Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
4501 |
MAK-UNK-8be7dca9-3
|
|
c1ccc2c(c1)cncc2NC(=O)C3c4cc(ccc4OCC3CN)Cl |
−8.5
± 0.1
|
6.19
± 0.09
|
4502 |
EN300-155498_2_1
|
|
CC([CH2-])[C@H](CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.5
± 0.2
|
6.2
± 0.2
|
4503 |
EN300-2923949_2_1
|
|
c1ccc(cc1)[C@@H]([C@@H](C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O)O |
−8.5
± 0.3
|
6.2
± 0.2
|
4504 |
EN300-100180_1_2
|
|
CC(=O)N1CC[C@H](C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.5
± 0.3
|
6.2
± 0.2
|
4505 |
EN300-1644723_2_8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5[C@H]6[C@H]5COCC6 |
−8.5
± 0.3
|
6.2
± 0.2
|
4506 |
EDG-MED-90036822-109
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCN5CCC(C5)F |
−8.5
± 0.2
|
6.2
± 0.1
|
4507 |
EN300-205622_2_1
|
|
CS(=O)(=O)c1nccc(n1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.5
± 0.3
|
6.2
± 0.2
|
4508 |
ALP-POS-477dc5b7-2
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCNc4c3cc(cc4)Cl |
−8.49
± 0.09
|
6.19
± 0.07
|
4509 |
EN300-31845_1_2
|
|
COCCN1C[C@H](CC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.5
± 0.4
|
6.2
± 0.3
|
4510 |
KAD-UNI-8a629cb0-27
|
|
C[C@@]1(CCN(C1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.5
± 0.3
|
6.2
± 0.2
|
4511 |
DAR-DIA-56cf811e-1
|
|
C#CC(=O)N(c1cncc2c1cccc2)C(=O)Cc3cccc(c3)Cl |
−8.5
± 0.3
|
6.2
± 0.2
|
4512 |
EN300-7445890_2_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCC6(C5)[C@@H](C[C@H]6O)O |
−8.5
± 0.4
|
6.2
± 0.3
|
4513 |
EN300-04492_2_1
|
|
COCCCNC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.5
± 0.3
|
6.2
± 0.2
|
4514 |
MAT-POS-8a69d52e-1
|
|
CC1CC(c2cc(ccc2O1)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.49
± 0.05
|
6.18
± 0.04
|
4515 |
EN300-23317_4_2
|
|
C[C@H](C(=O)NCCOC)OCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.5
± 0.4
|
6.2
± 0.3
|
4516 |
EN300-1702911_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC(C5)NC(=O)N |
−8.5
± 0.3
|
6.2
± 0.2
|
4517 |
MAT-POS-f39f51fd-1
|
|
c1ccc2c(c1)cncc2NC(=O)C3CC(=O)Nc4c3cc(cc4Cl)Cl |
−8.5
± 0.3
|
6.2
± 0.2
|
4518 |
EN300-7435544_1_2
|
|
CC(C)([C@H]1CN(CCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.5
± 0.3
|
6.2
± 0.2
|
4519 |
DAR-DIA-5ff57136-9
|
|
COC(=O)/C=C/C(=O)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−8.5
± 0.3
|
6.2
± 0.2
|
4520 |
EN300-6487407_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5[C@H](CC(=O)O5)O |
−8.5
± 0.3
|
6.2
± 0.2
|
4521 |
EN300-98648_4_1
|
|
CN1CC[C@@H](C1=O)OCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.5
± 0.4
|
6.2
± 0.3
|
4522 |
EN300-1706173_1_1
|
|
CC1(CS(=O)(=O)C1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.5
± 0.3
|
6.2
± 0.2
|
4523 |
EN300-785910_4_1
|
|
COCc1c(n[nH]n1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.5
± 0.3
|
6.2
± 0.2
|
4524 |
EN300-36690_3_1
|
|
Cn1c(=O)ccn(c1=O)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.5
± 0.3
|
6.2
± 0.2
|
4525 |
EN300-301690_2_1
|
|
