Rank |
Microstate |
SMILES |
ΔG / kcal M-1 |
101 |
EN300-3710141_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@]5(CCCO5)C#N |
−10.7
± 0.3
|
102 |
EN300-205486_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5c[nH]ccc5=O |
−10.7
± 0.3
|
103 |
EN300-861925_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCO[C@H](CO)F |
−10.7
± 0.3
|
104 |
EN300-203293_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]5CNC(=O)O5 |
−10.7
± 0.3
|
105 |
EN300-221518_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCCO |
−10.7
± 0.2
|
106 |
EN300-221518_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCCO |
−10.7
± 0.2
|
107 |
EN300-221518_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCCO |
−10.7
± 0.2
|
108 |
DAR-DIA-5ff57136-14_1
|
|
CC(C)(C#C)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−10.7
± 0.2
|
109 |
EN300-171766_4_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCc5n[nH]c(=O)s5 |
−10.7
± 0.3
|
110 |
EN300-248526_3_1 |
|
c1ccc(cc1)[C@@](COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(C(=O)N)O |
−10.7
± 0.6
|
111 |
EN300-1715993_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCn5ccnn5 |
−10.7
± 0.2
|
112 |
EN300-51736_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COc5cccc(c5)C(=O)N |
−10.7
± 0.3
|
113 |
VLA-UCB-34f3ed0c-4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5ccn[nH]5 |
−10.7
± 0.2
|
114 |
EN300-6494158_4_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC[C@H]5C[C@@H](CO5)CO |
−10.7
± 0.5
|
115 |
EN300-1705754_3_1 |
|
CC1(CS(=O)(=O)C1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.3
|
116 |
EN300-1911992_3_4 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]([C@H]5CCOC5)O |
−10.6
± 0.4
|
117 |
EN300-66432_3_1 |
|
CN(C)S(=O)(=O)CCCOCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.4
|
118 |
EN300-370967_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCN5CCOC5=O |
−10.6
± 0.3
|
119 |
EN300-370967_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCN5CCOC5=O |
−10.6
± 0.3
|
120 |
EN300-195924_3_2 |
|
C[C@]1(CCC(=O)NC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.3
|
121 |
DAR-DIA-5ff57136-11_1
|
|
C=C=CC(=O)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−10.6
± 0.2
|
122 |
EN300-222969_3_2 |
|
CN1C[C@H](OC1=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.3
|
123 |
EN300-7463171_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCS(=O)(=O)CCO |
−10.6
± 0.6
|
124 |
EN300-173216_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(=O)NCC5CC5 |
−10.6
± 0.2
|
125 |
EN300-175186_3_2 |
|
C[C@H](CO)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.3
|
126 |
EN300-198633_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5CCCCNC5=O |
−10.6
± 0.3
|
127 |
EN300-1248250_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CN(C5)C(=O)N |
−10.6
± 0.2
|
128 |
EN300-51028_1_1 |
|
CC(C)S(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.3
|
129 |
EN300-11934_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCC5=O |
−10.6
± 0.2
|
130 |
EN300-87334_3_1 |
|
Cn1c(ncn1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.3
|
131 |
EN300-6238494_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)[C@H]5COCCO5 |
−10.6
± 0.3
|
132 |
JAG-UCB-706446eb-5_1
|
|
COCCN([C@@H]1CCCOC1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.3
|
133 |
EN300-317082_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC5COC5 |
−10.6
± 0.2
|
134 |
EN300-264301_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5CCC(=O)N5 |
−10.5
± 0.2
|
135 |
EN300-264744_3_2 |
|
CC(C)([C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)F)O |
−10.5
± 0.3
|
136 |
EN300-343474_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5CCNC5=O |
−10.5
± 0.3
|
137 |
EN300-143564_1_2 |
|
CN\1C(=O)CS/C1=C/C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.2
|
138 |
EN300-783124_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]([C@@H]5CCOC5)F |
−10.5
± 0.2
|
139 |
EN300-05512_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N[C@@H]5CCS(=O)(=O)C5 |
−10.5
± 0.4
|
140 |
EN300-110012_3_2 |
|
CC[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)[NH+](C)C |
−10.5
± 0.4
|
141 |
DAR-DIA-23e5a6a0-3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4O[C@H]5CC6([NH2+]5)COC6)Cl |
−10.5
± 0.3
|
142 |
EN300-310888_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5nnc6n5CCOCC6 |
−10.5
± 0.3
|
143 |
EN300-7444316_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@@H](C5)C(=O)N)C(=O)N |
−10.5
± 0.5
|
144 |
EN300-152337_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CCC(=O)NCC5 |
−10.5
± 0.4
|
145 |
EN300-6238494_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)[C@@H]5COCCO5 |
−10.5
± 0.3
|
146 |
EN300-6482967_3_1 |
|
CNS(=O)(=O)CCOCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.3
|
147 |
EN300-195756_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]5CCC(=O)N5 |
−10.5
± 0.2
|
148 |
EN300-171766_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5n[nH]c(=O)s5 |
−10.5
± 0.2
|
149 |
EN300-244909_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCOCC5)CO |
−10.5
± 0.4
|
150 |
