Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
4201 |
EN300-103187_3_1
|
|
CCOCCNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.7
± 0.3
|
6.3
± 0.2
|
4202 |
EN300-1277662_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@@H]5C[C@H]5CO |
−8.7
± 0.2
|
6.3
± 0.2
|
4203 |
EN300-172481_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@](C5)(C(=O)N)O |
−8.7
± 0.4
|
6.3
± 0.3
|
4204 |
EN300-246808_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@@H]5CCCS5(=O)=O |
−8.7
± 0.3
|
6.3
± 0.2
|
4205 |
EN300-12929_3_1
|
|
Cc1cc(no1)OCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4206 |
EN300-89418_2_2
|
|
C[C@](CO)(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.7
± 0.4
|
6.3
± 0.3
|
4207 |
EN300-1657635_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5COC[C@@H]5F |
−8.7
± 0.2
|
6.3
± 0.2
|
4208 |
EN300-6738732_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@]56COC[C@H]5C6(F)F |
−8.7
± 0.3
|
6.3
± 0.2
|
4209 |
EN300-6759972_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H](CC5)NC(=O)N |
−8.7
± 0.3
|
6.3
± 0.2
|
4210 |
EN300-76205_4_1
|
|
CC(C)(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C |
−8.7
± 0.3
|
6.3
± 0.2
|
4211 |
ALP-POS-ce760d3f-7
|
|
c1cc2cncc(c2cc1F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−8.69
± 0.04
|
6.33
± 0.03
|
4212 |
EN300-221518_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCCO |
−8.7
± 0.2
|
6.3
± 0.1
|
4213 |
EN300-23317_1_1
|
|
C[C@@H](C(=O)NCCOC)O[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.7
± 0.3
|
6.3
± 0.2
|
4214 |
JOH-SUS-a69c159d-5
|
|
c1cc2c(cc1F)c(cnc2F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−8.69
± 0.05
|
6.33
± 0.04
|
4215 |
EN300-19515_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCC(=O)N5 |
−8.7
± 0.2
|
6.3
± 0.2
|
4216 |
EN300-135530_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccnc5C(=O)N |
−8.7
± 0.2
|
6.3
± 0.2
|
4217 |
EN300-14752_3_1
|
|
CC(=O)N1CCC[C@@H](C1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4218 |
ED_-GRI-5b13fbe2-73
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5(CC5)c6[nH]nnn6 |
−8.7
± 0.3
|
6.3
± 0.2
|
4219 |
EN300-249086_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CC[C@@H](C5)C(=O)N |
−8.7
± 0.3
|
6.3
± 0.2
|
4220 |
EN300-1717596_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC(C5)n6cnnc6 |
−8.7
± 0.3
|
6.3
± 0.2
|
4221 |
EN300-6486576_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5nnc(o5)N6CCOCC6 |
−8.7
± 0.2
|
6.3
± 0.2
|
4222 |
EN300-304187_1_1
|
|
C[C@@]1(C[C@@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC)CO |
−8.7
± 0.4
|
6.3
± 0.3
|
4223 |
DAR-DIA-23e5a6a0-6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4CC5CCC6(N5)CCC6)Cl |
−8.7
± 0.3
|
6.3
± 0.2
|
4224 |
EN300-253187_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@@H]5COCO5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4225 |
EN300-2723070_2_4
|
|
C[NH+](C)[C@H]1COC[C@H]1OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4226 |
LEE-CAM-7ab9b158-1
|
|
CN(C)C1COCC1OCC2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.2
|
6.3
± 0.1
|
4227 |
EN300-100768_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN6[C@@H](C5)CNC(=O)C6=O |
−8.7
± 0.3
|
6.3
± 0.2
|
4228 |
EN300-187060_2_1
|
|
Cn1nc(nn1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.2
|
6.3
± 0.2
|
4229 |
EN300-22245_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5ccon5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4230 |
EN300-6732376_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCC[C@@H]5CO |
−8.7
± 0.3
|
6.3
± 0.2
|
4231 |
EN300-244947_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCc5cn[nH]n5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4232 |
EN300-7430501_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCn6c(cnn6)C5 |
−8.7
± 0.2
|
6.3
± 0.1
|
4233 |
RAL-THA-8416115c-14
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCN(c4c3cc(cc4)Cl)Cc5cnn[nH]5 |