CS(=O)(=O)[N@]1CC[C@@H](C1)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.5
± 0.3
|
6.2
± 0.2
|
4526 |
EN300-156212_2_1
|
|
Cn1c(nnn1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.5
± 0.3
|
6.2
± 0.2
|
4527 |
MIC-UNK-644c43c7-1
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)CCNCC(F)(F)F |
−8.5
± 0.4
|
6.2
± 0.3
|
4528 |
EN300-6472573_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(=O)NC6(C5)CC6 |
−8.5
± 0.3
|
6.2
± 0.2
|
4529 |
EN300-141809_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CC56CCS(=O)(=O)CC6 |
−8.5
± 0.3
|
6.2
± 0.2
|
4530 |
KAD-UNI-8a629cb0-39
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)COC6 |
−8.5
± 0.3
|
6.2
± 0.2
|
4531 |
EN300-43972_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5[nH]ncn5 |
−8.5
± 0.2
|
6.2
± 0.1
|
4532 |
EN300-6762563_1_1
|
|
Cn1cc(cn1)OC2CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.5
± 0.3
|
6.2
± 0.2
|
4533 |
EN300-1725538_1_1
|
|
Cn1cc(nc1)C[C@@H](C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.5
± 0.3
|
6.2
± 0.2
|
4534 |
EN300-6494859_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[C@@H](OC5)Cn6cccn6 |
−8.5
± 0.4
|
6.2
± 0.3
|
4535 |
EN300-331941_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5C[C@H]5C(=O)N |
−8.5
± 0.3
|
6.2
± 0.2
|
4536 |
EN300-99064_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CC(=O)N(C5)c6c[nH][nH][cH+]6 |
−8.5
± 0.3
|
6.2
± 0.3
|
4537 |
DAR-DIA-23e5a6a0-2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4O[C@@H]5CC6([NH2+]5)CCC6)Cl |
−8.5
± 0.4
|
6.2
± 0.3
|
4538 |
MAK-UNK-8be7dca9-7_1
|
|
c1cc2cncc(c2cc1C(=O)[O-])NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−8.5
± 0.1
|
6.17
± 0.10
|
4539 |
EN300-331704_1_1
|
|
C[C@H]1CN(CCS1(=O)=O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.5
± 0.3
|
6.2
± 0.2
|
4540 |
ALP-UNI-0676e700-9
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccn6c(c5)nnn6 |
−8.5
± 0.3
|
6.2
± 0.2
|
4541 |
DAR-DIA-6be260fc-6
|
|
c1ccc2c(c1)cncc2N3CCCC4(C3=O)CNc5c4cc(cc5)Cl |
−8.5
± 0.3
|
6.2
± 0.2
|
4542 |
BEN-DND-c852c98b-7
|
|
c1cc2cncc(c2cc1C(F)F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−8.47
± 0.06
|
6.17
± 0.04
|
4543 |
EDG-MED-90036822-14
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CCN5CCOCC5)O |
−8.5
± 0.3
|
6.2
± 0.2
|
4544 |
EDG-MED-ba1ac7b9-27
|
|
CC1CN(CCN1C(=O)CC2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CCO |
−8.5
± 0.5
|
6.2
± 0.3
|
4545 |
EN300-35428_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(=O)NC5CC5 |
−8.5
± 0.2
|
6.2
± 0.2
|
4546 |
EN300-83280_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)c5ccccn5 |
−8.5
± 0.3
|
6.2
± 0.2
|
4547 |
EN300-200699_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@@]5(CCOC5)O |
−8.5
± 0.3
|
6.2
± 0.2
|
4548 |
LAU-MED-88a3970a-15
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4CCS(=O)(=O)N)Cl |
−8.5
± 0.2
|
6.2
± 0.2
|
4549 |
MIC-UNK-cdc2493e-2
|
|
c1ccc2c(c1)cncc2NC(=O)N(CCC3CCCO3)c4cccc(c4)Cl |
−8.5
± 0.3
|
6.2
± 0.2
|
4550 |
EN300-1588753_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)(c6cn[nH]n6)O |