EN300-1253178_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NC5CC5 |
−10.5
± 0.2
|
151 |
EN300-1253178_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NC5CC5 |
−10.5
± 0.2
|
152 |
EN300-181492_1_2 |
|
C=C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.5
± 0.3
|
153 |
EN300-62574_2_1 |
|
Cn1c(nnn1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
154 |
EN300-315963_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnoc5 |
−10.4
± 0.2
|
155 |
EN300-1726073_3_1 |
|
Cn1c(cnn1)C(C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(F)F |
−10.4
± 0.3
|
156 |
VLA-UCB-50c39ae8-6_1
|
|
c1ccc2c(c1)cncc2N(C(=O)CCl)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−10.4
± 0.2
|
157 |
EN300-59478_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCC(=O)N |
−10.4
± 0.3
|
158 |
EN300-21258_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCO |
−10.4
± 0.3
|
159 |
EN300-185378_3_2 |
|
C[C@H](COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.4
± 0.2
|
160 |
EN300-1600786_1_1 |
|
Cn1cc(nn1)CCO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.2
|
161 |
EN300-1600786_1_1 |
|
Cn1cc(nn1)CCO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.2
|
162 |
EN300-120282_3_1 |
|
Cn1cc(nn1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
163 |
JOH-SUS-a69c159d-7_1
|
|
c1cc2c(cc1F)c(c(nc2F)F)NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−10.42
± 0.07
|
164 |
EN300-115017_1_1 |
|
CC(C)[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.4
± 0.2
|
165 |
EN300-1708882_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5COC[C@H]5O |
−10.4
± 0.3
|
166 |
EN300-107048_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CC5)CO |
−10.4
± 0.3
|
167 |
EN300-139167_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5COCCO5 |
−10.4
± 0.4
|
168 |
EN300-139167_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5COCCO5 |
−10.4
± 0.4
|
169 |
EN300-139167_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5COCCO5 |
−10.4
± 0.4
|
170 |
EN300-17184_1_1 |
|
C=CCNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.2
|
171 |
JAG-UCB-706446eb-5_2
|
|
COCCN([C@H]1CCCOC1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
172 |
EN300-1659582_1_1 |
|
C#CCNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.2
|
173 |
EN300-1659582_1_1 |
|
C#CCNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.2
|
174 |
EN300-1659582_1_1 |
|
C#CCNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.2
|
175 |
VLA-UCB-50c39ae8-9_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4O[C@H]5CC(=O)N5)Cl)CCC6CCCCC6 |
−10.4
± 0.3
|
176 |
EN300-65839_3_2 |
|
CC[C@H](C(=O)N)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.3
|
177 |
EN300-4293814_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CS(=O)(=O)CCO |
−10.4
± 0.5
|
178 |
EN300-18249_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N |
−10.4
± 0.2
|
179 |
EN300-62857_3_1 |
|
COCCS(=O)(=O)CCCOCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.5
|
180 |
DAR-DIA-5ff57136-18_1
|
|
c1ccc2c(c1)cncc2N(C(=O)[C@@H]3CCOc4c3cc(cc4)Cl)N=C=S |
−10.3
± 0.1
|
181 |
DAR-DIA-5ff57136-2_1
|
|
C[C@H]1COc2ccc(cc2[C@@H]1C(=O)N(c3cncc4c3cccc4)C(=O)C=C)Cl |
−10.3
± 0.2
|
182 |
EN300-1072972_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5CCOC5=O |
−10.3
± 0.3
|
183 |
VLA-UCB-50c39ae8-10_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC5CCCCC5 |
−10.3
± 0.3
|
184 |
MAK-UNK-83e0a0b4-2_1
|
|
c1cc2c(cc1CN3CC[NH2+]CC3)cncc2N(CCNC4C[NH2+]C4)C(=O)[C@@H]5CCOc6c5cc(cc6)Cl |
−10.3
± 0.5
|
185 |
EN300-120586_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NCC(F)F |
−10.3
± 0.3
|
186 |
EN300-364992_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC[C@H]5CC[C@H](O5)C(=O)N |
−10.3
± 0.4
|
187 |
EN300-216673_3_1 |
|
Cn1c(cnn1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
188 |
EN300-7463171_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCS(=O)(=O)CCO |
−10.3
± 0.5
|
189 |
EN300-10414_1_1 |
|
C[C@@]1(CCS(=O)(=O)C1)NC(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
190 |
EN300-317555_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5=NCCO5 |
−10.3
± 0.3
|
191 |
EN300-102347_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5(COC5)CO |
−10.3
± 0.3
|
192 |
EN300-216063_3_1 |
|
CN(C)C(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.3
|
193 |
EN300-216063_3_1 |
|
CN(C)C(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.3
|
194 |
EN300-216063_3_1 |
|
CN(C)C(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.3
|
195 |
EN300-295905_1_4 |
|
C[C@H]1CN(C[C@H](O1)C(=O)N)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.3
± 0.3
|
196 |
EN300-153257_1_1 |
|
CC(C)[C@@H](CO)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.3
± 0.2
|
197 |
EN300-62574_4_1 |
|
Cn1c(nnn1)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.2
± 0.4
|
198 |
EN300-55072_1_1 |
|
C[C@@H](CO)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.2
± 0.3
|
199 |
VLA-UCB-50c39ae8-1_1
|
|
CC(=O)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−10.2
± 0.1
|
200 |
EN300-6487407_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5[C@H](CC(=O)O5)O |
−10.2
± 0.4
|