Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
801 |
EN300-109540_1_2
|
|
C[C@H](c1cn(nn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.9
± 0.3
|
8.0
± 0.3
|
802 |
VLA-UCB-50c39ae8-1_1
|
|
CC(=O)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−10.9
± 0.1
|
7.95
± 0.10
|
803 |
KAD-UNI-8a629cb0-13
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCN(C5=O)C6CC6 |
−10.9
± 0.3
|
8.0
± 0.2
|
804 |
EN300-7457159_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5cc(on5)C6(COC6)O |
−10.9
± 0.4
|
8.0
± 0.3
|
805 |
EN300-297872_1_1
|
|
COCCCn1c(=O)ccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
8.0
± 0.2
|
806 |
EN300-248982_1_1
|
|
Cn1c(cc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C#N |
−10.9
± 0.2
|
7.9
± 0.2
|
807 |
EN300-6762327_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](Cc5ccccn5)O |
−10.9
± 0.3
|
7.9
± 0.2
|
808 |
EN300-1722017_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)n6nccn6 |
−10.9
± 0.3
|
7.9
± 0.2
|
809 |
EN300-315836_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5[nH]ccn5 |
−10.9
± 0.2
|
7.9
± 0.1
|
810 |
EN300-195756_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5CCC(=O)N5 |
−10.9
± 0.3
|
7.9
± 0.2
|
811 |
ED_-GRI-5b13fbe2-5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H](c5[nH]nnn5)N |
−10.9
± 0.3
|
7.9
± 0.2
|
812 |
EN300-7426383_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6c(ccn5)n[nH]n6 |
−10.9
± 0.2
|
7.9
± 0.2
|
813 |
EN300-210084_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5CCCC(=O)N5 |
−10.9
± 0.2
|
7.9
± 0.1
|
814 |
EN300-6734171_3_1
|
|
C[C@@]1(CCC(=O)N(C1)C)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.4
|
7.9
± 0.3
|
815 |
EN300-159633_3_1
|
|
C[C@@](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C(F)(F)F)O |
−10.9
± 0.3
|
7.9
± 0.2
|
816 |
EN300-17161_1_1
|
|
CCOC(=O)CCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.9
± 0.3
|
7.9
± 0.2
|
817 |
ADA-UCB-dc2b944c-18
|
|
c1ccc2c(c1)cncc2NC(=O)N(c3cccc(c3)Cl)C(=O)CC4CCOCC4 |
−10.9
± 0.3
|
7.9
± 0.2
|
818 |
EN300-6746918_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(C5)(CO)F |
−10.9
± 0.3
|
7.9
± 0.2
|
819 |
EN300-755161_1_1
|
|
Cn1ncc(n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.2
|
7.9
± 0.2
|
820 |
EN300-657320_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CSCC(=O)N5 |
−10.9
± 0.2
|
7.9
± 0.2
|
821 |
EN300-125140_3_1
|
|
COCC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.9
± 0.3
|
7.9
± 0.2
|
822 |
EN300-40947_1_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C(C)C |
−10.9
± 0.3
|
7.9
± 0.3
|
823 |
EN300-6494474_1_1
|
|
Cn1cnnc1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
7.9
± 0.2
|
824 |
EN300-6495717_1_1
|
|
C[C@@H]1CC(CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(CO)CO |
−10.9
± 0.3
|
7.9
± 0.2
|
825 |
EN300-82179_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC(=O)N |
−10.9
± 0.3
|
7.9
± 0.2
|
826 |
EN300-10895_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NCCC#N |
−10.9
± 0.3
|
7.9
± 0.2
|
827 |
EN300-157776_1_3
|
|
C[C@@H]1CN(C[C@H](O1)CO)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.4
|
7.9
± 0.3
|
828 |
EN300-316193_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]6COC(=O)[C@H]6C5 |
−10.9
± 0.3
|
7.9
± 0.2
|
829 |
EN300-188341_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5ccc(cn5)O |
−10.9
± 0.2
|
7.9
± 0.2
|
830 |
EN300-42270_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnsn5 |
−10.9
± 0.2
|
7.9
± 0.1
|
831 |
EN300-69588_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCS(=O)CC5 |
−10.9
± 0.3
|
7.9
± 0.2
|
832 |
DAR-DIA-5ff57136-15_1
|
|
C#CC1(CC1)N(c2cncc3c2cccc3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−10.9
± 0.2
|
7.9
± 0.1
|
833 |
EN300-11714_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5ccccc5=O |
−10.9
± 0.3
|
7.9
± 0.2
|
834 |