−8.5
± 0.4
|
6.2
± 0.3
|
4551 |
DAR-DIA-6a508060-3
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4)C#N |
−8.46
± 0.06
|
6.16
± 0.05
|
4552 |
EN300-1071940_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[C@@]5(CCCOC5)O |
−8.5
± 0.4
|
6.2
± 0.3
|
4553 |
EN300-72272_1_3
|
|
C[C@@H]([C@H](C)O)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.5
± 0.3
|
6.2
± 0.2
|
4554 |
EN300-114133_3_2
|
|
CCC(=O)N1CC[C@H](C1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.5
± 0.4
|
6.2
± 0.3
|
4555 |
EN300-2008120_2_1
|
|
C[C@H]1[C@H](CCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.5
± 0.2
|
6.2
± 0.1
|
4556 |
EN300-6494474_2_1
|
|
Cn1cnnc1CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.5
± 0.3
|
6.2
± 0.2
|
4557 |
EDG-MED-90036822-46
|
|
COCCNCC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(F)F |
−8.5
± 0.4
|
6.2
± 0.3
|
4558 |
EN300-1718424_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@]6(C5)CCC(=O)N6 |
−8.5
± 0.3
|
6.2
± 0.2
|
4559 |
EN300-172640_3_1
|
|
C[C@@H]1[C@@H](NC(=O)O1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.5
± 0.3
|
6.2
± 0.2
|
4560 |
EN300-65853_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)c5ccc(cc5)C#N |
−8.4
± 0.3
|
6.2
± 0.2
|
4561 |
EN300-1716880_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOCC5)Cc6cn[nH]n6 |
−8.4
± 0.2
|
6.2
± 0.2
|
4562 |
EN300-109535_4_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C[C@H]5CC(=O)OC5 |
−8.4
± 0.3
|
6.2
± 0.2
|
4563 |
EN300-6498888_1_1
|
|
C[C@@H](COC1CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.4
± 0.3
|
6.2
± 0.2
|
4564 |
EN300-120586_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NCC(F)F |
−8.4
± 0.3
|
6.2
± 0.2
|
4565 |
MAT-POS-f7918075-1
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4)Cl |
−8.44
± 0.04
|
6.15
± 0.03
|
4566 |
BEN-DND-c852c98b-2
|
|
c1cc2cncc(c2cc1OC(F)(F)F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−8.44
± 0.06
|
6.15
± 0.05
|
4567 |
EN300-109827_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN6[C@@H](C5)COC6=O |
−8.4
± 0.3
|
6.2
± 0.2
|
4568 |
ALP-POS-ce760d3f-1
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4O)Cl |
−8.4
± 0.1
|
6.15
± 0.10
|
4569 |
EN300-7444106_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H]5CCc6nnnn6C5 |
−8.4
± 0.2
|
6.1
± 0.2
|
4570 |
MIC-UNK-cdc2493e-6
|
|
c1ccc2c(c1)cncc2NC(=O)N(c3cccc(c3)Cl)C4Cc5ccccc5C4 |
−8.4
± 0.4
|
6.1
± 0.3
|
4571 |
EN300-1718675_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnnn5C6CC6 |
−8.4
± 0.3
|
6.1
± 0.2
|
4572 |
EN300-6733147_1_1
|
|
C[C@@H]1CCNC(=O)[C@@H]1CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.4
± 0.3
|
6.1
± 0.2
|
4573 |
EN300-7355477_1_7
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]6C[C@@H]([C@@H](C[C@H]6C5)O)O |
−8.4
± 0.3
|
6.1
± 0.2
|
4574 |
EN300-122847_2_1
|
|
Cn1ccc(n1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.4
± 0.2
|
6.1
± 0.2
|
4575 |
VLA-UCB-1dbca3b4-15
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4)Cl |
