Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
1101 |
EN300-6486576_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5nnc(o5)N6CCOCC6 |
−7.2
± 0.3
|
5.3
± 0.2
|
1102 |
EN300-131093_2
|
|
CC(C(=O)NCC(=O)C)OC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.2
± 0.3
|
5.3
± 0.2
|
1103 |
EN300-127629_2
|
|
CC1(COCCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−7.2
± 0.3
|
5.3
± 0.2
|
1104 |
EN300-310173_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5[C@H](CCO5)Cn6ccnc6 |
−7.2
± 0.3
|
5.3
± 0.2
|
1105 |
EN300-6255179_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCn5cncn5 |
−7.2
± 0.3
|
5.2
± 0.2
|
1106 |
EN300-52325_2
|
|
CCCS(=O)(=O)CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.2
± 0.6
|
5.2
± 0.4
|
1107 |
DAR-DIA-5ff57136-19
|
|
CN(C)C/C=C/C(=O)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−7.2
± 0.3
|
5.2
± 0.2
|
1108 |
VLA-UCB-34f3ed0c-19
|
|
c1ccc2c(c1)cncc2N(C(=O)c3ccco3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−7.2
± 0.2
|
5.2
± 0.1
|
1109 |
ADA-UCB-dc2b944c-8
|
|
c1cc2c(cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl)c(c1)Cl |
−7.17
± 0.07
|
5.23
± 0.05
|
1110 |
NAU-LAT-0543f7f2-10
|
|
CC(=O)NCCOc1cc(cc2c1OCCC2C(=O)Nc3cncc4c3cccc4)Cl |
−7.2
± 0.2
|
5.2
± 0.2
|
1111 |
EN300-6735421_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5(CN(C5)C6CC6)CO |
−7.2
± 0.5
|
5.2
± 0.3
|
1112 |
EN300-378316_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCc5nnc6n5cc[nH]c6=O |
−7.2
± 0.4
|
5.2
± 0.3
|
1113 |
EN300-6501360_3
|
|
CN(C)C(=O)NCC(COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−7.2
± 0.5
|
5.2
± 0.3
|
1114 |
EN300-73102_2
|
|
CC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C5CCOCC5 |
−7.1
± 0.5
|
5.2
± 0.4
|
1115 |
EN300-69215_2
|
|
CN(C)C(=O)CCCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.1
± 0.4
|
5.2
± 0.3
|
1116 |
EN300-6732769_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)C6CC(=O)NC6=O |
−7.1
± 0.3
|
5.2
± 0.2
|
1117 |
EN300-1087187_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6CCC(=O)NC6C5 |
−7.1
± 0.4
|
5.2
± 0.3
|
1118 |
EN300-39005_2
|
|
CN(CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)OC |
−7.1
± 0.3
|
5.2
± 0.2
|
1119 |
EN300-185398_3
|
|
CC(C(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(F)F)O |
−7.1
± 0.2
|
5.2
± 0.1
|
1120 |
EN300-96886_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@@H](C[C@@H](C5)O)O |
−7.1
± 0.3
|
5.2
± 0.2
|
1121 |
EN300-7355737_4
|
|
Cn1cc(c(n1)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)N |
−7.1
± 0.6
|
5.2
± 0.5
|
1122 |
EN300-2009111_2
|
|
Cn1c(cc(n1)CO)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.1
± 0.3
|
5.2
± 0.2
|
1123 |
EN300-204419_2
|
|
C[C@@H](CO)N(C)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.1
± 0.3
|
5.2
± 0.2
|
1124 |
DAR-DIA-0d514e7d-5
|
|
C[C@H]1COc2c(cc(cc2NC3CCCC3)Cl)[C@@H]1C(=O)Nc4cncc5c4cccc5 |
−7.1
± 0.2
|
5.2
± 0.1
|
1125 |
EN300-135078_2
|
|
CCN1CCN(CC1=O)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.1
± 0.3
|
5.2
± 0.2
|
1126 |
EN300-1693852_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]([C@@H](C5)F)CO |
−7.1
± 0.3
|
5.2
± 0.2
|
1127 |
EN300-218962_2
|
|
CCC(C(=O)N)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.1
± 0.2
|
5.1
± 0.2
|
1128 |
EN300-1703852_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5COC(=O)N5 |
−7.1
± 0.5
|
5.1
± 0.4
|
1129 |
EN300-36850_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCNC(=O)C5CC5 |
−7.1
± 0.2
|
5.1
± 0.2
|
1130 |
EN300-306144_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(C5)(CO)CO |
−7.1
± 0.3
|
5.1
± 0.2
|
1131 |
EN300-266565_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC(C5)C(=O)N |
−7.0
± 0.3
|
5.1
± 0.2
|
1132 |
EN300-60035_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCCNC5=O |
−7.0
± 0.2
|
5.1
± 0.2
|
1133 |
MAK-UNK-8be7dca9-1
|
|
c1cc2c(cc1CN3CCNCC3)cncc2NC(=O)C4CCOc5c4cc(cc5)Cl |
−7.0
± 0.1
|
5.1
± 0.1
|
1134 |
