Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
6101 |
LON-WEI-5e7d1b3e-37
|
|
CCN(CC)S(=O)(=O)c1ccc(cc1)NC(=O)Nc2cn(c(=O)c3c2cccc3)C |
−3.7
± 0.7
|
2.7
± 0.5
|
6102 |
VLA-UCB-50c39ae8-4
|
|
CC(=O)N1CCN(CC1)CC(=O)N(c2cncc3c2cccc3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−3.6
± 0.4
|
2.7
± 0.3
|
6103 |
ALP-UNI-0676e700-14
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnc6c(cnn6c5)C#N |
−3.6
± 0.2
|
2.6
± 0.1
|
6104 |
LON-WEI-4d77710c-33
|
|
CC1c2cc(c(cc2CCN1C(=O)Nc3cn(c(=O)c4c3cccc4)C)OC)OC |
−3.6
± 0.4
|
2.6
± 0.3
|
6105 |
EN300-1387104_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CCS5(=O)=O |
−3.6
± 0.2
|
2.6
± 0.1
|
6106 |
EN300-52325_2_1
|
|
CCCS(=O)(=O)CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−3.6
± 0.2
|
2.6
± 0.2
|
6107 |
EN300-146051_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(nc5)CO |
−3.5
± 0.2
|
2.6
± 0.1
|
6108 |
MAK-UNK-c749d764-24
|
|
CCN(c1cncc2c1cccc2)C(=O)CC3CCCC(C3O)C(F)F |
−3.5
± 0.3
|
2.6
± 0.2
|
6109 |
MAT-POS-b5746674-99
|
|
CC(C)Cn1cc(c2ccccc2c1=O)NC(=O)N3CCN(CC3)c4ccccn4 |
−3.5
± 0.7
|
2.6
± 0.5
|
6110 |
EN300-305454_2_1
|
|
Cn1cc(cn1)[C@@H]2CCO[C@@H]2C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−3.5
± 0.2
|
2.6
± 0.1
|
6111 |
MAT-POS-2492181e-10
|
|
CC1CCCCN1CCCNC(=O)Nc2cn(c(=O)c3c2cccc3)CC(C)C |
−3.5
± 0.5
|
2.5
± 0.4
|
6112 |
MAT-POS-b5746674-103
|
|
CC(C)Cn1cc(c2ccccc2c1=O)NC(=O)N3CCN(CC3)c4ccccc4F |
−3.4
± 0.6
|
2.5
± 0.4
|
6113 |
LON-WEI-4d77710c-20
|
|
CC(C)Cn1cc(c2ccccc2c1=O)NC(=O)NCCc3c[nH]c4c3cccc4 |
−3.4
± 0.7
|
2.5
± 0.5
|
6114 |
EN300-31210_4_2
|
|
C[C@H](C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NS(=O)(=O)C |
−3.4
± 0.4
|
2.5
± 0.3
|
6115 |
EN300-368758_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)C[C@@H]6CCCO6 |
−3.4
± 0.2
|
2.5
± 0.2
|
6116 |
MAT-POS-b5746674-35
|
|
Cn1cc(c2ccccc2c1=O)NC(=O)NCCN(Cc3ccco3)C4CCCC4 |
−3.4
± 0.5
|
2.5
± 0.4
|
6117 |
PET-UNK-4dc48bbe-6
|
|
c1ccc2c(c1)cncc2N3C(=O)[C@@H](NC3=O)c4cccc(c4)Cl |
−3.3
± 0.2
|
2.4
± 0.2
|
6118 |
EN300-195855_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(cn5)n6cncn6 |
−3.3
± 0.2
|
2.4
± 0.1
|
6119 |
EDG-MED-971238d3-10
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)O |
−3.3
± 0.2
|
2.4
± 0.1
|
6120 |
EN300-1253122_4_1
|
|
CCN(C)C(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−3.3
± 0.3
|
2.4
± 0.2
|
6121 |
EN300-716207_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)C(CO)(F)F |
−3.3
± 0.2
|
2.4
± 0.2
|
6122 |
