Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
1901 |
EN300-124376_1
|
|
CN(C[C@@H](CO)O)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.5
|
7.7
± 0.3
|
1902 |
EN300-1704723_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CCCF |
−10.5
± 0.3
|
7.7
± 0.2
|
1903 |
EN300-227055_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CC(=O)NC5=O |
−10.5
± 0.2
|
7.7
± 0.1
|
1904 |
EN300-155362_1
|
|
CC1CC(=O)NC1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.2
|
7.7
± 0.1
|
1905 |
EN300-187060_1
|
|
Cn1nc(nn1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1906 |
EN300-42591_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CNC(=O)NC5CC5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1907 |
EN300-7461217_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5C[C@H]([C@@H](C5)F)O |
−10.5
± 0.2
|
7.7
± 0.2
|
1908 |
EN300-13668_2
|
|
CN(CC(=O)NC1CC1)C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1909 |
EN300-184446_1
|
|
Cc1ccn(c(=O)c1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1910 |
EN300-372748_2
|
|
C[C@H]1C(=O)NCCCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1911 |
EN300-213358_1
|
|
Cn1c(ncn1)COCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.7
± 0.3
|
1912 |
EN300-318344_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ncco5 |
−10.5
± 0.1
|
7.7
± 0.1
|
1913 |
EN300-255496_3
|
|
CN1CCC(S1(=O)=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1914 |
EN300-59386_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(s5)S(=O)(=O)N |
−10.5
± 0.3
|
7.6
± 0.2
|
1915 |
EN300-70064_3
|
|
CNC(=O)C1(CCC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.4
|
7.6
± 0.3
|
1916 |
EN300-128464_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC(=O)NC5CC5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1917 |
EN300-6477724_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@@H]5c6[nH]cnn6 |
−10.5
± 0.3
|
7.6
± 0.2
|
1918 |
EN300-71405_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5ccn[nH]5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1919 |
EN300-250126_3
|
|
CC(C)CC(C(=O)N)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.3
|
7.6
± 0.2
|
1920 |
EN300-104746_3
|
|
CCC(C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.5
± 0.2
|
7.6
± 0.2
|
1921 |
EN300-305282_3
|
|
COCC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−10.5
± 0.4
|
7.6
± 0.3
|
1922 |
EN300-6489696_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(Cc6ccn[nH]6)O |
−10.5
± 0.4
|
7.6
± 0.3
|
1923 |
EN300-7439043_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5cc(n[nH]5)CO |
−10.5
± 0.2
|
7.6
± 0.2
|
1924 |
EN300-18564_4
|
|
CC(=O)NCCCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.3
|
7.6
± 0.2
|
1925 |
EN300-366050_1
|
|
CCC(Cn1cc(nn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.5
± 0.2
|
7.6
± 0.1
|
1926 |
EN300-119126_1
|
|
Cc1[nH]c(nn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.2
|
7.6
± 0.2
|
1927 |
EN300-6493892_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCCc5c[nH]nn5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1928 |
EN300-2008120_1
|
|
C[C@H]1[C@H](CCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.5
± 0.2
|
7.6
± 0.2
|
1929 |
EN300-84476_1
|
|
C[C@@H](CNC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.5
± 0.3
|
7.6
± 0.2
|
1930 |
EN300-259847_1
|
|
COC1CCCCN(C1=O)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1931 |
EN300-10729_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCNC(=O)N |
−10.5
± 0.3
|
7.6
± 0.2
|
1932 |
EN300-128277_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(=O)NCC(F)F |
−10.5
± 0.3
|
7.6
± 0.2
|
1933 |
EN300-263153_2
|
|
Cn1cc(nn1)C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1934 |
EN300-179091_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COC(F)F |
