Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
5301 |
EN300-82616_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5CCCNC5=O |
−7.7
± 0.4
|
5.6
± 0.3
|
5302 |
EN300-205110_1_1
|
|
C[C@H](CO)N(C)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.7
± 0.3
|
5.6
± 0.2
|
5303 |
KAD-UNI-8a629cb0-41
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCS(=O)(=O)CC5)C#N |
−7.7
± 0.4
|
5.6
± 0.3
|
5304 |
EN300-100830_3_1
|
|
CCS(=O)(=O)[N@@](C)CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.7
± 0.4
|
5.6
± 0.3
|
5305 |
EN300-7443667_1_1
|
|
CSCC(=O)N1CCN(CC1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.7
± 0.3
|
5.6
± 0.2
|
5306 |
EN300-150022_1_1
|
|
CC(=O)NCCN(C)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.7
± 0.3
|
5.6
± 0.2
|
5307 |
ALP-UNI-0676e700-18
|
|
Cc1nnc2n1C[C@@H](N(C2)C)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−7.7
± 0.4
|
5.6
± 0.3
|
5308 |
EN300-6766359_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5[C@H]6C[C@H]6C(=O)N5 |
−7.7
± 0.3
|
5.6
± 0.2
|
5309 |
BEN-DND-f2e727cd-4
|
|
c1ccc2c(c1)cncc2NC(=O)C3COCc4c3cc(cc4)Cl |
−7.7
± 0.2
|
5.6
± 0.2
|
5310 |
EN300-257790_1_1
|
|
CCC(=O)N1CCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.7
± 0.3
|
5.6
± 0.2
|
5311 |
EDG-MED-4c68219f-12
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)O |
−7.7
± 0.2
|
5.6
± 0.1
|
5312 |
EN300-321053_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H]5CCOC[C@@H]5O |
−7.7
± 0.3
|
5.6
± 0.2
|
5313 |
MIC-UNK-cdc2493e-16
|
|
c1ccc2c(c1)cncc2NC(=O)N(CCc3ccco3)c4cccc(c4)Cl |
−7.7
± 0.4
|
5.6
± 0.3
|
5314 |
EN300-101443_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(COC5)O |
−7.7
± 0.2
|
5.6
± 0.1
|
5315 |
EN300-6764836_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5C[C@H]6[C@@H]([C@@H]([C@@H]5O6)O)O |
−7.7
± 0.3
|
5.6
± 0.2
|
5316 |
EN300-217526_1_1
|
|
CCn1c(c(nn1)C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.7
± 0.3
|
5.6
± 0.2
|
5317 |
EN300-7355477_1_8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6C[C@H]([C@H](C[C@H]6C5)O)O |
−7.7
± 0.4
|
5.6
± 0.3
|
5318 |
EN300-1653482_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CCn6c(nnn6)C5 |
−7.7
± 0.2
|
5.6
± 0.1
|
5319 |
EN300-249764_4_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H](C5CCC5)O |
−7.7
± 0.3
|
5.6
± 0.2
|
5320 |
EN300-6762327_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H](Cc5ccccn5)O |
−7.7
± 0.3
|
5.6
± 0.2
|
5321 |
EN300-385235_3_2
|
|
C[C@]1(CCS(=O)(=O)N1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.2
|
5.6
± 0.1
|
5322 |
LON-WEI-4d77710c-54
|
|
CC(C)Cn1cc(c2ccccc2c1=O)NC(=O)N3CCC(CC3)Cc4ccccc4 |
−7.6
± 0.4
|
5.6
± 0.3
|
5323 |
EDG-MED-ba1ac7b9-30
|
|
CN1CCC(CC1)N(CCO)C(=O)CC2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.4
|
5.6
± 0.3
|
5324 |
EN300-77778_4_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H]5CCCS(=O)(=O)C5 |
−7.6
± 0.3
|
5.6
± 0.2
|
5325 |
KAD-UNI-8a629cb0-23
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@@H]6[C@@H]5C[C@H](C6)C(=O)N |
