Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
501 |
EN300-205622_1_1
|
|
CS(=O)(=O)c1nccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
8.3
± 0.2
|
502 |
EN300-42131_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6c([nH]c(=O)[nH]c6=O)nc5 |
−11.3
± 0.3
|
8.3
± 0.2
|
503 |
EN300-107892_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(nn5)C6CC6 |
−11.3
± 0.3
|
8.3
± 0.2
|
504 |
EDJ-MED-d203f206-3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC[C@@H]5c6ncon6 |
−11.3
± 0.4
|
8.3
± 0.3
|
505 |
EN300-6238494_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)[C@@H]5COCCO5 |
−11.3
± 0.3
|
8.3
± 0.2
|
506 |
EN300-41423_1_1
|
|
Cc1ccc(c(=O)n1C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
8.2
± 0.2
|
507 |
EN300-6733459_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@]56CCC[N@@]5S(=O)(=O)CC6 |
−11.3
± 0.5
|
8.2
± 0.4
|
508 |
VLA-UCB-50c39ae8-1
|
|
CC(=O)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−11.3
± 0.1
|
8.2
± 0.1
|
509 |
EDJ-MED-d203f206-41
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@H]5CO |
−11.3
± 0.3
|
8.2
± 0.2
|
510 |
EN300-102347_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5(COC5)CO |
−11.3
± 0.3
|
8.2
± 0.2
|
511 |
EN300-6744028_1_6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[C@H]6C[C@@H]5[C@@H]([C@H]6O)O |
−11.3
± 0.2
|
8.2
± 0.2
|
512 |
EN300-1268016_1_11
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@H]6[C@@H]5C[C@H](C6)C(=O)N |
−11.3
± 0.4
|
8.2
± 0.3
|
513 |
EN300-59285_3_1
|
|
CC(C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.3
± 0.3
|
8.2
± 0.2
|
514 |
EN300-2011083_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCC(=O)OCC5 |
−11.3
± 0.3
|
8.2
± 0.2
|
515 |
EN300-52983_1_1
|
|
CN1C[C@@H](CCC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
8.2
± 0.2
|
516 |
EN300-298552_1_2
|
|
CO[C@H]([C@@H]1CCOC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.2
|
8.2
± 0.2
|
517 |
EN300-111863_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cnc(n5)C#N |
−11.3
± 0.3
|
8.2
± 0.2
|
518 |
EN300-226964_1_1
|
|
Cc1ccn(n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.2
|
8.2
± 0.2
|
519 |
EN300-169955_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@@H](CC(=O)N5)C(F)(F)F |
−11.3
± 0.2
|
8.2
± 0.2
|
520 |
EDG-MED-90036822-94
|
|
CC1CC1C(C(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)F)O |
−11.30
± 0.09
|
8.23
± 0.07
|
521 |
EN300-227218_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[N@@H+]6CC[C@H]5C6 |
−11.3
± 0.3
|
8.2
± 0.2
|
522 |
EN300-195924_3_2
|
|
C[C@]1(CCC(=O)NC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.4
|
8.2
± 0.3
|
523 |
EDJ-MED-28ec730d-5_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCc5c[nH]nc5 |
−11.3
± 0.3
|
8.2
± 0.2
|
524 |
EN300-6759512_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)[C@@H]6COC[C@@H]6F |
−11.3
± 0.3
|
8.2
± 0.2
|
525 |
EN300-731622_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5COCCO5 |
−11.3
± 0.2
|
8.2
± 0.2
|
526 |
EN300-140582_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5COCC[N@H+]5CC(F)F |
−11.3
± 0.3
|
8.2
± 0.2
|
527 |
EN300-1696962_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCCn5cnnn5 |
−11.3
± 0.3
|
8.2
± 0.2
|
528 |
EN300-7434209_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cncc6c5[nH]c(=O)[nH]6 |
−11.3
± 0.3
|
8.2
± 0.2
|
529 |
ALP-UNI-44c99a80-3
|
|
c1ccc2c(c1)cncc2N(Cc3cnco3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−11.3
± 0.2
|
8.2
± 0.1
|
530 |
EN300-29220_1_1
|
|
Cc1c(n[nH]c(=O)c1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−11.3
± 0.3
|
8.2
± 0.2
|
531 |
EN300-23942_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cccn5 |
−11.3
± 0.2
|
8.2
± 0.2
|
532 |
EN300-54304_1_1
|
|
CCOCCOCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.3
± 0.2
|
8.2
± 0.2
|
533 |
