Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
1101 |
EN300-366468_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCNC(=O)C5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1102 |
DAR-DIA-5ff57136-1
|
|
C[C@@H]1COc2ccc(cc2[C@@H]1C(=O)N(c3cncc4c3cccc4)C(=O)C=C)Cl |
−11.1
± 0.3
|
8.1
± 0.2
|
1103 |
EN300-1664603_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCc5ccn[nH]5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1104 |
EN300-171766_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5n[nH]c(=O)s5 |
−11.1
± 0.2
|
8.1
± 0.2
|
1105 |
EN300-28871_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5ccnn5 |
−11.1
± 0.2
|
8.1
± 0.1
|
1106 |
EN300-25702_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CC5)O |
−11.1
± 0.2
|
8.1
± 0.2
|
1107 |
EN300-201346_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5COC(=O)N5 |
−11.1
± 0.2
|
8.1
± 0.2
|
1108 |
EN300-1696962_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCCn5cnnn5 |
−11.1
± 0.2
|
8.0
± 0.2
|
1109 |
EN300-66849_1
|
|
COCCN(CCO)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.0
± 0.5
|
8.0
± 0.3
|
1110 |
EN300-259004_3
|
|
CC(=O)N1CC(C1)OCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.4
|
8.0
± 0.3
|
1111 |
DAR-DIA-0d514e7d-4
|
|
C[C@H]1COc2c(cc(cc2OC3CCCC3)Cl)[C@@H]1C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.2
|
8.0
± 0.2
|
1112 |
EN300-19542_4
|
|
CC(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.0
± 0.3
|
8.0
± 0.2
|
1113 |
EN300-188377_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc6c5[nH]nn6 |
−11.0
± 0.2
|
8.0
± 0.2
|
1114 |
EN300-72730_3
|
|
CC(C#N)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.0
± 0.2
|
8.0
± 0.1
|
1115 |
EN300-270710_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCS(=O)(=O)N |
−11.0
± 0.2
|
8.0
± 0.2
|
1116 |
EN300-69162_3
|
|
CC(COC)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.0
± 0.3
|
8.0
± 0.2
|
1117 |
EN300-219020_3
|
|
Cn1ncc(n1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.2
|
8.0
± 0.1
|
1118 |
EN300-178876_3
|
|
CC1(CCCNC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.4
|
8.0
± 0.3
|
1119 |
EN300-7354033_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C56CC(C5)S(=O)(=O)C6 |
−11.0
± 0.3
|
8.0
± 0.2
|
1120 |
EN300-181558_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5(CCC(CC5)O)O |
−11.0
± 0.2
|
8.0
± 0.2
|
1121 |
EN300-82553_1
|
|
COc1ccc(nn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.2
|
8.0
± 0.2
|
1122 |
EN300-7355519_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CC6C(O5)CCO6 |
−11.0
± 0.2
|
8.0
± 0.1
|
1123 |
EN300-100741_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5[nH]cnn5 |
−11.0
± 0.2
|
8.0
± 0.1
|
1124 |
EN300-159633_3
|
|
CC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C(F)(F)F)O |
−11.0
± 0.2
|
8.0
± 0.2
|
1125 |
EN300-222969_1
|
|
CN1CC(OC1=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.4
|
8.0
± 0.3
|
1126 |
EN300-135530_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccnc5C(=O)N |
−11.0
± 0.2
|
8.0
± 0.2
|
1127 |
EN300-93573_3
|
|
CN(C)C(=O)CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.0
± 0.3
|
8.0
± 0.2
|
1128 |
EN300-92605_1
|
|
Cn1cc(cn1)C2=NOC(C2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.0
± 0.2
|
8.0
± 0.1
|
1129 |
EN300-77359_3
|
|
CC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OCCOC |
−11.0
± 0.4
|
8.0
± 0.3
|
1130 |
EN300-41366_1
|
|
Cc1nc(n(n1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−11.0
± 0.3
|
8.0
± 0.2
|
1131 |
EN300-91609_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC6C5C6 |
−11.0
± 0.2
|
8.0
± 0.2
|
1132 |
EN300-321703_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCOC5COC5 |
−11.0
± 0.2
|
8.0
± 0.2
|
1133 |
EN300-6746890_2
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)CNC(=O)[C@H]5C[C@@](C5)(F)CO)cc1 |
