Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
5201 |
MAT-POS-8d5af1ef-1
|
|
c1ccc2c(c1)cncc2NC(=O)C3CC(=O)Nc4c3cc(cc4)Br |
−7.84
± 0.09
|
5.71
± 0.07
|
5202 |
EN300-299215_2_1
|
|
C[C@H]1[C@H](OCCO1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.8
± 0.3
|
5.7
± 0.2
|
5203 |
EDG-MED-90036822-23
|
|
CC(CCc1c(nn[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)N |
−7.8
± 0.4
|
5.7
± 0.3
|
5204 |
DAR-DIA-0cde14eb-54
|
|
c1ccc2c(c1)cncc2NC(=O)Nc3cccc(c3)C4(CC4)C#N |
−7.8
± 0.4
|
5.7
± 0.3
|
5205 |
EN300-125379_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOC[C@]56CCOC6 |
−7.8
± 0.3
|
5.7
± 0.2
|
5206 |
EN300-366540_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CCOC[C@H]5O |
−7.8
± 0.3
|
5.7
± 0.2
|
5207 |
EN300-6729572_4_5
|
|
C[C@@H]([C@@H]1C[C@H]1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−7.8
± 0.4
|
5.7
± 0.3
|
5208 |
EN300-7457160_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5C[C@@H](ON5)CC6(COC6)O |
−7.8
± 0.3
|
5.7
± 0.2
|
5209 |
EN300-40947_2_2
|
|
C[C@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C(C)C |
−7.8
± 0.4
|
5.7
± 0.3
|
5210 |
EN300-256759_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CCC(=O)NCC5 |
−7.8
± 0.3
|
5.7
± 0.2
|
5211 |
KAD-UNI-8a629cb0-36
|
|
CS(=O)(=O)N1CCC(CC1)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.8
± 0.2
|
5.7
± 0.2
|
5212 |
MAK-UNK-83e0a0b4-4
|
|
CCCCc1ccc2c(c1)C(CCO2)C(=O)N(CCNC3CNC3)c4cncc5c4cccc5 |
−7.8
± 0.4
|
5.7
± 0.3
|
5213 |
EN300-2008102_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC[C@@H]5CN6C[C@H](O5)CCC6=O |
−7.8
± 0.5
|
5.7
± 0.4
|
5214 |
EN300-6743781_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCCNS(=O)(=O)CC5 |
−7.8
± 0.6
|
5.7
± 0.5
|
5215 |
MAT-POS-e9e99895-1
|
|
CC(c1ccc(c(c1)Cl)Cl)(C(=O)Nc2cncc3c2cccc3)N |
−7.8
± 0.2
|
5.7
± 0.2
|
5216 |
EDG-MED-5d232de5-7
|
|
c1ccc2c(c1)cncc2N3CC[C@@H](C3=O)c4cccc(c4)Cl |
−7.8
± 0.3
|
5.7
± 0.2
|
5217 |
EN300-23942_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5cccn5 |
−7.8
± 0.2
|
5.7
± 0.1
|
5218 |
EDG-MED-ba1ac7b9-18
|
|
CC1Cn2c(ccn2)CN1C(=O)CC3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−7.8
± 0.2
|
5.7
± 0.2
|
5219 |
EN300-18610_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H](C5)C(=O)N |
−7.8
± 0.2
|
5.7
± 0.1
|
5220 |
EN300-238405_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@H]5CC(=O)NC5 |
−7.8
± 0.3
|
5.7
± 0.2
|
5221 |
LAU-MED-88a3970a-18
|
|
CNC(=O)CCc1cc(cc2c1OCC[C@@H]2C(=O)Nc3cncc4c3cccc4)Cl |
−7.8
± 0.3
|
5.7
± 0.3
|
5222 |
EN300-341337_2_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@]56CCO[C@H]5CCOC6 |
−7.8
± 0.3
|
5.7
± 0.2
|
5223 |
EN300-23214_1_2
|
|
CCCNC(=O)[C@H](C)NC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.8
± 0.3
|
5.7
± 0.3
|
5224 |
EN300-197715_1_1
|
|
CC1NNN[N@@]1CCCO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.8
± 0.5
|
5.7
± 0.3
|
5225 |
LEE-CAM-7ab9b158-2
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)COCc5[nH]c(=O)c6c(n5)CCOC6 |
−7.8
± 0.2
|
5.7
± 0.2
|
5226 |
