Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
5001 |
EN300-31186_4_1
|
|
CCC(=O)NCCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.1
± 0.3
|
5.9
± 0.3
|
5002 |
RAL-THA-05e671eb-8
|
|
COc1ccc2c(c1)C(CCO2)C(=O)Nc3cncc4c3cccc4 |
−8.1
± 0.1
|
5.87
± 0.08
|
5003 |
MAK-UNK-c749d764-8
|
|
c1ccc2c(c1)cncc2NC(=O)CC3CCCC(C3O)C(F)F |
−8.1
± 0.1
|
5.9
± 0.1
|
5004 |
BEN-DND-a7517465-2
|
|
c1cc2cncc(c2c(c1)O)NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−8.1
± 0.1
|
5.87
± 0.09
|
5005 |
EN300-50657_2_1
|
|
Cc1nc(on1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.1
± 0.3
|
5.9
± 0.2
|
5006 |
EDG-MED-4c68219f-16
|
|
CNCCO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.1
± 0.4
|
5.9
± 0.3
|
5007 |
EN300-6746890_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC(C5)(CO)F |
−8.1
± 0.3
|
5.9
± 0.2
|
5008 |
EN300-70656_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCC5)O |
−8.1
± 0.3
|
5.9
± 0.2
|
5009 |
EN300-116249_2_1
|
|
C[C@@](CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C[NH+](C)C)O |
−8.1
± 0.7
|
5.9
± 0.5
|
5010 |
EDG-MED-90036822-83
|
|
CN1CCC(C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.2
|
5.9
± 0.1
|
5011 |
EN300-262204_4_1
|
|
CS(=O)(=O)CC1(COC1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.4
|
5.9
± 0.3
|
5012 |
EN300-76205_2_1
|
|
CC(C)(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C |
−8.0
± 0.4
|
5.9
± 0.3
|
5013 |
RAL-THA-2d450e86-16
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)F)F |
−8.0
± 0.3
|
5.9
± 0.2
|
5014 |
JOH-UNI-6fede743-1
|
|
c1ccc2c(c1)c(cnc2C(F)F)NC(=O)Cc3cccc(c3)Cl |
−8.0
± 0.4
|
5.9
± 0.3
|
5015 |
EN300-90142_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CCC[C@@H](C5)C(=O)N |
−8.0
± 0.4
|
5.9
± 0.3
|
5016 |
EDG-MED-90036822-3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](CN)F |
−8.0
± 0.6
|
5.9
± 0.4
|
5017 |
MAK-UNK-ffc90da7-8
|
|
CC(C)OCCCc1ccc2c(c1)cncc2NC(=O)Cc3cccc(c3)Cl |
−8.0
± 0.4
|
5.9
± 0.3
|
5018 |
DAR-DIA-0d514e7d-9
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)c5ccccc5 |
−8.0
± 0.2
|
5.9
± 0.1
|
5019 |
EN300-120068_1_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)OC |
−8.0
± 0.3
|
5.9
± 0.2
|
5020 |
LAU-MED-88a3970a-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCOc4c3cc(cc4OCCCO)Cl |
−8.0
± 0.4
|
5.9
± 0.3
|
5021 |
RAL-THA-2d450e86-31
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cccc(c3)C(F)(F)F |
−8.0
± 0.3
|
5.9
± 0.2
|
5022 |
EN300-124063_1_1
|
|
Cn1c(ncn1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.3
|
5.9
± 0.2
|
5023 |
EDG-MED-90036822-62
|
|
CN(C)CCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.0
± 0.4
|
5.9
± 0.3
|
5024 |
EDG-MED-5d232de5-6
|
|
CN1CC[C@H](c2c1ccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.0
± 0.2
|
5.8
± 0.1
|
5025 |
EN300-73582_3_1
|
|
CCS(=O)(=O)NCCOCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.0
± 0.3
|
5.8
± 0.2
|
5026 |
EN300-224665_2_1
|
|
C[C@@]1(CN(CCOC1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−8.0
± 0.5
|
5.8
± 0.3
|
5027 |
EN300-245098_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC[C@@H]5C(=O)N |
−8.0
± 0.4
|
5.8
± 0.3
|
5028 |
EN300-6487755_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5C[C@H]6C[C@@H](C5)[C@@H]([C@@H](C6)O)O |
−8.0
± 0.3
|
5.8
± 0.2
|
5029 |
DAR-DIA-0cde14eb-50
|
|
CC1(CC1)c2cccc(c2)NC(=O)Nc3cncc4c3cccc4 |
−8.0
± 0.3
|
5.8
± 0.3
|
5030 |
EN300-67533_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@H](C5CC5)O |
−8.0
± 0.3
|
5.8
± 0.2
|
5031 |
EN300-155362_2_1
|
|
C[C@@H]1CC(=O)N[C@@H]1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5032 |
JOH-UNI-ee5ed7c8-7
|
|
CN(c1cncc2c1cccc2)C(=O)C(CC#N)c3cccc(c3)Cl |
−8.0
± 0.2
|
5.8
± 0.2
|
5033 |
EN300-04073_4_1
|
|
CC(=O)NCCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.0
± 0.4
|
5.8
± 0.3
|
5034 |
RAL-THA-2d450e86-33
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3ccc(cn3)Cl |
−8.0
± 0.3
|
5.8
± 0.2
|
5035 |
