Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
4301 |
MAT-POS-c74bc7b3-1
|
|
C[C@]1(CCNc2c1cc(c(c2)Cl)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.6
± 0.3
|
6.3
± 0.2
|
4302 |
EN300-304135_2_2
|
|
CC[C@]1(CCNC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.6
± 0.4
|
6.3
± 0.3
|
4303 |
EN300-226314_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)[C@@H]5CCS(=O)(=O)C5 |
−8.6
± 0.3
|
6.3
± 0.2
|
4304 |
DAR-DIA-0d514e7d-3
|
|
CC1(COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)C |
−8.6
± 0.2
|
6.3
± 0.2
|
4305 |
ADA-UCB-dc2b944c-2
|
|
COc1ccc(cc1N(CCC2CCCCC2)C(=O)Nc3cncc4c3cccc4)Cl |
−8.6
± 0.5
|
6.3
± 0.3
|
4306 |
EN300-139130_1_1
|
|
C[C@@H](C[C@@H]1COCCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.6
± 0.4
|
6.3
± 0.3
|
4307 |
ED_-GRI-5b13fbe2-10
|
|
CC(CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(c5[nH]nnn5)N |
−8.6
± 0.2
|
6.3
± 0.2
|
4308 |
EN300-221122_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@](C5)(c6cn[nH]n6)O |
−8.6
± 0.4
|
6.3
± 0.3
|
4309 |
DAR-DIA-0cde14eb-48
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cccc(c3)C4(CC4)F |
−8.6
± 0.3
|
6.3
± 0.2
|
4310 |
MAT-POS-fce787c2-3
|
|
CC(c1ccc(c(c1)Cl)Cl)C(=O)Nc2cncc3c2cccc3 |
−8.6
± 0.3
|
6.3
± 0.2
|
4311 |
RAL-THA-05e671eb-7
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4)C#N |
−8.64
± 0.09
|
6.29
± 0.07
|
4312 |
EN300-118647_1_1
|
|
CN(C)C(=O)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.6
± 0.2
|
6.3
± 0.2
|
4313 |
EN300-7499295_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H](CCCO)CO |
−8.6
± 0.3
|
6.3
± 0.2
|
4314 |
EN300-141645_1_1
|
|
CN(CCCO)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.6
± 0.3
|
6.3
± 0.2
|
4315 |
EN300-6744028_2_6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5C[C@H]6C[C@@H]5[C@@H]([C@H]6O)O |
−8.6
± 0.3
|
6.3
± 0.2
|
4316 |
ALP-POS-696356e4-1
|
|
c1cc2cncc(c2cc1F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−8.63
± 0.04
|
6.29
± 0.03
|
4317 |
EDJ-MED-50011917-2
|
|
Cc1c(cc(cc1OC2CC(=O)N2)Cl)CC(=O)Nc3cncc4c3cccc4 |
−8.6
± 0.3
|
6.3
± 0.2
|
4318 |
EN300-138676_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N(CC(=O)N)CC(F)(F)F |
−8.6
± 0.2
|
6.3
± 0.2
|
4319 |
EDG-MED-90036822-70
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC[C@@](C5)(CN)F |
−8.6
± 0.4
|
6.3
± 0.3
|
4320 |
EN300-50639_1_2
|
|
C[C@H](C(=O)N(C)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cccn5 |
−8.6
± 0.4
|
6.3
± 0.3
|
4321 |
EN300-222969_2_1
|
|
CN1C[C@@H](OC1=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.6
± 0.3
|
6.3
± 0.2
|
4322 |
EN300-82539_1_2
|
|
CCOC(=O)C[C@H](CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.6
± 0.4
|
6.3
± 0.3
|
4323 |
EN300-6494158_2_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@H]5C[C@H](CO5)CO |
−8.6
± 0.3
|
6.3
± 0.2
|
4324 |
EN300-39458_2_1
|
|
Cc1c(c(n(n1)CCO)C)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.6
± 0.3
|
6.3
± 0.2
|
4325 |
ALP-UNI-0676e700-11
