Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
3801 |
EN300-113234_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CC(=O)OC5 |
−9.0
± 0.2
|
6.5
± 0.2
|
3802 |
EN300-195756_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5CCC(=O)N5 |
−9.0
± 0.2
|
6.5
± 0.2
|
3803 |
KAD-UNI-8a629cb0-3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cc(sc5)S(=O)(=O)N |
−9.0
± 0.3
|
6.5
± 0.2
|
3804 |
EN300-94856_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CC(C5)O |
−9.0
± 0.3
|
6.5
± 0.2
|
3805 |
EN300-237224_2_1
|
|
C[NH+]1CCC(CC1)OCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.5
± 0.2
|
3806 |
PET-UNK-dd44aeb6-1
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(ccc3F)Cl |
−9.0
± 0.2
|
6.5
± 0.2
|
3807 |
EN300-176877_3_1
|
|
CN(C)C(=O)CCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.3
|
6.5
± 0.2
|
3808 |
BEN-BAS-c2bc0d80-4
|
|
c1ccc2c(c1)cncc2NC(=O)C3CC=Nc4c3[nH]c(cc4=O)Cl |
−9.0
± 0.3
|
6.5
± 0.2
|
3809 |
EN300-1911992_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC[C@@H]([C@@H]5CCOC5)O |
−9.0
± 0.4
|
6.5
± 0.3
|
3810 |
PET-UNK-dd44aeb6-2
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(ccc3Cl)Cl |
−9.0
± 0.3
|
6.5
± 0.2
|
3811 |
EDJ-MED-e4b030d8-2
|
|
C[C@@H]1C[C@H](c2cc(ccc2O1)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.95
± 0.05
|
6.52
± 0.03
|
3812 |
EN300-7442332_1_1
|
|
Cc1c(n(cn1)OC)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.2
|
3813 |
EN300-13489_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCN(CC5)C(=O)N |
−8.9
± 0.3
|
6.5
± 0.2
|
3814 |
EN300-247617_1_1
|
|
Cc1cc(ncc1C(=O)N)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.2
|
3815 |
EN300-103144_4_1
|
|
CSCC[C@@H](C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.9
± 0.4
|
6.5
± 0.3
|
3816 |
EN300-6745453_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5Cc6nncn6C5 |
−8.9
± 0.3
|
6.5
± 0.2
|
3817 |
EN300-260696_1_6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H]5C[C@@H]([C@H]5n6cccn6)O |
−8.9
± 0.3
|
6.5
± 0.2
|
3818 |
EN300-174603_2_1
|
|
CN(C(=O)CCOC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−8.9
± 0.3
|
6.5
± 0.2
|
3819 |
DAR-DIA-6a508060-10
|
|
CC1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.1
|
6.51
± 0.07
|
3820 |
EN300-158274_1_1
|
|
CC(=O)N1C[C@H](C[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.9
± 0.3
|
6.5
± 0.3
|
3821 |
EN300-31845_3_1
|
|
COCCN1C[C@@H](CC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.4
|
6.5
± 0.3
|
3822 |
EDG-MED-ba1ac7b9-10
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCCC5c6cc[nH]n6 |
−8.9
± 0.4
|
6.5
± 0.3
|
3823 |
EN300-173562_1_3
|
|
C[C@@H]1C[C@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.9
± 0.2
|
6.5
± 0.2
|
3824 |
MIC-UNK-d36ab305-4
|
|
CN(C)c1ccc(cc1)C(c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
3825 |
EDJ-MED-e4b030d8-7
|
|
COc1cc(cc2c1OCC[C@H]2C(=O)Nc3cncc4c3cccc4)Cl |
−8.9
± 0.1
|
6.51
± 0.08
|
3826 |
EN300-264301_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5CCC(=O)N5 |
−8.9
± 0.3
|
6.5
± 0.2
|
3827 |
EN300-23318_3_1
|
|
C[C@@H](C(=O)N[C@@H]1CCS(=O)(=O)C1)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.4
|
6.5
± 0.3
|
3828 |
EN300-81038_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(C5)COC6 |
−8.9
± 0.3
|
6.5
± 0.2
|
3829 |
EN300-6489289_1_1
|
|
Cc1nnc2n1[C@@H](CC2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.9
± 0.2
|
6.5
± 0.2
|
3830 |
EN300-39007_1_1
|
|
CCN(CC(=O)NC)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
3831 |
EN300-211482_2_1
|
|
C[C@@H](C(=O)NC)OC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.2
|
6.5
± 0.1
|
3832 |
DAR-DIA-0cde14eb-47
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cccc(c3)C4(CC4)Cl |
−8.9
± 0.3
|
6.5
± 0.3
|
3833 |
EN300-395719_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCO[C@H]6COC[C@H]6C5 |
