Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
1001 |
EN300-113234_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(=O)OC5 |
−11.1
± 0.2
|
8.1
± 0.2
|
1002 |
EN300-305996_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5COC(=O)N5 |
−11.1
± 0.2
|
8.1
± 0.2
|
1003 |
EN300-13499_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCCNC(=O)N |
−11.1
± 0.3
|
8.1
± 0.2
|
1004 |
EN300-7439284_4
|
|
COc1cn[nH]c1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.4
|
8.1
± 0.3
|
1005 |
EN300-331993_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)Nc5[nH]ccn5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1006 |
EN300-244659_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H](C[C@H]5CO)F |
−11.1
± 0.3
|
8.1
± 0.2
|
1007 |
EN300-131219_1
|
|
Cc1nc(no1)Cn2cc(cn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.1
± 0.3
|
8.1
± 0.2
|
1008 |
EN300-2923949_1
|
|
c1ccc(cc1)C(C(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O)O |
−11.1
± 0.2
|
8.1
± 0.2
|
1009 |
EN300-105267_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)Nc5cnccn5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1010 |
EN300-7463161_2
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)CNC(=O)[C@H]5C[C@H](C5)n6cnnc6)cc1 |
−11.1
± 0.2
|
8.1
± 0.2
|
1011 |
EN300-60033_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)COCC5CCCO5 |
−11.1
± 0.3
|
8.1
± 0.3
|
1012 |
EN300-70489_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC(C5)C#N |
−11.1
± 0.3
|
8.1
± 0.2
|
1013 |
EN300-6472771_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5[C@H](CCC[C@H]5CO)CO |
−11.1
± 0.5
|
8.1
± 0.4
|
1014 |
EN300-14628_1
|
|
CN(CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C5CCS(=O)(=O)C5 |
−11.1
± 0.4
|
8.1
± 0.3
|
1015 |
EN300-204936_1
|
|
Cn1c(cnn1)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.2
|
8.1
± 0.2
|
1016 |
EN300-155498_3
|
|
CC(=C)[C@H](CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.1
± 0.2
|
8.1
± 0.1
|
1017 |
ALP-UNI-44c99a80-3
|
|
c1ccc2c(c1)cncc2N(Cc3cnco3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−11.1
± 0.2
|
8.1
± 0.2
|
1018 |
EN300-91314_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)Cc6cccnc6 |
−11.1
± 0.3
|
8.1
± 0.2
|
1019 |
EN300-124918_1
|
|
Cn1c(=O)[nH]c(n1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.2
|
8.1
± 0.2
|
1020 |
EN300-314274_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cncc6c5CCNC6=O |
−11.1
± 0.3
|
8.1
± 0.2
|
1021 |
EN300-19242_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CO |
−11.1
± 0.3
|
8.1
± 0.2
|
1022 |
EN300-3710141_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCCO5)C#N |
−11.1
± 0.2
|
8.1
± 0.2
|
1023 |
EN300-7432415_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5C6(CCC6)OC(=O)N5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1024 |
EN300-298184_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCNC5=O |
−11.1
± 0.3
|
8.1
± 0.2
|
1025 |
EN300-31077_1
|
|
Cn1c(ccn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.2
|
8.1
± 0.1
|
1026 |
EN300-105110_3
|
|
Cc1cc(n[nH]1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.4
|
8.1
± 0.3
|
1027 |
EN300-7473378_3
|
|
CN1CCC(CC1)(C#N)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.4
|
8.1
± 0.3
|
1028 |
EN300-23942_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cccn5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1029 |
EN300-135660_1
|
|
CC1(COC1)Cn2cc(nn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.1
± 0.3
|
8.1
± 0.2
|
1030 |
EN300-34542_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCCC5C(=O)N |
−11.1
± 0.4
|
8.1
± 0.3
|
1031 |
EN300-6481960_1
|
|
Cn1c(c2c(n1)CCOC2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.1
± 0.3
|
8.1
± 0.2
|
1032 |
EN300-20375_3
|
|
COCCOCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.3
|
8.1
± 0.2
|
1033 |