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(cc5)CC(=O)N |
−8.6
± 0.3
|
6.3
± 0.2
|
4326 |
DAR-DIA-0d514e7d-20
|
|
C[C@H]1COc2c(cc(cc2N3CCOCC3)Cl)[C@@H]1C(=O)Nc4cncc5c4cccc5 |
−8.6
± 0.2
|
6.3
± 0.1
|
4327 |
RAL-THA-4aa06b95-1
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCN(c4c3cc(cc4)Cl)C(=O)N |
−8.6
± 0.3
|
6.3
± 0.2
|
4328 |
EN300-343562_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC[C@H]([C@H]5CO)CO |
−8.6
± 0.4
|
6.3
± 0.3
|
4329 |
EN300-211482_1_2
|
|
C[C@H](C(=O)NC)O[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.6
± 0.2
|
6.3
± 0.2
|
4330 |
EN300-7501753_2_1
|
|
C[C@@H](Cn1cnnc1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.6
± 0.3
|
6.3
± 0.2
|
4331 |
EN300-191904_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCn5cnnn5 |
−8.6
± 0.4
|
6.3
± 0.3
|
4332 |
EDJ-MED-ee07cf00-16
|
|
c1ccc2c(c1)cncc2NC(=O)C(c3cccc(c3)Cl)NC(=O)Cn4cc(c(=O)[nH]c4=O)Cl |
−8.6
± 0.5
|
6.3
± 0.3
|
4333 |
EN300-77343_2_1
|
|
Cc1nnnn1CCNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.6
± 0.3
|
6.3
± 0.2
|
4334 |
JOH-UNI-3fc3434e-7
|
|
CN(c1cncc2c1cccc2)C(=O)C(CC#N)c3cccc(c3)Cl |
−8.6
± 0.2
|
6.3
± 0.2
|
4335 |
EDG-MED-ba1ac7b9-29
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)CC(=O)N(Cc5ccc(cn5)O)C6CC6 |
−8.6
± 0.3
|
6.3
± 0.2
|
4336 |
EN300-6472952_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6(CC5)NC(=O)CO6 |
−8.6
± 0.4
|
6.3
± 0.3
|
4337 |
EN300-204936_2_1
|
|
Cn1c(cnn1)C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.6
± 0.3
|
6.3
± 0.2
|
4338 |
EN300-1253122_2_1
|
|
CCN(C)C(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.6
± 0.2
|
6.3
± 0.1
|
4339 |
EN300-75819_1_1
|
|
CCN(CC)S(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.6
± 0.4
|
6.3
± 0.3
|
4340 |
EN300-1726150_2_1
|
|
Cn1cc(cn1)n2cc(nc2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.6
± 0.4
|
6.3
± 0.3
|
4341 |
RAL-THA-2d450e86-15
|
|
Cc1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2cccc3 |
−8.6
± 0.3
|
6.3
± 0.2
|
4342 |
EN300-384241_1_1
|
|
Cc1[nH]nc(n1)C2CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.6
± 0.5
|
6.3
± 0.4
|
4343 |
DAR-DIA-6a508060-4
|
|
COc1cc(cc2c1OCCC2C(=O)Nc3cncc4c3cccc4)Cl |
−8.6
± 0.1
|
6.28
± 0.08
|
4344 |
MIC-UNK-cdc2493e-1
|
|
c1ccc2c(c1)cncc2NC(=O)N(CCC3CCCC3)c4cccc(c4)Cl |
−8.6
± 0.3
|
6.3
± 0.2
|
4345 |
EN300-7471076_1_1
|
|
C[C@@H]1[C@@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.6
± 0.3
|
6.3
± 0.2
|
4346 |
ED_-GRI-5b13fbe2-51
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5(COC5)COC6CNC6 |
−8.6
± 0.3
|
6.3
± 0.2
|
4347 |
EN300-238405_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@H]5CC(=O)NC5 |
−8.6
± 0.2
|
6.3
± 0.2
|
4348 |
EDJ-MED-a6bd50ad-1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CC(=O)Nc4c3cc(cc4)Cl |
−8.6
± 0.3
|
6.3
± 0.2
|
4349 |
ALP-POS-3b848b35-2
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)OC4CC(=O)N4 |
−8.61
± 0.08
|
6.28
± 0.06
|
4350 |
EDG-MED-ba1ac7b9-26
|
|
