Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
201 |
EN300-1700710_1
|
|
Cn1ccnc1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.3
± 0.2
|
9.0
± 0.1
|
202 |
EN300-115017_1
|
|
CC(C)[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−12.3
± 0.2
|
9.0
± 0.1
|
203 |
EN300-1073320_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C5(CCC5)O)O |
−12.3
± 0.3
|
9.0
± 0.2
|
204 |
EN300-128324_1
|
|
Cn1cc(c(=O)c2c1n(nc2)C)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−12.3
± 0.3
|
9.0
± 0.2
|
205 |
EN300-133058_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6c(n5)n[nH]n6 |
−12.3
± 0.3
|
9.0
± 0.2
|
206 |
EN300-58864_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(nc5)C(=O)N |
−12.3
± 0.3
|
9.0
± 0.2
|
207 |
EN300-6474341_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCn6cnnc6C5 |
−12.3
± 0.3
|
9.0
± 0.2
|
208 |
EN300-92790_1
|
|
Cn1ccc(n1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.3
± 0.3
|
9.0
± 0.2
|
209 |
EN300-244278_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6n(n5)CCOC6 |
−12.3
± 0.2
|
9.0
± 0.2
|
210 |
EN300-7431629_3
|
|
Cc1nnc2n1CCC2(C)C(=O)NCC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−12.3
± 0.2
|
9.0
± 0.2
|
211 |
EN300-181688_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6n(n5)CCO6 |
−12.3
± 0.2
|
9.0
± 0.2
|
212 |
EN300-298552_1
|
|
COC(C1CCOC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.3
± 0.2
|
9.0
± 0.1
|
213 |
EN300-323327_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccn6c(n5)ccn6 |
−12.3
± 0.2
|
8.9
± 0.1
|
214 |
EN300-120119_1
|
|
CN(C1CCNC1=O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.3
± 0.3
|
8.9
± 0.2
|
215 |
EN300-222969_3
|
|
CN1CC(OC1=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.3
± 0.3
|
8.9
± 0.2
|
216 |
EN300-359842_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6ccnn6ccn5 |
−12.3
± 0.3
|
8.9
± 0.2
|
217 |
EN300-6526669_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5C(=O)NCC6 |
−12.3
± 0.3
|
8.9
± 0.2
|
218 |
EN300-186929_1
|
|
Cc1c(nc[nH]1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.3
± 0.2
|
8.9
± 0.2
|
219 |
EN300-19762_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CCO)CCO |
−12.3
± 0.4
|
8.9
± 0.3
|
220 |
EN300-1072199_1
|
|
COC1(CCCOC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.3
± 0.2
|
8.9
± 0.2
|
221 |
EN300-6764836_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC6C(C(C5O6)O)O |
−12.3
± 0.2
|
8.9
± 0.1
|
222 |
EN300-04520_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc(c5)S(=O)(=O)N |
−12.3
± 0.3
|
8.9
± 0.2
|
223 |
EN300-12067_1
|
|
Cc1csc(=O)n1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.3
± 0.3
|
8.9
± 0.2
|
224 |
EN300-1072199_3
|
|
COC1(CCCOC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.3
± 0.4
|
8.9
± 0.3
|
225 |
EN300-249093_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCC5CC(=O)N |
−12.3
± 0.3
|
8.9
± 0.2
|
226 |
EN300-217107_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCC5C(=O)N |
−12.2
± 0.2
|
8.9
± 0.1
|
227 |
EN300-862094_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC5C(=O)N |
−12.2
± 0.3
|
8.9
± 0.2
|
228 |
EN300-1425677_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCCO5)CO |
−12.2
± 0.3
|
8.9
± 0.2
|
229 |
EN300-209316_1
|
|
Cn1c(ncn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.2
± 0.2
|
8.9
± 0.2
|
230 |
EN300-175186_3
|
|
CC(CO)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−12.2
± 0.2
|
8.9
± 0.2
|
231 |
EN300-07879_1
|
|
CSCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−12.2
± 0.2
|
8.9
± 0.2
|
232 |
EN300-263456_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(=O)n(n5)CCF |
−12.2
± 0.3
|
8.9
± 0.2
|
233 |
EN300-651307_1
|
|
CCC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cncn5 |
−12.2
± 0.3
|
8.9
± 0.2
