Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
901 |
EN300-217107_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CC[C@@H]5C(=O)N |
−10.8
± 0.3
|
7.9
± 0.2
|
902 |
EN300-233951_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOC[C@H](C5)O |
−10.8
± 0.3
|
7.9
± 0.2
|
903 |
EN300-6974806_3_1
|
|
C[C@H]([C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−10.8
± 0.3
|
7.9
± 0.3
|
904 |
EDG-MED-90036822-57
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCC(C(F)F)N |
−10.8
± 0.3
|
7.9
± 0.2
|
905 |
EN300-365398_4_1
|
|
Cn1c(nnn1)CCOCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.4
|
7.9
± 0.3
|
906 |
EN300-295905_1_4
|
|
C[C@H]1CN(C[C@H](O1)C(=O)N)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
7.9
± 0.2
|
907 |
EN300-393148_3_2
|
|
C[N@@]1[C@H](CCS1(=O)=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
7.9
± 0.2
|
908 |
EN300-42591_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CNC(=O)NC5CC5 |
−10.8
± 0.3
|
7.9
± 0.2
|
909 |
EN300-120820_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5[cH+][nH][nH]c5=O |
−10.8
± 0.3
|
7.9
± 0.2
|
910 |
EN300-206646_1_1
|
|
CS(=O)(=O)c1cncc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
7.9
± 0.2
|
911 |
EN300-6953121_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5C[C@H]5F |
−10.8
± 0.2
|
7.9
± 0.2
|
912 |
EN300-90142_3_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCC[C@H](C5)C(=O)N |
−10.8
± 0.3
|
7.9
± 0.2
|
913 |
EN300-1988306_1_1
|
|
CS(=O)(=O)CCC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.8
± 0.3
|
7.9
± 0.2
|
914 |
EN300-246747_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5CC(=O)NC5 |
−10.8
± 0.3
|
7.9
± 0.2
|
915 |
EN300-765003_1_1
|
|
COC(=O)[C@@H]1C[C@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
7.9
± 0.2
|
916 |
EN300-128715_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC(=O)NCC(F)(F)F |
−10.8
± 0.2
|
7.9
± 0.2
|
917 |
MIC-UNK-c66144cb-1
|
|
c1ccc2c(c1)cncc2NC(=O)C(CCc3cccc(c3)F)c4cccc(c4)Cl |
−10.8
± 0.3
|
7.9
± 0.2
|
918 |
MAT-POS-e69ad64a-1
|
|
C=CC(=O)N(c1cncc2c1cccc2)C(=O)C3CCNc4c3cc(cc4)Cl |
−10.8
± 0.4
|
7.9
± 0.3
|
919 |
EN300-6764836_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@H]6[C@@H]([C@@H]([C@@H]5O6)O)O |
−10.8
± 0.3
|
7.9
± 0.2
|
920 |
DAR-DIA-5ff57136-11
|
|
C=C=CC(=O)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−10.8
± 0.2
|
7.9
± 0.2
|
921 |
EN300-3710141_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@]5(CCCO5)C#N |
−10.8
± 0.2
|
7.9
± 0.2
|
922 |
EN300-2910941_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(nn5)C(F)(F)F |
−10.8
± 0.2
|
7.9
± 0.2
|
923 |
EN300-182913_3_1
|
|
CC(C)(C(=O)N)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.8
± 0.3
|
7.9
± 0.2
|
924 |
EN300-115017_1_1
|
|
CC(C)[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.8
± 0.2
|
7.9
± 0.2
|
925 |
EN300-259694_3_2
|
|
CCO[C@]1(CCOC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.4
|
7.9
± 0.3
|
926 |
EN300-198240_1_2
|
|
Cn1cc(cn1)[C@H](C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−10.8
± 0.3
|
7.9
± 0.2
|
927 |
EN300-221518_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCCO |
−10.8
± 0.1
|
7.86
± 0.09
|
928 |
EN300-13890_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CS[C@@H]5CCS(=O)(=O)C5 |
−10.8
± 0.3
|
7.9
± 0.2
|
929 |
EN300-399606_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6n(n5)CCC[C@H]6O |
−10.8
± 0.3
|
7.9
± 0.2
|
930 |
RAL-THA-065e0743-2
|
|
Cc1c(c2ccccc2cn1)NC(=O)Cc3cc(cc(c3)Cl)OC4CC(=O)N4 |
−10.8
± 0.3
|
7.9
± 0.2
|
931 |
EDG-MED-90036822-37
|
|
CC(C(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)F)O |
−10.8
± 0.2
|
7.9
± 0.1
|
932 |
EN300-68618_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cocn5 |
−10.8
± 0.2
|
7.9
± 0.1
|
933 |
VLA-UCB-50c39ae8-7_1
|
|
C=CC(=O)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−10.8
± 0.2
|
7.9
± 0.1