−7.6
± 0.3
|
5.6
± 0.2
|
5326 |
RAL-THA-2d450e86-2
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3ccc(cc3)Cl |
−7.6
± 0.3
|
5.6
± 0.2
|
5327 |
EN300-1251424_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5ccn(n5)CC#N |
−7.6
± 0.3
|
5.6
± 0.2
|
5328 |
ADA-UCB-dc2b944c-7
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4)F |
−7.64
± 0.06
|
5.57
± 0.04
|
5329 |
DAR-DIA-0d514e7d-10
|
|
C[C@H]1COc2c(cc(cc2Nc3cnn(c3)C)Cl)[C@@H]1C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.2
|
5.6
± 0.2
|
5330 |
EN300-70323_1_1
|
|
Cc1nnc(n1C)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.3
|
5.6
± 0.2
|
5331 |
EN300-191771_2_1
|
|
CS(=O)(=O)C1(CCC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.3
|
5.6
± 0.2
|
5332 |
EN300-245036_2_1
|
|
C[C@H]1[C@@H](CCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−7.6
± 0.3
|
5.6
± 0.2
|
5333 |
EDG-MED-90036822-59
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC[C@@H](CF)N |
−7.6
± 0.6
|
5.6
± 0.4
|
5334 |
EN300-1587691_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCNC(=O)[C@H]5CCO |
−7.6
± 0.4
|
5.6
± 0.3
|
5335 |
EN300-705386_4_1
|
|
COC[C@@H]1C[C@H]1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.2
|
5.6
± 0.2
|
5336 |
EN300-142333_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H](C6(C5)CC6)O |
−7.6
± 0.3
|
5.6
± 0.2
|
5337 |
NAU-LAT-2fed8305-4
|
|
c1ccc2c(c1)cncc2NC(=O)CN3CCC=C(C3)F |
−7.6
± 0.3
|
5.6
± 0.2
|
5338 |
PET-UNK-c5865d42-1
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)CC4CCN4 |
−7.6
± 0.3
|
5.6
± 0.2
|
5339 |
EDG-MED-4c68219f-3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CC(C5)NC6COC6 |
−7.6
± 0.3
|
5.6
± 0.2
|
5340 |
KAD-UNI-8a629cb0-20
|
|
C[C@@H](C(=O)N1CCC(CC1)C(=O)N)O[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.4
|
5.6
± 0.3
|
5341 |
LAU-MED-88a3970a-14
|
|
COCCCc1cc(cc2c1OCC[C@@H]2C(=O)Nc3cncc4c3cccc4)Cl |
−7.6
± 0.4
|
5.6
± 0.3
|
5342 |
EN300-16216_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(=O)N |
−7.6
± 0.2
|
5.6
± 0.2
|
5343 |
ADA-UCB-dc2b944c-5
|
|
Cc1ccc2c(c1)[C@@H](CCO2)C(=O)Nc3cncc4c3cccc4 |
−7.62
± 0.06
|
5.55
± 0.05
|
5344 |
EN300-7432898_1_1
|
|
CCOC1(CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−7.6
± 0.4
|
5.5
± 0.3
|
5345 |
EN300-172640_2_2
|
|
C[C@H]1[C@@H](NC(=O)O1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.3
|
5.5
± 0.2
|
5346 |
EN300-259251_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCn6c(c(cn6)CO)C5 |
−7.6
± 0.3
|
5.5
± 0.2
|
5347 |
EN300-09239_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccc(c5)n6cnnn6 |
−7.6
± 0.4
|
5.5
± 0.3
|
5348 |
EN300-132615_4_1
|
|
C[C@@H](C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)N |
−7.6
± 0.4
|
5.5
± 0.3
|
5349 |
EDJ-MED-ee07cf00-1
|
|
Cn1c(=O)ccn(c1=O)CC(=O)NC(c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.6
± 0.4
|
5.5
± 0.3
|
5350 |
EN300-36931_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCOCC5)C(=O)N |
−7.6
± 0.3
|
5.5
± 0.2
|
5351 |