EN300-1587691_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCNC(=O)[C@H]5CCO |
−7.8
± 0.3
|
5.7
± 0.2
|
5227 |
EN300-21200_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c(nccn5)C(=O)N |
−7.8
± 0.4
|
5.7
± 0.3
|
5228 |
EN300-7431964_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CN(C5)C(=O)N |
−7.8
± 0.3
|
5.7
± 0.2
|
5229 |
EN300-297561_2_1
|
|
CC(C)[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnnn5 |
−7.8
± 0.3
|
5.7
± 0.2
|
5230 |
EN300-148421_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@]5(CCOC5)O |
−7.8
± 0.4
|
5.7
± 0.3
|
5231 |
EN300-248888_2_2
|
|
C[C@](C=C)(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−7.8
± 0.2
|
5.7
± 0.1
|
5232 |
EN300-60049_2_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@@H]5C[N@@H+]6CCC[C@H]6CO5 |
−7.8
± 0.4
|
5.7
± 0.3
|
5233 |
EN300-181688_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6n(n5)CCO6 |
−7.8
± 0.2
|
5.7
± 0.2
|
5234 |
EN300-217494_4_4
|
|
C[C@]([C@H]1CCOC1)(C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−7.8
± 0.4
|
5.7
± 0.3
|
5235 |
DAR-DIA-0cde14eb-59
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cccc(c3)C4(CC4)C#N |
−7.8
± 0.4
|
5.7
± 0.3
|
5236 |
VLA-UCB-05e51b3f-17
|
|
CC(=O)N(c1cncc2c1cccc2)C(=O)Cc3cccc(c3)Cl |
−7.8
± 0.3
|
5.7
± 0.3
|
5237 |
DAR-DIA-e7614d05-3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@]3(CCOc4c3cc(cc4)Cl)OC(F)(F)F |
−7.8
± 0.3
|
5.7
± 0.2
|
5238 |
KAD-UNI-8a629cb0-46
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5ccc(=O)[nH]n5 |
−7.8
± 0.3
|
5.7
± 0.2
|
5239 |
EN300-22245_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccon5 |
−7.8
± 0.2
|
5.7
± 0.2
|
5240 |
EN300-7349829_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(=O)NCC56CCC6 |
−7.8
± 0.3
|
5.7
± 0.2
|
5241 |
RAL-THA-8416115c-4
|
|
CCCN1CCC(c2c1ccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.8
± 0.1
|
5.7
± 0.1
|
5242 |
EN300-201164_2_2
|
|
CC(C)(C)[C@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−7.8
± 0.3
|
5.7
± 0.2
|
5243 |
EN300-66845_1_2
|
|
COC(=O)N1CCC[C@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.8
± 0.3
|
5.7
± 0.3
|
5244 |
MAT-POS-5d65ec79-2
|
|
CNC(=O)CC1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.8
± 0.2
|
5.7
± 0.1
|
5245 |
EN300-7443527_1_4
|
|
C[C@H](c1[nH]nc(n1)[C@H](C)O)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.8
± 0.4
|
5.7
± 0.3
|
5246 |
EN300-1073264_2_1
|
|
Cn1cc(nn1)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.8
± 0.3
|
5.7
± 0.2
|
5247 |
EN300-1265949_2_1
|
|
C[C@@H](C(=O)N1CCS(=O)(=O)CC1)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.8
± 0.3
|
5.7
± 0.2
|
5248 |
EN300-266299_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CC[C@@H](C5)O |
−7.8
± 0.2
|
5.7
± 0.2
|
5249 |
MAT-POS-e9e99895-6
|
|
CC(c1ccc(c(c1)Cl)Cl)(C(=O)Nc2cncc3c2cccc3)NC(=O)CN4CCN(C4=O)C5CC5 |
−7.8
± 0.5
|
5.7
± 0.3
|
5250 |
EN300-305282_2_1
|
|
COC[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−7.8
± 0.4
|
5.7
± 0.3
|
5251 |
MAK-UNK-c749d764-1