EN300-7431365_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6n(c5)CCCNC6=O |
−3.3
± 0.2
|
2.4
± 0.2
|
6123 |
LON-WEI-4d77710c-34
|
|
CC(C)Cn1cc(c2ccccc2c1=O)NC(=O)N3CCC(C3)c4ccccc4 |
−3.3
± 0.5
|
2.4
± 0.4
|
6124 |
LON-WEI-4d77710c-16
|
|
CC(C)Cn1cc(c2ccccc2c1=O)NC(=O)NCCN3CCOCC3 |
−3.3
± 0.7
|
2.4
± 0.5
|
6125 |
LON-WEI-5e7d1b3e-22
|
|
CC(C)Cn1cc(c2ccccc2c1=O)NC(=O)Nc3cccnc3 |
−3.3
± 0.4
|
2.4
± 0.3
|
6126 |
LON-WEI-5e7d1b3e-44
|
|
CC(C)Cn1cc(c2ccccc2c1=O)NC(=O)NCc3ccco3 |
−3.2
± 0.4
|
2.4
± 0.3
|
6127 |
MAT-POS-b5746674-108
|
|
Cc1ccc(cc1)CN2CCC(C2)CNC(=O)Nc3cn(c(=O)c4c3cccc4)CC(C)C |
−3.2
± 0.4
|
2.3
± 0.3
|
6128 |
MAK-UNK-c749d764-20
|
|
CCCN(c1cncc2c1cccc2)C(=O)CC3CCCC(C3O)C(F)F |
−3.2
± 0.4
|
2.3
± 0.3
|
6129 |
EN300-2690393_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc(cnc5)n6cnnn6 |
−3.1
± 0.2
|
2.3
± 0.2
|
6130 |
EN300-314455_2_1
|
|
CS(=O)(=O)[N@]1CCC[C@@H](C1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−3.1
± 0.2
|
2.3
± 0.2
|
6131 |
LON-WEI-5e7d1b3e-49
|
|
Cn1cc(c2ccccc2c1=O)NC(=O)NCc3ccccn3 |
−3.1
± 0.4
|
2.3
± 0.3
|
6132 |
NAU-LAT-4ce8bf23-2
|
|
c1ccc2c(c1)cncc2N(CCC(=O)N)C(=O)Cc3cccc(c3)Cl |
−3.0
± 0.4
|
2.2
± 0.3
|
6133 |
EN300-31183_2_2
|
|
C[C@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)COC |
−3.0
± 0.2
|
2.2
± 0.1
|
6134 |
EDJ-MED-d203f206-21
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H](C5)c6[nH]nnn6 |
−3.0
± 0.4
|
2.2
± 0.3
|
6135 |
LON-WEI-4d77710c-56
|
|
CC(C)Cn1cc(c2ccccc2c1=O)NC(=O)Nc3ccsc3C(=O)OC |
−3.0
± 0.5
|
2.2
± 0.3
|
6136 |
MAT-POS-b5746674-110
|
|
CC(C)Cn1cc(c2ccccc2c1=O)NC(=O)N3CCN(CC3)Cc4ccccc4 |
−3.0
± 0.8
|
2.2
± 0.6
|
6137 |
EN300-6477475_2_1
|
|
COCc1cc(no1)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−3.0
± 0.2
|
2.2
± 0.1
|
6138 |
EN300-366852_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H](C5)c6[nH]nnn6 |
−2.9
± 0.3
|
2.1
± 0.2
|
6139 |
EN300-88656_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CCCS5(=O)=O |
−2.9
± 0.2
|
2.1
± 0.1
|
6140 |
EN300-685492_2_1
|
|
COCc1[nH]c(=O)c(cn1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−2.9
± 0.3
|
2.1
± 0.2
|
6141 |
EN300-24014_2_1
|
|
CS(=O)(=O)[N@@]1CCCC[C@@H]1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−2.8
± 0.3
|
2.0
± 0.3
|
6142 |
ALP-UNI-0676e700-13
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(nc5)S(=O)(=O)N |
−2.8
± 0.3
|
2.0
± 0.2
|
6143 |
VLA-UCB-05e51b3f-7
|
|
CC(=O)N1CCN(CC1)CC(=O)N(c2cncc3c2cccc3)C(=O)[C@H]4CCOc5c4cc(cc5)Cl |
−2.8
± 0.6
|
2.0
± 0.4
|
6144 |
ALP-UNI-0676e700-25