EN300-138676_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CC(=O)N)CC(F)(F)F |
−11.3
± 0.3
|
8.2
± 0.2
|
534 |
MIC-UNK-50cce87d-11
|
|
Cc1cccc2c1c(cnc2)N3CCCC(C3=O)c4cccc(c4)Cl |
−11.3
± 0.2
|
8.2
± 0.2
|
535 |
EN300-254883_3_1
|
|
Cc1c(non1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
8.2
± 0.2
|
536 |
EN300-1273362_3_1
|
|
C[C@@]1(CN(C1=O)C)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
8.2
± 0.2
|
537 |
EDJ-MED-d203f206-13
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5cnncn5 |
−11.3
± 0.2
|
8.2
± 0.2
|
538 |
VLA-UCB-50c39ae8-8_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4O[C@H]5C[C@@H](N5)O)Cl |
−11.3
± 0.3
|
8.2
± 0.2
|
539 |
EN300-175186_3_2
|
|
C[C@H](CO)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.3
± 0.3
|
8.2
± 0.2
|
540 |
EN300-18928_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CSCN5C(=O)C6CC6 |
−11.3
± 0.3
|
8.2
± 0.3
|
541 |
EN300-131465_1_1
|
|
COc1cc(on1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.2
|
8.2
± 0.2
|
542 |
EN300-28262_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5C=CNc6n5ncn6 |
−11.3
± 0.3
|
8.2
± 0.2
|
543 |
EN300-21258_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCO |
−11.3
± 0.2
|
8.2
± 0.2
|
544 |
EN300-322400_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5[C@H](OCCO5)C(F)(F)F |
−11.3
± 0.3
|
8.2
± 0.2
|
545 |
EN300-178876_1_1
|
|
C[C@@]1(CCCNC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.4
|
8.2
± 0.3
|
546 |
EN300-83527_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6ncccn6n5 |
−11.3
± 0.2
|
8.2
± 0.2
|
547 |
EN300-1644723_1_7
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5[C@H]6[C@H]5COCC6 |
−11.3
± 0.2
|
8.2
± 0.2
|
548 |
EN300-217343_1_1
|
|
Cn1c2c(nn1)CC[C@@H](C2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.3
± 0.3
|
8.2
± 0.2
|
549 |
EN300-246248_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@H]5CCNC5=O |
−11.3
± 0.2
|
8.2
± 0.2
|
550 |
EN300-637522_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C6CCC5(CC6)C(=O)N |
−11.3
± 0.3
|
8.2
± 0.2
|
551 |
EN300-20375_1_1
|
|
COCCOCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.3
± 0.2
|
8.2
± 0.2
|
552 |
EN300-270710_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCS(=O)(=O)N |
−11.3
± 0.2
|
8.2
± 0.2
|
553 |
EN300-114526_1_1
|
|
Cc1c(c([nH]n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−11.3
± 0.2
|
8.2
± 0.2
|
554 |
EN300-238234_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6c([nH]c5=O)CCC[C@H]6O |
−11.2
± 0.4
|
8.2
± 0.3
|
555 |
EN300-139268_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(=O)NCC(F)(F)F |
−11.2
± 0.2
|
8.2
± 0.2
|
556 |
EN300-343474_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5CCNC5=O |
−11.2
± 0.3
|
8.2
± 0.2
|
557 |
EN300-11934_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCC5=O |
−11.2
± 0.3
|
8.2
± 0.2
|
558 |
EN300-90225_3_1
|
|
Cn1nc(nn1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.2
± 0.2
|
559 |
EN300-332606_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCC(=O)O5 |
−11.2
± 0.2
|
8.2
± 0.2
|
560 |
EN300-658559_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)n6ccnn6 |
−11.2
± 0.3
|
8.2
± 0.3
|
561 |
EN300-311920_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@]5(CCS(=O)(=O)C5)F |
−11.2
± 0.3
|
8.2
± 0.2
|
562 |
EDJ-MED-d203f206-8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@H]5CC(=O)N |
−11.2
± 0.3
|
8.2
± 0.2
|
563 |
EN300-20980_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cnnn5 |
−11.2
± 0.2
|
8.2
± 0.2
|
564 |
EN300-211482_3_2
|
|
C[C@H](C(=O)NC)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.2
|
8.2
± 0.2
|
565 |
EN300-248888_3_2
|
|
C[C@](C=C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.2
± 0.3
|
8.2
± 0.3
|
566 |
VLA-UCB-05e51b3f-12_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@]3(CCOc4c3cc(cc4O[C@@H]5CC(=O)N5)Cl)CCC6CCCCC6 |