−8.7
± 0.2
|
6.3
± 0.2
|
4234 |
EN300-185729_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CCc6c(n[nH]n6)C5 |
−8.7
± 0.4
|
6.3
± 0.3
|
4235 |
MAK-UNK-c749d764-32
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cccc(c3CO)Cl |
−8.7
± 0.3
|
6.3
± 0.2
|
4236 |
EN300-199290_1_1
|
|
Cn1c(cnn1)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4237 |
EN300-79538_1_1
|
|
Cc1c(non1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4238 |
EN300-33398_1_1
|
|
CC(C)N1C[C@@H](CC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4239 |
EN300-76841_3_1
|
|
C[C@@](COC)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.7
± 0.3
|
6.3
± 0.2
|
4240 |
EN300-761746_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5c(=O)[nH]c(=O)[nH]n5 |
−8.7
± 0.2
|
6.3
± 0.2
|
4241 |
EN300-202922_1_2
|
|
C[C@H]([C@@](C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−8.7
± 0.3
|
6.3
± 0.2
|
4242 |
RAL-THA-1d44ff04-6
|
|
COC(=O)NCc1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2cccc3 |
−8.7
± 0.4
|
6.3
± 0.3
|
4243 |
KAD-UNI-8a629cb0-40
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(c(=O)[nH]c5=O)Cl |
−8.7
± 0.3
|
6.3
± 0.2
|
4244 |
EN300-30768_1_4
|
|
C[C@H]1C[C@H]1C(=O)NCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4245 |
EN300-153257_2_1
|
|
CC(C)[C@@H](CO)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.7
± 0.3
|
6.3
± 0.2
|
4246 |
EN300-365791_1_1
|
|
C[C@H](C1CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.7
± 0.3
|
6.3
± 0.2
|
4247 |
EN300-134204_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCc5[nH]nnn5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4248 |
EDJ-MED-9e38fd34-6
|
|
C[C@@]1(c2cc(c(cc2NC1=O)Cl)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.7
± 0.3
|
6.3
± 0.2
|
4249 |
EN300-259847_1_2
|
|
CO[C@H]1CCCCN(C1=O)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4250 |
EN300-1911992_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@@H]([C@@H]5CCOC5)O |
−8.7
± 0.3
|
6.3
± 0.3
|
4251 |
EN300-2803713_1_1
|
|
CC(C)[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)[N@H+]5[NH2+]S5(=O)=O |
−8.7
± 0.4
|
6.3
± 0.3
|
4252 |
EN300-199481_2_1
|
|
CC1(CNC(=O)CN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−8.7
± 0.3
|
6.3
± 0.2
|
4253 |
DAR-DIA-56cf811e-5
|
|
c1ccc2c(c1)cncc2N(C(=O)Cc3cccc(c3)Cl)C(=O)/C=C/C(F)(F)F |
−8.7
± 0.4
|
6.3
± 0.3
|
4254 |
EN300-223491_3_1
|
|
Cn1cnn(c1=O)CCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4255 |
EN300-305294_1_8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]6C[C@H]([C@H]6C5)O |
−8.7
± 0.3
|
6.3
± 0.2
|
4256 |
EN300-198633_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5CCCCNC5=O |
−8.7
± 0.3
|
6.3
± 0.2
|
4257 |
EN300-1726150_1_1
|
|
Cn1cc(cn1)n2cc(nc2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.7
± 0.2
|
6.3
± 0.2
|
4258 |
MAK-UNK-ffc90da7-3
|
|
CC(C)OCC(c1ccc2c(c1)cncc2NC(=O)Cc3cccc(c3)Cl)NC |
−8.7
± 0.3
|
6.3
± 0.2
|
4259 |
EN300-6498351_2_1
|
|
Cc1c(n(cn1)C)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4260 |
EN300-246333_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@@H]6[C@H](C5)C(=O)NC6=O |
−8.7
± 0.3
|
6.3
± 0.2
|
4261 |
JOH-UNI-ee5ed7c8-6
|
|
c1ccc2c(c1)cncc2NC(=O)C(CC#N)c3cccc(c3)Cl |
−8.7
± 0.3
|
6.3
± 0.2
|
4262 |
EN300-81629_2_1
|
|
Cc1nncn1CCNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.2
|
6.3
± 0.2
|
4263 |
EN300-31186_1_1
|
|
CCC(=O)NCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.7
± 0.3
|
6.3
± 0.2
|
4264 |
MIC-UNK-644c43c7-3
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)CNCC(F)(F)F |
−8.7
± 0.4
|
6.3
± 0.3
|
4265 |
EDG-MED-90036822-86
|
|
CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.7
± 0.2
|
6.3
± 0.1
|
4266 |
EN300-60831_1_1
|
|
CS(=O)(=O)C1(CCCC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.4
|
6.3
± 0.3
|
4267 |
EN300-1609922_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@](C5)(c6ccn[nH]6)O |
