Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
601 |
EN300-124652_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@H]5CC(=O)N |
−11.2
± 0.2
|
8.1
± 0.2
|
602 |
EN300-107048_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5(CC5)CO |
−11.2
± 0.3
|
8.1
± 0.2
|
603 |
EN300-746830_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@H]6CCOC[C@H]6CO5 |
−11.2
± 0.2
|
8.1
± 0.2
|
604 |
EN300-370753_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CC[C@H](C5)C(=O)N |
−11.2
± 0.3
|
8.1
± 0.2
|
605 |
EN300-7501017_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5[C@@H]6[C@H]5C(=O)NC6 |
−11.2
± 0.3
|
8.1
± 0.2
|
606 |
EN300-180069_1_1
|
|
Cn1c(c(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)C |
−11.2
± 0.3
|
8.1
± 0.2
|
607 |
EN300-6505003_1_3
|
|
C[C@@H]1CC[C@H](C(=O)N1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.2
|
8.1
± 0.2
|
608 |
EN300-113218_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CS[C@H]5CCOC5=O |
−11.2
± 0.3
|
8.1
± 0.2
|
609 |
EN300-171766_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5NNC(=O)S5 |
−11.2
± 0.2
|
8.1
± 0.1
|
610 |
EN300-225053_1_1
|
|
COc1cnc(nc1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.2
|
8.1
± 0.1
|
611 |
EN300-75482_1_1
|
|
Cc1c(c(n(n1)C)OC)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.1
± 0.2
|
612 |
EN300-3710141_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@]5(CCCO5)C#N |
−11.2
± 0.3
|
8.1
± 0.2
|
613 |
EN300-1425677_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@]5(CCCO5)CO |
−11.2
± 0.3
|
8.1
± 0.2
|
614 |
EN300-20375_3_1
|
|
COCCOCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.3
|
8.1
± 0.2
|
615 |
EN300-91315_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)Cc6ccccn6 |
−11.2
± 0.3
|
8.1
± 0.2
|
616 |
EN300-77092_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5OCCO5 |
−11.2
± 0.3
|
8.1
± 0.2
|
617 |
EN300-111863_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cnc(n5)C#N |
−11.2
± 0.2
|
8.1
± 0.2
|
618 |
EN300-6764836_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[C@H]6[C@@H]([C@@H]([C@@H]5O6)O)O |
−11.2
± 0.3
|
8.1
± 0.2
|
619 |
EN300-6764836_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@H]6[C@H]([C@@H]([C@@H]5O6)O)O |
−11.2
± 0.2
|
8.1
± 0.2
|
620 |
EN300-51832_1_1
|
|
Cc1cnn(c1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.2
|
8.1
± 0.2
|
621 |
EN300-7431629_3_1
|
|
Cc1nnc2n1CC[C@@]2(C)C(=O)NCC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.1
± 0.4
|
8.1
± 0.3
|
622 |
EN300-107048_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CC5)CO |
−11.1
± 0.3
|
8.1
± 0.2
|
623 |
EN300-183231_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCc5[nH]nnn5 |
−11.1
± 0.4
|
8.1
± 0.3
|
624 |
MAT-POS-090737b9-1
|
|
C=CC(=O)N(c1cncc2c1cccc2)C(=O)C3CCOc4c3cc(cc4)Cl |
−11.1
± 0.3
|
8.1
± 0.2
|
625 |
EN300-191915_1_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnnn5 |
−11.1
± 0.3
|
8.1
± 0.2
|
626 |
EN300-718785_3_2
|
|
CCN1[C@H](CCC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.4
|
8.1
± 0.3
|
627 |
EN300-69368_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCOCC5)O |
−11.1
± 0.3
|
8.1
± 0.2
|
628 |
EN300-135060_1_1
|
|
COC(=O)CSCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.3
|
8.1
± 0.2
|
629 |
EN300-132157_1_2
|
|
C[C@]1(CC(=O)NC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.3
|
8.1
± 0.2
|
630 |
EN300-18249_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N |
−11.1
± 0.2
|
8.1
± 0.1
|
631 |
EN300-6494158_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5C[C@H](CO5)CO |
−11.1
± 0.3
|
8.1
± 0.2
|
632 |
EN300-14458_3_2
|
|
C[C@H](C(=O)N(C)C)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.3
|
8.1
± 0.2
|
633 |
EN300-300217_1_4
|
|
C/C=C/[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.1
± 0.2
|
8.1
± 0.2
|
634 |
EN300-247951_3_1
