Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
101 |
EN300-160277_1
|
|
COCCn1ccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.8
± 0.2
|
9.3
± 0.2
|
102 |
EN300-24297_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5csnn5 |
−12.7
± 0.2
|
9.3
± 0.2
|
103 |
EN300-42591_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CNC(=O)NC5CC5 |
−12.7
± 0.4
|
9.3
± 0.3
|
104 |
EN300-254854_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@H]5N(=O)=O |
−12.7
± 0.2
|
9.3
± 0.2
|
105 |
EN300-124652_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC5CC(=O)N |
−12.7
± 0.3
|
9.3
± 0.2
|
106 |
EN300-332002_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCc6n5c(=O)ccc6 |
−12.7
± 0.3
|
9.3
± 0.2
|
107 |
EN300-304627_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@H](CCO5)Cn6cccn6 |
−12.7
± 0.3
|
9.3
± 0.2
|
108 |
EN300-6735902_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@@H]6CC[C@@H]6C(=O)N5 |
−12.7
± 0.3
|
9.3
± 0.2
|
109 |
EN300-1715993_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCn5ccnn5 |
−12.7
± 0.3
|
9.3
± 0.2
|
110 |
EN300-364679_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCn5cnnn5 |
−12.7
± 0.3
|
9.3
± 0.2
|
111 |
EN300-116234_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCO5 |
−12.7
± 0.2
|
9.3
± 0.2
|
112 |
EN300-42270_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnsn5 |
−12.7
± 0.2
|
9.3
± 0.1
|
113 |
EN300-7352736_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[C@@H]([C@@H](CO5)O)O |
−12.7
± 0.3
|
9.2
± 0.2
|
114 |
EN300-211777_1
|
|
CC(=O)N1CCC[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.7
± 0.3
|
9.2
± 0.2
|
115 |
DAR-DIA-5ff57136-10
|
|
c1ccc2c(c1)cncc2N(C#CC#N)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−12.7
± 0.1
|
9.24
± 0.09
|
116 |
EN300-297561_1
|
|
CC(C)C(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnnn5 |
−12.7
± 0.3
|
9.2
± 0.2
|
117 |
EN300-208236_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCc6c5nn[nH]6 |
−12.7
± 0.2
|
9.2
± 0.2
|
118 |
EN300-7463171_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCS(=O)(=O)CCO |
−12.7
± 0.8
|
9.2
± 0.5
|
119 |
EN300-269453_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCc6nnnn6C5 |
−12.7
± 0.2
|
9.2
± 0.2
|
120 |
EN300-23417_1
|
|
COCCn1c(=O)ccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.7
± 0.4
|
9.2
± 0.3
|
121 |
EN300-124555_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6c(nc5)n[nH]n6 |
−12.7
± 0.2
|
9.2
± 0.2
|
122 |
EN300-6497444_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5OCC(C6)O |
−12.7
± 0.2
|
9.2
± 0.2
|
123 |
EN300-142240_1
|
|
Cn1c(cc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−12.7
± 0.3
|
9.2
± 0.2
|
124 |
EN300-315854_1
|
|
CC1(CCNC(=O)C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.7
± 0.3
|
9.2
± 0.2
|
125 |
EN300-151423_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5(CCOCC5)O |
−12.6
± 0.2
|
9.2
± 0.1
|
126 |
EN300-1244816_3
|
|
Cc1nnnn1CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.6
± 0.3
|
9.2
± 0.2
|
127 |
EN300-6488240_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5nncs5 |
−12.6
± 0.2
|
9.2
± 0.2
|
128 |
EN300-123712_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc(n5)n6cncn6 |
−12.6
± 0.3
|
9.2
± 0.2
|
129 |
EN300-100467_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5ccnn5 |
−12.6
± 0.3
|
9.2
± 0.2
|
130 |
EN300-1273362_3
|
|
CC1(CN(C1=O)C)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.6
± 0.3
|
9.2
± 0.2
|
131 |
EN300-243828_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnncc5O |
−12.6
± 0.3
|
9.2
± 0.2
|
132 |
EN300-1248250_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CN(C5)C(=O)N |
−12.6
± 0.3
|
9.2
± 0.2
|
133 |
EN300-1262608_1
|
|
CCNC(=O)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−12.6
± 0.2
|
9.2
± 0.2
|
134 |