−8.44
± 0.03
|
6.15
± 0.03
|
4576 |
EN300-24014_1_1
|
|
CS(=O)(=O)[N@]1CCCC[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.4
± 0.2
|
6.1
± 0.2
|
4577 |
EN300-6501360_3_1
|
|
CN(C)C(=O)NC[C@@H](COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.4
± 0.4
|
6.1
± 0.3
|
4578 |
EN300-203293_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5CNC(=O)O5 |
−8.4
± 0.3
|
6.1
± 0.2
|
4579 |
EN300-386200_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC[C@H]([C@H](CC5)O)O |
−8.4
± 0.3
|
6.1
± 0.2
|
4580 |
EN300-00271_1_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−8.4
± 0.2
|
6.1
± 0.2
|
4581 |
EN300-306495_3_1
|
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)[NH+](C)C |
−8.4
± 0.4
|
6.1
± 0.3
|
4582 |
EN300-7547467_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CCN(C5=O)c6ccn[nH]6 |
−8.4
± 0.3
|
6.1
± 0.2
|
4583 |
EN300-109920_1_4
|
|
C[C@H]1CO[C@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−8.4
± 0.4
|
6.1
± 0.3
|
4584 |
EN300-1968342_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@H](CF)O |
−8.4
± 0.3
|
6.1
± 0.2
|
4585 |
ALP-UNI-dbbfd3db-2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c(=O)c(=O)n6c(n5)CCC6 |
−8.4
± 0.3
|
6.1
± 0.3
|
4586 |
MAT-POS-9db1e783-2
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)CO |
−8.4
± 0.1
|
6.14
± 0.09
|
4587 |
DAR-DIA-0d514e7d-13
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)c5ccc(cc5)F |
−8.4
± 0.2
|
6.1
± 0.1
|
4588 |
EN300-128277_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(=O)NCC(F)F |
−8.4
± 0.3
|
6.1
± 0.2
|
4589 |
EN300-682529_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@@]5(CCOC5)CO |
−8.4
± 0.3
|
6.1
± 0.2
|
4590 |
MIC-UNK-08fa0751-2
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)C(CO)(F)F |
−8.4
± 0.4
|
6.1
± 0.3
|
4591 |
EN300-211482_4_2
|
|
C[C@H](C(=O)NC)OCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.4
± 0.2
|
6.1
± 0.2
|
4592 |
EN300-07268_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6c(c5)[nH]c(=O)c(=O)[nH]6 |
−8.4
± 0.3
|
6.1
± 0.2
|
4593 |
EN300-48886_2_2
|
|
CC(=O)N[C@H]1CCCN(C1)C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.4
± 0.3
|
6.1
± 0.2
|
4594 |
EN300-92684_1_1
|
|
Cc1c(cn(n1)C)C2C[C@H](ON2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.4
± 0.3
|
6.1
± 0.2
|
4595 |
MAK-UNK-8be7dca9-7
|
|
c1cc2cncc(c2cc1C(=O)O)NC(=O)C3CCOc4c3cc(cc4)Cl |
−8.42
± 0.08
|
6.14
± 0.06
|
4596 |
EN300-153668_1_1
|
|
C[C@@H]1CNC(=O)CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.4
± 0.4
|
6.1
± 0.3
|
4597 |
EDG-MED-ba1ac7b9-25
|
|
CC1CN(CCN1CCO)C(=O)CC2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.4
± 0.5
|
6.1
± 0.3
|
4598 |
EN300-71558_4_1
|
|
COC(=O)NCCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.4
± 0.3
|
6.1
± 0.2
|
4599 |
MIC-UNK-5a93dd5f-10
|
|
CC(=O)N1CCN(CC1)C(c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.4
± 0.6
|
6.1
± 0.4
|
4600 |
EN300-1600786_2_1
|
|
Cn1cc(nn1)CCOC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.4
± 0.2
|
6.1
± 0.1
|