EN300-35778_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCC(CC5)C(=O)N |
−11.1
± 0.3
|
8.1
± 0.2
|
1034 |
EN300-1703143_1
|
|
CC(C)(C)c1nnn(n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1035 |
JOH-SUS-a69c159d-7
|
|
c1cc2c(cc1F)c(c(nc2F)F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−11.11
± 0.06
|
8.09
± 0.04
|
1036 |
EN300-51832_3
|
|
Cc1cnn(c1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1037 |
EN300-181492_3
|
|
C=CC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.1
± 0.2
|
8.1
± 0.2
|
1038 |
EN300-349304_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC[C@H]([C@H](C5)O)O |
−11.1
± 0.2
|
8.1
± 0.1
|
1039 |
EN300-96159_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5[nH]cnn5 |
−11.1
± 0.2
|
8.1
± 0.2
|
1040 |
EN300-1725529_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CCCO)C5COC5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1041 |
EN300-40888_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCC(=O)N |
−11.1
± 0.2
|
8.1
± 0.1
|
1042 |
EN300-6729572_3
|
|
CC(C1CC1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−11.1
± 0.2
|
8.1
± 0.1
|
1043 |
EN300-6486576_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5nnc(o5)N6CCOCC6 |
−11.1
± 0.2
|
8.1
± 0.2
|
1044 |
EN300-205616_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCC5c6[nH]cnn6 |
−11.1
± 0.3
|
8.1
± 0.2
|
1045 |
EN300-301925_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCCOC5)C#N |
−11.1
± 0.3
|
8.1
± 0.2
|
1046 |
EN300-36111_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCCC5=O |
−11.1
± 0.3
|
8.1
± 0.2
|
1047 |
EN300-77359_1
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OCCOC |
−11.1
± 0.2
|
8.1
± 0.1
|
1048 |
EN300-82037_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5ccon5 |
−11.1
± 0.2
|
8.1
± 0.2
|
1049 |
EN300-1722017_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)n6nccn6 |
−11.1
± 0.3
|
8.1
± 0.2
|
1050 |
EN300-204133_3
|
|
COC1(CCOCC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.4
|
8.1
± 0.3
|
1051 |
EN300-1212400_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(CC5CO)CO |
−11.1
± 0.2
|
8.1
± 0.2
|
1052 |
EN300-649743_2
|
|
C[C@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)Cn5cnnn5 |
−11.1
± 0.4
|
8.1
± 0.3
|
1053 |
EN300-188341_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5ccc(cn5)O |
−11.1
± 0.4
|
8.1
± 0.3
|
1054 |
EN300-10170_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(CO)NC(=O)N |
−11.1
± 0.2
|
8.1
± 0.2
|
1055 |
EN300-11934_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCC5=O |
−11.1
± 0.3
|
8.1
± 0.2
|
1056 |
EN300-157776_1
|
|
CC1CN(CC(O1)CO)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.2
|
8.1
± 0.1
|
1057 |
EN300-20496_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC5CCOC5=O |
−11.1
± 0.2
|
8.1
± 0.1
|
1058 |
EN300-1697005_3
|
|
CCC(=O)N1CSC[C@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.3
|
8.1
± 0.3
|
1059 |
EN300-6970573_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(COC5)CF |
−11.1
± 0.3
|
8.1
± 0.2
|
1060 |
EN300-18610_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC(C5)C(=O)N |
−11.1
± 0.2
|
8.1
± 0.2
|
1061 |
EN300-7439284_1
|
|
COc1cn[nH]c1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1062 |
EN300-6486793_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCCC5)S(=O)(=O)N |
−11.1
± 0.6
|
8.1
± 0.4
|
1063 |
EN300-30397_1
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cncn5 |
−11.1
± 0.1
|
8.1
± 0.1
|
1064 |
EN300-244947_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCc5c[nH]nn5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1065 |
EN300-10414_1
|
|
CC1(CCS(=O)(=O)C1)NC(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.2
|
8.1
± 0.2
|
1066 |
EN300-1600517_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(CO)F |
−11.1
± 0.2
|
8.1
± 0.2
|
1067 |
