Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
2001 |
EN300-124973_1
|
|
Cc1cc(=O)n2c(n1)N(CC2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.4
± 0.3
|
7.6
± 0.2
|
2002 |
EN300-736753_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@H]5CCC(=O)N5 |
−10.4
± 0.2
|
7.6
± 0.2
|
2003 |
EN300-70487_2
|
|
Cc1[nH]c(nn1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2004 |
EN300-7500524_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H]6[C@@H](C5)COC(=O)N6 |
−10.4
± 0.4
|
7.6
± 0.3
|
2005 |
EN300-1707870_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)(CCO)CO |
−10.4
± 0.4
|
7.6
± 0.3
|
2006 |
EN300-367383_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@]56C[C@H]5COC6 |
−10.4
± 0.3
|
7.6
± 0.2
|
2007 |
EN300-152913_3
|
|
CN(C)c1nc(on1)CCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2008 |
EN300-218288_1
|
|
Cn1c(c(nn1)Br)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.2
|
7.6
± 0.2
|
2009 |
EN300-246178_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnn(c5)CC(CO)O |
−10.4
± 0.5
|
7.6
± 0.3
|
2010 |
EN300-87528_3
|
|
CC(C)[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−10.4
± 0.4
|
7.6
± 0.3
|
2011 |
EN300-182124_1
|
|
COC1(CC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.2
|
7.6
± 0.2
|
2012 |
EN300-135530_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccnc5C(=O)N |
−10.4
± 0.3
|
7.6
± 0.2
|
2013 |
EN300-247343_2
|
|
CC1(CC(C1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.4
± 0.3
|
7.6
± 0.2
|
2014 |
EN300-97904_3
|
|
CS(=O)(=O)CC1(CC1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.4
|
7.6
± 0.3
|
2015 |
EN300-216673_1
|
|
Cn1c(cnn1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.2
|
7.6
± 0.2
|
2016 |
EN300-183231_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCc5[nH]nnn5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2017 |
EN300-196140_1
|
|
CC1(CCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)NC |
−10.4
± 0.3
|
7.6
± 0.2
|
2018 |
EN300-6762563_1
|
|
Cn1cc(cn1)OC2CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.4
± 0.4
|
7.6
± 0.3
|
2019 |
EN300-107892_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cc(nn5)C6CC6 |
−10.4
± 0.3
|
7.6
± 0.2
|
2020 |
EN300-130825_3
|
|
CN1[C@@H](CCC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2021 |
EN300-2008240_1
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)NC(=O)[C@H]5C[C@@H](C5)n6nncc6)cc1 |
−10.4
± 0.2
|
7.6
± 0.2
|
2022 |
EN300-181688_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6n(n5)CCO6 |
−10.4
± 0.2
|
7.6
± 0.2
|
2023 |
EN300-67073_1
|
|
CC(=O)NC(C)(C1CC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2024 |
EN300-244403_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CNC(=O)O5 |
−10.4
± 0.2
|
7.6
± 0.2
|
2025 |
JAG-UCB-706446eb-8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)Cc5cccc(c5)CN |
−10.4
± 0.3
|
7.6
± 0.2
|
2026 |
EN300-6504714_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6[C@H]([C@H]5CO6)O |
−10.4
± 0.3
|
7.6
± 0.2
|
2027 |
EN300-74965_1
|
|
Cc1c2c(=O)cc([nH]c2n(n1)C)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.4
± 0.3
|
7.6
± 0.2
|
2028 |
EN300-261986_3
|
|
CS(=O)(=O)N1CCC(C1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2029 |
EN300-19342_1
|
|
CN(CCO)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.3
|
7.6
± 0.2
|
2030 |
EN300-264184_1
|
|
CCn1c(c[nH]c1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2031 |
EN300-37195_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NC5CCCCNC5=O |
−10.4
± 0.3
|
7.6
± 0.2
|
2032 |
ADA-UCB-dc2b944c-16
|
|
CC1(C[C@H](c2cc(ccc2O1)Cl)C(=O)Nc3cncc4c3cccc4)C |
−10.4
± 0.1
|
7.60
± 0.07
|
2033 |
EN300-1703852_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C[C@H]5COC(=O)N5 |