EN300-20980_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cnnn5 |
−12.6
± 0.2
|
9.2
± 0.2
|
135 |
EN300-170463_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCOC5 |
−12.6
± 0.3
|
9.2
± 0.2
|
136 |
EN300-99391_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COC5CCOC5 |
−12.6
± 0.2
|
9.2
± 0.1
|
137 |
EN300-100467_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5ccnn5 |
−12.6
± 0.2
|
9.2
± 0.2
|
138 |
EN300-191915_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnnn5 |
−12.6
± 0.3
|
9.2
± 0.2
|
139 |
EN300-250126_1
|
|
CC(C)CC(C(=O)N)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−12.6
± 0.3
|
9.2
± 0.2
|
140 |
EN300-198515_3
|
|
CC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnc(n5)C#N |
−12.6
± 0.2
|
9.2
± 0.2
|
141 |
EN300-76541_1
|
|
CCC(C)C(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NS(=O)(=O)C |
−12.6
± 0.5
|
9.2
± 0.3
|
142 |
EN300-685077_1
|
|
COCCn1cccc(c1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.6
± 0.3
|
9.1
± 0.2
|
143 |
EN300-315238_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CC[C@H](O5)C(=O)N |
−12.6
± 0.3
|
9.1
± 0.2
|
144 |
EN300-90225_3
|
|
Cn1nc(nn1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.6
± 0.2
|
9.1
± 0.2
|
145 |
EN300-1600786_3
|
|
Cn1cc(nn1)CCOCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.6
± 0.2
|
9.1
± 0.2
|
146 |
FRA-DIA-13af2da5-2
|
|
CN(C)c1ccc(cc1)[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.5
± 0.2
|
9.1
± 0.1
|
147 |
EN300-264744_3
|
|
CC(C)(C(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)F)O |
−12.5
± 0.1
|
9.1
± 0.1
|
148 |
EN300-102901_1
|
|
CCC[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−12.5
± 0.4
|
9.1
± 0.3
|
149 |
EN300-203293_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5CNC(=O)O5 |
−12.5
± 0.2
|
9.1
± 0.2
|
150 |
EN300-702756_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CS(=O)(=O)CC(=O)N5 |
−12.5
± 0.2
|
9.1
± 0.2
|
151 |
EN300-640698_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc([nH]c5=O)C#N |
−12.5
± 0.3
|
9.1
± 0.2
|
152 |
EN300-102347_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5(COC5)CO |
−12.5
± 0.2
|
9.1
± 0.2
|
153 |
EN300-149296_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ncc(cn5)F |
−12.5
± 0.2
|
9.1
± 0.2
|
154 |
EN300-122340_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCSCC5)O |
−12.5
± 0.4
|
9.1
± 0.3
|
155 |
EN300-245264_3
|
|
CCC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnc(n5)C#N |
−12.5
± 0.3
|
9.1
± 0.2
|
156 |
EN300-52983_1
|
|
CN1CC(CCC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.5
± 0.3
|
9.1
± 0.2
|
157 |
VLA-UCB-34f3ed0c-3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)C(=O)NCc5cc[nH]n5 |
−12.5
± 0.2
|
9.1
± 0.2
|
158 |
EN300-259187_1
|
|
CCN1CC(CCC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.5
± 0.3
|
9.1
± 0.2
|
159 |
EN300-13489_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCN(CC5)C(=O)N |
−12.5
± 0.3
|
9.1
± 0.2
|
160 |
EN300-244148_1
|
|
Cn1cc(c(n1)COC)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.5
± 0.2
|
9.1
± 0.2
|
161 |
EN300-09239_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc(c5)n6cnnn6 |
−12.5
± 0.3
|
9.1
± 0.2
|
162 |
EN300-13890_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CSC5CCS(=O)(=O)C5 |
−12.5
± 0.3
|
9.1
± 0.2
|
163 |
EN300-304695_1
|
|
CN1CCCCC(C1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.5
± 0.3
|
9.1
± 0.2
|
164 |
EN300-20496_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC5CCOC5=O |
−12.5
± 0.2
|
9.1
± 0.1
|
165 |
EN300-1273016_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCc6n5ncn6 |
−12.5
± 0.2
|
9.1
± 0.2
|
166 |
EN300-1722017_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)n6nccn6 |
−12.5
± 0.3
|
9.1
± 0.2
|
167 |
EN300-222120_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC(C5)(c6cnn[nH]6)O |
