Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
4001 |
EN300-17381_2_2
|
|
C[C@H](C(=O)N)OC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.1
|
6.43
± 0.09
|
4002 |
EN300-33398_3_2
|
|
CC(C)N1C[C@H](CC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.3
|
4003 |
DAR-DIA-6be260fc-5
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CCNc5c4cc(cc5)Cl |
−8.8
± 0.3
|
6.4
± 0.2
|
4004 |
EN300-185378_4_1
|
|
C[C@@H](COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.8
± 0.3
|
6.4
± 0.2
|
4005 |
EN300-6487134_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC56CC(C5)C(=O)NC6 |
−8.8
± 0.4
|
6.4
± 0.3
|
4006 |
EN300-7445890_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC6(C5)[C@@H](C[C@H]6O)O |
−8.8
± 0.5
|
6.4
± 0.4
|
4007 |
EN300-6499531_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CCCCCS5(=O)=O |
−8.8
± 0.2
|
6.4
± 0.2
|
4008 |
EN300-153257_3_1
|
|
CC(C)[C@@H](CO)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.4
|
6.4
± 0.3
|
4009 |
BEN-DND-c852c98b-6
|
|
c1cc2cncc(c2cc1OC(F)F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−8.82
± 0.07
|
6.43
± 0.05
|
4010 |
EN300-19515_4_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H]5CCC(=O)N5 |
−8.8
± 0.3
|
6.4
± 0.3
|
4011 |
EN300-73772_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5NC(=O)NN5 |
−8.8
± 0.3
|
6.4
± 0.2
|
4012 |
EN300-65063_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCN(CC5)C(=O)N |
−8.8
± 0.3
|
6.4
± 0.2
|
4013 |
EN300-24297_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5csnn5 |
−8.8
± 0.2
|
6.4
± 0.2
|
4014 |
DAR-DIA-0d514e7d-15
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)c5cc(ccc5F)F |
−8.8
± 0.2
|
6.4
± 0.1
|
4015 |
BEN-DND-c852c98b-5
|
|
CS(=O)(=O)c1ccc2cncc(c2c1)NC(=O)C3CCOc4c3cc(cc4)Cl |
−8.82
± 0.08
|
6.42
± 0.06
|
4016 |
EN300-237298_1_1
|
|
CS(=O)(=O)N1CC(C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
4017 |
EN300-129424_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CC[C@H]5O |
−8.8
± 0.3
|
6.4
± 0.2
|
4018 |
ALP-UNI-3735e77e-2
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4Cl)Cl |
−8.82
± 0.08
|
6.42
± 0.06
|
4019 |
EN300-7459768_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC(C5)(C6(CCC6)O)O |
−8.8
± 0.3
|
6.4
± 0.2
|
4020 |
EN300-300020_1_1
|
|
C[N@@H+]1CCS(=O)(=O)C[C@@H]1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.4
|
6.4
± 0.3
|
4021 |
EN300-1699797_1_1
|
|
Cc1[nH]nc(n1)[C@@H](CO)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
4022 |
EN300-55109_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H]5CO |
−8.8
± 0.3
|
6.4
± 0.2
|
4023 |
EDJ-MED-d203f206-42
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H]([C@H]5CO)CO |
−8.8
± 0.5
|
6.4
± 0.3
|
4024 |
EN300-191495_1_1
|
|
CS(=O)(=O)C1(CC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
4025 |
EN300-1703714_2_1
|
|
CN(CCCS(=O)(=O)C)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.3
|
6.4
± 0.2
|
4026 |
ALP-POS-e0fe77e5-7
|
|
c1ccc2c(c1)cncc2N3CCCC4(C3=O)CCOc5c4cc(cc5)Cl |
−8.8
± 0.3
|
6.4
± 0.2
|
4027 |
FRA-DIA-b66f7109-3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCOc4c3cc(cc4Cl)OC5CC(=O)N5 |
−8.8
± 0.3
|
6.4
± 0.2
|
4028 |
EN300-210254_2_1
|
|
C[C@@H](CN(C)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.8
± 0.2
|
6.4
± 0.1
|
4029 |
EN300-682529_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@]5(CCOC5)CO |
−8.8
± 0.3
|
6.4
± 0.2
|
4030 |
EN300-7549621_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5COC[C@H]5F |
−8.8
± 0.3
|
6.4
± 0.2
|
4031 |
EN300-3044054_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCC(=O)N5C6CC6 |
−8.8
± 0.2
|
6.4
± 0.2
|
4032 |
MAK-UNK-8be7dca9-2
|
|
c1cc2c(cc1CC(=O)N)cncc2NC(=O)C3CCOc4c3cc(cc4)Cl |
−8.81
± 0.08
|
6.41
± 0.06
|
4033 |
DAR-DIA-5ff57136-5
|
|
C=CC(=O)N(c1cncc2c1cccc2)C(=O)C3=CCCc4c3cc(cc4)Cl |
−8.8
± 0.4
|
6.4
± 0.3
|
4034 |
EDG-MED-90036822-54