|
|
c1ccc2c(c1)cncc2NC(=O)CC3CCCC(C3O)C4CC4 |
−7.8
± 0.2
|
5.7
± 0.2
|
5252 |
RAL-THA-2d450e86-26
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(ccc3F)F |
−7.8
± 0.3
|
5.7
± 0.2
|
5253 |
MAT-POS-e9e99895-11
|
|
CC(c1ccc(c(c1)Cl)Cl)(C(=O)Nc2cncc3c2cccc3)NC(=O)COC |
−7.8
± 0.2
|
5.7
± 0.2
|
5254 |
EN300-108407_2_2
|
|
CC(=O)N1CC[C@H](C1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.8
± 0.3
|
5.7
± 0.2
|
5255 |
EDG-MED-90036822-11
|
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N |
−7.8
± 0.2
|
5.6
± 0.2
|
5256 |
EN300-78135_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(=O)NC5CC5 |
−7.8
± 0.2
|
5.6
± 0.2
|
5257 |
EN300-132615_1_2
|
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)N |
−7.7
± 0.3
|
5.6
± 0.2
|
5258 |
ED_-GRI-5b13fbe2-13
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5CN[C@H](CN5)CO |
−7.7
± 0.3
|
5.6
± 0.2
|
5259 |
EN300-6505003_4_4
|
|
C[C@H]1CC[C@H](C(=O)N1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.7
± 0.4
|
5.6
± 0.3
|
5260 |
DAR-DIA-23e5a6a0-6_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4C[C@H]5CCC6([NH2+]5)CCC6)Cl |
−7.7
± 0.3
|
5.6
± 0.2
|
5261 |
VLA-UCB-1dbca3b4-14
|
|
CC1(c2cc(ccc2OCC1=O)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.7
± 0.1
|
5.64
± 0.08
|
5262 |
EN300-209048_2_2
|
|
CN1CC[C@H](C1=O)N(C)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.7
± 0.2
|
5.6
± 0.2
|
5263 |
EDG-MED-ba1ac7b9-17
|
|
Cn1ccnc1CN(C2CC2)C(=O)CC3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−7.7
± 0.3
|
5.6
± 0.2
|
5264 |
EN300-96797_1_2
|
|
C[C@H]1CN(CC(=O)N1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.7
± 0.3
|
5.6
± 0.2
|
5265 |
EN300-343433_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCc5c[nH]c(=O)nc5 |
−7.7
± 0.3
|
5.6
± 0.2
|
5266 |
EN300-30480_2_1
|
|
Cn1ccc(cc1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.7
± 0.3
|
5.6
± 0.2
|
5267 |
ALP-UNI-3496895b-6
|
|
CCN1CCN(CC1)C2CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−7.7
± 0.3
|
5.6
± 0.3
|
5268 |
RAL-THA-4aa06b95-4
|
|
CN(C)C(=O)N1CCC(c2c1ccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.7
± 0.3
|
5.6
± 0.2
|
5269 |
ED_-GRI-5b13fbe2-42
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@H](CF)N |
−7.7
± 0.6
|
5.6
± 0.4
|
5270 |
EN300-75674_2_1
|
|
Cc1c(non1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.7
± 0.2
|
5.6
± 0.2
|
5271 |
JAG-UCB-7b680c2b-1
|
|
CC(C)(C)OC(=O)NCc1cccc(c1)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.7
± 0.4
|
5.6
± 0.3
|
5272 |
EN300-254840_1_4
|
|
C[C@H]([C@H]1CN(CCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−7.7
± 0.5
|
5.6
± 0.3
|
5273 |
EDG-MED-971238d3-11
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)C(=O)O |
−7.7
± 0.2
|
5.6
± 0.1
|
5274 |
MIC-UNK-5a93dd5f-9
|
|
CN(C)C1CCN(C1)C(c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.7
± 0.3
|
5.6
± 0.2
|
5275 |
EDG-MED-ba1ac7b9-5
|
|
CCC(CO)N1CCN(CC1)C(=O)CC2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.7
± 0.4
|
5.6
± 0.3
|
5276 |