EN300-250458_2
|
|
Cn1c(ccn1)C(CO)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.0
± 0.4
|
5.1
± 0.3
|
1135 |
EN300-2008102_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5CN6CC(O5)CCC6=O |
−7.0
± 0.7
|
5.1
± 0.5
|
1136 |
EN300-82457_1
|
|
CCN(CC)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.0
± 0.2
|
5.1
± 0.2
|
1137 |
EN300-66432_1
|
|
CN(C)S(=O)(=O)CCCO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.0
± 0.3
|
5.1
± 0.3
|
1138 |
EN300-178293_4
|
|
CN1CCN(CC1)C(=O)CCOCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.0
± 0.5
|
5.1
± 0.3
|
1139 |
EN300-31213_2
|
|
CCS(=O)(=O)NC(C)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.0
± 0.5
|
5.1
± 0.4
|
1140 |
BEN-DND-c852c98b-3
|
|
CC(C)(c1ccc2cncc(c2c1)NC(=O)C3CCOc4c3cc(cc4)Cl)O |
−7.03
± 0.09
|
5.12
± 0.07
|
1141 |
EN300-305282_2
|
|
COCC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−7.0
± 0.4
|
5.1
± 0.3
|
1142 |
EN300-384241_2
|
|
Cc1[nH]c(nn1)C2CN(C2)C(=O)CC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−7.0
± 0.3
|
5.1
± 0.2
|
1143 |
EN300-6497238_2
|
|
C[C@@H]1CS(=O)(=O)CCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.0
± 0.4
|
5.1
± 0.3
|
1144 |
EN300-6491697_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCc5cccc(=O)[nH]5 |
−7.0
± 0.3
|
5.1
± 0.2
|
1145 |
EN300-703023_2
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)CCC(=O)N[C@H]5C[C@@H](C5)CO)cc1 |
−7.0
± 0.3
|
5.1
± 0.2
|
1146 |
EN300-259847_2
|
|
COC1CCCCN(C1=O)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.0
± 0.4
|
5.1
± 0.3
|
1147 |
ADA-UCB-dc2b944c-7
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4)F |
−7.00
± 0.06
|
5.10
± 0.04
|
1148 |
EN300-6495717_2
|
|
CC1CC(CN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(CO)CO |
−7.0
± 0.5
|
5.1
± 0.4
|
1149 |
EN300-250593_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5CC(=O)N5 |
−7.0
± 0.1
|
5.1
± 0.1
|
1150 |
EN300-343103_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5[nH]c(=O)c6c(n5)CCOC6 |
−7.0
± 0.3
|
5.1
± 0.2
|
1151 |
EN300-261986_4
|
|
CS(=O)(=O)N1CCC(C1)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.0
± 0.2
|
5.1
± 0.2
|
1152 |
EN300-6356960_2
|
|
Cn1cnnc1CCCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.0
± 0.4
|
5.1
± 0.3
|
1153 |
EN300-311771_2
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)CCC(=O)N[C@H]5C[C@@H](C5)C(=O)N)cc1 |
−7.0
± 0.3
|
5.1
± 0.2
|
1154 |
EN300-26953_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC(C(=O)N)C(=O)N |
−7.0
± 0.3
|
5.1
± 0.2
|
1155 |
EN300-95639_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(C(C5)O)CO |
−7.0
± 0.3
|
5.1
± 0.2
|
1156 |
EN300-6335413_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5C[C@H]5C(=O)NCCO |
−7.0
± 0.4
|
5.1
± 0.3
|
1157 |
EN300-1265948_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)N5CCS(=O)(=O)CC5 |
−6.9
± 0.4
|
5.1
± 0.3
|
1158 |
DAR-DIA-6a508060-8
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4)C5CC5 |
−6.9
± 0.1
|
5.05
± 0.08
|
1159 |
EN300-395654_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C6(C5)COC6)CO |
−6.9
± 0.3
|
5.0
± 0.2
|
1160 |
EN300-31099_2
|
|
CCC(=O)NCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.9
± 0.3
|
5.0
± 0.2
|
1161 |
EN300-301543_2
|
|
CCOC1CN(CC1CO)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.9
± 0.4
|
5.0
± 0.3
|
1162 |
EN300-35642_1
|
|
CN(CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C |
−6.9
± 0.5
|
5.0
± 0.4
|
1163 |
EN300-306495_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N(C)C |
−6.9
± 0.2
|
5.0
± 0.2
|
1164 |
ADA-UCB-dc2b944c-5
|
|
Cc1ccc2c(c1)[C@@H](CCO2)C(=O)Nc3cncc4c3cccc4 |
−6.89
± 0.07
|
5.02
± 0.05
|
1165 |
EN300-1600887_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCC5COCCO5 |
−6.9
± 0.3
|
5.0
± 0.2
|
1166 |
EN300-1265434_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC(C5CC5)C(=O)N |
−6.9
± 0.3
|
5.0
± 0.2
|
1167 |
EN300-97699_2
|
|
CC(CS(=O)(=O)C)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.9