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6nccn6c(=O)[nH]5 |
−2.7
± 0.2
|
2.0
± 0.2
|
6145 |
EDJ-MED-4c7486ba-12
|
|
c1ccc2c(c1)cncc2NC(=O)[C@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@]5(CCSC5)O |
−2.7
± 0.2
|
2.0
± 0.2
|
6146 |
MAT-POS-281d2ee9-3
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)c4[nH]nnn4 |
−2.7
± 0.3
|
2.0
± 0.2
|
6147 |
MAT-POS-b5746674-100
|
|
CC(C)Cn1cc(c2ccccc2c1=O)NC(=O)NCCCN3CCCC3=O |
−2.6
± 0.7
|
1.9
± 0.5
|
6148 |
MAT-POS-b5746674-97
|
|
CCOC(=O)N1CCC(CC1)NC(=O)Nc2cn(c(=O)c3c2cccc3)C |
−2.6
± 0.6
|
1.9
± 0.4
|
6149 |
EN300-118045_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnc([nH]c5=O)C6CC6 |
−2.5
± 0.2
|
1.9
± 0.2
|
6150 |
EN300-7430501_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CCn6c(cnn6)C5 |
−2.5
± 0.1
|
1.80
± 0.08
|
6151 |
EN300-255086_2_1
|
|
C[NH+](C)CCn1cc(cn1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−2.4
± 0.3
|
1.8
± 0.2
|
6152 |
LON-WEI-4d77710c-35
|
|
Cc1ccc(cc1)CN2CCC(C2)CNC(=O)Nc3cn(c(=O)c4c3cccc4)CC(C)C |
−2.4
± 0.5
|
1.7
± 0.3
|
6153 |
EN300-14752_4_1
|
|
CC(=O)N1CCC[C@@H](C1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−2.4
± 0.3
|
1.7
± 0.3
|
6154 |
LON-WEI-5e7d1b3e-60
|
|
CC1CCN(CC1)CCCNC(=O)Nc2cn(c(=O)c3c2cccc3)CC(C)C |
−2.2
± 0.6
|
1.6
± 0.4
|
6155 |
EN300-95698_3_2
|
|
C[C@H]1CC(=O)NC[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−2.1
± 0.3
|
1.5
± 0.2
|
6156 |
MAK-UNK-c749d764-19
|
|
c1ccc2c(c1)cncc2N(CN)C(=O)CC3CCCC(C3O)C(F)F |
−2.1
± 0.2
|
1.5
± 0.1
|
6157 |
EN300-4287199_2_1
|
|
Cc1cc(cc(=O)n1C)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−2.1
± 0.2
|
1.5
± 0.1
|
6158 |
MAT-POS-2492181e-7
|
|
CC1CCN(CC1)CCNC(=O)Nc2cn(c(=O)c3c2cccc3)CC(C)C |
−2.0
± 0.5
|
1.5
± 0.4
|
6159 |
EN300-51028_2_1
|
|
CC(C)S(=O)(=O)CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−2.0
± 0.2
|
1.5
± 0.1
|
6160 |
EDJ-MED-d203f206-16
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H]5c6[nH]nnn6 |
−2.0
± 0.4
|
1.5
± 0.3
|
6161 |
MAT-POS-2492181e-12
|
|
CCCN(CCC)CCNC(=O)Nc1cn(c(=O)c2c1cccc2)CC(C)C |
−1.9
± 0.7
|
1.4
± 0.5
|
6162 |
EN300-259187_1_2
|
|
CCN1C[C@H](CCC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−1.9
± 0.3
|
1.4
± 0.2
|
6163 |
LON-WEI-4d77710c-15
|
|
CC(C)Cn1cc(c2ccccc2c1=O)NC(=O)NCCCN3CCCC3=O |
−1.8
± 0.8
|
1.3
± 0.6
|
6164 |
EDJ-MED-4c7486ba-5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5ccnc5 |
−1.7
± 0.2
|
1.3
± 0.2
|
6165 |
MAT-POS-2492181e-6
|
|
CC1CCN(CC1)CCCNC(=O)Nc2cn(c(=O)c3c2cccc3)CC(C)C |
