Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
1201 |
MAK-UNK-83e0a0b4-1
|
|
CCCCc1ccc2c(c1)C(CCO2)C(=O)N(CCNC3CNC3)c4cncc5c4ccc(c5)CN6CCNCC6 |
−6.7
± 0.4
|
4.9
± 0.3
|
1202 |
EN300-16091_2
|
|
CCS(=O)(=O)N1CCCC1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.7
± 0.4
|
4.9
± 0.3
|
1203 |
EN300-304187_2
|
|
CC1(CC(CN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC)CO |
−6.7
± 0.3
|
4.9
± 0.2
|
1204 |
EN300-203118_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(C5)(CO)F |
−6.7
± 0.3
|
4.9
± 0.2
|
1205 |
MAK-UNK-3875bbc8-3
|
|
CN(c1cncc2c1cccc2)C(=O)C3CCOc4c3cccc4 |
−6.7
± 0.2
|
4.9
± 0.1
|
1206 |
EN300-7355477_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6CC(C(CC6C5)O)O |
−6.7
± 0.2
|
4.9
± 0.1
|
1207 |
EN300-1718424_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC6(C5)CCC(=O)N6 |
−6.7
± 0.3
|
4.9
± 0.2
|
1208 |
JOH-SUS-a69c159d-4
|
|
c1ccc2c(c1)c(cnc2C(F)(F)F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−6.7
± 0.1
|
4.86
± 0.08
|
1209 |
EN300-99776_2
|
|
CCNC(=O)C1CN(C1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.7
± 0.3
|
4.9
± 0.2
|
1210 |
EN300-1664865_2
|
|
Cn1c2c(nn1)CCCC2C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−6.7
± 0.3
|
4.9
± 0.2
|
1211 |
EN300-217107_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCC5C(=O)N |
−6.7
± 0.2
|
4.9
± 0.1
|
1212 |
EN300-701244_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]6CS(=O)(=O)C[C@]6(C5)C#N |
−6.7
± 0.4
|
4.9
± 0.3
|
1213 |
EN300-151268_2
|
|
CC(C)NS(=O)(=O)NC(C)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.6
± 0.6
|
4.8
± 0.4
|
1214 |
EN300-1655839_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCn5cccnc5=O |
−6.6
± 0.4
|
4.8
± 0.3
|
1215 |
EN300-140179_2
|
|
CNC(=O)C1CN(C1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.6
± 0.3
|
4.8
± 0.2
|
1216 |
BRU-THA-01b12488-1
|
|
C[C@@H]1COc2ccc(cc2[C@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−6.6
± 0.2
|
4.8
± 0.1
|
1217 |
EN300-35778_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCC(CC5)C(=O)N |
−6.5
± 0.3
|
4.8
± 0.2
|
1218 |
VLA-UCB-05e51b3f-11
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCOc4c3cc(cc4OC5CC(=O)N5)Cl |
−6.5
± 0.2
|
4.8
± 0.2
|
1219 |
EN300-31146_2
|
|
CN(CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)C5CC5 |
−6.5
± 0.3
|
4.8
± 0.2
|
1220 |
EN300-157541_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCS(=O)(=O)CC5CO |
−6.5
± 0.4
|
4.8
± 0.3
|
1221 |
EN300-100830_2
|
|
CCS(=O)(=O)N(C)CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.5
± 0.4
|
4.7
± 0.3
|
1222 |
EN300-96037_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@@H]([C@H](C5)O)O |
−6.5
± 0.3
|
4.7
± 0.2
|
1223 |
EN300-814104_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC[C@H]6CC(=O)N[C@H]6C5 |
−6.5
± 0.3
|
4.7
± 0.2
|
1224 |
EN300-28871_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCn5ccnn5 |
−6.5
± 0.1
|
4.74
± 0.09
|
1225 |
EN300-153668_2
|
|
