Rank |
Microstate |
SMILES |
ΔG / kcal M-1 |
1701 |
EN300-260658_1_1 |
|
CC(=O)NC[C@@H]1CCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−5.7
± 0.3
|
1702 |
EN300-52528_2_1 |
|
CCN1CC[NH+](CC1)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−5.7
± 0.4
|
1703 |
EN300-299920_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H](C([C@H](C5)O)O)O |
−5.6
± 0.3
|
1704 |
EN300-299920_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H](C([C@H](C5)O)O)O |
−5.6
± 0.3
|
1705 |
EN300-6732040_2_1 |
|
Cc1c(c(n(n1)C)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)N |
−5.6
± 0.3
|
1706 |
MAT-POS-b3e365b9-2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−5.6
± 0.2
|
1707 |
EN300-7355117_1_1 |
|
C[NH+]1CC2(C1)CCN(C[C@@H]2CO)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−5.6
± 0.4
|
1708 |
EN300-1644723_2_3 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5[C@H]6[C@@H]5COCC6 |
−5.6
± 0.2
|
1709 |
MAK-UNK-8be7dca9-3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3c4cc(ccc4OC[C@@H]3C[NH3+])Cl |
−5.6
± 0.4
|
1710 |
EN300-05841_1_2 |
|
CN([C@H]1CCS(=O)(=O)C1)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−5.6
± 0.6
|
1711 |
EN300-6489145_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCNS(=O)(=O)CC5 |
−5.6
± 0.3
|
1712 |
JOH-UNI-f51e3bbc-2_1
|
|
COc1c2ccccc2c(cn1)NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−5.6
± 0.1
|
1713 |
VLA-UCB-1dbca3b4-14_2
|
|
C[C@]1(c2cc(ccc2OCC1=O)Cl)C(=O)Nc3cncc4c3cccc4 |
−5.6
± 0.2
|
1714 |
EN300-31210_2_2 |
|
C[C@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NS(=O)(=O)C |
−5.6
± 0.4
|
1715 |
EN300-191904_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCn5cnnn5 |
−5.5
± 0.1
|
1716 |
ALP-UNI-4b8a177c-1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCOc4c3c(ccc4O)Cl |
−5.5
± 0.2
|
1717 |
EN300-172020_2_2 |
|
Cn1cc(cn1)C[C@H](C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−5.4
± 0.2
|
1718 |
MAK-UNK-8be7dca9-9_2
|
|
c1cc2c(cc1C(=O)[O-])cncc2NC(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−5.4
± 0.2
|
1719 |
EN300-142412_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCCC(=O)N |
−5.4
± 0.2
|
1720 |
MAK-UNK-8be7dca9-7_2
|
|
c1cc2cncc(c2cc1C(=O)[O-])NC(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−5.4
± 0.2
|
1721 |
EN300-31387_2_1 |
|
CS(=O)(=O)CCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−5.3
± 0.2
|
1722 |
DAR-DIA-6a508060-8_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCOc4c3cc(cc4)C5CC5 |
−5.3
± 0.2
|
1723 |
EN300-182725_2_2 |
|
C[C@H]([C@@H](C)S(=O)(=O)C)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−5.3
± 0.2
|
1724 |
EN300-12929_2_1 |
|
Cc1cc(no1)OCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−5.3
± 0.2
|
1725 |
EN300-74706_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C[NH+]5CCC(CC5)C(=O)N |
−5.3
± 0.5
|
1726 |
BEN-DND-c852c98b-3_2
|
|
CC(C)(c1ccc2cncc(c2c1)NC(=O)[C@H]3CCOc4c3cc(cc4)Cl)O |
−5.2
± 0.2
|
1727 |
EN300-171215_2_1 |
|
C[C@@H]1CS(=O)(=O)CCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−5.2
± 0.3
|
1728 |
EN300-171215_2_1 |
|
C[C@@H]1CS(=O)(=O)CCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−5.2
± 0.3
|
1729 |
DAR-DIA-6a508060-13_1
|
|
CS(=O)(=O)NCC[C@@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−5.2
± 0.3
|
1730 |
EN300-227055_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C[C@H]5CC(=O)NC5=O |