EN300-365017_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(on5)C6(COC6)O |
−10.9
± 0.3
|
7.9
± 0.2
|
835 |
EN300-125409_1_2
|
|
C[C@H](C(=O)N)N(C)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.9
± 0.3
|
7.9
± 0.2
|
836 |
EN300-7435545_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CCO[C@@H]5C(=O)N |
−10.9
± 0.3
|
7.9
± 0.2
|
837 |
EN300-1589101_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5c[nH]nc5 |
−10.9
± 0.3
|
7.9
± 0.2
|
838 |
EN300-04492_3_1
|
|
COCCCNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.9
± 0.3
|
7.9
± 0.2
|
839 |
EN300-313410_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(ncn5)N6CCOCC6 |
−10.9
± 0.3
|
7.9
± 0.2
|
840 |
EN300-216978_4_1
|
|
Cn1nc(nn1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
7.9
± 0.2
|
841 |
EN300-10729_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCNC(=O)N |
−10.9
± 0.3
|
7.9
± 0.2
|
842 |
EN300-103031_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6c([nH]n5)CCOC6 |
−10.9
± 0.2
|
7.9
± 0.2
|
843 |
EN300-6494158_1_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@H]5C[C@H](CO5)CO |
−10.9
± 0.3
|
7.9
± 0.2
|
844 |
EN300-120414_1_4
|
|
C[C@H]1C[N@H+]2CC[N@@H+]1C[C@H]2C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.9
± 0.4
|
7.9
± 0.3
|
845 |
EN300-1600517_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@H](CO)F |
−10.9
± 0.3
|
7.9
± 0.2
|
846 |
EN300-1073533_1_1
|
|
COC1(CC(C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C#N |
−10.9
± 0.2
|
7.9
± 0.2
|
847 |
EDJ-MED-d203f206-23
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CCCNC5=O |
−10.9
± 0.2
|
7.9
± 0.2
|
848 |
EDJ-MED-d203f206-33
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H](C[C@@H]5C(=O)N)O |
−10.9
± 0.3
|
7.9
± 0.2
|
849 |
EN300-702615_1_1
|
|
CCc1nc(on1)COCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
7.9
± 0.2
|
850 |
EN300-302058_1_2
|
|
CON1CC[C@H](C1=O)O[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.2
|
7.9
± 0.2
|
851 |
EN300-51257_3_1
|
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−10.9
± 0.2
|
7.9
± 0.2
|
852 |
EN300-861925_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCO[C@H](CO)F |
−10.9
± 0.3
|
7.9
± 0.2
|
853 |
EDG-MED-90036822-45
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(c5[nH]ccn5)(F)F |
−10.9
± 0.2
|
7.9
± 0.2
|
854 |
VLA-UNK-f702bf1c-2
|
|
c1ccc2c(c1)cncc2N3C(=O)[C@@]4(CCOc5c4cc(cc5)Cl)N(C3=O)Cc6cc[nH]n6 |
−10.9
± 0.3
|
7.9
± 0.2
|
855 |
EN300-1696962_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCCn5cnnn5 |
−10.9
± 0.3
|
7.9
± 0.2
|
856 |
EN300-224741_1_2
|
|
CC[C@H](CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.9
± 0.2
|
7.9
± 0.2
|
857 |
EN300-51244_1_1
|
|
Cc1cc(n(n1)C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.2
|
7.9
± 0.1
|
858 |
EN300-7352438_1_1
|
|
COC[C@H]1C[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
7.9
± 0.2
|
859 |
EN300-14405_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc6n(c5=O)CCS6 |
−10.9
± 0.3
|
7.9
± 0.2
|
860 |
EN300-7473378_1_1
|
|
C[NH+]1CCC(CC1)(C#N)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
7.9
± 0.2
|
861 |
EDG-MED-90036822-40
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CN5CC(C5)O)(F)F |
−10.9
± 0.3
|
7.9
± 0.2
|
862 |
EN300-304662_1_1
|
|
Cc1nnc(o1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
7.9
± 0.2
|
863 |
EN300-97300_3_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5C[C@H]5F |
−10.8
± 0.2
|
7.9
± 0.2
|
864 |
EN300-66770_1_1
|
|
CNC(=O)C1(CC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.2
|
7.9
± 0.2
|
865 |
EN300-82179_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC(=O)N |
−10.8
± 0.2
|
7.9
± 0.2
|
866 |
EN300-37195_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N[C@@H]5CCCCNC5=O |
−10.8
± 0.3
|
7.9
± 0.2
|
867 |
EN300-36158_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5COCCO5 |