−1.7
± 0.6
|
1.2
± 0.5
|
6166 |
EN300-42154_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CS(=O)(=O)C5CCCC5 |
−1.6
± 0.3
|
1.2
± 0.2
|
6167 |
EDJ-MED-4c7486ba-10
|
|
c1ccc2c(c1)cncc2NC(=O)[C@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5COCCN5CC(F)(F)F |
−1.4
± 0.2
|
1.0
± 0.1
|
6168 |
EN300-28177_2_3
|
|
C[C@@H](C(=O)N1CCC[C@H](C1)C(=O)N)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−1.4
± 0.3
|
1.0
± 0.2
|
6169 |
EN300-52983_1_2
|
|
CN1C[C@H](CCC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−1.1
± 0.3
|
0.8
± 0.2
|
6170 |
LON-WEI-5e7d1b3e-56
|
|
CC(C)Cn1cc(c2ccccc2c1=O)NC(=O)Nc3ccsc3C(=O)OC |
−1.1
± 0.5
|
0.8
± 0.3
|
6171 |
EN300-36845_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CNC(=O)C5CCCC5 |
−1.1
± 0.2
|
0.8
± 0.1
|
6172 |
EDJ-MED-4c7486ba-6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cc5cnc[nH]5 |
−0.9
± 0.2
|
0.6
± 0.1
|
6173 |
ALP-UNI-0676e700-29
|
|
CS(=O)(=O)c1ccc(cn1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−0.8
± 0.2
|
0.6
± 0.1
|
6174 |
LON-WEI-4d77710c-60
|
|
CC1CCN(CC1)CCCNC(=O)Nc2cn(c(=O)c3c2cccc3)CC(C)C |
−0.7
± 0.7
|
0.5
± 0.5
|
6175 |
EN300-51889_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCC(=O)N5CCC(CC5)O |
−0.7
± 0.2
|
0.5
± 0.2
|
6176 |
EN300-90225_1_1
|
|
C[N@@]1NC(NN1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−0.5
± 0.3
|
0.4
± 0.2
|
6177 |
ALP-UNI-0676e700-6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(cn5)c6n[nH]nn6 |
−0.2
± 0.3
|
0.2
± 0.2
|
6178 |
MAT-POS-2492181e-9
|
|
CC1CCN(CC1)Cc2ccc(cc2)NC(=O)Nc3cn(c(=O)c4c3cccc4)CC(C)C |
0.1
± 0.7
|
−0.1
± 0.5
|
6179 |
MAT-POS-2492181e-8
|
|
CC1CCN(CC1)c2ccc(cc2)NC(=O)Nc3cn(c(=O)c4c3cccc4)CC(C)C |
0.3
± 0.7
|
−0.2
± 0.5
|
6180 |
EDJ-MED-4c7486ba-4
|
|
CN(C)CC(=O)NC[C@@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
0.8
± 0.2
|
−0.6
± 0.2
|
6181 |
EDJ-MED-4c7486ba-11
|
|
c1ccc2c(c1)cncc2NC(=O)[C@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn[nH]c5S(=O)(=O)N |
1.0
± 0.2
|
−0.7
± 0.2
|
6182 |
ALP-UNI-0676e700-17
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(nc5)c6n[nH]nn6 |
2.1
± 0.3
|
−1.5
± 0.2
|
6183 |
EN300-1653482_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CCN6C(C5)NNN6 |
3.6
± 0.8
|
−2.6
± 0.6
|
6184 |
EN300-1726073_2_1
|
|
Cn1c(cnn1)C(C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(F)F |
5.9
± 0.3
|
−4.3
± 0.2
|
6185 |
EN300-77343_1_1
|
|
CC1NNN[N@]1CCNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
14.2
± 0.5
|
−10.3
± 0.3
|