−10.5
± 0.2
|
7.6
± 0.2
|
1935 |
EN300-20980_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5cnnn5 |
−10.5
± 0.2
|
7.6
± 0.2
|
1936 |
EN300-111159_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(cc(=O)[nH]n5)O |
−10.5
± 0.2
|
7.6
± 0.2
|
1937 |
EN300-19700_2
|
|
COC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.1
|
7.64
± 0.08
|
1938 |
EN300-378276_1
|
|
Cc1cn2c(cc(n2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)c(=O)[nH]1 |
−10.5
± 0.3
|
7.6
± 0.2
|
1939 |
EN300-704025_1
|
|
COC1(CS(=O)(=O)C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1940 |
EN300-41473_1
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N5CCOCC5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1941 |
EN300-77265_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5cc(=O)c(co5)O |
−10.5
± 0.3
|
7.6
± 0.3
|
1942 |
EN300-142412_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCCC(=O)N |
−10.5
± 0.3
|
7.6
± 0.2
|
1943 |
EN300-1241327_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N5CCOCC5 |
−10.5
± 0.2
|
7.6
± 0.2
|
1944 |
EN300-4293814_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CS(=O)(=O)CCO |
−10.5
± 0.6
|
7.6
± 0.4
|
1945 |
EN300-96797_1
|
|
CC1CN(CC(=O)N1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.2
|
7.6
± 0.1
|
1946 |
EN300-35789_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cccnc5=O |
−10.5
± 0.3
|
7.6
± 0.2
|
1947 |
EN300-378722_1
|
|
CN1CCC(C1=O)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1948 |
EN300-1706036_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5C(=O)NCCO5 |
−10.5
± 0.2
|
7.6
± 0.2
|
1949 |
EN300-21009_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCO5 |
−10.5
± 0.2
|
7.6
± 0.1
|
1950 |
EN300-42243_3
|
|
CC(C)CS(=O)(=O)CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.5
|
7.6
± 0.3
|
1951 |
EN300-1253178_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NC5CC5 |
−10.5
± 0.2
|
7.6
± 0.1
|
1952 |
EN300-38979_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5ccnc5 |
−10.5
± 0.2
|
7.6
± 0.2
|
1953 |
EN300-321459_1
|
|
CN(C(=O)C[C@@]1(c2c(ccc(c2)Cl)OCC1)C(=O)Nc3c4c(cnc3)cccc4)[C@H]5C[C@H](C5)C(=O)N |
−10.5
± 0.3
|
7.6
± 0.2
|
1954 |
EN300-6481287_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CO[C@H]5[C@@H](C[C@H]6[C@@H]5CC6=O)O |
−10.5
± 0.2
|
7.6
± 0.2
|
1955 |
EN300-97758_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCF |
−10.5
± 0.2
|
7.6
± 0.2
|
1956 |
EN300-1654957_2
|
|
CN(CC(CO)CO)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.3
|
7.6
± 0.2
|
1957 |
EN300-7436306_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5=NO[C@H]6[C@@H]5COC6 |
−10.5
± 0.2
|
7.6
± 0.2
|
1958 |
EN300-18249_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)N |
−10.5
± 0.2
|
7.6
± 0.1
|
1959 |
EN300-6499639_3
|
|
Cc1cc(n(n1)C)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.2
|
7.6
± 0.2
|
1960 |
EN300-6762327_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(Cc5ccccn5)O |
−10.5
± 0.2
|
7.6
± 0.2
|
1961 |
EN300-83864_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCC(CC5)S(=O)(=O)N |
−10.5
± 0.3
|
7.6
± 0.3
|
1962 |
EN300-297561_2
|
|
CC(C)C(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnnn5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1963 |
EN300-1698981_1
|
|
Cc1nc(on1)C(CO)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.4
|
7.6
± 0.3
|
1964 |
EN300-1667084_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@H](C5)C(=O)N |
−10.5
± 0.4
|
7.6
± 0.3
|
1965 |
EN300-26147_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5cncn5 |
−10.5
± 0.2
|
7.6
± 0.2
|
1966 |
EN300-4726186_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCNS5(=O)=O |
−10.5
± 0.6
|
7.6
± 0.4
|
1967 |
EN300-36855_1
|
|
CN(CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)c5cnccn5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1968 |