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5ccnc5 |
−8.8
± 0.2
|
6.4
± 0.2
|
4035 |
EN300-7471076_2_3
|
|
C[C@@H]1[C@H](CN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.8
± 0.3
|
6.4
± 0.2
|
4036 |
EN300-72896_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CCC(=O)N5 |
−8.8
± 0.2
|
6.4
± 0.1
|
4037 |
EN300-6792206_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H](C5CCOCC5)O |
−8.8
± 0.4
|
6.4
± 0.3
|
4038 |
EN300-172485_2_1
|
|
Cc1nnc(n1C)CCNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.2
|
6.4
± 0.2
|
4039 |
EDG-MED-4c68219f-10
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCN |
−8.8
± 0.4
|
6.4
± 0.3
|
4040 |
ADA-UCB-dc2b944c-15
|
|
CC1(COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)C |
−8.8
± 0.2
|
6.4
± 0.2
|
4041 |
EN300-92790_2_1
|
|
Cn1ccc(n1)CCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
4042 |
EN300-69556_1_1
|
|
Cc1ccc(=O)n(n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
4043 |
EN300-124904_2_1
|
|
Cn1c(nnn1)CCNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
4044 |
EN300-1703852_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C[C@H]5COC(=O)N5 |
−8.8
± 0.2
|
6.4
± 0.1
|
4045 |
EN300-263153_2_1
|
|
Cn1cc(nn1)C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.4
|
6.4
± 0.3
|
4046 |
EN300-194132_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@@H]6COC[C@H](C5)O6 |
−8.8
± 0.3
|
6.4
± 0.2
|
4047 |
EN300-6277108_1_1
|
|
CO[C@@H]([C@@H]1CCCO1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
4048 |
ADA-UCB-dc2b944c-17
|
|
c1ccc2c(c1)cncc2NC(=O)N(CCC3CCCCC3)c4cc(ccc4Cl)Cl |
−8.8
± 0.6
|
6.4
± 0.5
|
4049 |
EN300-248526_1_2
|
|
c1ccc(cc1)[C@](CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(C(=O)N)O |
−8.8
± 0.3
|
6.4
± 0.2
|
4050 |
EN300-123400_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]([C@@H]5CCOC5)C(=O)N |
−8.8
± 0.2
|
6.4
± 0.2
|
4051 |
ED_-GRI-5b13fbe2-46
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCN5CCC(CC5=O)C(=O)O |
−8.8
± 0.5
|
6.4
± 0.4
|
4052 |
EN300-203853_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNS(=O)(=O)C5CC5 |
−8.8
± 0.4
|
6.4
± 0.3
|
4053 |
EN300-7355835_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCn6c(c(cn6)O)C5 |
−8.8
± 0.3
|
6.4
± 0.2
|
4054 |
EN300-1662365_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CCc6ncnn6C5 |
−8.8
± 0.3
|
6.4
± 0.2
|
4055 |
EN300-785910_2_1
|
|
COCc1c(n[nH]n1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
4056 |
EN300-117931_4_1
|
|
CC(C)(CC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.8
± 0.3
|
6.4
± 0.2
|
4057 |
EN300-7456499_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCS(=O)(=O)CCCO |
−8.8
± 0.5
|
6.4
± 0.3
|
4058 |
ALF-EVA-0b412456-4
|
|
CCc1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)OC4CC(=O)N4 |
−8.8
± 0.4
|
6.4
± 0.3
|
4059 |
EN300-108022_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCn5cnnn5 |
−8.8
± 0.2
|
6.4
± 0.2
|
4060 |
EN300-75807_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCS(=O)(=O)CC5 |
−8.8
± 0.2
|
6.4
± 0.2
|
4061 |
EN300-14006_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5CCS(=O)(=O)C5 |
−8.8
± 0.3
|
6.4
± 0.2
|
4062 |
EN300-139167_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@H]5COCCO5 |
−8.8
± 0.2
|
6.4
± 0.1
|
4063 |
EN300-00271_4_2
|
|
C[C@H](C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−8.8
± 0.4
|
6.4
± 0.3
|
4064 |
EN300-396329_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@@H]5C[C@@H]5CO |
−8.8
± 0.3
|
6.4
± 0.2
|
4065 |
EN300-314455_1_1
|
|
CS(=O)(=O)[N@]1CCC[C@@H](C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
4066 |
EN300-6505003_3_2
|
|
C[C@H]1CC[C@@H](C(=O)N1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.3
|
4067 |
MAK-UNK-ffc90da7-6
|
|
CC(CNCCCO)c1ccc2cncc(c2c1)NC(=O)Cc3cccc(c3)Cl |
−8.8
± 0.3
|
6.4
± 0.3
|
4068 |
EN300-1588613_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC[N@@H+]6[C@@H]5COCC6 |
