Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
2201 |
EN300-1911992_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(C5CCOC5)O |
−10.3
± 0.3
|
7.5
± 0.2
|
2202 |
EN300-41507_1
|
|
Cc1nccn1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.2
|
7.5
± 0.2
|
2203 |
EN300-1704785_1
|
|
CS(=NC(=O)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(=O)C |
−10.3
± 0.2
|
7.5
± 0.2
|
2204 |
EN300-1703340_1
|
|
Cc1cc(cn(c1=O)C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.2
|
7.5
± 0.2
|
2205 |
EN300-52009_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCC5)O |
−10.3
± 0.2
|
7.5
± 0.2
|
2206 |
EN300-208993_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)N6CCNC6=O |
−10.3
± 0.3
|
7.5
± 0.2
|
2207 |
EN300-1726150_2
|
|
Cn1cc(cn1)n2cc(nc2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.3
± 0.4
|
7.5
± 0.3
|
2208 |
EN300-1718675_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnnn5C6CC6 |
−10.3
± 0.2
|
7.5
± 0.2
|
2209 |
EN300-07752_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(CC5C(=O)N)O |
−10.3
± 0.3
|
7.5
± 0.2
|
2210 |
EN300-24804_1
|
|
COC(=O)CCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.3
|
7.5
± 0.2
|
2211 |
EN300-36096_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCNC5=O |
−10.3
± 0.3
|
7.5
± 0.2
|
2212 |
EN300-6953121_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[C@H]5F |
−10.3
± 0.2
|
7.5
± 0.2
|
2213 |
EN300-17381_4
|
|
CC(C(=O)N)OCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.2
|
7.5
± 0.1
|
2214 |
EN300-23129_3
|
|
CC(=O)NCCNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.3
|
7.5
± 0.2
|
2215 |
EN300-152705_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−10.3
± 0.3
|
7.5
± 0.2
|
2216 |
EN300-261986_1
|
|
CS(=O)(=O)N1CCC(C1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.2
|
7.5
± 0.2
|
2217 |
EN300-314088_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@@H](C5)CO)CO |
−10.3
± 0.4
|
7.5
± 0.3
|
2218 |
EN300-1253122_2
|
|
CCN(C)C(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.2
|
7.5
± 0.1
|
2219 |
EN300-17184_1
|
|
C=CCNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.3
|
7.5
± 0.2
|
2220 |
EN300-246747_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5CC(=O)NC5 |
−10.3
± 0.2
|
7.5
± 0.2
|
2221 |
EN300-31969_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CC(=O)N(C5)CC6CC6 |
−10.3
± 0.3
|
7.5
± 0.2
|
2222 |
EN300-39005_3
|
|
CN(CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)OC |
−10.3
± 0.4
|
7.5
± 0.3
|
2223 |
EN300-153245_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H](C[C@H]5CO)O |
−10.3
± 0.3
|
7.5
± 0.2
|
2224 |
EN300-124918_2
|
|
Cn1c(=O)[nH]c(n1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.2
|
7.5
± 0.2
|
2225 |
EN300-08259_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCCCN5CCCC5=O |
−10.3
± 0.4
|
7.5
± 0.3
|
2226 |
EN300-83918_1
|
|
CC(C)[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)COC |
−10.3
± 0.3
|
7.5
± 0.2
|
2227 |
EN300-195756_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5CCC(=O)N5 |
−10.3
± 0.2
|
7.5
± 0.2
|
2228 |
EN300-39007_1
|
|
CCN(CC(=O)NC)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.3
|
7.5
± 0.2
|
2229 |
EN300-314455_1
|
|
CS(=O)(=O)N1CCC[C@@H](C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.4
|
7.5
± 0.3
|
2230 |
EN300-1073391_1
|
|
CN1CC(C1)N(C)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2231 |
EN300-20233_4
|
|
COCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.3
|
7.5
± 0.2
|
2232 |
EN300-156212_1
|
|
Cn1c(nnn1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2233 |
EN300-67573_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NC5CCOCC5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2234 |
