Rank |
Microstate |
SMILES |
ΔG / kcal M-1 |
601 |
EN300-04492_1_1 |
|
COCCCNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.2
|
602 |
EN300-246423_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CCC5)O |
−9.2
± 0.3
|
603 |
EN300-08063_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCC(CC5)C(=O)N |
−9.2
± 0.2
|
604 |
JAG-UCB-7b680c2b-1_1
|
|
CC(C)(C)OC(=O)NCc1cccc(c1)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.4
|
605 |
EN300-219330_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCN5CCOCC5=O |
−9.2
± 0.3
|
606 |
EN300-248888_3_2 |
|
C[C@](C=C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.2
± 0.4
|
607 |
EN300-1265071_1_1 |
|
CN(Cc1cn[nH]n1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
608 |
EN300-342462_3_1 |
|
C[NH+]1CCC(CC1)NC(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.4
|
609 |
EN300-155498_1_1 |
|
CC(=C)[C@H](CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.2
± 0.3
|
610 |
EN300-17184_4_1 |
|
C=CCNC(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.4
|
611 |
DAR-DIA-0d514e7d-30_1
|
|
C[C@@]1(c2cc(ccc2OCC1(C)C)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.2
|
612 |
EN300-73662_1_1 |
|
COC(=O)C[C@H](CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.2
± 0.3
|
613 |
EN300-31242_1_1 |
|
COCC(=O)NCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.3
|
614 |
EN300-124301_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCn5ccnn5 |
−9.2
± 0.3
|
615 |
EN300-1699871_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]5CCS(=O)(=O)N5 |
−9.2
± 0.3
|
616 |
EN300-22884_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N5CCNC(=O)C5 |
−9.2
± 0.3
|
617 |
EN300-17381_2_2 |
|
C[C@H](C(=O)N)OC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.2
|
618 |
EN300-17381_2_2 |
|
C[C@H](C(=O)N)OC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.2
|
619 |
EN300-17381_2_2 |
|
C[C@H](C(=O)N)OC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.2
|
620 |
EN300-46832_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NC[C@@H]5CCOC5 |
−9.2
± 0.4
|
621 |
EN300-195756_4_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC[C@@H]5CCC(=O)N5 |
−9.2
± 0.4
|
622 |
EN300-7456499_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCS(=O)(=O)CCCO |
−9.1
± 0.4
|
623 |
EN300-1724086_1_1 |
|
C[C@@H]1C[C@@H](CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−9.1
± 0.3
|
624 |
EN300-316216_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCn5cncn5 |
−9.1
± 0.3
|
625 |
EN300-316216_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCn5cncn5 |
−9.1
± 0.3
|
626 |
EN300-6498726_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H](CO)CF |
−9.1
± 0.4
|
627 |
EN300-226314_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)[C@H]5CCS(=O)(=O)C5 |
−9.1
± 0.3
|
628 |
EN300-1258964_3_2 |
|
C[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)NC |
−9.1
± 0.5
|
629 |
DAR-DIA-23e5a6a0-2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4O[C@H]5CC6([NH2+]5)CCC6)Cl |
−9.1
± 0.3
|
630 |
FRA-DIA-b66f7109-3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCOc4c3cc(cc4Cl)O[C@@H]5CC(=O)N5 |
−9.1
± 0.2
|
631 |
EN300-6494158_4_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC[C@@H]5C[C@@H](CO5)CO |
−9.1
± 0.5
|
632 |
EN300-267469_3_1 |
|
CS(=NC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(=O)C |
−9.1
± 0.4
|
633 |
EN300-221518_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCCO |
−9.1
± 0.2
|
634 |
EN300-221518_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCCO |
−9.1
± 0.2
|
635 |
EN300-221518_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCCO |
−9.1
± 0.2
|
636 |
EN300-22879_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N5CCCC[C@@H]5C(=O)N |
−9.1
± 0.4
|
637 |
EN300-87334_1_1 |
|
Cn1c(ncn1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
638 |
EN300-1911992_4_3 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC[C@@H]([C@H]5CCOC5)O |
−9.1
± 0.4
|
639 |
EN300-131093_1_2 |
|
C[C@H](C(=O)NCC(=O)C)O[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
640 |
EN300-270710_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCS(=O)(=O)N |
−9.1
± 0.3
|
641 |
EN300-378760_2_1 |
|
CS(=O)(=O)[C@H]1C[C@@H](C1)NC(=O)CC[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5 |
−9.1
± 0.3
|
642 |
DAR-DIA-6a508060-5_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4C[C@@H]5CC(=O)N5)Cl |
−9.1
± 0.2
|
643 |
EN300-127487_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H]5CC(=O)NC5 |
−9.1
± 0.3
|
644 |
EN300-312850_3_1 |
|
C[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)[NH+](C)C |
−9.1
± 0.4
|
645 |
EN300-1911992_1_4 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@H]([C@H]5CCOC5)O |
−9.1
± 0.3
|
646 |
EN300-101197_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCc5[nH]ncn5 |
−9.1
± 0.3
|
647 |
EN300-393148_3_2 |
|
C[N@@]1[C@H](CCS1(=O)=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
648 |
EN300-23019_2_1 |
|
CC(C)(C)NC(=O)CN(C)C(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.4
|
649 |
EN300-42520_1_1 |
|