|
|
C[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−11.1
± 0.3
|
8.1
± 0.2
|
635 |
EDG-MED-90036822-78
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C(C5CC5)O)F |
−11.1
± 0.1
|
8.1
± 0.1
|
636 |
EDJ-MED-d203f206-22
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@H]5C(=O)N |
−11.1
± 0.3
|
8.1
± 0.2
|
637 |
EN300-206870_1_1
|
|
Cc1nnc(s1)COCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.3
|
8.1
± 0.2
|
638 |
EN300-31969_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CC(=O)N(C5)CC6CC6 |
−11.1
± 0.4
|
8.1
± 0.3
|
639 |
EN300-22245_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccon5 |
−11.1
± 0.2
|
8.1
± 0.1
|
640 |
EN300-1911992_3_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]([C@H]5CCOC5)O |
−11.1
± 0.4
|
8.1
± 0.3
|
641 |
EN300-202922_3_3
|
|
C[C@@H]([C@](C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−11.1
± 0.3
|
8.1
± 0.2
|
642 |
EN300-261210_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@]5(CCOC5)C#N |
−11.1
± 0.2
|
8.1
± 0.2
|
643 |
EN300-72211_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H](C5CC5)O |
−11.1
± 0.3
|
8.1
± 0.2
|
644 |
EN300-216978_1_1
|
|
Cn1nc(nn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.2
|
8.1
± 0.1
|
645 |
EN300-1212400_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H](C[C@H]5CO)CO |
−11.1
± 0.4
|
8.1
± 0.3
|
646 |
EN300-33601_1_1
|
|
CN1C[C@@H](CC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.2
|
8.1
± 0.2
|
647 |
EN300-113112_3_1
|
|
Cn1cnnc1COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.2
|
8.1
± 0.2
|
648 |
MAT-POS-e9e99895-2
|
|
CC(C)N1CCOC(C1)C(=O)NC(C)(c2ccc(c(c2)Cl)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.2
|
8.1
± 0.2
|
649 |
EN300-249804_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCOC(=O)N5 |
−11.1
± 0.3
|
8.1
± 0.2
|
650 |
EN300-341337_3_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@]56CCO[C@H]5CCOC6 |
−11.1
± 0.5
|
8.1
± 0.3
|
651 |
EN300-152337_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCC(=O)NCC5 |
−11.1
± 0.3
|
8.1
± 0.2
|
652 |
EN300-154942_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5OCCO5 |
−11.1
± 0.2
|
8.1
± 0.1
|
653 |
EN300-6493972_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@]56C[C@H]5[C@@H](C6)O |
−11.1
± 0.2
|
8.1
± 0.1
|
654 |
EN300-1709315_3_2
|
|
C[C@]1(CCCNS1(=O)=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.5
|
8.1
± 0.4
|
655 |
EN300-1715993_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCn5ccnn5 |
−11.1
± 0.3
|
8.1
± 0.2
|
656 |
EN300-385235_1_2
|
|
C[C@]1(CCS(=O)(=O)N1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.3
|
8.1
± 0.2
|
657 |
DAR-DIA-076fb6ea-9
|
|
c1ccc2c(c1)cncc2N(C#CC3CCCN3)C(=O)Cc4cccc(c4)Cl |
−11.1
± 0.4
|
8.1
± 0.3
|
658 |
EN300-702714_1_1
|
|
Cc1c(c(=O)cco1)OCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.3
|
8.1
± 0.2
|
659 |
EN300-17381_3_2
|
|
C[C@H](C(=O)N)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.1
|
8.1
± 0.1
|
660 |
EN300-51886_1_1
|
|
C[NH+]1CCC(CC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.4
|
8.1
± 0.3
|
661 |
EN300-120820_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5[cH+][nH][nH]c5=O |
−11.1
± 0.2
|
8.1
± 0.2
|
662 |
EN300-194199_1_1
|
|
COCCn1cc(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.3
|
8.1
± 0.2
|
663 |
EN300-306316_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5[nH]ncn5 |
−11.1
± 0.2
|
8.1
± 0.2
|
664 |
EN300-226314_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)[C@@H]5CCS(=O)(=O)C5 |
−11.1
± 0.3
|
8.1
± 0.2
|
665 |
EN300-93573_1_1
|
|
CN(C)C(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.3
|
8.1
± 0.2
|
666 |
EN300-383904_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCNC(=O)CO |
−11.1
± 0.3
|
8.1
± 0.2
|
667 |
EN300-04614_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(=O)[nH]n5 |