EN300-126389_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5COC(=O)N5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2235 |
EN300-2007648_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C56CC(C5)CO6 |
−10.3
± 0.3
|
7.5
± 0.2
|
2236 |
EN300-96037_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]([C@H](C5)O)O |
−10.3
± 0.3
|
7.5
± 0.2
|
2237 |
EN300-1709745_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5cn(nn5)C6COC6 |
−10.3
± 0.2
|
7.5
± 0.2
|
2238 |
EN300-36931_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5(CCOCC5)C(=O)N |
−10.3
± 0.3
|
7.5
± 0.2
|
2239 |
EN300-251851_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCc5[nH]nnn5 |
−10.3
± 0.2
|
7.5
± 0.2
|
2240 |
EN300-196962_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@H]5CO |
−10.3
± 0.3
|
7.5
± 0.2
|
2241 |
EN300-1265949_2
|
|
CC(C(=O)N1CCS(=O)(=O)CC1)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2242 |
EN300-138953_1
|
|
CC(C)N(CC(CO)O)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.5
|
7.5
± 0.4
|
2243 |
EN300-78368_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCCCC5)NC(=O)N |
−10.3
± 0.4
|
7.5
± 0.3
|
2244 |
EN300-6478433_1
|
|
CCn1c(nn(c1=O)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−10.3
± 0.4
|
7.5
± 0.3
|
2245 |
EN300-109827_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN6C(C5)COC6=O |
−10.3
± 0.3
|
7.5
± 0.2
|
2246 |
EN300-47500_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NCCCn5cccn5 |
−10.3
± 0.3
|
7.5
± 0.3
|
2247 |
EN300-1588907_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5[C@H]6CCO[C@H]6C[C@H]5CO |
−10.3
± 0.4
|
7.5
± 0.3
|
2248 |
MAK-UNK-83e0a0b4-2
|
|
c1cc2c(cc1CN3CCNCC3)cncc2N(CCNC4CNC4)C(=O)C5CCOc6c5cc(cc6)Cl |
−10.3
± 0.3
|
7.5
± 0.2
|
2249 |
EN300-71558_4
|
|
COC(=O)NCCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.3
|
7.5
± 0.2
|
2250 |
EN300-6492179_1
|
|
CNC(=O)C1COCCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.4
|
7.5
± 0.3
|
2251 |
EN300-31969_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(=O)N(C5)CC6CC6 |
−10.3
± 0.3
|
7.5
± 0.2
|
2252 |
EN300-6744028_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CC6CC5C(C6O)O |
−10.3
± 0.2
|
7.5
± 0.2
|
2253 |
EN300-54891_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC[C@@H]5CO |
−10.3
± 0.3
|
7.5
± 0.2
|
2254 |
EN300-1608590_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5nc(on5)N6CCOCC6 |
−10.3
± 0.2
|
7.5
± 0.2
|
2255 |
EN300-259004_1
|
|
CC(=O)N1CC(C1)OCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2256 |
EN300-383904_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCNC(=O)CO |
−10.3
± 0.2
|
7.5
± 0.2
|
2257 |
EN300-10895_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NCCC#N |
−10.3
± 0.2
|
7.5
± 0.2
|
2258 |
EN300-1425608_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C(C5)CO)CCO |
−10.3
± 0.2
|
7.5
± 0.2
|
2259 |
EN300-315854_2
|
|
CC1(CCNC(=O)C1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2260 |
EN300-7432898_1
|
|
CCOC1(CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−10.3
± 0.4
|
7.5
± 0.3
|
2261 |
EN300-4287199_2
|
|
Cc1cc(cc(=O)n1C)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2262 |
EN300-198540_4
|
|
Cn1cc(cn1)C(C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.3
± 0.3
|
7.5
± 0.3
|
2263 |
EN300-184446_3
|
|
Cc1ccn(c(=O)c1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2264 |
EN300-31387_1
|
|
CS(=O)(=O)CCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.3
|
7.5
± 0.2
|
2265 |
EN300-41507_3
|
|
Cc1nccn1CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2266 |
EN300-11441_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cc(=O)[nH]c(=O)[nH]5 |
−10.3
± 0.2
|
7.5
± 0.2
|
2267 |