−11.0
± 0.2
|
8.0
± 0.2
|
1134 |
EN300-331828_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CO[C@@H]5COC[C@H]5O |
−11.0
± 0.3
|
8.0
± 0.2
|
1135 |
EN300-657211_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5[nH]c(nn5)C6CC6 |
−11.0
± 0.3
|
8.0
± 0.2
|
1136 |
EN300-268198_1
|
|
CC(CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−11.0
± 0.2
|
8.0
± 0.1
|
1137 |
EN300-05754_3
|
|
CC(C(=O)N1CCOCC1)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1138 |
EN300-6731226_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@]56CCO[C@H]5CC(=O)NC6 |
−11.0
± 0.4
|
8.0
± 0.3
|
1139 |
EN300-226964_3
|
|
Cc1ccn(n1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.4
|
8.0
± 0.3
|
1140 |
EN300-70064_1
|
|
CNC(=O)C1(CCC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1141 |
EN300-6734171_1
|
|
CC1(CCC(=O)N(C1)C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1142 |
EN300-90225_1
|
|
Cn1nc(nn1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.2
|
8.0
± 0.1
|
1143 |
EN300-101505_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CC(=O)N5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1144 |
EN300-364679_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCn5cnnn5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1145 |
EN300-10397_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CNC(=O)N |
−11.0
± 0.2
|
8.0
± 0.2
|
1146 |
EN300-1387104_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCS5(=O)=O |
−11.0
± 0.2
|
8.0
± 0.2
|
1147 |
EN300-5253939_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5COC(=O)O5 |
−11.0
± 0.2
|
8.0
± 0.2
|
1148 |
EN300-146174_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)CO |
−11.0
± 0.3
|
8.0
± 0.2
|
1149 |
EN300-306026_1
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)NC(=O)[C@H]5C[C@H](C5)O)cc1 |
−11.0
± 0.2
|
8.0
± 0.2
|
1150 |
EN300-260816_1
|
|
CN1CCC(C1=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.2
|
8.0
± 0.2
|
1151 |
EN300-7121836_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn[nH]c5F |
−11.0
± 0.2
|
8.0
± 0.1
|
1152 |
EN300-17184_3
|
|
C=CCNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.0
± 0.3
|
8.0
± 0.2
|
1153 |
EN300-14405_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc6n(c5=O)CCS6 |
−11.0
± 0.3
|
8.0
± 0.2
|
1154 |
EN300-6482296_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5COC6C5COC6 |
−11.0
± 0.2
|
8.0
± 0.2
|
1155 |
EN300-96933_3
|
|
CC(C)c1nnnn1CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1156 |
EN300-174668_3
|
|
COC1(CCOC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1157 |
EN300-7003350_3
|
|
CCNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.0
± 0.1
|
8.0
± 0.1
|
1158 |
EN300-152705_3
|
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−11.0
± 0.3
|
8.0
± 0.2
|
1159 |
EN300-765003_1
|
|
COC(=O)[C@@H]1C[C@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.2
|
8.0
± 0.2
|
1160 |
EN300-189672_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5ccc(=O)[nH]c5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1161 |
EN300-246248_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5CCNC5=O |
−11.0
± 0.2
|
8.0
± 0.2
|
1162 |
EN300-7399047_1
|
|
CC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.0
± 0.3
|
8.0
± 0.2
|
1163 |
EN300-99983_3
|
|
CNC(=O)Cc1nc(on1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1164 |
EN300-217107_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCC5C(=O)N |
−11.0
± 0.1
|
8.0
± 0.1
|
1165 |
EN300-35843_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5[nH]c(=O)[nH]n5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1166 |
EN300-67267_1
|
|
Cc1[nH]c(=O)c(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1167 |
EN300-306097_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CCOCC5)n6cnnn6 |
−11.0
± 0.3
|
8.0
± 0.2
|
1168 |
EN300-6734171_3