ALP-UNI-76695c4f-1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC56CC(C5)(CO6)C(=O)N |
−7.6
± 0.3
|
5.5
± 0.2
|
5352 |
EN300-92662_2_1
|
|
Cn1c(ccn1)CCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.3
|
5.5
± 0.2
|
5353 |
ALP-UNI-0676e700-19
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCS(=O)(=O)CC5)C#N |
−7.6
± 0.4
|
5.5
± 0.3
|
5354 |
KAD-UNI-8a629cb0-11
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5c(=O)[nH]cnc5O |
−7.6
± 0.4
|
5.5
± 0.3
|
5355 |
ALP-UNI-3496895b-16
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5ccc(cc5)S(=O)(=O)N |
−7.6
± 0.3
|
5.5
± 0.2
|
5356 |
EN300-380827_1_1
|
|
Cn1c(cnn1)C2(CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)OC |
−7.6
± 0.3
|
5.5
± 0.2
|
5357 |
EN300-05512_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)N[C@@H]5CCS(=O)(=O)C5 |
−7.6
± 0.5
|
5.5
± 0.3
|
5358 |
RAL-THA-1d44ff04-4
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)C(=O)N |
−7.6
± 0.3
|
5.5
± 0.2
|
5359 |
EDG-MED-4c68219f-8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5[nH]nnn5 |
−7.6
± 0.2
|
5.5
± 0.1
|
5360 |
EN300-77438_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H]5CCN(C5=O)C6CC6 |
−7.6
± 0.2
|
5.5
± 0.1
|
5361 |
EN300-217107_4_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5CC[C@H]5C(=O)N |
−7.6
± 0.4
|
5.5
± 0.3
|
5362 |
EN300-7456801_1_1
|
|
CC1=CC(N(N1)C)C(=O)NCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.2
|
5.5
± 0.2
|
5363 |
EN300-254121_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H](c5cnc[nH]5)O |
−7.6
± 0.4
|
5.5
± 0.3
|
5364 |
EN300-366931_2_1
|
|
COc1cnnc(c1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−7.6
± 0.3
|
5.5
± 0.2
|
5365 |
EN300-373791_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccnn5CC#N |
−7.6
± 0.2
|
5.5
± 0.2
|
5366 |
MAT-POS-f9802937-1
|
|
CN1c2ccc(cc2C(CC1=O)(C(=O)Nc3cncc4c3cccc4)OC)Cl |
−7.6
± 0.2
|
5.5
± 0.1
|
5367 |
PET-UNK-b87f07d0-1
|
|
CC(=O)NCCCc1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2cccc3 |
−7.6
± 0.4
|
5.5
± 0.3
|
5368 |
EN300-26031_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5NN[C@H]6[NH+]5CCC6 |
−7.6
± 0.2
|
5.5
± 0.1
|
5369 |
LON-WEI-4d77710c-36
|
|
Cc1cc(c(cc1Cl)OC)NC(=O)Nc2cn(c(=O)c3c2cccc3)C |
−7.6
± 0.4
|
5.5
± 0.3
|
5370 |
EN300-233678_2_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC[C@H]([C@H](C5)CO)O |
−7.6
± 0.3
|
5.5
± 0.2
|
5371 |
EN300-341011_2_1
|
|
Cn1c2c(nn1)CC[C@@H](C2)NC(=O)CC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−7.6
± 0.3
|
5.5
± 0.2
|
5372 |
MAK-UNK-ffc90da7-7
|
|
CC(C)OCC(C(c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3)NC |
−7.6
± 0.4
|
5.5
± 0.3
|
5373 |
FRA-DIA-0fa076fe-2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3COc4c3cc(cc4Cl)O |
−7.6
± 0.2
|
5.5
± 0.2
|
5374 |
EDJ-MED-ee07cf00-3
|
|
Cn1c2c(cn1)c(=O)n(cn2)CC(=O)NC(c3cccc(c3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.5
|
5.5
± 0.3
|
5375 |
RAL-THA-2d450e86-27
|
|
Cc1ccc(cc1CC(=O)Nc2cncc3c2cccc3)Cl |
−7.6
± 0.2
|
5.5
± 0.2
|