EN300-75464_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c(=O)c6ccnn6cn5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1068 |
EN300-5253939_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5COC(=O)O5 |
−11.1
± 0.2
|
8.1
± 0.1
|
1069 |
EN300-717276_1
|
|
CCn1cc(nn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1070 |
EN300-6746918_3
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)CCNC(=O)[C@H]5C[C@](C5)(F)CO)cc1 |
−11.1
± 0.3
|
8.1
± 0.2
|
1071 |
EN300-332838_3
|
|
CN1C(COC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1072 |
EN300-360157_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CCOC5)O |
−11.1
± 0.2
|
8.1
± 0.2
|
1073 |
EN300-2977549_3
|
|
CNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.2
|
8.1
± 0.1
|
1074 |
EN300-25986_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5cccn5 |
−11.1
± 0.2
|
8.1
± 0.2
|
1075 |
EN300-6496666_1
|
|
CO[C@@H]1CN([C@@H]2[C@H]1COC2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.1
± 0.3
|
8.1
± 0.2
|
1076 |
EN300-7183657_1
|
|
C[C@]1(C[C@@H](C1)C(=O)N[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5)O |
−11.1
± 0.2
|
8.1
± 0.2
|
1077 |
EN300-872798_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c(nnn5)C6CC6 |
−11.1
± 0.3
|
8.1
± 0.2
|
1078 |
EN300-305984_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cccn6c5nnn6 |
−11.1
± 0.3
|
8.1
± 0.2
|
1079 |
EN300-216063_3
|
|
CN(C)C(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.1
|
8.07
± 0.09
|
1080 |
EN300-153257_3
|
|
CC(C)C(CO)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.3
|
8.1
± 0.2
|
1081 |
EN300-7426383_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6c(ccn5)[nH]nn6 |
−11.1
± 0.2
|
8.1
± 0.2
|
1082 |
EN300-61140_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCc5nc(no5)c6[nH]cnn6 |
−11.1
± 0.3
|
8.1
± 0.2
|
1083 |
EN300-154156_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(=O)NC5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1084 |
EN300-259062_1
|
|
CNC(=O)CC1(CCCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−11.1
± 0.4
|
8.1
± 0.3
|
1085 |
EN300-219531_3
|
|
CCCC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.1
± 0.3
|
8.1
± 0.3
|
1086 |
EN300-4698402_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5C[C@H]5F |
−11.1
± 0.2
|
8.1
± 0.2
|
1087 |
EN300-19700_3
|
|
COC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.1
|
8.06
± 0.09
|
1088 |
EN300-6480588_3
|
|
COc1ccnc(n1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1089 |
EN300-107493_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCNC(=O)C5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1090 |
EN300-25960_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCCC5)O |
−11.1
± 0.5
|
8.1
± 0.4
|
1091 |
EN300-649738_3
|
|
Cc1c(n(nn1)C)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.3
|
8.1
± 0.2
|
1092 |
EN300-1588617_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5C[C@@H]5C#N |
−11.1
± 0.3
|
8.1
± 0.2
|
1093 |
EN300-98648_2
|
|
CN1CCC(C1=O)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.1
|
8.06
± 0.08
|
1094 |
EN300-1722072_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6C[C@H]5[C@H]([C@H]6O)O |
−11.1
± 0.3
|
8.1
± 0.2
|
1095 |
EN300-191495_3
|
|
CS(=O)(=O)C1(CC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.4
|
8.1
± 0.3
|
1096 |
EDJ-MED-28ec730d-2
|
|
COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.2
|
8.1
± 0.1
|
1097 |
EN300-332601_3
|
|
CCC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−11.1
± 0.3
|
8.1
± 0.2
|
1098 |
EN300-261365_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CS(=O)(=O)C5 |
−11.1
± 0.2
|
8.1
± 0.2
|
1099 |
EN300-138787_1
|
|
COC(=O)C1(CC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.2
|
8.1
± 0.2
|
1100 |
EN300-1440321_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCC5)S(=O)(=O)N |
−11.1
± 0.5
|
8.1
± 0.4
|