−8.9
± 0.3
|
6.5
± 0.2
|
3834 |
EN300-249245_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(C(F)F)O |
−8.9
± 0.2
|
6.5
± 0.2
|
3835 |
JOH-UNI-ee5ed7c8-9
|
|
CN(c1c2ccccc2cnc1C#N)C(=O)Cc3cccc(c3)Cl |
−8.9
± 0.3
|
6.5
± 0.2
|
3836 |
EN300-44873_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC[N@@]5CCCS5(=O)=O |
−8.9
± 0.4
|
6.5
± 0.3
|
3837 |
EN300-1588613_3_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CC[N@H+]6[C@H]5COCC6 |
−8.9
± 0.5
|
6.5
± 0.3
|
3838 |
EN300-24014_3_1
|
|
CS(=O)(=O)[N@@]1CCCC[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.4
|
6.5
± 0.3
|
3839 |
EDJ-MED-d08626de-4
|
|
CO[C@]1(CCOc2c1cc(c(c2)Cl)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.1
|
6.50
± 0.09
|
3840 |
EN300-318305_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC6(C5)CS(=O)(=O)C6 |
−8.9
± 0.2
|
6.5
± 0.2
|
3841 |
EN300-26603_1_1
|
|
Cn1c2ccccc2n(c1=O)CC(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.9
± 0.3
|
6.5
± 0.2
|
3842 |
MAT-POS-8a69d52e-1_4
|
|
C[C@H]1C[C@H](c2cc(ccc2O1)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.92
± 0.10
|
6.50
± 0.07
|
3843 |
EDG-MED-ba1ac7b9-7
|
|
CC1N(CCO1)C(=O)CC2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.2
|
3844 |
EN300-65115_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)O |
−8.9
± 0.2
|
6.5
± 0.2
|
3845 |
EN300-6255179_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCn5cncn5 |
−8.9
± 0.2
|
6.5
± 0.1
|
3846 |
EN300-1724771_3_1
|
|
CC(=O)N1CCN(CC1)C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.2
|
3847 |
EN300-1268016_1_15
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@H]6[C@H]5C[C@H](C6)C(=O)N |
−8.9
± 0.3
|
6.5
± 0.2
|
3848 |
ALP-UNI-3496895b-12
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5ccn(n5)C6CCNC6=O |
−8.9
± 0.3
|
6.5
± 0.2
|
3849 |
EN300-373446_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCO[C@@H](C5)[C@H](CO)O |
−8.9
± 0.6
|
6.5
± 0.4
|
3850 |
EN300-152705_1_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−8.9
± 0.2
|
6.5
± 0.2
|
3851 |
EN300-144970_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H](C5)CO |
−8.9
± 0.2
|
6.5
± 0.1
|
3852 |
EN300-1644723_2_5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5[C@@H]6[C@H]5COCC6 |
−8.9
± 0.3
|
6.5
± 0.2
|
3853 |
EN300-1789253_2_1
|
|
Cn1cc(nn1)c2cc(no2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.9
± 0.3
|
6.5
± 0.2
|
3854 |
EN300-80083_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCCCC(=O)N5 |
−8.9
± 0.4
|
6.5
± 0.3
|
3855 |
EN300-704025_2_1
|
|
COC1(CS(=O)(=O)C1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
3856 |
EN300-6763470_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H](C(=O)N)C(F)(F)F |
−8.9
± 0.2
|
6.5
± 0.2
|
3857 |
EN300-66494_3_1
|
|
CNC(=O)NCCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
3858 |
EN300-297144_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H](CCO)CO |
−8.9
± 0.3
|
6.5
± 0.2
|
3859 |
EN300-217107_4_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H]5CC[C@@H]5C(=O)N |
−8.9
± 0.4
|
6.5
± 0.3
|
3860 |
EN300-6498351_3_1
|
|
Cc1c(n(cn1)C)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.1
|
3861 |
EN300-7536177_3_1
|
|
Cc1ncnn1CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.3
|
3862 |
EN300-378373_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)COC5CC5 |
−8.9
± 0.3
|
6.5
± 0.2
|
3863 |
JOH-SUS-a69c159d-2_1
|
|
c1ccc2c(c1)c(cnc2F)NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−8.91
± 0.06
|
6.49
± 0.04
|
3864 |
EDG-MED-90036822-5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](CF)N |
−8.9
± 0.3
|
6.5
± 0.2
|
3865 |
MAT-POS-fce787c2-11
|
|
c1ccc2c(c1)cncc2NC(=O)C(CO)c3ccc(c(c3)Cl)Cl |
−8.9
± 0.2
|
6.5
± 0.2
|
3866 |
EN300-366974_1_1
|
|
CN(CCS(=O)(=O)N)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