C[C@@H]1CN([C@H](CN1C(=O)CC2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C)CCO |
−8.6
± 0.4
|
6.3
± 0.3
|
4351 |
EN300-1721331_1_1
|
|
CO[C@@]1(CCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−8.6
± 0.4
|
6.3
± 0.3
|
4352 |
EN300-343103_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5[nH]c(=O)c6c(n5)CCOC6 |
−8.6
± 0.3
|
6.3
± 0.2
|
4353 |
BEN-BAS-5c03e89e-1
|
|
CC(C)(C1COc2ccc(cc2C1C(=O)Nc3cncc4c3cccc4)Cl)O |
−8.61
± 0.10
|
6.27
± 0.07
|
4354 |
EN300-62166_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCC[C@@H]5CNC(=O)N |
−8.6
± 0.3
|
6.3
± 0.2
|
4355 |
ED_-GRI-5b13fbe2-28
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCn5c(c(nn5)CN)C(F)F |
−8.6
± 0.3
|
6.3
± 0.2
|
4356 |
EN300-18928_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CSCN5C(=O)C6CC6 |
−8.6
± 0.5
|
6.3
± 0.4
|
4357 |
DAR-DIA-0cde14eb-60
|
|
CC(c1cccc(c1)C2(CC2)C#N)C(=O)Nc3cncc4c3cccc4 |
−8.6
± 0.3
|
6.3
± 0.2
|
4358 |
EN300-6482296_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CO[C@@H]6[C@@H]5COC6 |
−8.6
± 0.3
|
6.3
± 0.2
|
4359 |
EN300-12204_3_1
|
|
CCCNC(=O)CN(C)C(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.6
± 0.4
|
6.3
± 0.3
|
4360 |
MIC-UNK-bcd487e9-5
|
|
c1ccc2c(c1)cncc2NC(=O)N(Cc3ccco3)c4cccc(c4)Cl |
−8.6
± 0.3
|
6.3
± 0.2
|
4361 |
EN300-633533_4_1
|
|
CS(=O)(=O)[C@@H]1C[C@]1(COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C#N |
−8.6
± 0.4
|
6.3
± 0.3
|
4362 |
EN300-210084_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5CCCC(=O)N5 |
−8.6
± 0.3
|
6.3
± 0.2
|
4363 |
EN300-82539_1_1
|
|
CCOC(=O)C[C@@H](CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.6
± 0.3
|
6.3
± 0.2
|
4364 |
EN300-117059_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CC5)CO |
−8.6
± 0.2
|
6.3
± 0.2
|
4365 |
EN300-48886_1_1
|
|
CC(=O)N[C@@H]1CCCN(C1)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.6
± 0.3
|
6.3
± 0.2
|
4366 |
EN300-344753_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)C(=O)NCCO |
−8.6
± 0.3
|
6.3
± 0.2
|
4367 |
MIC-UNK-5a93dd5f-2
|
|
c1ccc2c(c1)cncc2NC(=O)C(c3cccc(c3)Cl)N4CC5CCCCC5C4 |
−8.6
± 0.2
|
6.3
± 0.2
|
4368 |
EN300-1988306_2_1
|
|
CS(=O)(=O)CCC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.6
± 0.5
|
6.3
± 0.3
|
4369 |
EN300-25446_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cnco5 |
−8.6
± 0.3
|
6.3
± 0.2
|
4370 |
EN300-65414_1_1
|
|
CC(=O)NC(C)(C)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.6
± 0.3
|
6.3
± 0.2
|
4371 |
RAL-THA-05e671eb-10
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(c(c4)F)Cl |
−8.60
± 0.05
|
6.26
± 0.04
|
4372 |
EN300-36851_1_4
|
|
C[C@H]1C[C@H]1C(=O)NCCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.6
± 0.3
|
6.3
± 0.2
|
4373 |
EDJ-MED-ee07cf00-12
|
|
c1ccc2c(c1)cncc2NC(=O)C(c3cccc(c3)Cl)NC(=O)COc4ccc(cc4)C(=O)N |
−8.6
± 0.5
|
6.3
± 0.4
|
4374 |
ALF-EVA-5b152d2f-6
|
|
C[C@H]1CCOc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−8.6
± 0.2
|
6.3
± 0.2
|
4375 |
BEN-DND-a7517465-1
|
|
