Rank |
Microstate |
SMILES |
ΔG / kcal M-1 |
501 |
EN300-6739235_3_1 |
|
C[NH+]([C@H]1C[C@@H](C1)C(=O)NCC[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5)C |
−9.4
± 0.3
|
502 |
EN300-05512_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)N[C@H]5CCS(=O)(=O)C5 |
−9.4
± 0.5
|
503 |
EN300-208191_3_1 |
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)[NH+]5CCOCC5 |
−9.4
± 0.3
|
504 |
EN300-02015_3_1 |
|
COCCNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.3
|
505 |
EN300-220194_3_3 |
|
C[C@@H]([C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)OC |
−9.4
± 0.4
|
506 |
EN300-1667046_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(c6ccn[nH]6)O |
−9.4
± 0.3
|
507 |
EN300-95639_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H]([C@@H](C5)O)CO |
−9.4
± 0.4
|
508 |
EN300-120586_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCC(F)F |
−9.4
± 0.3
|
509 |
EN300-6482967_1_1 |
|
CNS(=O)(=O)CCO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.2
|
510 |
EN300-11300_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5cc(=O)[nH]c(=O)[nH]5 |
−9.4
± 0.3
|
511 |
EN300-55072_1_2 |
|
C[C@H](CO)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.3
|
512 |
EN300-10414_3_2 |
|
C[C@]1(CCS(=O)(=O)C1)NC(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.3
|
513 |
EN300-68875_3_1 |
|
CNS(=O)(=O)CCCOCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.4
|
514 |
EN300-349304_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H]([C@H](C5)O)O |
−9.4
± 0.3
|
515 |
EN300-6494859_2_3 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5C[C@H](OC5)Cn6cccn6 |
−9.4
± 0.4
|
516 |
EN300-7436306_4_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5=NO[C@H]6[C@@H]5COC6 |
−9.4
± 0.3
|
517 |
EN300-22880_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N5CCC[C@@H](C5)C(=O)N |
−9.4
± 0.4
|
518 |
DAR-DIA-0d514e7d-25_1
|
|
C[C@H]1COc2c(cc(cc2OC)Cl)[C@]1(C)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.1
|
519 |
EN300-6491682_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H]5CCc6c(n[nH]n6)C5 |
−9.4
± 0.3
|
520 |
EN300-52467_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCOCCO |
−9.4
± 0.3
|
521 |
EN300-52467_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCOCCO |
−9.4
± 0.3
|
522 |
EN300-52467_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCOCCO |
−9.4
± 0.3
|
523 |
EN300-22879_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCCC[C@H]5C(=O)N |
−9.4
± 0.3
|
524 |
EN300-317082_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC5COC5 |
−9.4
± 0.2
|
525 |
EN300-18249_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)N |
−9.4
± 0.2
|
526 |
EN300-05620_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCNC(=O)N |
−9.4
± 0.3
|
527 |
EN300-204935_1_1 |
|
Cn1ncc(n1)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.3
|
528 |
DAR-DIA-0d514e7d-24_1
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)CC(C)C |
−9.4
± 0.2
|
529 |
EN300-6505003_3_2 |
|
C[C@H]1CC[C@@H](C(=O)N1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.4
|
530 |
DAR-DIA-23e5a6a0-5_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4O[C@@H]5CC6([NH2+]5)CC6)Cl |
−9.4
± 0.4
|
531 |
EN300-203118_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@](C5)(CO)F |
−9.4
± 0.5
|
532 |
EN300-23317_4_2 |
|
C[C@H](C(=O)NCCOC)OCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.4
|
533 |
EN300-174603_1_1 |
|
CN(C(=O)CCO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−9.3
± 0.3
|
534 |
EN300-89418_3_1 |
|
C[C@@](CO)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.3
± 0.4
|
535 |
EN300-68203_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5CCC(=O)N5 |
−9.3
± 0.3
|
536 |
EN300-261986_1_1 |
|
CS(=O)(=O)[N@@]1CC[C@@H](C1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
537 |
EN300-261986_1_1 |
|
CS(=O)(=O)[N@@]1CC[C@@H](C1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
538 |
EN300-256053_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H](C5)CO |
−9.3
± 0.3
|
539 |
EN300-256053_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H](C5)CO |
−9.3
± 0.3
|
540 |
EN300-303908_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@]6(C[C@H]6C5)O |
−9.3
± 0.4
|
541 |
DAR-DIA-23e5a6a0-8_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4C[C@H]5CC6([NH2+]5)COC6)Cl |
−9.3
± 0.4
|
542 |
EN300-260696_1_8 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H]5C[C@H]([C@H]5n6cccn6)O |
−9.3
± 0.6
|
543 |
EN300-246248_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@@H]5CCNC5=O |
−9.3
± 0.3
|
544 |
EN300-94900_2_1 |
|
CS(=O)(=O)Cc1nc(on1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.5
|
545 |
EN300-189495_2_1 |
|
CC(=O)NCC(C)(C)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.3
|
546 |
EN300-1270211_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@]6(C[C@]6(C5)CO)CO |
−9.3
± 0.3
|
547 |
EN300-248888_3_1 |
|
C[C@@](C=C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.3
± 0.4
|
548 |
EN300-25572_3_2 |
|
C[C@H]1CN(CCO1)C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
549 |
EN300-46832_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NC[C@@H]5CCOC5 |
−9.3
± 0.3
|
550 |