−8.7
± 0.4
|
6.3
± 0.3
|
4268 |
EN300-3451857_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[C@@H]5CCC(=O)NC5=O |
−8.7
± 0.3
|
6.3
± 0.3
|
4269 |
JOH-SUS-a69c159d-2
|
|
c1ccc2c(c1)c(cnc2F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−8.66
± 0.05
|
6.31
± 0.04
|
4270 |
EN300-79180_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H](C5CCOCC5)O |
−8.7
± 0.4
|
6.3
± 0.3
|
4271 |
EN300-309457_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5C[NH+](C5)[C@H]6CCOC6 |
−8.7
± 0.4
|
6.3
± 0.3
|
4272 |
EN300-22880_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCC[C@H](C5)C(=O)N |
−8.7
± 0.4
|
6.3
± 0.3
|
4273 |
ALP-UNI-dbbfd3db-12
|
|
Cc1c(c(=O)ccn1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.7
± 0.3
|
6.3
± 0.2
|
4274 |
EN300-366299_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CC(C5)O |
−8.7
± 0.3
|
6.3
± 0.2
|
4275 |
EDG-MED-5d232de5-3
|
|
CC(=O)N1CC[C@H](c2c1ccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.7
± 0.2
|
6.3
± 0.2
|
4276 |
EN300-7456499_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCS(=O)(=O)CCCO |
−8.7
± 0.5
|
6.3
± 0.4
|
4277 |
EN300-137734_1_2
|
|
C[C@H]1CN(CCS1(=O)=O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4278 |
EN300-304187_1_4
|
|
C[C@]1(C[C@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC)CO |
−8.7
± 0.4
|
6.3
± 0.3
|
4279 |
DAR-DIA-23e5a6a0-5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OC5CC6(N5)CC6)Cl |
−8.7
± 0.2
|
6.3
± 0.1
|
4280 |
JOH-UNI-3fc3434e-9
|
|
CN(c1c2ccccc2cnc1C#N)C(=O)Cc3cccc(c3)Cl |
−8.7
± 0.4
|
6.3
± 0.3
|
4281 |
EN300-70487_1_1
|
|
Cc1[nH]nc(n1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4282 |
EN300-244909_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOCC5)CO |
−8.7
± 0.3
|
6.3
± 0.2
|
4283 |
EDG-MED-4c68219f-7
|
|
CN(C)CCNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.7
± 0.3
|
6.3
± 0.2
|
4284 |
EN300-246178_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn(c5)C[C@H](CO)O |
−8.7
± 0.3
|
6.3
± 0.2
|
4285 |
EN300-226889_1_1
|
|
Cn1cc([nH]c1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.2
|
6.3
± 0.2
|
4286 |
EN300-97300_2_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5C[C@H]5F |
−8.7
± 0.2
|
6.3
± 0.1
|
4287 |
EN300-36851_1_1
|
|
C[C@@H]1C[C@@H]1C(=O)NCCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4288 |
ALP-UNI-3735e77e-4
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCNc4c3cc(c(c4)Cl)Cl |
−8.7
± 0.3
|
6.3
± 0.2
|
4289 |
EN300-316193_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]6COC(=O)[C@H]6C5 |
−8.7
± 0.2
|
6.3
± 0.2
|
4290 |
EN300-247497_1_1
|
|
CO[C@H]1C[C@H](N(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−8.7
± 0.3
|
6.3
± 0.2
|
4291 |
EN300-264301_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC[C@@H]5CCC(=O)N5 |
−8.7
± 0.3
|
6.3
± 0.2
|
4292 |
EN300-1589101_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cc5c[nH]nc5 |
−8.6
± 0.2
|
6.3
± 0.1
|
4293 |
EN300-78753_1_1
|
|
CC1(COC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.6
± 0.2
|
6.3
± 0.2
|
4294 |
EN300-04491_1_1
|
|
COCCN(CCOC)C(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.6
± 0.4
|
6.3
± 0.3
|
4295 |
EN300-254883_4_1
|
|
Cc1c(non1)CC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.6
± 0.3
|
6.3
± 0.2
|
4296 |
EN300-2977549_4_1
|
|
CNC(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.6
± 0.2
|
6.3
± 0.1
|
4297 |
EN300-7355737_4_1
|
|
CN1C=C(C(N1)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)N |
−8.6
± 0.4
|
6.3
± 0.3
|
4298 |
EN300-306774_1_2
|
|
C[C@]1(C(=O)NC(=O)N1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.6
± 0.2
|
6.3
± 0.2
|
4299 |
EDG-MED-90036822-90
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(c5ccccc5F)N |
−8.6
± 0.3
|
6.3
± 0.2
|
4300 |
EN300-67023_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CS(=O)(=O)C[C@@H]5CCCO5 |
−8.6
± 0.4
|
6.3
± 0.3
|