EN300-359750_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CCC(=O)O5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5036 |
PET-UNK-6c2be958-1
|
|
c1ccc2c(c1)cncc2N(C(=O)Cc3cccc(c3)Cl)C(=O)CCl |
−8.0
± 0.3
|
5.8
± 0.2
|
5037 |
EN300-657222_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@@H]5C[C@@H]6COC[C@@H]6O5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5038 |
EN300-1718428_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@]6(CCC[C@]6(C5)CO)CO |
−8.0
± 0.3
|
5.8
± 0.3
|
5039 |
EN300-79538_2_1
|
|
Cc1c(non1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5040 |
FRA-DIA-b66f7109-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCNc4c3cc(cc4Cl)OC5CC(=O)N5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5041 |
EN300-250458_2_2
|
|
Cn1c(ccn1)[C@H](CO)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5042 |
EDG-MED-971238d3-6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCN |
−8.0
± 0.2
|
5.8
± 0.1
|
5043 |
EN300-7352438_4_1
|
|
COC[C@H]1C[C@@H]1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.4
|
5.8
± 0.3
|
5044 |
EN300-1588613_1_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CC[N@H+]6[C@H]5COCC6 |
−8.0
± 0.4
|
5.8
± 0.3
|
5045 |
NAU-LAT-0543f7f2-10
|
|
CC(=O)NCCOc1cc(cc2c1OCCC2C(=O)Nc3cncc4c3cccc4)Cl |
−8.0
± 0.3
|
5.8
± 0.2
|
5046 |
EN300-25572_2_1
|
|
C[C@@H]1CN(CCO1)C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.3
|
5.8
± 0.3
|
5047 |
EN300-117430_1_1
|
|
C[C@H](CNC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.0
± 0.3
|
5.8
± 0.2
|
5048 |
EN300-6763291_1_7
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@@H]6C[C@H]5[C@H]([C@H]6O)O |
−8.0
± 0.3
|
5.8
± 0.2
|
5049 |
LAU-MED-88a3970a-2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCOc4c3cc(cc4OCCO)Cl |
−8.0
± 0.3
|
5.8
± 0.2
|
5050 |
MAK-UNK-ffc90da7-2
|
|
c1ccc2c(c1)cncc2NC(=O)CC3CCCC(C3O)Cl |
−8.0
± 0.1
|
5.83
± 0.09
|
5051 |
EN300-761746_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5c(=O)[nH]c(=O)[nH]n5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5052 |
EN300-6504697_4_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC[C@H]5CC6(CC6)S(=O)(=O)N5 |
−8.0
± 0.4
|
5.8
± 0.3
|
5053 |
MAK-UNK-c749d764-11
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cccc(c3O)C(F)F |
−8.0
± 0.4
|
5.8
± 0.3
|
5054 |
EN300-55072_4_1
|
|
C[C@@H](CO)C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.0
± 0.4
|
5.8
± 0.3
|
5055 |
EN300-6482296_4_6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H]5CO[C@@H]6[C@H]5COC6 |
−8.0
± 0.5
|
5.8
± 0.4
|
5056 |
DAR-DIA-0cde14eb-51
|
|
c1ccc2c(c1)cncc2NC(=O)Nc3cccc(c3)C4(CC4)Cl |
−8.0
± 0.3
|
5.8
± 0.2
|
5057 |
EN300-171605_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCC5CS(=O)(=O)C5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5058 |
MAT-POS-f7918075-2
|
|
c1ccc2c(c1)cncc2NC(=O)C3COc4c3cc(cc4)Cl |
−7.99
± 0.09
|
5.82
± 0.06
|
5059 |
EDG-MED-4c68219f-18
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCC(CC5)C(=O)O |
−8.0
± 0.3
|
5.8
± 0.2
|
5060 |
EN300-137734_1_1
|
|
C[C@@H]1CN(CCS1(=O)=O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5061 |
ED_-GRI-5b13fbe2-43
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H](CF)N |
−8.0
± 0.5
|
5.8
± 0.4
|
5062 |
MAT-POS-8a69d52e-7
|
|
C[C@@H]1COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−7.99
± 0.09
|
5.82
± 0.07
|
5063 |
EN300-15308_1_1
|
|
CS(=O)(=O)N1CCN(CC1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.4
|
5.8
± 0.3
|
5064 |
EDJ-MED-e4b030d8-3
|
|
C[C@H]1C[C@H](c2cc(ccc2O1)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.98
± 0.07
|
5.81
± 0.05
|
5065 |
EN300-53423_4_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H]5CCOC5 |
−8.0
± 0.5
|
5.8
± 0.3
|
5066 |
EN300-1717630_1_1
|
|
C[C@@]1(CCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−8.0
± 0.3
|
5.8
± 0.2
|
5067 |
EN300-718785_4_2
|
|
CCN1[C@H](CCC1=O)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.4
|
5.8