−10.4
± 0.2
|
7.6
± 0.2
|
2034 |
EN300-80241_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC(C5)Cn6cncn6 |
−10.4
± 0.4
|
7.6
± 0.3
|
2035 |
EN300-1659582_1
|
|
C#CCNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.1
|
7.60
± 0.10
|
2036 |
EN300-201553_1
|
|
Cn1cc(cn1)OCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.2
|
7.6
± 0.1
|
2037 |
EN300-68203_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CCC(=O)N5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2038 |
EN300-1262640_4
|
|
CC(C)NC(=O)C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.3
|
7.6
± 0.2
|
2039 |
EN300-741926_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C(C5)F)O |
−10.4
± 0.2
|
7.6
± 0.1
|
2040 |
EN300-1703718_1
|
|
CC(=O)N1C[C@@H](C[C@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.4
± 0.4
|
7.6
± 0.3
|
2041 |
EN300-72896_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCC(=O)N5 |
−10.4
± 0.2
|
7.6
± 0.1
|
2042 |
EN300-197715_4
|
|
Cc1nnnn1CCCOCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.4
|
7.6
± 0.3
|
2043 |
EN300-02067_1
|
|
CC(COC)NC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.2
|
7.6
± 0.2
|
2044 |
EN300-299532_3
|
|
CC(C)(C(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−10.4
± 0.3
|
7.6
± 0.2
|
2045 |
EN300-55250_4
|
|
COCCOCCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.4
|
7.6
± 0.3
|
2046 |
EN300-314890_1
|
|
CN(C)C(=O)[C@@H]1CC[C@@H](O1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2047 |
EN300-10397_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CNC(=O)N |
−10.4
± 0.2
|
7.6
± 0.2
|
2048 |
EN300-206282_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)C#N |
−10.4
± 0.2
|
7.6
± 0.2
|
2049 |
EN300-300217_2
|
|
CC=CC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.4
± 0.2
|
7.6
± 0.1
|
2050 |
EN300-118045_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnc([nH]c5=O)C6CC6 |
−10.4
± 0.3
|
7.6
± 0.3
|
2051 |
EN300-185751_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5cncnc5 |
−10.4
± 0.2
|
7.6
± 0.1
|
2052 |
EN300-34636_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc(=O)[nH]5 |
−10.4
± 0.2
|
7.6
± 0.2
|
2053 |
EN300-43206_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCCS5(=O)=O |
−10.4
± 0.3
|
7.6
± 0.2
|
2054 |
EN300-1644723_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5C6C5COCC6 |
−10.4
± 0.2
|
7.6
± 0.2
|
2055 |
EN300-217494_4
|
|
CC(C1CCOC1)(C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.4
± 0.3
|
7.6
± 0.2
|
2056 |
EN300-1915260_1
|
|
COCC(CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.4
± 0.3
|
7.6
± 0.2
|
2057 |
EN300-1716006_1
|
|
CN(Cc1[nH]c(=O)[nH]n1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2058 |
EN300-393334_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC(C5)CC(=O)N |
−10.4
± 0.3
|
7.6
± 0.3
|
2059 |
EN300-317272_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CC6CCOC6 |
−10.4
± 0.2
|
7.6
± 0.2
|
2060 |
EN300-344121_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H]5CCC[C@H]5O |
−10.4
± 0.3
|
7.6
± 0.2
|
2061 |
EN300-141224_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCn6c(ncn6)C5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2062 |
EN300-7436306_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5=NO[C@H]6[C@@H]5COC6 |
−10.4
± 0.3
|
7.6
± 0.2
|
2063 |
EN300-132963_3
|
|
CN1C(CCC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.2
|
7.6
± 0.2
|
2064 |
EN300-82179_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC(=O)N |
−10.4
± 0.3
|
7.6
± 0.2
|
2065 |
EN300-87334_3
|
|
Cn1c(ncn1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2066 |
EN300-1718675_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cnnn5C6CC6 |
−10.4
± 0.3
|
7.6
± 0.2
|
2067 |
EN300-31186_4
|
|