−11.1
± 0.2
|
8.1
± 0.1
|
668 |
EN300-246423_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CCC5)O |
−11.1
± 0.2
|
8.1
± 0.2
|
669 |
EN300-07879_1_1
|
|
CSCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.2
|
8.1
± 0.1
|
670 |
EN300-1726073_1_1
|
|
Cn1c(cnn1)C(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(F)F |
−11.1
± 0.3
|
8.1
± 0.2
|
671 |
EN300-297561_3_1
|
|
CC(C)[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnnn5 |
−11.1
± 0.4
|
8.1
± 0.3
|
672 |
EN300-1248250_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CN(C5)C(=O)N |
−11.1
± 0.3
|
8.1
± 0.2
|
673 |
PET-UNK-5ecb6237-1
|
|
c1ccc2c(c1)cncc2N(C#N)C(=O)Cc3cccc(c3)Cl |
−11.1
± 0.3
|
8.1
± 0.2
|
674 |
EN300-227310_1_1
|
|
Cn1c(c(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−11.1
± 0.3
|
8.1
± 0.2
|
675 |
EN300-221156_1_1
|
|
Cn1c(c2n(c1=O)CCCC2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.1
± 0.3
|
8.1
± 0.2
|
676 |
EN300-100467_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5ccnn5 |
−11.1
± 0.2
|
8.1
± 0.2
|
677 |
EN300-210552_3_1
|
|
CC(=O)N1CCC[C@@](C1)(C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−11.1
± 0.5
|
8.1
± 0.4
|
678 |
EN300-123489_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(CO)(F)F |
−11.1
± 0.2
|
8.1
± 0.2
|
679 |
EN300-66849_1_1
|
|
COCCN(CCO)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.5
|
8.1
± 0.3
|
680 |
EN300-1239522_1_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)OC |
−11.1
± 0.2
|
8.1
± 0.2
|
681 |
EN300-155176_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5CCCS5(=O)=O |
−11.1
± 0.3
|
8.1
± 0.2
|
682 |
EN300-77359_1_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OCCOC |
−11.1
± 0.3
|
8.1
± 0.2
|
683 |
EN300-103638_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCCOC5=O |
−11.1
± 0.3
|
8.1
± 0.2
|
684 |
EN300-1664865_1_1
|
|
Cn1c2c(nn1)CCC[C@@H]2C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.1
± 0.2
|
8.1
± 0.2
|
685 |
EN300-128464_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC(=O)NC5CC5 |
−11.1
± 0.3
|
8.1
± 0.2
|
686 |
EN300-14628_1_1
|
|
C[N@H+](CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)[C@@H]5CCS(=O)(=O)C5 |
−11.1
± 0.4
|
8.1
± 0.3
|
687 |
CHO-MSK-5891c1ff-2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)[C@H]5COCCO5 |
−11.1
± 0.3
|
8.1
± 0.2
|
688 |
EDJ-MED-d203f206-19
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5[C@H](CCC[C@H]5CO)CO |
−11.1
± 0.5
|
8.1
± 0.4
|
689 |
EN300-220527_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5[nH]ccn5 |
−11.1
± 0.2
|
8.1
± 0.1
|
690 |
EN300-250593_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5CC(=O)N5 |
−11.1
± 0.2
|
8.1
± 0.2
|
691 |
DAR-DIA-5ff57136-14
|
|
CC(C)(C#C)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−11.1
± 0.2
|
8.1
± 0.1
|
692 |
EN300-7459768_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(C5)(C6(CCC6)O)O |
−11.1
± 0.3
|
8.1
± 0.2
|
693 |
EN300-122319_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(=O)[nH]c(=O)[nH]n5 |
−11.1
± 0.2
|
8.1
± 0.1
|
694 |
EN300-72730_3_2
|
|
C[C@H](C#N)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.2
|
8.1
± 0.2
|
695 |
EN300-6736413_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCO[C@H]5CCNC5=O |
−11.1
± 0.2
|
8.1
± 0.1
|
696 |
EN300-98143_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(cn[nH]5)F |
−11.1
± 0.2
|
8.1
± 0.1
|
697 |
EDG-MED-90036822-6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CC6CNC6 |
−11.1
± 0.3
|
8.1
± 0.2
|
698 |
EN300-54837_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5C(=O)CCCC5=O |
−11.1
± 0.3
|
8.1
± 0.2
|
699 |
EN300-7465222_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@@H]5C[C@H]5N(=O)=O |
−11.1
± 0.2
|
8.1
± 0.2
|
700 |
EN300-1911992_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@H]([C@@H]5CCOC5)O |
−11.1
± 0.3
|
8.1
± 0.2
|