EN300-208236_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CCCc6c5n[nH]n6 |
−7.7
± 0.3
|
5.6
± 0.2
|
5277 |
EN300-1448603_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@@H]5CCS(=O)(=O)C5 |
−7.7
± 0.3
|
5.6
± 0.2
|
5278 |
ALF-EVA-5b152d2f-8
|
|
c1cc2c(cc1CC3CC3)cncc2NC(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−7.71
± 0.08
|
5.62
± 0.06
|
5279 |
EN300-10334_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@]56CCC(=O)N5CCS6 |
−7.7
± 0.2
|
5.6
± 0.2
|
5280 |
EN300-80940_1_3
|
|
C[C@@H]1[C@H](S(=O)(=O)CCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−7.7
± 0.3
|
5.6
± 0.2
|
5281 |
EN300-148421_4_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@]5(CCOC5)O |
−7.7
± 0.4
|
5.6
± 0.3
|
5282 |
KAD-UNI-80f122c8-4
|
|
CCN1CCN(CC1)C2CN(C2)C(=O)CC3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−7.7
± 0.3
|
5.6
± 0.2
|
5283 |
EN300-23648_2_1
|
|
C[C@@H](C(=O)N)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.7
± 0.2
|
5.6
± 0.1
|
5284 |
EN300-248178_2_1
|
|
Cc1cn[nH]c1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.7
± 0.2
|
5.6
± 0.2
|
5285 |
EN300-393300_2_1
|
|
C[C@@H](c1cn(nn1)C)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.7
± 0.3
|
5.6
± 0.2
|
5286 |
LAU-MED-88a3970a-9
|
|
CS(=O)(=O)CCc1cc(cc2c1OCC[C@H]2C(=O)Nc3cncc4c3cccc4)Cl |
−7.7
± 0.2
|
5.6
± 0.2
|
5287 |
JOH-UNI-a38a7bdd-6
|
|
c1ccc2c(c1)cncc2N(C(=O)Cc3cccc(c3)Cl)C(=O)C4CC4C(F)(F)F |
−7.7
± 0.3
|
5.6
± 0.2
|
5288 |
EDG-MED-90036822-96
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCC(CCF)N |
−7.7
± 0.3
|
5.6
± 0.2
|
5289 |
VLA-UNK-f702bf1c-8
|
|
c1ccc2c(c1)cncc2N3C(=O)[C@@]4(CCOc5c4cc(cc5)Cl)N(C3=O)CCc6nc[nH]n6 |
−7.7
± 0.3
|
5.6
± 0.2
|
5290 |
EN300-28871_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCn5ccnn5 |
−7.7
± 0.2
|
5.6
± 0.1
|
5291 |
EN300-226314_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)[C@H]5CCS(=O)(=O)C5 |
−7.7
± 0.3
|
5.6
± 0.2
|
5292 |
EN300-114133_1_1
|
|
CCC(=O)N1CC[C@@H](C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.7
± 0.4
|
5.6
± 0.3
|
5293 |
EN300-87527_1_1
|
|
CC[C@H](C)[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−7.7
± 0.3
|
5.6
± 0.2
|
5294 |
EN300-97453_1_1
|
|
COCCCS(=O)(=O)NCCO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.7
± 0.4
|
5.6
± 0.3
|
5295 |
EN300-6499531_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CCCCCS5(=O)=O |
−7.7
± 0.4
|
5.6
± 0.3
|
5296 |
LON-WEI-5e7d1b3e-53
|
|
CC(C)Cn1cc(c2ccccc2c1=O)NC(=O)N3CCCN(C3)Cc4ccccc4F |
−7.7
± 0.6
|
5.6
± 0.4
|
5297 |
EDG-MED-90036822-58
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCC(CF)N |
−7.7
± 0.3
|
5.6
± 0.2
|
5298 |
EN300-313062_2_1
|
|
CC(=O)N1C[C@@H]2C[C@@]2(C1)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−7.7
± 0.3
|
5.6
± 0.2
|
5299 |
EN300-31969_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CC(=O)N(C5)CC6CC6 |
−7.7
± 0.3
|
5.6
± 0.2
|
5300 |
EN300-6491316_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc6[cH+][nH][nH][n+]6c5 |
−7.7
± 0.2
|
5.6
± 0.2
|