Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
1501 |
EN300-107048_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5(CC5)CO |
−10.8
± 0.3
|
7.8
± 0.2
|
1502 |
EN300-39476_1
|
|
Cc1c(cn(n1)CCO)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.4
|
7.8
± 0.3
|
1503 |
EN300-1452069_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CC5CCOCC5)O |
−10.8
± 0.2
|
7.8
± 0.2
|
1504 |
EN300-133058_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc6c(n5)n[nH]n6 |
−10.8
± 0.3
|
7.8
± 0.2
|
1505 |
EN300-52589_1
|
|
Cn1c(nc2c1c(=O)[nH]c(=O)n2C)CO[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.8
± 0.3
|
7.8
± 0.3
|
1506 |
EN300-378316_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5nnc6n5cc[nH]c6=O |
−10.8
± 0.3
|
7.8
± 0.2
|
1507 |
EN300-1440321_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CCC5)S(=O)(=O)N |
−10.7
± 0.5
|
7.8
± 0.3
|
1508 |
EN300-52009_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCC5)O |
−10.7
± 0.3
|
7.8
± 0.2
|
1509 |
EDJ-MED-28ec730d-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5c[nH]nc5 |
−10.7
± 0.2
|
7.8
± 0.2
|
1510 |
EN300-25866_1
|
|
Cc1c(cnn1C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1511 |
EN300-189563_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCC5CS(=O)(=O)C5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1512 |
EN300-203118_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)(CO)F |
−10.7
± 0.2
|
7.8
± 0.2
|
1513 |
EN300-1693852_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@@H](C5)F)CO |
−10.7
± 0.3
|
7.8
± 0.2
|
1514 |
EN300-188582_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@H](C5)O |
−10.7
± 0.3
|
7.8
± 0.2
|
1515 |
EN300-1707879_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CNC(=O)CC56CCOC6 |
−10.7
± 0.2
|
7.8
± 0.1
|
1516 |
EN300-315453_3
|
|
Cc1cncn1CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1517 |
EN300-1703852_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5COC(=O)N5 |
−10.7
± 0.2
|
7.8
± 0.2
|
1518 |
EN300-7540889_3
|
|
COc1ccc(nn1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1519 |
DAR-DIA-0d514e7d-18
|
|
C[C@H]1COc2c(cc(cc2OC(F)(F)F)Cl)[C@@H]1C(=O)Nc3cncc4c3cccc4 |
−10.7
± 0.2
|
7.8
± 0.1
|
1520 |
EN300-73772_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5[nH]c(=O)[nH]n5 |
−10.7
± 0.2
|
7.8
± 0.2
|
1521 |
EN300-53918_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCN5CCOC5=O |
−10.7
± 0.3
|
7.8
± 0.2
|
1522 |
EN300-79497_1
|
|
Cn1cc(c(=O)n(c1=O)C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1523 |
EN300-126389_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5COC(=O)N5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1524 |
EN300-300217_3
|
|
CC=CC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.7
± 0.2
|
7.8
± 0.1
|
1525 |
EN300-1710153_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C(C5)(F)F)O |
−10.7
± 0.2
|
7.8
± 0.2
|
1526 |
EN300-262604_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cnc(n5)C(=O)N |
−10.7
± 0.3
|
7.8
± 0.2
|
1527 |
EN300-2617222_3
|
|
CNC(=O)c1cn(nn1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1528 |
EN300-260418_3
|
|
Cn1c(nc(n1)C2CC2)CC(=O)NCC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.7
± 0.4
|
7.8
± 0.3
|
1529 |
EN300-79536_1
|
|
C=CCN(CCO)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.7
± 0.3
|
7.8
± 0.2
|
1530 |
EN300-55072_1
|
|
CC(CO)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.7
± 0.2
|
7.8
± 0.1
|
1531 |
EN300-126555_1
|
|
CC(=O)NCCOCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.7
± 0.4
|
7.8
± 0.3
|
1532 |
EN300-145616_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCc5cnc[nH]5 |
−10.7
± 0.2
|
7.8
± 0.2
|
1533 |
EN300-123916_1
|
|
CN(C)c1cnc(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.2