−8.8
± 0.3
|
6.4
± 0.2
|
4069 |
EN300-1719143_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@@H](C5)O)CC#N |
−8.8
± 0.3
|
6.4
± 0.2
|
4070 |
EN300-1911992_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]([C@@H]5CCOC5)O |
−8.8
± 0.3
|
6.4
± 0.2
|
4071 |
EDG-MED-ba1ac7b9-23
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6C[C@H]5CN6CC(F)F |
−8.8
± 0.2
|
6.4
± 0.2
|
4072 |
DAR-DIA-0cde14eb-46
|
|
CC1(CC1)c2cccc(c2)CC(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.3
|
6.4
± 0.2
|
4073 |
EN300-217107_2_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CC[C@H]5C(=O)N |
−8.8
± 0.3
|
6.4
± 0.2
|
4074 |
EN300-92633_1_2
|
|
Cn1cc(cn1)N2C[C@H](CC2=O)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.8
± 0.3
|
6.4
± 0.2
|
4075 |
EN300-7432415_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C6(CCC6)OC(=O)N5 |
−8.8
± 0.2
|
6.4
± 0.2
|
4076 |
EN300-379533_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)O |
−8.8
± 0.2
|
6.4
± 0.2
|
4077 |
MAT-POS-1f3f1a6f-4
|
|
c1ccc2c(c1)cncc2NC(=O)C(c3ccc(c(c3)Cl)Cl)NCC4CC4 |
−8.8
± 0.4
|
6.4
± 0.3
|
4078 |
EN300-216594_2_1
|
|
Cn1cncc1CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.2
|
6.4
± 0.2
|
4079 |
EN300-171215_1_2
|
|
C[C@H]1CS(=O)(=O)CCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.2
|
6.4
± 0.2
|
4080 |
MAK-UNK-8be7dca9-1_1
|
|
c1cc2c(cc1C[NH+]3CC[NH2+]CC3)cncc2NC(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−8.8
± 0.1
|
6.4
± 0.1
|
4081 |
EN300-7464289_1_1
|
|
C[C@@](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C(=O)OC)F |
−8.8
± 0.3
|
6.4
± 0.2
|
4082 |
EN300-6729572_4_1
|
|
C[C@@H]([C@@H]1C[C@@H]1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.8
± 0.4
|
6.4
± 0.3
|
4083 |
EN300-148865_2_1
|
|
C[C@@H](CCO)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.3
|
6.4
± 0.2
|
4084 |
EN300-86282_2_1
|
|
C[C@@H](CO)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.3
|
6.4
± 0.2
|
4085 |
ALP-UNI-3496895b-15
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC6C5C[C@H](C6)C(=O)N |
−8.8
± 0.2
|
6.4
± 0.1
|
4086 |
EN300-297611_1_2
|
|
C[C@H]1CN(CC[N@@]1S(=O)(=O)C)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.4
|
6.4
± 0.3
|
4087 |
EN300-39785_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5ccn[nH]5 |
−8.8
± 0.3
|
6.4
± 0.2
|
4088 |
EDJ-MED-28ec730d-3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC5CCOCC5 |
−8.8
± 0.2
|
6.4
± 0.2
|
4089 |
EN300-311920_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@]5(CCS(=O)(=O)C5)F |
−8.8
± 0.2
|
6.4
± 0.1
|
4090 |
EN300-754584_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CS(=O)(=O)CC(=O)N5 |
−8.8
± 0.3
|
6.4
± 0.2
|
4091 |
EN300-383664_1_1
|
|
Cn1cc(ncc1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.2
|
6.4
± 0.2
|
4092 |
EN300-20284_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC[C@H](C5)O |
−8.8
± 0.2
|
6.4
± 0.2
|
4093 |
EN300-155498_3_1
|
|
CC(=C)[C@H](CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.8
± 0.3
|
6.4
± 0.2
|
4094 |
EN300-190353_1_1
|
|
Cc1cccc(=O)n1C[C@@](C)(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.8
± 0.3
|
6.4
± 0.2
|
4095 |
ED_-GRI-5b13fbe2-12
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCN(CCO)CCOCCO |
−8.8
± 0.8
|
6.4
± 0.6
|
4096 |
EN300-1272704_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CCO[C@@H]5c6[nH]ncn6 |
−8.8
± 0.3
|
6.4
± 0.2
|
4097 |
EN300-91905_2_1
|
|
C[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.8
± 0.2
|
6.4
± 0.2
|
4098 |
EDJ-MED-ee07cf00-17
|
|
c1ccc2c(c1)cncc2NC(=O)C(c3cccc(c3)Cl)NC(=O)Cn4c(=O)c5ccnn5cn4 |
−8.8
± 0.3
|
6.4
± 0.2
|
4099 |
EDG-MED-90036822-1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CNCC(=O)N)(F)F |
−8.8
± 0.3
|
6.4
± 0.2
|
4100 |
EN300-1448674_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCn6c(ncn6)C5 |
−8.8
± 0.3
|
6.4
± 0.2
|