± 0.3
|
5068 |
EN300-109535_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C[C@H]5CC(=O)OC5 |
−8.0
± 0.2
|
5.8
± 0.1
|
5069 |
EN300-256798_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5CCc6nnnn6CC5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5070 |
EDJ-MED-9e38fd34-3
|
|
C[C@@]1(c2cc(ccc2NC1=O)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.0
± 0.3
|
5.8
± 0.2
|
5071 |
EN300-217494_2_3
|
|
C[C@@]([C@H]1CCOC1)(C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.0
± 0.3
|
5.8
± 0.2
|
5072 |
MAK-UNK-c749d764-25
|
|
COC(=O)N(c1cncc2c1cccc2)C(=O)CC3CCCC(C3O)C(F)F |
−8.0
± 0.2
|
5.8
± 0.1
|
5073 |
RAL-THA-4aa06b95-6
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCN(c4c3cc(cc4)Cl)CCO |
−8.0
± 0.2
|
5.8
± 0.2
|
5074 |
IVS-FNM-f9a14d04-1
|
|
COc1c(cccc1Cl)CCCC(=O)Nc2cncc3c2cccc3 |
−8.0
± 0.4
|
5.8
± 0.3
|
5075 |
MIC-UNK-50cce87d-3
|
|
Cc1cccc2c1c(cnc2)NC(=O)Cc3cccc(c3)Cl |
−8.0
± 0.2
|
5.8
± 0.2
|
5076 |
EN300-246440_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CC5)n6cncn6 |
−8.0
± 0.3
|
5.8
± 0.2
|
5077 |
EN300-1268020_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[NH+](CC5)Cc6[nH]nnn6 |
−8.0
± 0.4
|
5.8
± 0.3
|
5078 |
ADA-UCB-dc2b944c-12
|
|
Cc1c2ccccc2c(cn1)NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−7.97
± 0.08
|
5.81
± 0.06
|
5079 |
EN300-269525_1_1
|
|
CC1NN(C(=O)N1C)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5080 |
EN300-183231_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCc5[nH]nnn5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5081 |
MAT-POS-e9e99895-7
|
|
CC(c1ccc(c(c1)Cl)Cl)(C(=O)Nc2cncc3c2cccc3)NC(=O)Cc4ccc(cc4)n5cnnn5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5082 |
EN300-1265948_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)N5CCS(=O)(=O)CC5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5083 |
EN300-6745081_3_1
|
|
C[C@@]1(CCCCNC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5084 |
EN300-182725_2_1
|
|
C[C@@H]([C@@H](C)S(=O)(=O)C)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.0
± 0.3
|
5.8
± 0.2
|
5085 |
EN300-173536_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@H]5CCS5(=O)=O |
−8.0
± 0.3
|
5.8
± 0.2
|
5086 |
EN300-120119_2_1
|
|
CN([C@@H]1CCNC1=O)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5087 |
RAL-THA-05e671eb-18
|
|
Cc1cc(cc2c1OCCC2C(=O)Nc3cncc4c3cccc4)Cl |
−8.0
± 0.1
|
5.80
± 0.08
|
5088 |
EN300-260642_2_1
|
|
Cc1c(c(=O)[nH][nH]1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5089 |
MAT-POS-43fe65f4-1
|
|
COc1cc(cc2c1OCC[C@@H]2C(=O)Nc3cncc4c3cccc4)Cl |
−8.0
± 0.2
|
5.8
± 0.2
|
5090 |
EN300-1448603_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@H]5CCS(=O)(=O)C5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5091 |
EN300-219330_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCN5CCOCC5=O |
−8.0
± 0.3
|
5.8
± 0.2
|
5092 |
EN300-36123_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6[C@H](C5)C6CO |
−8.0
± 0.3
|
5.8
± 0.2
|
5093 |
EN300-6505003_4_3
|
|
C[C@@H]1CC[C@H](C(=O)N1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.4
|
5.8
± 0.3
|
5094 |
KAD-UNI-8a629cb0-28
|
|
Cc1ccnc2n1nc(n2)C(=O)NCC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.0
± 0.3
|
5.8
± 0.2
|
5095 |
EDG-MED-4c68219f-2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)c5[nH]nnn5 |
−8.0
± 0.3
|
5.8
± 0.2
|
5096 |
EN300-6477724_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5C[C@@H]5c6[nH]ncn6 |
−8.0
± 0.4
|
5.8
± 0.3
|
5097 |
EN300-6497444_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnn6c5OC[C@H](C6)O |
−8.0
± 0.4
|
5.8
± 0.3
|
5098 |
EN300-177118_1_1
|
|
C[C@@]1(CCC(=O)N1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.0
± 0.2
|
5.8
± 0.1
|
5099 |
EN300-1387104_4_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H]5CCS5(=O)=O |
−8.0
± 0.4
|
5.8
± 0.3
|
5100 |
MIC-UNK-91acba05-5
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCNc4c3cc(cc4)Cl |
−8.0
± 0.2
|
5.8
± 0.2
|