|
7.8
± 0.2
|
1534 |
EN300-76205_1
|
|
CC(C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C |
−10.7
± 0.3
|
7.8
± 0.2
|
1535 |
EN300-7494324_1
|
|
Cc1c(nc[nH]1)CC(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.7
± 0.2
|
7.8
± 0.2
|
1536 |
EN300-63872_3
|
|
Cn1cc(cn1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1537 |
EN300-317082_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC5COC5 |
−10.7
± 0.2
|
7.8
± 0.2
|
1538 |
EN300-67533_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(C5CC5)O |
−10.7
± 0.3
|
7.8
± 0.2
|
1539 |
EN300-105267_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)Nc5cnccn5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1540 |
EN300-380820_2
|
|
Cc1cn2c(c(nn2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)c(=O)[nH]1 |
−10.7
± 0.3
|
7.8
± 0.2
|
1541 |
EN300-260816_2
|
|
CN1CCC(C1=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.2
|
7.8
± 0.2
|
1542 |
EN300-150749_1
|
|
Cn1c(=O)cc([nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.2
|
7.8
± 0.2
|
1543 |
EN300-1664105_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)n6cc(nn6)CO |
−10.7
± 0.3
|
7.8
± 0.2
|
1544 |
EN300-313366_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C56CCN(C5)CC6 |
−10.7
± 0.3
|
7.8
± 0.2
|
1545 |
EN300-305294_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6CC(C6C5)O |
−10.7
± 0.2
|
7.8
± 0.2
|
1546 |
EN300-1265071_2
|
|
CN(Cc1c[nH]nn1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1547 |
EN300-264744_1
|
|
CC(C)(C(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)F)O |
−10.7
± 0.2
|
7.8
± 0.1
|
1548 |
EN300-80522_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COCC5CCOC5 |
−10.7
± 0.2
|
7.8
± 0.2
|
1549 |
EN300-373552_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cncc(n5)F |
−10.7
± 0.3
|
7.8
± 0.2
|
1550 |
EN300-172640_3
|
|
CC1C(NC(=O)O1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.2
|
7.8
± 0.1
|
1551 |
EN300-100180_2
|
|
CC(=O)N1CCC(C1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.2
|
7.8
± 0.2
|
1552 |
EN300-11934_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCCC5=O |
−10.7
± 0.4
|
7.8
± 0.3
|
1553 |
EN300-1654606_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5C[C@@H]5F |
−10.7
± 0.2
|
7.8
± 0.1
|
1554 |
EN300-10895_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCCC#N |
−10.7
± 0.3
|
7.8
± 0.2
|
1555 |
EN300-1692858_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5cnn(c5)CCO |
−10.7
± 0.2
|
7.8
± 0.1
|
1556 |
EN300-126705_1
|
|
C[C@H]1CN(CCN1S(=O)(=O)C)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1557 |
EN300-862647_3
|
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−10.7
± 0.3
|
7.8
± 0.2
|
1558 |
EN300-36158_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5COCCO5 |
−10.7
± 0.2
|
7.8
± 0.1
|
1559 |
EN300-23223_3
|
|
CNC(=O)CNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.7
± 0.3
|
7.8
± 0.2
|
1560 |
EN300-85707_1
|
|
COCC1CN(CCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.2
|
7.8
± 0.2
|
1561 |
EN300-301925_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CCCOC5)C#N |
−10.7
± 0.3
|
7.8
± 0.2
|
1562 |
EN300-208236_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCc6c5nn[nH]6 |
−10.7
± 0.2
|
7.8
± 0.1
|
1563 |
EN300-7493939_1
|
|
CC1(CN(CC(=O)N1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−10.7
± 0.2
|
7.8
± 0.2
|
1564 |
EN300-1723663_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCN(C(=O)C5)CCO |
−10.7
± 0.3
|
7.8
± 0.2
|
1565 |
EN300-120282_1
|
|
Cn1cc(nn1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.2
|
7.8
± 0.1
|
1566 |
EN300-201346_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5COC(=O)N5 |
−10.7
± 0.2
|
7.8
± 0.2
|
1567 |
EN300-686903_1
|
|