|
934 |
EN300-20496_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CO[C@H]5CCOC5=O |
−10.8
± 0.2
|
7.9
± 0.2
|
935 |
EN300-201551_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5COCC[N@H+]5CC(F)(F)F |
−10.8
± 0.3
|
7.9
± 0.2
|
936 |
EN300-6474341_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCn6cnnc6C5 |
−10.8
± 0.2
|
7.9
± 0.2
|
937 |
EN300-716207_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)C(CO)(F)F |
−10.8
± 0.3
|
7.9
± 0.2
|
938 |
EN300-33601_3_2
|
|
CN1C[C@H](CC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
7.9
± 0.2
|
939 |
EN300-1244816_3_1
|
|
Cc1nnnn1CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
7.9
± 0.2
|
940 |
EN300-307008_1_2
|
|
CN1[C@H](CNC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.2
|
7.9
± 0.2
|
941 |
EN300-321597_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC[C@H](C5)O |
−10.8
± 0.2
|
7.9
± 0.2
|
942 |
VLA-UCB-50c39ae8-8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OC5CC(=O)N5)Cl |
−10.8
± 0.2
|
7.9
± 0.1
|
943 |
DAR-DIA-5ff57136-15
|
|
C#CC1(CC1)N(c2cncc3c2cccc3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−10.8
± 0.2
|
7.8
± 0.1
|
944 |
EN300-2008240_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(C5)n6ccnn6 |
−10.8
± 0.3
|
7.8
± 0.2
|
945 |
ALP-UNI-44c99a80-3_1
|
|
c1ccc2c(c1)cncc2N(Cc3cnco3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−10.8
± 0.2
|
7.8
± 0.1
|
946 |
EN300-7459916_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COC(=O)CO |
−10.8
± 0.2
|
7.8
± 0.2
|
947 |
EN300-98648_2_2
|
|
CN1CC[C@H](C1=O)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.2
|
7.8
± 0.1
|
948 |
EN300-2666482_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cncc(n5)n6ccnc6 |
−10.8
± 0.2
|
7.8
± 0.2
|
949 |
EN300-297561_3_2
|
|
CC(C)[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnnn5 |
−10.8
± 0.3
|
7.8
± 0.2
|
950 |
EN300-5253939_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5COC(=O)O5 |
−10.8
± 0.3
|
7.8
± 0.2
|
951 |
EDJ-MED-fcba3f31-2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5(COC5)CO |
−10.8
± 0.3
|
7.8
± 0.2
|
952 |
EN300-82553_1_1
|
|
COc1ccc(nn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.2
|
7.8
± 0.2
|
953 |
MIC-UNK-50cce87d-6
|
|
c1cc(cc(c1)Cl)C2CCN(C2=O)c3cncc4c3c(ccc4)Cl |
−10.8
± 0.3
|
7.8
± 0.2
|
954 |
EN300-108413_1_1
|
|
C[C@@H](CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)OC |
−10.8
± 0.3
|
7.8
± 0.2
|
955 |
EN300-59487_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CC(=O)NC5 |
−10.8
± 0.3
|
7.8
± 0.2
|
956 |
PET-UNK-a692de38-1
|
|
c1ccc2c(c1)cncc2N(C(=O)Cc3cccc(c3)Cl)NC#N |
−10.8
± 0.3
|
7.8
± 0.2
|
957 |
EN300-128750_1_1
|
|
CC(=O)N(C)CCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.8
± 0.3
|
7.8
± 0.2
|
958 |
EN300-10402_3_1
|
|
CS(=O)(=O)[N@]1CCC[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
7.8
± 0.2
|
959 |
EN300-7471076_1_3
|
|
C[C@@H]1[C@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.8
± 0.3
|
7.8
± 0.2
|
960 |
EN300-258702_1_1
|
|
Cn1ccc(n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.2
|
7.8
± 0.1
|
961 |
EN300-10334_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@]56CCC(=O)N5CCS6 |
−10.8
± 0.3
|
7.8
± 0.3
|
962 |
EN300-302058_3_1
|
|
CON1CC[C@@H](C1=O)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
7.8
± 0.2
|
963 |
EN300-202922_2_4
|
|
C[C@H]([C@](C)(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−10.8
± 0.3
|
7.8
± 0.2
|
964 |
EN300-254883_1_1
|
|
Cc1c(non1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
7.8
± 0.2
|
965 |
EN300-1705754_3_1
|
|
CC1(CS(=O)(=O)C1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
7.8
± 0.2
|
966 |
EN300-21813_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c(=O)c6ccccc6nn5 |
−10.8
± 0.4
|
7.8
± 0.3
|
967 |
EN300-259694_3_1
|
|
CCO[C@@]1(CCOC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.4