3867 |
EN300-1600517_4_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC[C@H](CO)F |
−8.9
± 0.4
|
6.5
± 0.3
|
3868 |
EN300-52589_1_1
|
|
Cn1c(nc2c1c(=O)[nH]c(=O)n2C)CO[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.9
± 0.3
|
6.5
± 0.2
|
3869 |
EN300-120586_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)NCC(F)F |
−8.9
± 0.3
|
6.5
± 0.2
|
3870 |
EN300-296237_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H](CO)C(F)(F)F |
−8.9
± 0.4
|
6.5
± 0.3
|
3871 |
EN300-249804_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCOC(=O)N5 |
−8.9
± 0.2
|
6.5
± 0.2
|
3872 |
EN300-18074_4_1
|
|
CC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
3873 |
EN300-7435892_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5COC[C@@H]5C(=O)N |
−8.9
± 0.3
|
6.5
± 0.2
|
3874 |
EN300-734638_1_1
|
|
COc1cc(=O)[nH]cc1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.4
|
6.5
± 0.3
|
3875 |
EN300-307592_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC(C5)O |
−8.9
± 0.2
|
6.5
± 0.2
|
3876 |
EN300-01527_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NC[C@H]5CCCO5 |
−8.9
± 0.3
|
6.5
± 0.2
|
3877 |
EN300-1448603_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5CCS(=O)(=O)C5 |
−8.9
± 0.3
|
6.5
± 0.2
|
3878 |
MAT-POS-fce787c2-4
|
|
c1ccc2c(c1)cncc2NC(=O)C(c3ccc(c(c3)Cl)Cl)O |
−8.9
± 0.2
|
6.5
± 0.2
|
3879 |
EN300-88417_1_1
|
|
Cn1cncc1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.2
|
3880 |
RAL-THA-05e671eb-16
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4Cl)Cl |
−8.90
± 0.08
|
6.48
± 0.06
|
3881 |
ED_-GRI-5b13fbe2-70
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@H]5C[C@H]5N |
−8.9
± 0.3
|
6.5
± 0.2
|
3882 |
EN300-69070_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)C(=O)N |
−8.9
± 0.2
|
6.5
± 0.2
|
3883 |
EN300-28106_2_2
|
|
C[C@H](C(=O)N1CCN(CC1)C(=O)C)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
3884 |
DAR-DIA-6a508060-10_2
|
|
C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.1
|
6.48
± 0.08
|
3885 |
EN300-7353672_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H]([C@@H](CC5)O)CO |
−8.9
± 0.4
|
6.5
± 0.3
|
3886 |
EN300-33553_1_1
|
|
Cc1c(c(=O)[nH]cn1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
3887 |
EN300-1724086_2_2
|
|
C[C@H]1C[C@@H](CN(C1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−8.9
± 0.2
|
6.5
± 0.1
|
3888 |
EN300-28177_2_4
|
|
C[C@H](C(=O)N1CCC[C@H](C1)C(=O)N)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.4
|
6.5
± 0.3
|
3889 |
ED_-GRI-5b13fbe2-1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCNCc5cc(no5)C(=O)O |
−8.9
± 0.5
|
6.5
± 0.4
|
3890 |
DAR-DIA-23e5a6a0-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OC5CC6(CC6)CN5)Cl |
−8.9
± 0.2
|
6.5
± 0.2
|
3891 |
EDG-MED-4c68219f-11
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCCCC(=O)O |
−8.9
± 0.3
|
6.5
± 0.2
|
3892 |
RAL-THA-c11c1343-1
|
|
CC(=O)N1CCC(c2c1ccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.2
|
6.5
± 0.1
|
3893 |
EN300-79022_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cccnn5 |
−8.9
± 0.3
|
6.5
± 0.2
|
3894 |
EN300-269453_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CCc6nnnn6C5 |
−8.9
± 0.3
|
6.5
± 0.2
|
3895 |
EN300-19700_4_1
|
|
COC(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.2
|
6.5
± 0.1
|
3896 |
EN300-13000_1_1
|
|
CN(CC(=O)OC)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
3897 |
JAG-UCB-706446eb-4_1
|
|
CCOC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.2
|
6.5
± 0.2
|
3898 |
PET-UNK-8df914d1-1
|
|
COc1ccc2cncc(c2c1)NC(=O)Cc3cccc(c3)Cl |
−8.9
± 0.3
|
6.5
± 0.2
|
3899 |
KAD-UNI-8a629cb0-26
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)CCO6 |
−8.9
± 0.2
|
6.5
± 0.2
|
3900 |
EN300-262745_2_1
|
|
CCn1cc(nn1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.1
|