EN300-1600517_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@H](CO)F |
−9.3
± 0.3
|
551 |
EN300-02015_1_1 |
|
COCCNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.3
|
552 |
ADA-UCB-dc2b944c-10_1
|
|
Cc1c(c2ccccc2cn1)NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−9.30
± 0.09
|
553 |
EN300-87334_2_1 |
|
Cn1c(ncn1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
554 |
EDJ-MED-e4b030d8-11_1
|
|
C[C@H]1COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−9.29
± 0.05
|
555 |
JAG-UCB-706446eb-4_1
|
|
CCOC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.2
|
556 |
EN300-100700_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H](NC(=O)C5)CO |
−9.3
± 0.4
|
557 |
EN300-22884_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCNC(=O)C5 |
−9.3
± 0.3
|
558 |
EN300-157897_2_1 |
|
CC[C@@H](CO)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.4
|
559 |
EN300-123205_2_1 |
|
CNS(=O)(=O)CCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.4
|
560 |
EN300-60862_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCO[C@H](C5)C(=O)N |
−9.3
± 0.3
|
561 |
EN300-260816_3_1 |
|
CN1CC[C@@H](C1=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.5
|
562 |
EN300-202922_1_4 |
|
C[C@H]([C@](C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−9.3
± 0.3
|
563 |
EN300-31845_3_1 |
|
COCCN1C[C@@H](CC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.4
|
564 |
EN300-92662_1_1 |
|
Cn1c(ccn1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
565 |
EN300-216063_2_1 |
|
CN(C)C(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.2
|
566 |
EN300-216063_2_1 |
|
CN(C)C(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.2
|
567 |
EN300-216063_2_1 |
|
CN(C)C(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.2
|
568 |
EN300-139167_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]5COCCO5 |
−9.3
± 0.3
|
569 |
EN300-139167_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]5COCCO5 |
−9.3
± 0.3
|
570 |
EN300-139167_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]5COCCO5 |
−9.3
± 0.3
|
571 |
EN300-195756_4_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC[C@H]5CCC(=O)N5 |
−9.3
± 0.3
|
572 |
EN300-1630093_1_2 |
|
CC(C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)[C@]5(CCOC5)O |
−9.3
± 0.2
|
573 |
EN300-321459_1_1 |
|
CN(C(=O)C[C@@]1(c2c(ccc(c2)Cl)OCC1)C(=O)Nc3c4c(cnc3)cccc4)[C@H]5C[C@H](C5)C(=O)N |
−9.3
± 0.3
|
574 |
EN300-245265_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCn5cnc(n5)C#N |
−9.3
± 0.3
|
575 |
EN300-6494158_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5C[C@@H](CO5)CO |
−9.3
± 0.3
|
576 |
EN300-249475_1_1 |
|
CC(=O)NC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.2
|
577 |
EN300-226314_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)[C@@H]5CCS(=O)(=O)C5 |
−9.2
± 0.3
|
578 |
EN300-1253122_1_1 |
|
CCN(C)C(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.2
|
579 |
EN300-1253122_1_1 |
|
CCN(C)C(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.2
|
580 |
EN300-113112_1_1 |
|
Cn1cnnc1CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
581 |
EN300-299532_1_1 |
|
CC(C)([C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−9.2
± 0.3
|
582 |
EN300-861925_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CO[C@@H](CO)F |
−9.2
± 0.3
|
583 |
DAR-DIA-23e5a6a0-9_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4C[C@H]5CC6(CC6)C[NH2+]5)Cl |
−9.2
± 0.3
|
584 |
EN300-1600517_4_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC[C@H](CO)F |
−9.2
± 0.4
|
585 |
EN300-114134_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC[N@]5CCCS5(=O)=O |
−9.2
± 0.4
|
586 |
EN300-6736413_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)O[C@@H]5CCNC5=O |
−9.2
± 0.2
|
587 |
EN300-6736413_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)O[C@@H]5CCNC5=O |
−9.2
± 0.2
|
588 |
EN300-1588617_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5C[C@@H]5C#N |
−9.2
± 0.2
|
589 |
EN300-216916_3_2 |
|
C[NH+](C)C[C@H](CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.2
± 0.5
|
590 |
EN300-226314_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)[C@@H]5CCS(=O)(=O)C5 |
−9.2
± 0.4
|
591 |
EN300-114133_3_1 |
|
CCC(=O)N1CC[C@@H](C1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.4
|
592 |
EN300-105267_4_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)Nc5cnccn5 |
−9.2
± 0.3
|
593 |
EN300-299532_3_1 |
|
CC(C)([C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−9.2
± 0.4
|
594 |
EN300-42243_1_1 |
|
CC(C)CS(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.3
|
595 |
EN300-6473273_3_2 |
|
Cn1c(ccn1)[C@H](C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.2
± 0.4
|
596 |
EN300-6473273_3_2 |
|
Cn1c(ccn1)[C@H](C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.2
± 0.4
|
597 |
EN300-6974806_1_1 |
|
C[C@H]([C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−9.2
± 0.2
|
598 |
EN300-68635_1_1 |
|
CCNC(=O)CCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.3
|
599 |
MAT-POS-8a69d52e-4_2
|
|
C[C@H]1COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−9.19
± 0.07
|
600 |
EN300-302290_1_1 |
|
CS(=O)(=O)N1CC(C1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|