−12.5
± 0.3
|
9.1
± 0.2
|
168 |
EN300-198515_1
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnc(n5)C#N |
−12.5
± 0.2
|
9.1
± 0.2
|
169 |
EN300-112500_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CC(=O)N)C5CC5 |
−12.5
± 0.3
|
9.1
± 0.2
|
170 |
EN300-317082_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC5COC5 |
−12.5
± 0.2
|
9.1
± 0.1
|
171 |
EN300-260152_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnns5 |
−12.4
± 0.2
|
9.1
± 0.2
|
172 |
EN300-37102_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CCO)C5CC5 |
−12.4
± 0.4
|
9.1
± 0.3
|
173 |
EN300-1681046_1
|
|
Cn1c2c(c(n1)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)COCC2 |
−12.4
± 0.3
|
9.1
± 0.2
|
174 |
EN300-6499719_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccn6ccnc6n5 |
−12.4
± 0.2
|
9.1
± 0.2
|
175 |
EN300-7412943_1
|
|
CC1(CN(C[C@@H](O1)CO)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−12.4
± 0.4
|
9.1
± 0.3
|
176 |
ALP-UNI-44c99a80-2
|
|
c1ccc2c(c1)cncc2N(Cc3cnc[nH]3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−12.4
± 0.2
|
9.1
± 0.1
|
177 |
EN300-60049_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CN6CCCC6CO5 |
−12.4
± 0.4
|
9.1
± 0.3
|
178 |
EN300-42131_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6c([nH]c(=O)[nH]c6=O)nc5 |
−12.4
± 0.3
|
9.1
± 0.2
|
179 |
EN300-09325_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccccc5n6cnnn6 |
−12.4
± 0.3
|
9.1
± 0.2
|
180 |
EN300-12587_1
|
|
CC(=O)N1CCCC1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.4
± 0.4
|
9.0
± 0.3
|
181 |
EN300-173006_3
|
|
CC(c1nnnn1C)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.4
± 0.3
|
9.0
± 0.2
|
182 |
EN300-366857_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccn6c5ncn6 |
−12.4
± 0.2
|
9.0
± 0.2
|
183 |
EN300-1248064_3
|
|
CC(C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnnn5 |
−12.4
± 0.3
|
9.0
± 0.2
|
184 |
EN300-186943_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCOCC5=O |
−12.4
± 0.3
|
9.0
± 0.2
|
185 |
EN300-2908024_4
|
|
CCC(C)(C(=O)N)C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−12.4
± 0.4
|
9.0
± 0.3
|
186 |
EN300-141695_1
|
|
CN1CCC(C1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.4
± 0.3
|
9.0
± 0.2
|
187 |
EN300-65352_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CCO)c5ncccn5 |
−12.4
± 0.4
|
9.0
± 0.3
|
188 |
EN300-26973_1
|
|
Cc1nc(nn1c2[nH]cnn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−12.4
± 0.3
|
9.0
± 0.2
|
189 |
EN300-1601684_1
|
|
CC1(C(OCCO1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−12.4
± 0.2
|
9.0
± 0.1
|
190 |
EN300-250836_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCc5c[nH]nc5 |
−12.4
± 0.4
|
9.0
± 0.3
|
191 |
EN300-315963_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnoc5 |
−12.4
± 0.2
|
9.0
± 0.2
|
192 |
EN300-104395_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCO5 |
−12.4
± 0.2
|
9.0
± 0.2
|
193 |
EN300-149975_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCC5)CO |
−12.4
± 0.3
|
9.0
± 0.2
|
194 |
EN300-373476_1
|
|
CC1(CCCS1(=O)=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.4
± 0.4
|
9.0
± 0.3
|
195 |
EN300-36158_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5COCCO5 |
−12.4
± 0.2
|
9.0
± 0.2
|
196 |
EN300-1716880_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOCC5)Cc6c[nH]nn6 |
−12.4
± 0.4
|
9.0
± 0.3
|
197 |
EN300-263085_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)n6cnnn6 |
−12.4
± 0.3
|
9.0
± 0.2
|
198 |
EN300-225012_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6nccn6ccn5 |
−12.4
± 0.2
|
9.0
± 0.1
|
199 |
EN300-7431629_1
|
|
Cc1nnc2n1CCC2(C)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−12.4
± 0.4
|
9.0
± 0.3
|
200 |
EN300-103144_4
|
|
CSCCC(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−12.3
± 0.3
|
9.0
± 0.2
|