|
|
CC1(CCC(=O)N(C1)C)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.3
|
8.0
± 0.3
|
1169 |
EN300-5253939_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5COC(=O)O5 |
−11.0
± 0.2
|
8.0
± 0.2
|
1170 |
EN300-1968342_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(CF)O |
−11.0
± 0.2
|
8.0
± 0.1
|
1171 |
EN300-7539819_1
|
|
CC1(C[C@H]([C@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O)O)C |
−11.0
± 0.4
|
8.0
± 0.3
|
1172 |
EN300-109535_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5CC(=O)OC5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1173 |
EN300-1696962_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCCn5cnnn5 |
−11.0
± 0.4
|
8.0
± 0.3
|
1174 |
EN300-33398_1
|
|
CC(C)N1CC(CC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.2
|
8.0
± 0.2
|
1175 |
EN300-297927_1
|
|
CC(C)(C)n1nc(nn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1176 |
EN300-173903_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC[C@H]5CO |
−11.0
± 0.4
|
8.0
± 0.3
|
1177 |
EN300-1932780_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C(F)F)O |
−11.0
± 0.2
|
8.0
± 0.1
|
1178 |
EN300-135310_1
|
|
Cc1nc(on1)Cn2cc(cn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.0
± 0.3
|
8.0
± 0.2
|
1179 |
EN300-204419_1
|
|
C[C@@H](CO)N(C)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.0
± 0.3
|
8.0
± 0.2
|
1180 |
EN300-1726340_1
|
|
Cn1ccc(n1)n2cc(nc2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.0
± 0.2
|
8.0
± 0.2
|
1181 |
EN300-23223_2
|
|
CNC(=O)CNC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.0
± 0.3
|
8.0
± 0.2
|
1182 |
EN300-94900_4
|
|
CS(=O)(=O)Cc1nc(on1)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.4
|
8.0
± 0.3
|
1183 |
EN300-702756_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CS(=O)(=O)CC(=O)N5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1184 |
EN300-26147_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCn5cncn5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1185 |
EN300-383824_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6c([nH]c5=O)CCOC6 |
−11.0
± 0.4
|
8.0
± 0.3
|
1186 |
EN300-159633_2
|
|
CC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C(F)(F)F)O |
−11.0
± 0.2
|
8.0
± 0.2
|
1187 |
EN300-175487_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCO[C@@H](C5)CO |
−11.0
± 0.4
|
8.0
± 0.3
|
1188 |
EN300-211203_3
|
|
CC(C)C1(CC(=O)NC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.4
|
8.0
± 0.3
|
1189 |
EN300-30687_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc(c5)OCC(=O)N |
−11.0
± 0.3
|
8.0
± 0.2
|
1190 |
EN300-61860_1
|
|
Cc1cc2[nH]c(=O)c(cn2n1)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.0
± 0.3
|
8.0
± 0.2
|
1191 |
EN300-142412_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCCC(=O)N |
−11.0
± 0.3
|
8.0
± 0.2
|
1192 |
EN300-26603_1
|
|
Cn1c2ccccc2n(c1=O)CC(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.0
± 0.4
|
8.0
± 0.3
|
1193 |
EN300-7536177_1
|
|
Cc1ncnn1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1194 |
EN300-1717596_1
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)NC(=O)[C@H]5C[C@@H](C5)n6cnnc6)cc1 |
−11.0
± 0.3
|
8.0
± 0.2
|
1195 |
EN300-80940_1
|
|
CC1C(S(=O)(=O)CCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−11.0
± 0.3
|
8.0
± 0.2
|
1196 |
EN300-36911_1
|
|
CNC(=O)NCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.0
± 0.3
|
8.0
± 0.2
|
1197 |
EN300-134855_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(c5cccnc5)O |
−11.0
± 0.3
|
8.0
± 0.2
|
1198 |
EN300-11195_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N5CCC5 |
−11.0
± 0.3
|
8.0
± 0.2
|
1199 |
EN300-254121_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(c5cnc[nH]5)O |
−11.0
± 0.3
|
8.0
± 0.2
|
1200 |
EN300-42819_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCC(=O)NC5 |
−11.0
± 0.2
|
8.0
± 0.1
|