|
7.8
± 0.3
|
968 |
EN300-104746_3_2
|
|
CC[C@](C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.8
± 0.3
|
7.8
± 0.2
|
969 |
EN300-1718836_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5nnc6n5CCOC6 |
−10.8
± 0.3
|
7.8
± 0.2
|
970 |
EN300-185398_3_2
|
|
C[C@H](C(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(F)F)O |
−10.8
± 0.3
|
7.8
± 0.2
|
971 |
ED_-GRI-5b13fbe2-21
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5CNC[C@@H](O5)CO |
−10.7
± 0.3
|
7.8
± 0.3
|
972 |
EN300-118760_1_1
|
|
C[C@@](C1CC1)(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.7
± 0.3
|
7.8
± 0.2
|
973 |
JOH-SUS-a69c159d-6_1
|
|
c1ccc2c(c1)c(c(nc2F)F)NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−10.75
± 0.06
|
7.83
± 0.04
|
974 |
EN300-193399_3_1
|
|
CC(C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C5CC5 |
−10.7
± 0.4
|
7.8
± 0.3
|
975 |
EN300-861925_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCO[C@@H](CO)F |
−10.7
± 0.3
|
7.8
± 0.2
|
976 |
EN300-250126_1_2
|
|
CC(C)C[C@H](C(=O)N)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.7
± 0.3
|
7.8
± 0.2
|
977 |
EN300-202922_1_3
|
|
C[C@@H]([C@](C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−10.7
± 0.2
|
7.8
± 0.2
|
978 |
EN300-66082_1_2
|
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C5CCC5 |
−10.7
± 0.3
|
7.8
± 0.2
|
979 |
EN300-61636_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)C(=O)NC6CC6 |
−10.7
± 0.3
|
7.8
± 0.2
|
980 |
EN300-6735683_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H](O[C@@H](C5)CO)CO |
−10.7
± 0.4
|
7.8
± 0.3
|
981 |
EN300-1659582_1_1
|
|
C#CCNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.7
± 0.1
|
7.82
± 0.09
|
982 |
EN300-222969_3_1
|
|
CN1C[C@@H](OC1=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.3
|
7.8
± 0.2
|
983 |
EDG-MED-90036822-43
|
|
Cc1cncn1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.2
|
7.8
± 0.2
|
984 |
EN300-70064_3_1
|
|
CNC(=O)C1(CCC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.4
|
7.8
± 0.3
|
985 |
EN300-78135_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(=O)NC5CC5 |
−10.7
± 0.2
|
7.8
± 0.1
|
986 |
EN300-175186_4_2
|
|
C[C@H](CO)OCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.7
± 0.3
|
7.8
± 0.2
|
987 |
EN300-1273249_1_1
|
|
CO[C@@H]1COC[C@H]1n2cc(nn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.7
± 0.3
|
7.8
± 0.2
|
988 |
EN300-6238494_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)[C@H]5COCCO5 |
−10.7
± 0.4
|
7.8
± 0.3
|
989 |
EN300-383824_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6c([nH]c5=O)CCOC6 |
−10.7
± 0.3
|
7.8
± 0.2
|
990 |
EN300-36096_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCNC5=O |
−10.7
± 0.3
|
7.8
± 0.2
|
991 |
EN300-69070_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)C(=O)N |
−10.7
± 0.4
|
7.8
± 0.3
|
992 |
EN300-1911992_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]([C@@H]5CCOC5)O |
−10.7
± 0.4
|
7.8
± 0.3
|
993 |
EN300-6499531_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCCCS5(=O)=O |
−10.7
± 0.3
|
7.8
± 0.2
|
994 |
EN300-12139_1_1
|
|
CN(C)C(=O)CSCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.7
± 0.3
|
7.8
± 0.2
|
995 |
EN300-365398_1_1
|
|
Cn1c(nnn1)CCO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.3
|
7.8
± 0.2
|
996 |
EN300-3710141_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@]5(CCCO5)C#N |
−10.7
± 0.3
|
7.8
± 0.2
|
997 |
EN300-73967_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCS(=O)(=O)CC5)C#N |
−10.7
± 0.4
|
7.8
± 0.3
|
998 |
EN300-125140_2_1
|
|
COCC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.7
± 0.3
|
7.8
± 0.2
|
999 |
EN300-7089802_3_1
|
|
C[C@@H]([C@@H](C)O)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.7
± 0.3
|
7.8
± 0.2
|
1000 |
EN300-378722_1_1
|
|
CN1CC[C@@H](C1=O)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.7
± 0.2
|
7.8
± 0.2
|