−5.2
± 0.2
|
1731 |
MAK-UNK-8be7dca9-3_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3c4cc(ccc4OC[C@H]3C[NH3+])Cl |
−5.2
± 0.3
|
1732 |
EN300-30572_2_1 |
|
CS(=O)(=O)NCCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−5.1
± 0.5
|
1733 |
EN300-1296824_2_1 |
|
C[C@@](CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(COC)O |
−5.0
± 0.2
|
1734 |
EN300-33657_2_1 |
|
CC(=O)N(C)CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−4.9
± 0.2
|
1735 |
EN300-30397_2_2 |
|
C[C@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cncn5 |
−4.9
± 0.2
|
1736 |
EN300-30397_2_2 |
|
C[C@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cncn5 |
−4.9
± 0.2
|
1737 |
EN300-16091_2_2 |
|
CCS(=O)(=O)[N@]1CCC[C@H]1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−4.9
± 0.3
|
1738 |
EN300-7456948_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cc5cccnn5 |
−4.9
± 0.2
|
1739 |
EN300-05841_1_1 |
|
CN([C@@H]1CCS(=O)(=O)C1)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−4.9
± 0.5
|
1740 |
EN300-298552_2_2 |
|
CO[C@H]([C@@H]1CCOC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−4.9
± 0.5
|
1741 |
VLA-UCB-34f3ed0c-3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)C(=O)NCc5ccn[nH]5 |
−4.8
± 0.3
|
1742 |
MAK-UNK-8be7dca9-1_2
|
|
c1cc2c(cc1CN3CC[NH2+]CC3)cncc2NC(=O)[C@H]4CCOc5c4cc(cc5)Cl |
−4.8
± 0.3
|
1743 |
BEN-BAS-5c03e89e-1_4
|
|
CC(C)([C@H]1COc2ccc(cc2[C@H]1C(=O)Nc3cncc4c3cccc4)Cl)O |
−4.7
± 0.2
|
1744 |
EN300-863933_2_1 |
|
C[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N(C)C(=O)C |
−4.7
± 0.2
|
1745 |
JOH-UNI-f51e3bbc-2_2
|
|
COc1c2ccccc2c(cn1)NC(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−4.7
± 0.2
|
1746 |
EN300-43047_2_1 |
|
CC(=O)N[C@@H](CC=C)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−4.6
± 0.2
|
1747 |
MAK-UNK-8be7dca9-8_2
|
|
c1cc2cncc(c2cc1CC(=O)[O-])NC(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−4.6
± 0.2
|
1748 |
EN300-6474064_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)c6n[n-]nn6 |
−4.6
± 0.4
|
1749 |
EN300-315453_2_1 |
|
Cc1cncn1CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−4.5
± 0.2
|
1750 |
EN300-36855_2_1 |
|
CN(CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)c5cnccn5 |
−4.5
± 0.2
|
1751 |
EN300-201553_2_1 |
|
Cn1cc(cn1)OCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−4.4
± 0.2
|
1752 |
EN300-201553_2_1 |
|
Cn1cc(cn1)OCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−4.4
± 0.2
|
1753 |
JOH-SUS-a69c159d-3_2
|
|
c1ccc2c(c1)c(cnc2C(F)F)NC(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−4.3
± 0.3
|
1754 |
EN300-705386_2_1 |
|
COC[C@@H]1C[C@H]1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−4.3
± 0.2
|
1755 |
EN300-705386_2_1 |
|
COC[C@@H]1C[C@H]1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−4.3
± 0.2
|
1756 |
MAK-UNK-83e0a0b4-2_2
|
|
c1cc2c(cc1CN3CC[NH2+]CC3)cncc2N(CCNC4C[NH2+]C4)C(=O)[C@H]5CCOc6c5cc(cc6)Cl |
−4.3
± 0.6
|
1757 |
MAK-UNK-8be7dca9-10_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3C[C@@H](Oc4c3cc(cc4)Cl)C(=O)[O-] |
−4.2
± 0.1
|
1758 |
EN300-6739879_2_3 |
|
C[C@@H]1CCN([C@H]2[C@@H]1CNC2=O)C(=O)CC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−4.2
± 0.4
|
1759 |
NAU-LAT-b7d8c353-8_2
|
|
c1cc(c2cncc(c2c1)NC(=O)[C@H]3CCOc4c3cc(cc4)Cl)C[NH3+] |
−4.1
± 0.3
|
1760 |
EN300-132523_2_1 |
|
C[N@](CCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C |