C[NH+](C)CCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
650 |
EN300-6504697_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5CC6(CC6)S(=O)(=O)N5 |
−9.1
± 0.3
|
651 |
EN300-107267_4_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCO[C@@H]5CCCNC5=O |
−9.1
± 0.3
|
652 |
EN300-10895_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NCCC#N |
−9.1
± 0.3
|
653 |
EN300-01527_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NC[C@@H]5CCCO5 |
−9.1
± 0.3
|
654 |
EN300-268198_1_2 |
|
C[C@H](CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−9.1
± 0.3
|
655 |
EN300-23214_3_1 |
|
CCCNC(=O)[C@@H](C)NC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.4
|
656 |
EN300-48886_2_2 |
|
CC(=O)N[C@H]1CCCN(C1)C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.4
|
657 |
EN300-189563_4_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCC5CS(=O)(=O)C5 |
−9.1
± 0.3
|
658 |
EN300-7003350_3_1 |
|
CCNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
659 |
EN300-7003350_3_1 |
|
CCNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
660 |
EN300-7003350_3_1 |
|
CCNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
661 |
EN300-2977549_4_1 |
|
CNC(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
662 |
EN300-2977549_4_1 |
|
CNC(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
663 |
EN300-2977549_4_1 |
|
CNC(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
664 |
EN300-10397_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)N |
−9.1
± 0.2
|
665 |
EN300-204936_2_1 |
|
Cn1c(cnn1)C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
666 |
EN300-1268016_1_6 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H]5C[C@@H]6[C@H]5C[C@@H](C6)C(=O)N |
−9.1
± 0.3
|
667 |
EN300-134855_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H](c5cccnc5)O |
−9.1
± 0.5
|
668 |
EN300-23226_1_1 |
|
CC(=O)N1CCC(CC1)NC(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.4
|
669 |
EN300-46832_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NC[C@H]5CCOC5 |
−9.1
± 0.3
|
670 |
EN300-6494158_1_3 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5C[C@H](CO5)CO |
−9.1
± 0.3
|
671 |
EN300-110012_2_1 |
|
CC[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)[NH+](C)C |
−9.1
± 0.7
|
672 |
EN300-1425677_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@]5(CCCO5)CO |
−9.1
± 0.4
|
673 |
EN300-6501360_2_1 |
|
CN(C)C(=O)NC[C@@H](COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.1
± 0.5
|
674 |
EN300-741822_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H]5CC[C@H]([C@H](C5)O)O |
−9.1
± 0.4
|
675 |
EN300-364679_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCn5cnnn5 |
−9.1
± 0.3
|
676 |
EN300-52467_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCOCCO |
−9.1
± 0.3
|
677 |
EN300-52467_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCOCCO |
−9.1
± 0.3
|
678 |
EN300-52467_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCOCCO |
−9.1
± 0.3
|
679 |
EN300-1241327_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCOCC5 |
−9.1
± 0.2
|
680 |
EN300-1241327_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCOCC5 |
−9.1
± 0.2
|
681 |
FRA-DIA-b66f7109-3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCOc4c3cc(cc4Cl)O[C@H]5CC(=O)N5 |
−9.1
± 0.2
|
682 |
EN300-23318_3_3 |
|
C[C@@H](C(=O)N[C@H]1CCS(=O)(=O)C1)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.5
|
683 |
EN300-210553_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@](C5)(C(=O)N)O |
−9.1
± 0.5
|
684 |
EN300-210553_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@](C5)(C(=O)N)O |
−9.1
± 0.5
|
685 |
EN300-181492_3_2 |
|
C=C[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.1
± 0.3
|
686 |
EN300-1968342_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@H](CF)O |
−9.0
± 0.3
|
687 |
EN300-1968342_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@H](CF)O |
−9.0
± 0.3
|
688 |
EN300-2977549_2_1 |
|
CNC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.3
|
689 |
EN300-2977549_2_1 |
|
CNC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.3
|
690 |
EN300-2977549_2_1 |
|
CNC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.3
|
691 |
EN300-216673_1_1 |
|
Cn1c(cnn1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
692 |
EN300-19242_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CO |
−9.0
± 0.3
|
693 |
EN300-72730_1_2 |
|
C[C@H](C#N)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.2
|
694 |
EN300-25572_1_2 |
|
C[C@H]1CN(CCO1)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.2
|
695 |
EN300-67573_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NC5CCOCC5 |
−9.0
± 0.3
|
696 |
EN300-120282_4_1 |
|
Cn1cc(nn1)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
697 |
EN300-154332_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC[C@H]5CO |
−9.0
± 0.3
|
698 |
EN300-98648_4_2 |
|
CN1CC[C@H](C1=O)OCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
699 |
EN300-98648_4_2 |
|
CN1CC[C@H](C1=O)OCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
700 |
EN300-861925_4_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCO[C@@H](CO)F |
−9.0
± 0.5
|