EN300-246747_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5CC(=O)NC5 |
−10.3
± 0.2
|
7.5
± 0.1
|
2268 |
EN300-102007_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC(C5)CCO |
−10.3
± 0.3
|
7.5
± 0.2
|
2269 |
EN300-1179673_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cccc(c5)C(=O)N |
−10.3
± 0.2
|
7.5
± 0.2
|
2270 |
EN300-19507_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(F)F |
−10.3
± 0.2
|
7.5
± 0.2
|
2271 |
EN300-301690_2
|
|
CS(=O)(=O)N1CCC(C1)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.2
|
7.5
± 0.2
|
2272 |
EN300-2007620_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(OCC5)CO |
−10.3
± 0.3
|
7.5
± 0.2
|
2273 |
EN300-1987964_1
|
|
CS(=O)(=O)Cc1cc(no1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2274 |
EN300-123614_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)NC(=O)N |
−10.3
± 0.2
|
7.5
± 0.2
|
2275 |
EN300-246423_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5(CCC5)O |
−10.3
± 0.3
|
7.5
± 0.2
|
2276 |
EN300-237224_1
|
|
CN1CCC(CC1)OCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2277 |
EN300-6953121_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H]5C[C@H]5F |
−10.3
± 0.3
|
7.5
± 0.2
|
2278 |
EN300-6734977_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC56CC(C5)OC6 |
−10.3
± 0.3
|
7.5
± 0.2
|
2279 |
EN300-6763507_1
|
|
COC1CC(CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.3
± 0.2
|
7.5
± 0.2
|
2280 |
EN300-1667046_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(c6ccn[nH]6)O |
−10.3
± 0.2
|
7.5
± 0.2
|
2281 |
EN300-72211_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(C5CC5)O |
−10.3
± 0.3
|
7.5
± 0.2
|
2282 |
EN300-249764_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(C5CCC5)O |
−10.3
± 0.3
|
7.5
± 0.2
|
2283 |
EN300-6480588_1
|
|
COc1ccnc(n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.2
|
7.5
± 0.2
|
2284 |
EN300-302290_3
|
|
CS(=O)(=O)N1CC(C1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.4
|
7.5
± 0.3
|
2285 |
EN300-27672_1
|
|
Cc1c(cn[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.2
|
7.5
± 0.2
|
2286 |
EN300-219437_3
|
|
Cc1c(cnn1C)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.4
|
7.5
± 0.3
|
2287 |
EN300-1086925_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5COC[C@@H]5n6cccn6 |
−10.3
± 0.3
|
7.5
± 0.2
|
2288 |
EN300-33657_1
|
|
CC(=O)N(C)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.3
|
7.5
± 0.2
|
2289 |
EN300-155764_1
|
|
CC1C(=O)N(CCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−10.3
± 0.3
|
7.5
± 0.2
|
2290 |
EN300-73662_1
|
|
COC(=O)C[C@H](CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.3
± 0.3
|
7.5
± 0.2
|
2291 |
EN300-343787_3
|
|
CN1[C@H](CCC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2292 |
EN300-25572_3
|
|
CC1CN(CCO1)C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2293 |
EN300-705381_1
|
|
COC[C@H]1C[C@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2294 |
EN300-23221_1
|
|
CC(C)NC(=O)CNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.3
|
7.5
± 0.2
|
2295 |
EN300-24102_1
|
|
Cn1cc(cc1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)N |
−10.3
± 0.3
|
7.5
± 0.2
|
2296 |
EN300-697519_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCOC5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2297 |
EN300-114133_3
|
|
CCC(=O)N1CCC(C1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
7.5
± 0.2
|
2298 |
DAR-DIA-0d514e7d-8
|
|
C[C@H]1COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)C#N |
−10.28
± 0.08
|
7.49
± 0.05
|
2299 |
EN300-39504_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCS(=O)(=O)N |
−10.3
± 0.4
|
7.5
± 0.3
|
2300 |
EN300-155498_2
|
|
CC(=C)[C@H](CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.3
± 0.3
|
7.5
± 0.3
|