EN300-30419_3
|
|
CS(=O)(=O)NCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.3
|
7.6
± 0.2
|
1969 |
EN300-31553_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCS(=O)(=O)N |
−10.5
± 0.4
|
7.6
± 0.3
|
1970 |
EN300-244909_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCOCC5)CO |
−10.5
± 0.4
|
7.6
± 0.3
|
1971 |
EN300-92031_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5nc(no5)c6[nH]cnn6 |
−10.5
± 0.3
|
7.6
± 0.2
|
1972 |
EN300-69588_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCS(=O)CC5 |
−10.5
± 0.4
|
7.6
± 0.3
|
1973 |
EN300-52382_2
|
|
CN(C)C(=O)Cn1cc(nn1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1974 |
EN300-65839_4
|
|
CCC(C(=O)N)OCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.3
|
7.6
± 0.2
|
1975 |
EN300-305567_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccn6c(c5)nnn6 |
−10.5
± 0.3
|
7.6
± 0.2
|
1976 |
EN300-128750_3
|
|
CC(=O)N(C)CCCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.3
|
7.6
± 0.2
|
1977 |
EN300-33478_3
|
|
CCN1CC(CC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1978 |
EN300-1425677_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCCO5)CO |
−10.5
± 0.3
|
7.6
± 0.2
|
1979 |
EN300-6474220_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(CCn5ccnn5)(F)F |
−10.5
± 0.3
|
7.6
± 0.2
|
1980 |
EN300-52383_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)Cn5cncn5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1981 |
EN300-186943_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCOCC5=O |
−10.5
± 0.3
|
7.6
± 0.2
|
1982 |
EN300-1627945_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)COC5CCCOC5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1983 |
EN300-1915260_3
|
|
COCC(COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.5
± 0.3
|
7.6
± 0.2
|
1984 |
EN300-172870_2
|
|
COc1cncc(n1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1985 |
EN300-122866_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCSCC5C(=O)N |
−10.5
± 0.4
|
7.6
± 0.3
|
1986 |
EN300-249764_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(C5CCC5)O |
−10.5
± 0.2
|
7.6
± 0.2
|
1987 |
EN300-65063_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCN(CC5)C(=O)N |
−10.5
± 0.3
|
7.6
± 0.2
|
1988 |
EN300-1988306_4
|
|
CS(=O)(=O)CCC(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.4
|
7.6
± 0.3
|
1989 |
EN300-28177_2
|
|
CC(C(=O)N1CCCC(C1)C(=O)N)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.2
|
7.6
± 0.2
|
1990 |
EN300-92790_2
|
|
Cn1ccc(n1)CCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1991 |
EN300-1265948_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)N5CCS(=O)(=O)CC5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1992 |
EN300-6082676_1
|
|
CC1CC(CCS1(=O)=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.2
|
7.6
± 0.1
|
1993 |
EN300-6477207_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6COCC(C5)NC6=O |
−10.5
± 0.3
|
7.6
± 0.2
|
1994 |
EN300-46832_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCC5CCOC5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1995 |
EN300-246333_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@@H]6[C@H](C5)C(=O)NC6=O |
−10.5
± 0.4
|
7.6
± 0.3
|
1996 |
EN300-1587757_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCNS5(=O)=O |
−10.5
± 0.3
|
7.6
± 0.2
|
1997 |
EN300-22879_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCCCC5C(=O)N |
−10.5
± 0.3
|
7.6
± 0.2
|
1998 |
EN300-226889_1
|
|
Cn1cc([nH]c1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.2
|
7.6
± 0.2
|
1999 |
EN300-05512_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NC5CCS(=O)(=O)C5 |
−10.5
± 0.4
|
7.6
± 0.3
|
2000 |
EN300-1296824_1
|
|
CC(CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(COC)O |
−10.5
± 0.3
|
7.6
± 0.2
|