Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
1801 |
EN300-116313_3
|
|
CC(=O)N1CCOCC1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1802 |
EN300-174603_1
|
|
CN(C(=O)CCO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−10.6
± 0.2
|
7.7
± 0.2
|
1803 |
EN300-223741_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)S(=O)(=O)N |
−10.6
± 0.3
|
7.7
± 0.2
|
1804 |
EN300-188356_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCOC5)F |
−10.6
± 0.2
|
7.7
± 0.2
|
1805 |
EN300-139268_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(=O)NCC(F)(F)F |
−10.6
± 0.2
|
7.7
± 0.2
|
1806 |
EN300-100916_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cn5nccn5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1807 |
EN300-77006_4
|
|
Cc1nc(on1)COCC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1808 |
EN300-259849_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCCC(C5=O)O |
−10.6
± 0.3
|
7.7
± 0.2
|
1809 |
EN300-96886_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H](C[C@@H](C5)O)O |
−10.6
± 0.3
|
7.7
± 0.2
|
1810 |
EN300-12440_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CC(=O)N(C5)C6CC6 |
−10.6
± 0.4
|
7.7
± 0.3
|
1811 |
EN300-94643_1
|
|
CC(C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N5CCN(CC5)C |
−10.6
± 0.4
|
7.7
± 0.3
|
1812 |
EN300-53423_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCOC5 |
−10.6
± 0.2
|
7.7
± 0.2
|
1813 |
EN300-118760_1
|
|
CC(C1CC1)(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.6
± 0.2
|
7.7
± 0.2
|
1814 |
EN300-69556_3
|
|
Cc1ccc(=O)n(n1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.5
|
7.7
± 0.4
|
1815 |
EN300-31998_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5c[nH]nn5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1816 |
EN300-7465222_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@@H]5C[C@H]5N(=O)=O |
−10.6
± 0.2
|
7.7
± 0.2
|
1817 |
EN300-266117_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC[C@H](C5)O |
−10.6
± 0.3
|
7.7
± 0.2
|
1818 |
EN300-219020_4
|
|
Cn1ncc(n1)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.2
|
7.7
± 0.2
|
1819 |
EN300-23317_3
|
|
CC(C(=O)NCCOC)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.3
|
7.7
± 0.2
|
1820 |
EN300-55072_2
|
|
CC(CO)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.3
|
7.7
± 0.2
|
1821 |
EN300-07936_1
|
|
CCN(CC(=O)NC(C)C)C(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.4
|
7.7
± 0.3
|
1822 |
EN300-154942_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5OCCO5 |
−10.6
± 0.2
|
7.7
± 0.2
|
1823 |
EN300-120119_2
|
|
CN(C1CCNC1=O)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.2
|
7.7
± 0.2
|
1824 |
EN300-123489_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CO)(F)F |
−10.6
± 0.2
|
7.7
± 0.1
|
1825 |
EN300-6478432_1
|
|
Cn1c(nn(c1=O)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C6CC6 |
−10.6
± 0.4
|
7.7
± 0.3
|
1826 |
EN300-79588_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCCS(=O)(=O)N |
−10.6
± 0.2
|
7.7
± 0.2
|
1827 |
EN300-395719_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCO[C@H]6COC[C@H]6C5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1828 |
EN300-1709315_1
|
|
CC1(CCCNS1(=O)=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1829 |
EN300-143449_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCN(=O)=O |
−10.6
± 0.4
|
7.7
± 0.3
|
1830 |
EN300-67023_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CS(=O)(=O)CC5CCCO5 |
−10.6
± 0.4
|
7.7
± 0.3
|
1831 |
EN300-216063_2
|
|
CN(C)C(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.1
|
7.7
± 0.1
|
1832 |
EN300-97758_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCF |
−10.6
± 0.3
|
7.7
± 0.2
|
1833 |
EN300-14437_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCS(=O)(=O)C5 |
−10.6
± 0.2
|
7.7
± 0.2
|
1834 |
EN300-7089802_1
|
|