|
234 |
EN300-262204_3
|
|
CS(=O)(=O)CC1(COC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.2
± 0.3
|
8.9
± 0.2
|
235 |
EN300-204935_3
|
|
Cn1ncc(n1)C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.2
± 0.3
|
8.9
± 0.2
|
236 |
EN300-56202_1
|
|
CC(=O)N1CSCC1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.2
± 0.4
|
8.9
± 0.3
|
237 |
EN300-214172_1
|
|
Cn1cnc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.2
± 0.2
|
8.9
± 0.2
|
238 |
EN300-208236_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCc6c5nn[nH]6 |
−12.2
± 0.4
|
8.9
± 0.3
|
239 |
EN300-204133_1
|
|
COC1(CCOCC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.2
± 0.3
|
8.9
± 0.2
|
240 |
EN300-19926_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC#N |
−12.2
± 0.3
|
8.9
± 0.2
|
241 |
EN300-23942_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cccn5 |
−12.2
± 0.2
|
8.9
± 0.2
|
242 |
EN300-245098_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@H]5C(=O)N |
−12.2
± 0.3
|
8.9
± 0.2
|
243 |
EN300-268087_1
|
|
CC(C)(C)n1nc(nn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.2
± 0.3
|
8.9
± 0.2
|
244 |
EN300-254883_1
|
|
Cc1c(non1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.2
± 0.2
|
8.9
± 0.2
|
245 |
EN300-114082_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)C#N |
−12.2
± 0.2
|
8.9
± 0.2
|
246 |
EN300-7540889_1
|
|
COc1ccc(nn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.2
± 0.2
|
8.9
± 0.2
|
247 |
EN300-1589101_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5c[nH]nc5 |
−12.2
± 0.3
|
8.9
± 0.2
|
248 |
VLA-UCB-551c2366-1
|
|
CN(C)c1ccc(cc1)[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.2
± 0.2
|
8.9
± 0.1
|
249 |
EN300-315238_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CC[C@H](O5)C(=O)N |
−12.2
± 0.4
|
8.9
± 0.3
|
250 |
DAR-DIA-5ff57136-13
|
|
C#CCN(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−12.2
± 0.1
|
8.86
± 0.10
|
251 |
EN300-6499531_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCCCS5(=O)=O |
−12.2
± 0.4
|
8.9
± 0.3
|
252 |
EN300-1696962_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCCn5cnnn5 |
−12.2
± 0.3
|
8.9
± 0.2
|
253 |
EN300-2910941_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(nn5)C(F)(F)F |
−12.2
± 0.3
|
8.9
± 0.2
|
254 |
EN300-4293814_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CS(=O)(=O)CCO |
−12.2
± 0.5
|
8.9
± 0.4
|
255 |
EN300-111006_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccncn5 |
−12.1
± 0.2
|
8.9
± 0.1
|
256 |
EN300-174668_1
|
|
COC1(CCOC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.1
± 0.3
|
8.8
± 0.2
|
257 |
EN300-6481287_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCO[C@H]5[C@@H](C[C@H]6[C@@H]5CC6=O)O |
−12.1
± 0.3
|
8.8
± 0.2
|
258 |
EN300-12067_3
|
|
Cc1csc(=O)n1CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.1
± 0.3
|
8.8
± 0.2
|
259 |
EN300-301925_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCCOC5)C#N |
−12.1
± 0.3
|
8.8
± 0.2
|
260 |
EN300-7430501_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCn6c(cnn6)C5 |
−12.1
± 0.2
|
8.8
± 0.1
|
261 |
EN300-783124_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C5CCOC5)F |
−12.1
± 0.2
|
8.8
± 0.1
|
262 |
EN300-7473378_1
|
|
CN1CCC(CC1)(C#N)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.1
± 0.4
|
8.8
± 0.3
|
263 |
EN300-1244816_1
|
|
Cc1nnnn1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.1
± 0.3
|
8.8
± 0.2
|
264 |
EN300-657320_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CSCC(=O)N5 |
−12.1
± 0.3
|
8.8
± 0.2
|
265 |
EN300-11714_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5ccccc5=O |
−12.1
± 0.3
|
8.8
± 0.2
|
266 |
EN300-111863_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cnc(n5)C#N |
−12.1
± 0.2
|
8.8
± 0.2
|
267 |