CCC(=O)NCCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.3
|
7.6
± 0.2
|
2068 |
EN300-261596_2
|
|
C=CCn1cc(nn1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2069 |
EN300-761618_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)Nc5cccnn5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2070 |
EN300-6953121_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5C[C@H]5F |
−10.4
± 0.2
|
7.6
± 0.1
|
2071 |
EN300-6479181_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCC6N5C(=O)CC6 |
−10.4
± 0.2
|
7.6
± 0.2
|
2072 |
EN300-31970_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5ccc(cc5)n6cnnn6 |
−10.4
± 0.3
|
7.6
± 0.2
|
2073 |
EN300-52768_1
|
|
CCCS(=O)(=O)C(C)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.4
|
7.6
± 0.3
|
2074 |
EN300-7538678_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(=O)n6c5COCC6 |
−10.4
± 0.3
|
7.6
± 0.2
|
2075 |
EN300-66770_3
|
|
CNC(=O)C1(CC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2076 |
EN300-20375_4
|
|
COCCOCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.3
|
7.6
± 0.2
|
2077 |
EN300-2972220_2
|
|
CC(C)[C@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−10.4
± 0.3
|
7.6
± 0.2
|
2078 |
EN300-195756_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5CCC(=O)N5 |
−10.4
± 0.2
|
7.6
± 0.1
|
2079 |
EN300-143449_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCCN(=O)=O |
−10.4
± 0.3
|
7.6
± 0.2
|
2080 |
EN300-359750_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCC(=O)O5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2081 |
EN300-316216_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCn5cncn5 |
−10.4
± 0.2
|
7.6
± 0.2
|
2082 |
EN300-366974_1
|
|
CN(CCS(=O)(=O)N)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.3
|
7.6
± 0.2
|
2083 |
EN300-120282_4
|
|
Cn1cc(nn1)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2084 |
EN300-95094_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CSC5 |
−10.4
± 0.2
|
7.6
± 0.2
|
2085 |
EN300-1241327_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)N5CCOCC5 |
−10.4
± 0.2
|
7.6
± 0.2
|
2086 |
EN300-09239_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccc(c5)n6cnnn6 |
−10.4
± 0.3
|
7.6
± 0.2
|
2087 |
EN300-96175_3
|
|
CC(C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N5CCOC5=O |
−10.4
± 0.6
|
7.6
± 0.4
|
2088 |
EN300-71558_1
|
|
COC(=O)NCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.2
|
7.6
± 0.2
|
2089 |
EN300-154912_1
|
|
COc1nccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.2
|
7.6
± 0.2
|
2090 |
EN300-1072199_2
|
|
COC1(CCCOC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2091 |
EN300-45049_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCS(=O)(=O)N5 |
−10.4
± 0.2
|
7.6
± 0.1
|
2092 |
EN300-35450_1
|
|
CC(C)N(CC(=O)N)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.2
|
7.6
± 0.2
|
2093 |
EN300-310888_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5nnc6n5CCOCC6 |
−10.4
± 0.2
|
7.6
± 0.2
|
2094 |
EN300-7438088_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@@H]6CS(=O)(=O)C[C@@H]6C5 |
−10.4
± 0.4
|
7.6
± 0.3
|
2095 |
EN300-384241_1
|
|
Cc1[nH]c(nn1)C2CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.4
± 0.3
|
7.6
± 0.2
|
2096 |
DAR-DIA-5ff57136-14
|
|
CC(C)(C#C)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−10.4
± 0.2
|
7.6
± 0.1
|
2097 |
EN300-1709295_1
|
|
Cc1cnc(cn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
2098 |
EN300-7423123_3
|
|
Cc1nc(n(n1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−10.4
± 0.4
|
7.6
± 0.3
|
2099 |
EN300-71560_3
|
|
COC(=O)NCCCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.3
|
7.6
± 0.2
|
2100 |
EN300-39504_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCS(=O)(=O)N |
−10.4
± 0.4
|
7.6
± 0.3
|