C[C@@H]([C@@H](C)O)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.3
|
7.7
± 0.2
|
1835 |
EN300-47657_1
|
|
CC(C(=O)N(C)C)NC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.3
|
7.7
± 0.2
|
1836 |
EN300-267855_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN6C[C@@H](C[C@H]6C5)O |
−10.6
± 0.3
|
7.7
± 0.2
|
1837 |
EN300-244403_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CNC(=O)O5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1838 |
EN300-1588613_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCN6C5COCC6 |
−10.6
± 0.2
|
7.7
± 0.2
|
1839 |
EN300-305996_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5COC(=O)N5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1840 |
EN300-6503702_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C56CCC(C5)S(=O)(=O)CC6 |
−10.6
± 0.3
|
7.7
± 0.2
|
1841 |
EN300-205680_2
|
|
CN(C)CC1(CC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.4
|
7.7
± 0.3
|
1842 |
EN300-78121_1
|
|
CS(=O)(=O)c1cnn(c1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1843 |
EN300-217107_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCC5C(=O)N |
−10.5
± 0.2
|
7.7
± 0.1
|
1844 |
EN300-206769_1
|
|
CS(=O)(=O)c1ccc(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1845 |
EN300-6759512_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)[C@@H]6COC[C@@H]6F |
−10.5
± 0.3
|
7.7
± 0.2
|
1846 |
EN300-7433864_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c[nH]c(=O)n(c5=O)C6CC6 |
−10.5
± 0.6
|
7.7
± 0.4
|
1847 |
EN300-187385_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCc5ccc(=O)[nH]c5 |
−10.5
± 0.4
|
7.7
± 0.3
|
1848 |
EN300-761220_4
|
|
CC(=O)N1CSC[C@@H]1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.4
|
7.7
± 0.3
|
1849 |
EN300-247497_1
|
|
CO[C@H]1C[C@H](N(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−10.5
± 0.3
|
7.7
± 0.2
|
1850 |
EN300-73772_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5[nH]c(=O)[nH]n5 |
−10.5
± 0.2
|
7.7
± 0.2
|
1851 |
DAR-DIA-0d514e7d-30
|
|
C[C@@]1(c2cc(ccc2OCC1(C)C)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.2
|
7.7
± 0.1
|
1852 |
EN300-226314_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)C5CCS(=O)(=O)C5 |
−10.5
± 0.2
|
7.7
± 0.2
|
1853 |
EN300-1600786_2
|
|
Cn1cc(nn1)CCOC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.2
|
7.7
± 0.2
|
1854 |
EN300-1715993_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCn5ccnn5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1855 |
EN300-14752_3
|
|
CC(=O)N1CCCC(C1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1856 |
EN300-51071_1
|
|
CC(C)(C)NS(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.3
|
7.7
± 0.2
|
1857 |
EN300-263669_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@]56C[C@H]5COC6 |
−10.5
± 0.3
|
7.7
± 0.2
|
1858 |
EN300-217494_2
|
|
CC(C1CCOC1)(C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.5
± 0.2
|
7.7
± 0.2
|
1859 |
EN300-198540_3
|
|
Cn1cc(cn1)C(C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.5
± 0.4
|
7.7
± 0.3
|
1860 |
EN300-332606_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CCC(=O)O5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1861 |
EN300-1273362_1
|
|
CC1(CN(C1=O)C)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1862 |
EN300-117931_1
|
|
CC(C)(CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.5
± 0.2
|
7.7
± 0.2
|
1863 |
EN300-1253122_1
|
|
CCN(C)C(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.2
|
7.7
± 0.1
|
1864 |
DAR-DIA-6a508060-5
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4CC5CC(=O)N5)Cl |
−10.5
± 0.1
|
7.7
± 0.1
|
1865 |
EN300-48886_1
|
|
CC(=O)NC1CCCN(C1)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1866 |
EN300-156995_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCCc5c[nH]nn5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1867 |