−10.8
± 0.2
|
7.9
± 0.2
|
868 |
EN300-203402_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6c(n5)[nH]c(=O)[nH]6 |
−10.8
± 0.3
|
7.9
± 0.2
|
869 |
EN300-62574_2_1
|
|
Cn1c(nnn1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
7.9
± 0.2
|
870 |
EN300-863933_1_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N(C)C(=O)C |
−10.8
± 0.3
|
7.9
± 0.2
|
871 |
ALP-UNI-dbbfd3db-15
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C5CCC5 |
−10.8
± 0.3
|
7.9
± 0.2
|
872 |
EN300-783124_3_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]([C@H]5CCOC5)F |
−10.8
± 0.3
|
7.9
± 0.2
|
873 |
EN300-1718836_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5nnc6n5CCOC6 |
−10.8
± 0.3
|
7.9
± 0.2
|
874 |
EN300-217494_1_3
|
|
C[C@@]([C@H]1CCOC1)(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.8
± 0.3
|
7.9
± 0.2
|
875 |
EN300-651307_1_2
|
|
CC[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cncn5 |
−10.8
± 0.3
|
7.9
± 0.2
|
876 |
EN300-633533_3_1
|
|
CS(=O)(=O)[C@@H]1C[C@]1(COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C#N |
−10.8
± 0.3
|
7.9
± 0.2
|
877 |
EN300-127197_3_1
|
|
COc1cc(on1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
7.9
± 0.2
|
878 |
EN300-124384_1_1
|
|
Cn1c2c(cn1)c(=O)c(c[nH]2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.8
± 0.3
|
7.9
± 0.2
|
879 |
EN300-152418_1_1
|
|
Cn1cncc1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
7.9
± 0.2
|
880 |
EN300-150749_1_1
|
|
Cn1c(=O)cc([nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.2
|
7.9
± 0.2
|
881 |
EN300-219330_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCN5CCOCC5=O |
−10.8
± 0.3
|
7.9
± 0.2
|
882 |
VLA-UCB-50c39ae8-10_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC5CCCCC5 |
−10.8
± 0.3
|
7.9
± 0.2
|
883 |
EN300-207873_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CC5)O |
−10.8
± 0.2
|
7.9
± 0.2
|
884 |
EN300-31102_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCN(CC5)S(=O)(=O)N |
−10.8
± 0.2
|
7.9
± 0.2
|
885 |
EN300-135660_1_1
|
|
CC1(COC1)Cn2cc(nn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.8
± 0.3
|
7.9
± 0.2
|
886 |
EN300-123916_1_1
|
|
CN(C)c1cnc(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.2
|
7.9
± 0.2
|
887 |
CHO-MSK-5891c1ff-7
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5n[nH]c(=O)s5 |
−10.8
± 0.2
|
7.9
± 0.1
|
888 |
EN300-40225_1_1
|
|
Cc1c(cnn1CCO)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
7.9
± 0.2
|
889 |
EN300-6731226_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@]56CCO[C@H]5CC(=O)NC6 |
−10.8
± 0.4
|
7.9
± 0.3
|
890 |
EN300-42591_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)NC5CC5 |
−10.8
± 0.3
|
7.9
± 0.2
|
891 |
EN300-385267_1_1
|
|
CO[C@@]1(CCS(=O)(=O)C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.4
|
7.9
± 0.3
|
892 |
MAT-POS-e69ad64a-2
|
|
C=CC(=O)N(c1cncc2c1cccc2)C(=O)C3COc4c3cc(cc4)Cl |
−10.8
± 0.3
|
7.9
± 0.2
|
893 |
EN300-6479181_3_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CC[C@H]6N5C(=O)CC6 |
−10.8
± 0.3
|
7.9
± 0.3
|
894 |
EN300-6482296_1_8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CO[C@H]6[C@H]5COC6 |
−10.8
± 0.2
|
7.9
± 0.2
|
895 |
EN300-651307_1_1
|
|
CC[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cncn5 |
−10.8
± 0.3
|
7.9
± 0.2
|
896 |
EN300-1696058_1_1
|
|
CC(=O)OCCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.8
± 0.3
|
7.9
± 0.2
|
897 |
EN300-217107_1_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CC[C@H]5C(=O)N |
−10.8
± 0.2
|
7.9
± 0.2
|
898 |
VLA-UNK-f702bf1c-6
|
|
c1ccc2c(c1)cncc2N3C(=O)[C@@]4(CCOc5c4cc(cc5)Cl)N(C3=O)CC6CCCCC6 |
−10.8
± 0.3
|
7.9
± 0.2
|
899 |
EN300-6482967_3_1
|
|
CNS(=O)(=O)CCOCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.8
± 0.3
|
7.9
± 0.2
|
900 |
EN300-174668_3_1
|
|
CO[C@@]1(CCOC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
7.9
± 0.2
|