5376 |
EN300-1708637_1_2
|
|
C[C@H]([C@H]1CN(CCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−7.6
± 0.4
|
5.5
± 0.3
|
5377 |
EN300-6729572_4_4
|
|
C[C@H]([C@H]1C[C@@H]1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−7.6
± 0.3
|
5.5
± 0.2
|
5378 |
EN300-256053_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H](C5)CO |
−7.6
± 0.2
|
5.5
± 0.1
|
5379 |
MAT-POS-c7771779-1
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CC(=O)Nc4c3cc(cc4)Cl)O |
−7.6
± 0.3
|
5.5
± 0.2
|
5380 |
RAL-THA-2d450e86-21
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cccc(c3C#N)Cl |
−7.6
± 0.3
|
5.5
± 0.2
|
5381 |
EN300-174668_2_1
|
|
CO[C@@]1(CCOC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.4
|
5.5
± 0.3
|
5382 |
EN300-16091_3_2
|
|
CCS(=O)(=O)[N@@]1CCC[C@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.5
|
5.5
± 0.3
|
5383 |
RAL-THA-2d450e86-19
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cccc(c3F)Cl |
−7.6
± 0.3
|
5.5
± 0.2
|
5384 |
EN300-1968342_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H](CF)O |
−7.6
± 0.3
|
5.5
± 0.2
|
5385 |
EN300-39504_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCS(=O)(=O)N |
−7.6
± 0.3
|
5.5
± 0.3
|
5386 |
MAT-POS-fce787c2-10
|
|
CN(C)CCNC(c1ccc(c(c1)Cl)Cl)C(=O)Nc2cncc3c2cccc3 |
−7.6
± 0.4
|
5.5
± 0.3
|
5387 |
EN300-256075_1_1
|
|
C[NH+](C)CCn1c(ccn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.4
|
5.5
± 0.3
|
5388 |
EN300-244403_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CNC(=O)O5 |
−7.6
± 0.2
|
5.5
± 0.2
|
5389 |
EN300-1248250_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CN(C5)C(=O)N |
−7.5
± 0.3
|
5.5
± 0.2
|
5390 |
EN300-313267_2_2
|
|
CN1CCC[C@H](C1=O)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.5
± 0.3
|
5.5
± 0.2
|
5391 |
JOH-UNI-ea72002d-5
|
|
C=CS(=O)(=O)NN(c1cncc2c1cccc2)C(=O)C3(CCOc4c3cc(cc4)Cl)F |
−7.5
± 0.2
|
5.5
± 0.1
|
5392 |
ED_-GRI-5b13fbe2-33
|
|
CN(C)CCNCCO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.5
± 0.5
|
5.5
± 0.4
|
5393 |
EN300-4293814_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CS(=O)(=O)CCO |
−7.5
± 0.3
|
5.5
± 0.2
|
5394 |
EDG-MED-ba1ac7b9-13
|
|
CN1C[C@@H]2C[C@H]1CN2C(=O)CC3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−7.5
± 0.2
|
5.5
± 0.2
|
5395 |
EDG-MED-90036822-21
|
|
CN(C)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.5
± 0.3
|
5.5
± 0.2
|
5396 |
EN300-325729_1_1
|
|
COC[C@@H]1COCCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.5
± 0.3
|
5.5
± 0.2
|
5397 |
KAD-UNI-8a629cb0-8
|
|
C[C@@H](C(=O)N)N1CCN(CC1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.5
± 0.4
|
5.5
± 0.3
|
5398 |
MIC-UNK-5a93dd5f-7
|
|
CC(=O)N(C)C1CCN(C1)C(c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.5
± 0.3
|
5.5
± 0.2
|
5399 |
EN300-6763291_2_6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H]5C[C@H]6C[C@@H]5[C@@H]([C@H]6O)O |
−7.5
± 0.2
|
5.5
± 0.2
|
5400 |
EN300-77778_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCS(=O)(=O)C5 |
−7.5
± 0.3
|
5.5
± 0.2
|