Cc1cccc2c1c(cnc2)NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−8.60
± 0.06
|
6.26
± 0.05
|
4376 |
DAR-DIA-0d514e7d-15_1
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)c5cc(ccc5F)F |
−8.6
± 0.2
|
6.3
± 0.2
|
4377 |
BEN-DND-f2e727cd-2
|
|
c1ccc2c(c1)cncc2NC(=O)N3CCNc4c3cc(cc4)Cl |
−8.6
± 0.3
|
6.3
± 0.2
|
4378 |
EN300-314838_1_1
|
|
CCn1c(cnn1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.6
± 0.3
|
6.3
± 0.2
|
4379 |
EN300-40153_1_1
|
|
CN(CC(=O)N)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.6
± 0.2
|
6.3
± 0.2
|
4380 |
EN300-97300_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5C[C@@H]5F |
−8.6
± 0.2
|
6.3
± 0.2
|
4381 |
EN300-83434_1_2
|
|
C[C@H]([C@@H](C)S(=O)(=O)C)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.6
± 0.3
|
6.3
± 0.2
|
4382 |
EN300-92031_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5nc(no5)c6[nH]ncn6 |
−8.6
± 0.4
|
6.3
± 0.3
|
4383 |
EN300-1692359_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@]5(CC[C@@H]5CO)CO |
−8.6
± 0.3
|
6.3
± 0.2
|
4384 |
EN300-121078_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CC5)CCO |
−8.6
± 0.3
|
6.3
± 0.2
|
4385 |
EN300-187385_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCc5ccc(=O)[nH]c5 |
−8.6
± 0.3
|
6.3
± 0.2
|
4386 |
EN300-1215712_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(COC5)O |
−8.6
± 0.3
|
6.3
± 0.2
|
4387 |
EN300-183231_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCc5[nH]nnn5 |
−8.6
± 0.3
|
6.3
± 0.2
|
4388 |
EN300-1700710_4_1
|
|
Cn1ccnc1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.6
± 0.4
|
6.3
± 0.3
|
4389 |
EN300-99161_1_2
|
|
C[C@]1(CCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.6
± 0.3
|
6.3
± 0.2
|
4390 |
EN300-98038_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5NC(=O)NN5 |
−8.6
± 0.2
|
6.3
± 0.2
|
4391 |
EDG-MED-90036822-89
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CCC6(CNC6)CO5 |
−8.6
± 0.2
|
6.3
± 0.2
|
4392 |
EN300-169955_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5[C@H](CC(=O)N5)C(F)(F)F |
−8.6
± 0.3
|
6.3
± 0.2
|
4393 |
EN300-226776_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)(CO)O |
−8.6
± 0.4
|
6.3
± 0.3
|
4394 |
EN300-248526_2_1
|
|
c1ccc(cc1)[C@@](COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(C(=O)N)O |
−8.6
± 0.4
|
6.3
± 0.3
|
4395 |
EN300-222145_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CNC(=O)N5 |
−8.6
± 0.3
|
6.3
± 0.2
|
4396 |
EN300-66461_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CNC(=O)N5 |
−8.6
± 0.2
|
6.3
± 0.2
|
4397 |
EN300-1667046_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(c6ccn[nH]6)O |
−8.6
± 0.3
|
6.3
± 0.2
|
4398 |
EN300-93174_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(c5c[nH]c(=O)[nH]c5=O)(F)F |
−8.6
± 0.3
|
6.3
± 0.2
|
4399 |
EN300-3143295_1_1
|
|
Cn1cnnc1[C@@H]2CC[C@@H]2C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.6
± 0.2
|
6.3
± 0.2
|
4400 |
EN300-08705_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCNC(=O)C5 |
−8.6
± 0.3
|
6.3
± 0.2
|