± 0.3
|
5.0
± 0.2
|
1168 |
EN300-307155_2
|
|
Cn1cnnc1C(CO)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.9
± 0.3
|
5.0
± 0.2
|
1169 |
EN300-153245_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@@H](C[C@H]5CO)O |
−6.9
± 0.3
|
5.0
± 0.2
|
1170 |
EN300-6735421_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5(CN(C5)C6CC6)CO |
−6.9
± 0.5
|
5.0
± 0.4
|
1171 |
VLA-UCB-05e51b3f-9
|
|
c1ccc2c(c1)cncc2N(C(=O)CCl)C(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−6.9
± 0.3
|
5.0
± 0.2
|
1172 |
EN300-188125_2
|
|
CC1(CN(C1)C)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.9
± 0.3
|
5.0
± 0.2
|
1173 |
EN300-31145_2
|
|
CC(C)C(=O)N(C)CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.8
± 0.3
|
5.0
± 0.3
|
1174 |
EN300-1724771_2
|
|
CC(=O)N1CCN(CC1)C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.8
± 0.3
|
5.0
± 0.2
|
1175 |
EN300-7444783_2
|
|
CN(C)C1(CCN(C1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−6.8
± 0.3
|
5.0
± 0.2
|
1176 |
EN300-208204_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H](CO)C(=O)N |
−6.8
± 0.3
|
5.0
± 0.2
|
1177 |
EN300-7356782_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCNC(=O)CC5C(=O)N |
−6.8
± 0.3
|
5.0
± 0.2
|
1178 |
EN300-02067_2
|
|
CC(COC)NC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.8
± 0.2
|
5.0
± 0.2
|
1179 |
DAR-DIA-0d514e7d-2
|
|
C[C@@H]1COc2c(cc(cc2OC)Cl)[C@@H]1C(=O)Nc3cncc4c3cccc4 |
−6.8
± 0.2
|
5.0
± 0.1
|
1180 |
EN300-233439_2
|
|
CN(C)CC1CN(C1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.8
± 0.4
|
5.0
± 0.3
|
1181 |
EN300-182579_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CN(C5)CC(F)F |
−6.8
± 0.3
|
5.0
± 0.2
|
1182 |
EN300-195590_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5CCCNC(=O)C5 |
−6.8
± 0.3
|
5.0
± 0.2
|
1183 |
EN300-226446_2
|
|
C[C@H]([C@@H](CO)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−6.8
± 0.2
|
5.0
± 0.2
|
1184 |
EN300-52768_2
|
|
CCCS(=O)(=O)C(C)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.8
± 0.6
|
5.0
± 0.4
|
1185 |
EN300-68794_4
|
|
CS(=O)(=O)CCCOCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.8
± 0.2
|
5.0
± 0.1
|
1186 |
EN300-41518_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCOCC5 |
−6.8
± 0.3
|
5.0
± 0.2
|
1187 |
EN300-7432198_2
|
|
COCc1nc(on1)[C@@H]2C[C@@H]2C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−6.8
± 0.2
|
5.0
± 0.2
|
1188 |
EN300-7352438_2
|
|
COC[C@H]1C[C@@H]1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.8
± 0.2
|
5.0
± 0.1
|
1189 |
EN300-7444316_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]([C@@H](C5)C(=O)N)C(=O)N |
−6.8
± 0.4
|
4.9
± 0.3
|
1190 |
EN300-316216_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCn5cncn5 |
−6.8
± 0.3
|
4.9
± 0.2
|
1191 |
EN300-321703_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCOC5COC5 |
−6.8
± 0.3
|
4.9
± 0.2
|
1192 |
EN300-6735683_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H](O[C@@H](C5)CO)CO |
−6.8
± 0.4
|
4.9
± 0.3
|
1193 |
EN300-1703718_2
|
|
CC(=O)N1C[C@@H](C[C@H]1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−6.8
± 0.2
|
4.9
± 0.2
|
1194 |
EN300-1699797_2
|
|
Cc1[nH]c(nn1)[C@@H](CO)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.8
± 0.3
|
4.9
± 0.2
|
1195 |
EN300-30768_2
|
|
CC1CC1C(=O)NCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−6.8
± 0.3
|
4.9
± 0.2
|
1196 |
EN300-140582_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5COCCN5CC(F)F |
−6.7
± 0.2
|
4.9
± 0.2
|
1197 |
EN300-1719401_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H](CO)c5[nH]cnn5 |
−6.7
± 0.4
|
4.9
± 0.3
|
1198 |
EN300-3044054_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCC(=O)N5C6CC6 |
−6.7
± 0.5
|
4.9
± 0.4
|
1199 |
EN300-258326_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCn5cnccc5=O |
−6.7
± 0.3
|
4.9
± 0.2
|
1200 |
EN300-59478_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCC(=O)N |
−6.7
± 0.3
|
4.9
± 0.2
|