−4.1
± 0.4
|
1761 |
EN300-223964_2_1 |
|
CC[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)[NH+](C)C |
−4.1
± 0.3
|
1762 |
EN300-207873_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5(CC5)O |
−4.1
± 0.1
|
1763 |
EN300-68889_2_1 |
|
CCNC(=O)CCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−4.1
± 0.2
|
1764 |
EN300-306047_2_1 |
|
Cn1cc(nn1)CCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−4.0
± 0.2
|
1765 |
MAK-UNK-8be7dca9-6_2
|
|
c1cc(c2cncc(c2c1)NC(=O)[C@H]3CCOc4c3cc(cc4)Cl)C[NH3+] |
−4.0
± 0.2
|
1766 |
EN300-152913_2_1 |
|
CN(C)c1nc(on1)CCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−3.9
± 0.2
|
1767 |
EN300-67073_2_2 |
|
CC(=O)N[C@](C)(C1CC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−3.9
± 0.3
|
1768 |
JOH-UNI-f51e3bbc-1_1
|
|
c1ccc2c(c1)c(c[nH]c2=O)NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−3.8
± 0.2
|
1769 |
EN300-27268_2_1 |
|
Cc1nc(on1)CCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−3.8
± 0.2
|
1770 |
EN300-6762327_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H](Cc5ccccn5)O |
−3.8
± 0.2
|
1771 |
EN300-223491_2_1 |
|
Cn1cnn(c1=O)CCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−3.8
± 0.2
|
1772 |
JOH-UNI-f51e3bbc-1_2
|
|
c1ccc2c(c1)c(c[nH]c2=O)NC(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−3.8
± 0.3
|
1773 |
JOH-SUS-a69c159d-4_2
|
|
c1ccc2c(c1)c(cnc2C(F)(F)F)NC(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−3.7
± 0.2
|
1774 |
EN300-31210_2_1 |
|
C[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NS(=O)(=O)C |
−3.7
± 0.3
|
1775 |
JOH-UNI-f51e3bbc-3_2
|
|
c1ccc2c(c1)c[nH]c(=O)c2NC(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−3.6
± 0.3
|
1776 |
JAG-UCB-706446eb-3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)[O-] |
−3.5
± 0.2
|
1777 |
EN300-10402_2_2 |
|
CS(=O)(=O)[N@]1CCC[C@H]1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−3.5
± 0.2
|
1778 |
EN300-51071_2_1 |
|
CC(C)(C)NS(=O)(=O)CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−3.3
± 0.4
|
1779 |
VLA-UCB-50c39ae8-4_1
|
|
CC(=O)N1CC[NH+](CC1)CC(=O)N(c2cncc3c2cccc3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−3.2
± 0.4
|
1780 |
EN300-1725538_2_2 |
|
Cn1cc(nc1)C[C@H](C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−3.2
± 0.2
|
1781 |
EN300-259694_2_1 |
|
CCO[C@@]1(CCOC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−3.0
± 0.2
|
1782 |
EN300-6498076_2_1 |
|
Cc1c(c(=O)ccn1CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)[O-] |
−2.9
± 0.2
|
1783 |
EN300-24014_2_2 |
|
CS(=O)(=O)[N@]1CCCC[C@H]1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−2.6
± 0.3
|
1784 |
EN300-65383_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCn5cc[nH]c(=O)c5=O |
−2.5
± 0.2
|
1785 |
EN300-05841_2_2 |
|
CN([C@H]1CCS(=O)(=O)C1)C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−2.2
± 0.6
|
1786 |
EN300-6729572_2_1 |
|
C[C@@H]([C@@H]1C[C@@H]1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−1.8
± 0.2
|
1787 |
MAK-UNK-8be7dca9-10_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3C[C@@H](Oc4c3cc(cc4)Cl)C(=O)[O-] |
−0.7
± 0.3
|
1788 |
MAK-UNK-8be7dca9-10_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3C[C@H](Oc4c3cc(cc4)Cl)C(=O)[O-] |
−0.5
± 0.4
|
1789 |
EN300-128750_2_1 |
|
CC(=O)N(C)CCCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
7.1
± 0.3
|