EN300-140582_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5COCCN5CC(F)F |
−12.1
± 0.3
|
8.8
± 0.2
|
268 |
EN300-373552_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cncc(n5)F |
−12.1
± 0.2
|
8.8
± 0.1
|
269 |
EN300-216978_1
|
|
Cn1nc(nn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.1
± 0.2
|
8.8
± 0.2
|
270 |
EN300-6737762_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCCNC5=O |
−12.1
± 0.3
|
8.8
± 0.2
|
271 |
EN300-94945_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCNC5=O |
−12.1
± 0.2
|
8.8
± 0.1
|
272 |
EN300-322400_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5[C@H](OCCO5)C(F)(F)F |
−12.1
± 0.4
|
8.8
± 0.3
|
273 |
EN300-261210_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCOC5)C#N |
−12.1
± 0.3
|
8.8
± 0.2
|
274 |
EN300-7436306_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5=NO[C@H]6[C@@H]5COC6 |
−12.1
± 0.3
|
8.8
± 0.2
|
275 |
EN300-6763072_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CS(=O)(=O)C56CC(C5)C6 |
−12.1
± 0.3
|
8.8
± 0.2
|
276 |
EN300-28871_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCn5ccnn5 |
−12.1
± 0.2
|
8.8
± 0.1
|
277 |
EN300-7456948_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cccnn5 |
−12.1
± 0.2
|
8.8
± 0.2
|
278 |
EN300-310173_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@H](CCO5)Cn6ccnc6 |
−12.1
± 0.4
|
8.8
± 0.3
|
279 |
EN300-307008_2
|
|
CN1C(CNC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.1
± 0.2
|
8.8
± 0.2
|
280 |
EN300-04433_4
|
|
CSCCC(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−12.1
± 0.4
|
8.8
± 0.3
|
281 |
EN300-75482_1
|
|
Cc1c(c(n(n1)C)OC)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.1
± 0.3
|
8.8
± 0.2
|
282 |
EN300-92664_1
|
|
COCCn1c(ccn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.1
± 0.3
|
8.8
± 0.2
|
283 |
EDJ-MED-28ec730d-5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCc5c[nH]nc5 |
−12.1
± 0.2
|
8.8
± 0.2
|
284 |
EN300-754584_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CS(=O)(=O)CC(=O)N5 |
−12.1
± 0.2
|
8.8
± 0.2
|
285 |
EN300-25446_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnco5 |
−12.1
± 0.2
|
8.8
± 0.1
|
286 |
VLA-UCB-34f3ed0c-8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)C(=O)CCc5cc[nH]n5 |
−12.1
± 0.2
|
8.8
± 0.2
|
287 |
EN300-300217_1
|
|
CC=CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−12.1
± 0.2
|
8.8
± 0.1
|
288 |
EN300-6494474_3
|
|
Cn1cnnc1CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.1
± 0.3
|
8.8
± 0.2
|
289 |
EN300-1726073_1
|
|
Cn1c(cnn1)C(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(F)F |
−12.1
± 0.3
|
8.8
± 0.2
|
290 |
EN300-6505003_1
|
|
CC1CCC(C(=O)N1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.2
|
8.8
± 0.1
|
291 |
EN300-69107_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(=O)NCC5 |
−12.0
± 0.3
|
8.8
± 0.2
|
292 |
EN300-246440_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)n6cncn6 |
−12.0
± 0.3
|
8.8
± 0.2
|
293 |
EN300-97847_1
|
|
Cn1cc(nc1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.2
|
8.8
± 0.2
|
294 |
EN300-306316_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5[nH]cnn5 |
−12.0
± 0.2
|
8.8
± 0.2
|
295 |
EN300-18249_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N |
−12.0
± 0.2
|
8.8
± 0.1
|
296 |
EN300-311920_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCS(=O)(=O)C5)F |
−12.0
± 0.3
|
8.8
± 0.2
|
297 |
EN300-98648_3
|
|
CN1CCC(C1=O)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.2
|
8.8
± 0.1
|
298 |
EN300-171522_1
|
|
Cn1ccc(=O)c(c1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.3
|
8.8
± 0.2
|
299 |
EN300-246440_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)n6cncn6 |
−12.0
± 0.3
|
8.8
± 0.2
|
300 |
EN300-749499_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C5(CCOCC5)O)O |
−12.0
± 0.3
|
8.8
± 0.2
|