EN300-14458_2
|
|
CC(C(=O)N(C)C)OC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.2
|
7.7
± 0.2
|
1868 |
EN300-114805_3
|
|
Cn1c(ccn1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1869 |
EN300-195790_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H](CCO)CO |
−10.5
± 0.3
|
7.7
± 0.2
|
1870 |
EN300-19542_1
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.5
± 0.2
|
7.7
± 0.1
|
1871 |
EN300-82616_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCNC5=O |
−10.5
± 0.3
|
7.7
± 0.2
|
1872 |
EN300-105267_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)Nc5cnccn5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1873 |
EN300-7353672_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C(CC5)O)CO |
−10.5
± 0.3
|
7.7
± 0.2
|
1874 |
EN300-64193_1
|
|
Cc1nnc(o1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.2
|
7.7
± 0.2
|
1875 |
EN300-159633_1
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C(F)(F)F)O |
−10.5
± 0.3
|
7.7
± 0.2
|
1876 |
EN300-1654606_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@@H]5F |
−10.5
± 0.1
|
7.7
± 0.1
|
1877 |
EN300-16216_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(=O)N |
−10.5
± 0.2
|
7.7
± 0.2
|
1878 |
EN300-124301_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCn5ccnn5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1879 |
EN300-68635_1
|
|
CCNC(=O)CCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.3
|
7.7
± 0.2
|
1880 |
EN300-00271_1
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−10.5
± 0.2
|
7.7
± 0.1
|
1881 |
EN300-7439980_1
|
|
CC[C@@H]1C[C@@H](CC(=O)N1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1882 |
EN300-17184_4
|
|
C=CCNC(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.3
|
7.7
± 0.2
|
1883 |
EN300-51350_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCc6nncn6C5 |
−10.5
± 0.2
|
7.7
± 0.2
|
1884 |
EN300-244947_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCc5c[nH]nn5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1885 |
EN300-220527_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5[nH]ccn5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1886 |
EN300-260696_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC(C5n6cccn6)O |
−10.5
± 0.2
|
7.7
± 0.1
|
1887 |
EN300-318058_1
|
|
C[C@@]1(CN(C[C@@]1(C)CO)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−10.5
± 0.3
|
7.7
± 0.2
|
1888 |
EN300-210084_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5CCCC(=O)N5 |
−10.5
± 0.2
|
7.7
± 0.2
|
1889 |
EN300-66432_1
|
|
CN(C)S(=O)(=O)CCCO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.3
|
7.7
± 0.2
|
1890 |
EN300-7456499_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCS(=O)(=O)CCCO |
−10.5
± 0.4
|
7.7
± 0.3
|
1891 |
EN300-6489289_3
|
|
Cc1nnc2n1C(CC2)C(=O)NCC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.5
± 0.3
|
7.7
± 0.2
|
1892 |
EN300-183231_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCc5[nH]nnn5 |
−10.5
± 0.6
|
7.7
± 0.4
|
1893 |
EN300-04409_1
|
|
COC(=O)CNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.3
|
7.7
± 0.2
|
1894 |
EN300-299390_2
|
|
COCc1[nH]c(nn1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.2
|
7.7
± 0.2
|
1895 |
EN300-216673_4
|
|
Cn1c(cnn1)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1896 |
EN300-754584_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CS(=O)(=O)CC(=O)N5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1897 |
EN300-302290_1
|
|
CS(=O)(=O)N1CC(C1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1898 |
EN300-25386_3
|
|
Cn1c(cc(=O)n(c1=O)C)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.7
± 0.2
|
1899 |
EN300-121144_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5ccccc5C(=O)N |
−10.5
± 0.4
|
7.7
± 0.3
|
1900 |
EN300-72730_1
|
|
CC(C#N)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.1
|
7.7
± 0.1
|