−11.2
± 0.5
|
8.2
± 0.4
|
567 |
EN300-6255179_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCn5cncn5 |
−11.2
± 0.2
|
8.2
± 0.2
|
568 |
EN300-783124_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]([C@@H]5CCOC5)F |
−11.2
± 0.2
|
8.2
± 0.1
|
569 |
EN300-06654_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cncn5 |
−11.2
± 0.2
|
8.2
± 0.1
|
570 |
EN300-94900_3_1
|
|
CS(=O)(=O)Cc1nc(on1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.4
|
8.2
± 0.3
|
571 |
EDG-MED-90036822-27
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COC(CN)C(F)(F)F |
−11.2
± 0.4
|
8.2
± 0.3
|
572 |
EN300-260816_3_1
|
|
CN1CC[C@@H](C1=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.2
± 0.2
|
573 |
EN300-178876_3_2
|
|
C[C@]1(CCCNC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.5
|
8.2
± 0.3
|
574 |
EN300-10747_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CSCC5=O |
−11.2
± 0.3
|
8.2
± 0.2
|
575 |
EN300-7461217_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[C@H]([C@@H](C5)F)O |
−11.2
± 0.3
|
8.2
± 0.2
|
576 |
EN300-1717795_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6[C@H](C5)OCO6 |
−11.2
± 0.3
|
8.2
± 0.2
|
577 |
EN300-253571_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCc6nnnn6CC5 |
−11.2
± 0.3
|
8.2
± 0.2
|
578 |
EN300-54417_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)c5cccc(c5)O |
−11.2
± 0.3
|
8.2
± 0.2
|
579 |
EN300-1726277_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H](n5cccn5)F |
−11.2
± 0.3
|
8.2
± 0.2
|
580 |
EN300-27268_1_1
|
|
Cc1nc(on1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.2
|
8.2
± 0.2
|
581 |
EN300-7536177_1_1
|
|
Cc1ncnn1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.2
|
8.2
± 0.2
|
582 |
EN300-736749_3_1
|
|
CC(=O)N1CSC[C@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.2
± 0.2
|
583 |
EN300-120586_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCC(F)F |
−11.2
± 0.2
|
8.2
± 0.2
|
584 |
EN300-364679_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCn5cnnn5 |
−11.2
± 0.2
|
8.2
± 0.2
|
585 |
EN300-245205_1_1
|
|
COc1nc(co1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.2
|
8.2
± 0.2
|
586 |
EN300-182124_3_1
|
|
COC1(CC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.2
± 0.2
|
587 |
EN300-16091_1_1
|
|
CCS(=O)(=O)[N@]1CCC[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.6
|
8.2
± 0.4
|
588 |
EN300-67073_3_2
|
|
CC(=O)N[C@](C)(C1CC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.2
± 0.2
|
589 |
EN300-1715993_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCn5ccnn5 |
−11.2
± 0.2
|
8.2
± 0.1
|
590 |
EN300-173216_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(=O)NCC5CC5 |
−11.2
± 0.2
|
8.2
± 0.2
|
591 |
EN300-83766_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC#CCO |
−11.2
± 0.2
|
8.2
± 0.2
|
592 |
EN300-96362_1_1
|
|
C[C@@H]([C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C5CC5)O |
−11.2
± 0.3
|
8.2
± 0.2
|
593 |
EN300-21200_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(nccn5)C(=O)N |
−11.2
± 0.2
|
8.2
± 0.2
|
594 |
EN300-256174_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CCO)c5ccncn5 |
−11.2
± 0.4
|
8.2
± 0.3
|
595 |
EN300-396748_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc(c5)CO |
−11.2
± 0.2
|
8.2
± 0.2
|
596 |
EN300-78753_3_1
|
|
CC1(COC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.2
± 0.2
|
597 |
EN300-28571_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccnc5n6cncn6 |
−11.2
± 0.2
|
8.1
± 0.2
|
598 |
EN300-315453_3_1
|
|
Cc1cncn1CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.1
± 0.2
|
599 |
EN300-1724086_1_1
|
|
C[C@@H]1C[C@@H](CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−11.2
± 0.3
|
8.1
± 0.2
|
600 |
EN300-60033_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COC[C@@H]5CCCO5 |
−11.2
± 0.3
|
8.1
± 0.2
|