CCCCS(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.7
± 0.4
|
7.8
± 0.3
|
1568 |
EN300-1708848_1
|
|
C[C@@H](C1CN(CCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.7
± 0.3
|
7.8
± 0.3
|
1569 |
EN300-103720_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6n(n5)CCCO6 |
−10.7
± 0.2
|
7.8
± 0.2
|
1570 |
EN300-190283_3
|
|
Cn1cncc1C(C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.7
± 0.3
|
7.8
± 0.2
|
1571 |
EN300-31148_1
|
|
CCC(=O)NC(C)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.7
± 0.3
|
7.8
± 0.2
|
1572 |
EN300-178515_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCC(=O)N |
−10.7
± 0.2
|
7.8
± 0.2
|
1573 |
EN300-305567_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccn6c(c5)nnn6 |
−10.7
± 0.3
|
7.8
± 0.2
|
1574 |
EN300-182124_2
|
|
COC1(CC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1575 |
EN300-304662_1
|
|
Cc1nnc(o1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1576 |
EN300-6503811_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H](Cc5cnc[nH]5)O |
−10.7
± 0.4
|
7.8
± 0.3
|
1577 |
EN300-266117_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H](C5)O |
−10.7
± 0.3
|
7.8
± 0.2
|
1578 |
EN300-210254_1
|
|
C[C@@H](CN(C)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.7
± 0.2
|
7.8
± 0.1
|
1579 |
EN300-6238494_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)C5COCCO5 |
−10.7
± 0.2
|
7.8
± 0.2
|
1580 |
EN300-304771_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCN(C5=O)C6CC6 |
−10.7
± 0.4
|
7.8
± 0.3
|
1581 |
EN300-66082_1
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C5CCC5 |
−10.7
± 0.2
|
7.8
± 0.2
|
1582 |
EN300-217526_3
|
|
CCn1c(c(nn1)C)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.4
|
7.8
± 0.3
|
1583 |
EN300-175485_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCO[C@H](C5)CO |
−10.7
± 0.3
|
7.8
± 0.2
|
1584 |
EN300-185751_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cncnc5 |
−10.7
± 0.2
|
7.8
± 0.1
|
1585 |
EN300-1968342_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(CF)O |
−10.7
± 0.2
|
7.8
± 0.1
|
1586 |
EN300-7396882_2
|
|
CC1(CC(C1)O)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1587 |
EN300-101197_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCc5[nH]cnn5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1588 |
EN300-90142_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCC(C5)C(=O)N |
−10.7
± 0.2
|
7.8
± 0.2
|
1589 |
EN300-36938_2
|
|
Cc1cc(no1)NC(=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1590 |
EN300-217494_3
|
|
CC(C1CCOC1)(C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.7
± 0.3
|
7.8
± 0.2
|
1591 |
EN300-51028_1
|
|
CC(C)S(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.7
± 0.2
|
7.8
± 0.2
|
1592 |
EN300-207765_1
|
|
CN1C(CCC1=O)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.2
|
7.8
± 0.2
|
1593 |
EN300-380820_1
|
|
Cc1cn2c(c(nn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)c(=O)[nH]1 |
−10.7
± 0.2
|
7.8
± 0.2
|
1594 |
EN300-91315_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)Cc6ccccn6 |
−10.7
± 0.3
|
7.8
± 0.2
|
1595 |
EN300-155176_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CCCS5(=O)=O |
−10.7
± 0.3
|
7.8
± 0.2
|
1596 |
EN300-1717166_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CC56CC(C6)O |
−10.7
± 0.3
|
7.8
± 0.2
|
1597 |
EN300-686903_3
|
|
CCCCS(=O)(=O)CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.7
± 0.6
|
7.8
± 0.5
|
1598 |
EN300-6255179_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCn5cncn5 |
−10.7
± 0.2
|
7.8
± 0.1
|
1599 |
EN300-47500_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCCCn5cccn5 |
−10.7
± 0.3
|
7.8
± 0.2
|
1600 |
EN300-226964_1
|
|
Cc1ccn(n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.3
|
7.8
± 0.2
|