CC1CNC(=O)CN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.5
± 0.4
|
4.7
± 0.3
|
1226 |
MAK-UNK-8be7dca9-8
|
|
c1cc2cncc(c2cc1CC(=O)O)NC(=O)C3CCOc4c3cc(cc4)Cl |
−6.46
± 0.09
|
4.71
± 0.07
|
1227 |
MAT-POS-8e4737f4-1
|
|
C[C@@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.46
± 0.09
|
4.71
± 0.06
|
1228 |
EN300-210246_1
|
|
CN(C)S(=O)(=O)N(C)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.4
± 0.5
|
4.7
± 0.3
|
1229 |
EN300-1702911_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC(C5)NC(=O)N |
−6.4
± 0.3
|
4.7
± 0.2
|
1230 |
EN300-68875_1
|
|
CNS(=O)(=O)CCCO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.4
± 0.3
|
4.7
± 0.2
|
1231 |
EN300-212797_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(CN5CCCC5)CO |
−6.4
± 0.4
|
4.7
± 0.3
|
1232 |
EN300-172481_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(C5)(C(=O)N)O |
−6.4
± 0.4
|
4.7
± 0.3
|
1233 |
EN300-6764788_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@@H]6[C@H](C5)NC(=O)C(=O)N6 |
−6.4
± 0.3
|
4.7
± 0.2
|
1234 |
EN300-1644723_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5C6C5COCC6 |
−6.4
± 0.2
|
4.7
± 0.1
|
1235 |
EN300-265003_2
|
|
Cn1cnnc1C2CN(C2)C(=O)CC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−6.4
± 0.7
|
4.7
± 0.5
|
1236 |
EN300-6764893_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)OCCO |
−6.4
± 0.3
|
4.7
± 0.2
|
1237 |
EN300-62191_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCC(=O)NC5 |
−6.4
± 0.2
|
4.6
± 0.1
|
1238 |
MAK-UNK-8be7dca9-6
|
|
c1cc(c2cncc(c2c1)NC(=O)C3CCOc4c3cc(cc4)Cl)CN |
−6.3
± 0.2
|
4.6
± 0.1
|
1239 |
EN300-42243_2
|
|
CC(C)CS(=O)(=O)CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.3
± 0.5
|
4.6
± 0.4
|
1240 |
EN300-35642_2
|
|
CN(CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C |
−6.3
± 0.3
|
4.6
± 0.2
|
1241 |
EN300-821316_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)CC(=O)NCC6O |
−6.3
± 0.3
|
4.6
± 0.2
|
1242 |
EN300-267469_2
|
|
CS(=NC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(=O)C |
−6.3
± 0.3
|
4.6
± 0.2
|
1243 |
EN300-1296824_2
|
|
CC(CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(COC)O |
−6.3
± 0.4
|
4.6
± 0.3
|
1244 |
EN300-114134_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCN5CCCS5(=O)=O |
−6.3
± 0.5
|
4.6
± 0.4
|
1245 |
EN300-180172_2
|
|
CC(Cn1ccccc1=O)(C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−6.3
± 0.4
|
4.6
± 0.3
|
1246 |
DAR-DIA-0d514e7d-23
|
|
C[C@H]1COc2c(cc(cc2N3CCCC3)Cl)[C@@H]1C(=O)Nc4cncc5c4cccc5 |
−6.3
± 0.2
|
4.6
± 0.1
|
1247 |
EN300-120820_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5cn[nH]c5=O |
−6.2
± 0.2
|
4.5
± 0.1
|
1248 |
ALP-POS-d3acb8cc-2
|
|
C[C@@H]1C[C@@H](c2cc(ccc2O1)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.2
± 0.2
|
4.5
± 0.1
|
1249 |
EN300-83353_2
|
|
CN1CCN(CC1=O)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.2
± 0.2
|
4.5
± 0.1
|
1250 |
EN300-68875_4
|
|
CNS(=O)(=O)CCCOCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.2
± 0.4
|
