2
|
7.4
± 0.1
|
2556 |
EN300-226314_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)C5CCS(=O)(=O)C5 |
−10.1
± 0.3
|
7.4
± 0.2
|
2557 |
EN300-135182_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(=O)n6c([nH]5)ncn6 |
−10.1
± 0.2
|
7.4
± 0.2
|
2558 |
EN300-1630093_1
|
|
CC(C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C5(CCOC5)O |
−10.1
± 0.3
|
7.4
± 0.2
|
2559 |
EN300-321597_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5CC[C@H](C5)O |
−10.1
± 0.4
|
7.4
± 0.3
|
2560 |
EN300-77092_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5OCCO5 |
−10.1
± 0.2
|
7.4
± 0.2
|
2561 |
EN300-261410_1
|
|
CC1C(=O)N(CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−10.1
± 0.2
|
7.4
± 0.2
|
2562 |
EN300-1214616_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N([C@@H]5COC[C@H]5O)C6CC6 |
−10.1
± 0.3
|
7.4
± 0.2
|
2563 |
EN300-316679_4
|
|
CCC[C@@H](C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.1
± 0.4
|
7.4
± 0.3
|
2564 |
EN300-318341_1
|
|
CN(C1CS(=O)(=O)C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.3
|
2565 |
EN300-31015_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCSCC(=O)N |
−10.1
± 0.2
|
7.4
± 0.2
|
2566 |
EN300-21200_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c(nccn5)C(=O)N |
−10.1
± 0.3
|
7.4
± 0.2
|
2567 |
EN300-120068_3
|
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)OC |
−10.1
± 0.3
|
7.4
± 0.2
|
2568 |
EN300-741822_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC[C@H]([C@H](C5)O)O |
−10.1
± 0.3
|
7.4
± 0.2
|
2569 |
EN300-14949_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(cc5)OCC(=O)N |
−10.1
± 0.2
|
7.4
± 0.2
|
2570 |
EN300-199359_1
|
|
CC(C)[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.1
± 0.3
|
7.4
± 0.2
|
2571 |
EN300-75807_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCS(=O)(=O)CC5 |
−10.1
± 0.2
|
7.4
± 0.2
|
2572 |
EN300-100768_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN6C(C5)CNC(=O)C6=O |
−10.1
± 0.3
|
7.4
± 0.2
|
2573 |
EN300-2972220_3
|
|
CC(C)[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−10.1
± 0.3
|
7.4
± 0.2
|
2574 |
EN300-7445540_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(nn5)C6(COC6)O |
−10.1
± 0.3
|
7.4
± 0.2
|
2575 |
EN300-207765_3
|
|
CN1C(CCC1=O)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
2576 |
EN300-7461217_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5C[C@H]([C@@H](C5)F)O |
−10.1
± 0.2
|
7.4
± 0.1
|
2577 |
EN300-158274_3
|
|
CC(=O)N1C[C@H](C[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.1
± 0.4
|
7.4
± 0.3
|
2578 |
EN300-14767_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCN(C5)C(=O)N |
−10.1
± 0.4
|
7.4
± 0.3
|
2579 |
EN300-53677_3
|
|
CS(=O)(=O)CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.3
|
7.4
± 0.2
|
2580 |
EN300-373446_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCO[C@@H](C5)[C@H](CO)O |
−10.1
± 0.4
|
7.4
± 0.3
|
2581 |
EN300-257573_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CCC[C@@H]5C(=O)N |
−10.1
± 0.3
|
7.4
± 0.2
|
2582 |
EN300-51257_2
|
|
CC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−10.1
± 0.2
|
7.4
± 0.1
|
2583 |
EN300-04491_3
|
|
COCCN(CCOC)C(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.5
|
7.4
± 0.4
|
2584 |
EN300-61636_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CC5)C(=O)NC6CC6 |
−10.1
± 0.4
|
7.4
± 0.3
|
2585 |
EN300-248883_2
|
|
COCC1(CCOC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.4
|
7.4
± 0.3
|
2586 |
EN300-21303_4
|
|
CCOCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.4
|
7.4
± 0.3
|
2587 |
EN300-31146_1
|
|
CN(CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)C5CC5 |
−10.1
± 0.4
|
7.4
± 0.3
|
2588 |
EN300-182913_3
|
|
CC(C)(C(=O)N)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.3
|
7.4
± 0.2
|
2589 |
EN300-7102031_3
|
|
COCC(CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)COC |
−10.1
± 0.5
|
7.4
± 0.3
|
2590 |
EN300-147397_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnc6nccn6c5 |
−10.1
± 0.3
|
7.4
± 0.2
|
2591 |
EN300-155447_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5nnc6n5CCOC6 |
−10.1
± 0.3
|
7.4
± 0.2
|
2592 |
EN300-83529_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5nc6ncccn6n5 |
−10.1
± 0.3
|
7.4
± 0.2
|
2593 |
EN300-181178_1
|
|
Cc1cc(n2c(n1)c(cn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)O |
−10.1
± 0.3
|
7.4
± 0.2
|
2594 |
EN300-10397_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CNC(=O)N |
−10.1
± 0.2
|
7.4
± 0.2
|
2595 |
JOH-SUS-a69c159d-5
|
|
c1cc2c(cc1F)c(cnc2F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−10.11
± 0.04
|
7.37
± 0.03
|
2596 |
EN300-1605226_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)CNC(=O)N6 |
−10.1
± 0.3
|
7.4
± 0.2
|
2597 |
EN300-31148_3
|
|
CCC(=O)NC(C)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.3
|
7.4
± 0.2
|
2598 |
EN300-7444533_2
|
|
CC1CC(C(=O)O1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.1
|
7.37
± 0.10
|
2599 |
EN300-14752_4
|
|
CC(=O)N1CCCC(C1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.4
|
7.4
± 0.3
|
2600 |
EN300-155589_1
|
|
CC(=O)OC(C)(C)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.3
|
7.4
± 0.2
|