4.5
± 0.3
|
1251 |
EN300-41507_2
|
|
Cc1nccn1CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.2
± 0.2
|
4.5
± 0.2
|
1252 |
ALP-POS-477dc5b7-3
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)CCC5CC5 |
−6.14
± 0.07
|
4.47
± 0.05
|
1253 |
EN300-1726277_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(n5cccn5)F |
−6.1
± 0.2
|
4.5
± 0.1
|
1254 |
ADA-UCB-dc2b944c-14
|
|
C[C@H]1COc2ccc(cc2[C@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−6.1
± 0.2
|
4.5
± 0.1
|
1255 |
VLA-UCB-05e51b3f-10
|
|
C=CC(=O)N(c1cncc2c1cccc2)C(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−6.1
± 0.3
|
4.4
± 0.2
|
1256 |
EN300-202757_2
|
|
CC(CC(=O)N)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.1
± 0.2
|
4.4
± 0.1
|
1257 |
EN300-262604_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5cnc(n5)C(=O)N |
−6.1
± 0.4
|
4.4
± 0.3
|
1258 |
EN300-1605046_1
|
|
CN1CC2(C1)CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−6.1
± 0.3
|
4.4
± 0.2
|
1259 |
ALP-POS-d3acb8cc-3
|
|
C[C@H]1C[C@@H](c2cc(ccc2O1)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.1
± 0.2
|
4.4
± 0.1
|
1260 |
NAU-LAT-b7d8c353-8
|
|
c1cc(c2cncc(c2c1)NC(=O)C3CCOc4c3cc(cc4)Cl)CN |
−6.0
± 0.1
|
4.40
± 0.09
|
1261 |
MAT-POS-8a69d52e-6
|
|
C[C@@H]1COc2ccc(cc2[C@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−6.0
± 0.2
|
4.4
± 0.1
|
1262 |
EN300-169955_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5C(CC(=O)N5)C(F)(F)F |
−6.0
± 0.3
|
4.4
± 0.2
|
1263 |
EN300-155764_2
|
|
CC1C(=O)N(CCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−6.0
± 0.3
|
4.4
± 0.2
|
1264 |
EN300-1268087_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(CC5)c6[nH]nnn6 |
−6.0
± 0.4
|
4.4
± 0.3
|
1265 |
MAT-POS-8a69d52e-3
|
|
C[C@H]1C[C@@H](c2cc(ccc2O1)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.02
± 0.09
|
4.39
± 0.06
|
1266 |
MAT-POS-8a69d52e-5
|
|
C[C@H]1COc2ccc(cc2[C@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−6.0
± 0.2
|
4.4
± 0.1
|
1267 |
EN300-80940_2
|
|
CC1C(S(=O)(=O)CCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−6.0
± 0.4
|
4.4
± 0.3
|
1268 |
EN300-126104_2
|
|
Cc1cccn(c1=O)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.0
± 0.3
|
4.4
± 0.2
|
1269 |
EN300-244842_2
|
|
C[C@@H]1CN(C[C@H]1C(=O)N)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.0
± 0.2
|
4.4
± 0.2
|
1270 |
EN300-11714_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5ccccc5=O |
−6.0
± 0.2
|
4.4
± 0.2
|
1271 |
EN300-74129_1
|
|
CNC(=O)C1CCCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.0
± 0.4
|
4.3
± 0.3
|
1272 |
ADA-UCB-dc2b944c-13
|
|
C[C@@H]1COc2ccc(cc2[C@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−6.0
± 0.2
|
4.3
± 0.1
|
1273 |
EN300-31845_2
|
|
COCCN1CC(CC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−5.9
± 0.3
|
4.3
± 0.2
|
1274 |
EN300-75342_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCn5ccnc5 |
−5.9
± 0.1
|
4.31
± 0.09
|
1275 |
EN300-67073_2
|
|
CC(=O)NC(C)(C1CC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−5.9
± 0.3
|
4.3
± 0.2
|
1276 |
EN300-67191_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCN5CCCC5=O |
−5.9
± 0.2
|
4.3
± 0.2
|
1277 |
EN300-53433_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCNC(=O)c5cnccn5 |
−5.9
± 0.3
|
4.3
± 0.2
|
1278 |
EN300-31994_1
|
|
CN(C)CC(CNC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−5.9
± 0.6
|
4.3
± 0.4
|
1279 |
EN300-306495_2
|
|
C[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N(C)C |
−5.8
± 0.3
|
4.2
± 0.2
|
1280 |
EN300-154179_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6CC6(C5)CO |
−5.8
± 0.3
|
4.2
± 0.2
|
1281 |
EN300-818709_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)Cc6[nH]nnn6 |
−5.8
± 0.4
|
4.2
± 0.3
|
1282 |
ALP-UNI-4b8a177c-1
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3c(ccc4O)Cl |
−5.8
± 0.2
|
4.2
± 0.1
|
1283 |
EN300-41828_2
|
|
CCOC(=O)CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−5.8
± 0.2
|
4.2
± 0.1
|
1284 |
EN300-261410_2
|
|
CC1C(=O)N(CN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−5.8
± 0.7
|
4.2
± 0.5
|
1285 |
JOH-UNI-f51e3bbc-3
|
|
c1ccc2c(c1)cnc(c2NC(=O)C3CCOc4c3cc(cc4)Cl)O |
−5.7
± 0.1
|
4.2
± 0.1
|
1286 |
EN300-755481_2
|
|
Cn1ccnc1CCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−5.7
± 0.3
|
4.2
± 0.2
|
1287 |
VLA-UCB-05e51b3f-7
|
|
CC(=O)N1CCN(CC1)CC(=O)N(c2cncc3c2cccc3)C(=O)[C@H]4CCOc5c4cc(cc5)Cl |
−5.7
± 0.6
|
4.2
± 0.4
|
1288 |
EN300-260658_1
|
|
CC(=O)NCC1CCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−5.7
± 0.2
|
4.1
± 0.1
|
1289 |
EN300-52528_2
|
|
CCN1CCN(CC1)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−5.7
± 0.4
|
4.1
± 0.3
|
1290 |
EN300-299920_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]([C@H]([C@H](C5)O)O)O |
−5.6
± 0.2
|
4.1
± 0.2
|
1291 |
EN300-6732040_2
|
|
Cc1c(c(n(n1)C)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)N |
−5.6
± 0.3
|
4.1
± 0.2
|
1292 |
MAT-POS-b3e365b9-2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−5.6
± 0.2
|
4.1
± 0.1
|
1293 |
EN300-7355117_1
|
|
CN1CC2(C1)CCN(CC2CO)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−5.6
± 0.4
|
4.1
± 0.3
|
1294 |
EN300-6489145_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCNS(=O)(=O)CC5 |
−5.6
± 0.3
|
4.1
± 0.2
|
1295 |
JOH-SUS-a69c159d-3
|
|
c1ccc2c(c1)c(cnc2C(F)F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−5.5
± 0.2
|
4.0
± 0.1
|
1296 |
EN300-191904_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCn5cnnn5 |
−5.5
± 0.1
|
4.0
± 0.1
|
1297 |
MAK-UNK-8be7dca9-10
|
|
c1ccc2c(c1)cncc2NC(=O)C3CC(Oc4c3cc(cc4)Cl)C(=O)O |
−5.48
± 0.08
|
3.99
± 0.06
|
1298 |
EN300-172020_2
|
|
Cn1cc(cn1)CC(C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−5.4
± 0.2
|
4.0
± 0.1
|
1299 |
EN300-142412_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCCC(=O)N |
−5.4
± 0.2
|
3.9
± 0.1
|
1300 |
EN300-05841_1
|
|
CN(C1CCS(=O)(=O)C1)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−5.4
± 0.5
|
3.9
± 0.3
|