Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
3601 |
EN300-69162_4_1
|
|
C[C@@H](COC)C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
6.6
± 0.2
|
3602 |
EN300-219531_2_1
|
|
CCC[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.1
± 0.3
|
6.6
± 0.3
|
3603 |
RAL-THA-1d44ff04-13
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)C(=O)NO |
−9.1
± 0.3
|
6.6
± 0.2
|
3604 |
EDG-MED-971238d3-2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CO |
−9.1
± 0.1
|
6.6
± 0.1
|
3605 |
EN300-24804_1_1
|
|
COC(=O)CCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.2
|
6.6
± 0.2
|
3606 |
EN300-60862_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCO[C@H](C5)C(=O)N |
−9.1
± 0.3
|
6.6
± 0.2
|
3607 |
EN300-817777_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC[C@H]6[C@@]5(C6)C(=O)N |
−9.1
± 0.3
|
6.6
± 0.2
|
3608 |
EN300-1264816_1_2
|
|
CN1CC[C@H](C1=O)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
6.6
± 0.1
|
3609 |
EN300-65115_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)O |
−9.1
± 0.3
|
6.6
± 0.2
|
3610 |
EN300-99391_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CO[C@@H]5CCOC5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3611 |
EN300-188217_1_1
|
|
CC(C)(CS(=O)(=O)C)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
6.6
± 0.2
|
3612 |
EN300-43090_1_1
|
|
Cc1nnc(o1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3613 |
EN300-1387145_3_4
|
|
CS(=O)(=O)[C@H]1CCC[C@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.4
|
6.6
± 0.3
|
3614 |
ED_-GRI-5b13fbe2-16
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(c5cn(nn5)CC6CC6)N |
−9.1
± 0.3
|
6.6
± 0.2
|
3615 |
ALP-POS-fab80cf2-1
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)C(C4CC(=O)N4)(F)F |
−9.1
± 0.4
|
6.6
± 0.3
|
3616 |
EN300-220194_1_1
|
|
C[C@@H]([C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)OC |
−9.1
± 0.3
|
6.6
± 0.2
|
3617 |
KAD-UNI-8a629cb0-22
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cc6c([nH]c(=O)[nH]6)nc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3618 |
EN300-52009_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CCC5)O |
−9.1
± 0.3
|
6.6
± 0.2
|
3619 |
EN300-75342_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5ccnc5 |
−9.1
± 0.2
|
6.6
± 0.1
|
3620 |
EN300-7353672_1_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H]([C@H](CC5)O)CO |
−9.1
± 0.4
|
6.6
± 0.3
|
3621 |
EN300-783124_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]([C@@H]5CCOC5)F |
−9.1
± 0.3
|
6.6
± 0.2
|
3622 |
EN300-1707870_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@](C5)(CCO)CO |
−9.1
± 0.4
|
6.6
± 0.3
|
3623 |
EN300-1072199_2_2
|
|
CO[C@]1(CCCOC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3624 |
EN300-68889_3_1
|
|
CCNC(=O)CCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
6.6
± 0.2
|
3625 |
ED_-GRI-5b13fbe2-54
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCCn5c(c(nn5)CN)C(F)F |
−9.1
± 0.4
|
6.6
± 0.3
|
3626 |
EN300-84785_1_1
|
|
C[C@@H](CC(=O)N)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
6.6
± 0.2
|
3627 |
DAR-DIA-e7614d05-1
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)OC(F)(F)F |
−9.1
± 0.1
|
6.6
± 0.1
|
3628 |
ALP-POS-696356e4-1_1
|
|
c1cc2cncc(c2cc1F)NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−9.06
± 0.05
|
6.60
± 0.04
|
3629 |
EN300-7431629_1_1
|
|
Cc1nnc2n1CC[C@@]2(C)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.1
± 0.3
|
6.6
± 0.2
|
3630 |
EN300-7121836_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn[nH]c5F |
−9.1
± 0.2
|
6.6
± 0.2
|
3631 |
EN300-42819_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCC(=O)NC5 |
−9.1
± 0.2
|
6.6
± 0.2
|
3632 |
EN300-1707774_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)OC(=O)N |
−9.1
± 0.2
|
6.6
± 0.2
|
3633 |
BEN-DND-c852c98b-1
|
|
c1cc2cncc(c2cc1C#N)NC(=O)C3CCOc4c3cc(cc4)Cl |
−9.06
± 0.05
|
6.60
± 0.04
|
3634 |
EN300-212266_3_1
|
|
CC(C)C(=O)N[C@@H](CO)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.4
|
6.6
± 0.3
|
3635 |
EN300-82616_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCCNC5=O |
−9.1
± 0.3
|
6.6
± 0.2
|
3636 |
EN300-31242_4_1
|
|
COCC(=O)NCCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
6.6
± 0.2
|
3637 |
EN300-208959_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CNC(=O)C[C@@H]5C(F)(F)F |
−9.1
± 0.3
|
6.6
± 0.2
|
3638 |
EN300-1644703_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CC5)O |
−9.1
± 0.2
|
6.6
± 0.2
|
3639 |
DAR-DIA-0d514e7d-16
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)c5ccccc5F |
−9.1
± 0.2
|
6.6
± 0.2
|
3640 |
EDG-MED-ba1ac7b9-11
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCCC5c6c[nH]nc6 |
−9.1
± 0.3
|
6.6
± 0.2
|
3641 |
EN300-314088_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@@H](C5)CO)CO |
−9.1
± 0.3
|
6.6
± 0.2
|
3642 |
EN300-14752_1_1
|
|
CC(=O)N1CCC[C@@H](C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
6.6
± 0.1
|
3643 |
EN300-7444533_4_2
|
|
C[C@H]1C[C@@H](C(=O)O1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3644 |
EN300-28177_2_1
|
|
C[C@@H](C(=O)N1CCC[C@@H](C1)C(=O)N)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.4
|
6.6
± 0.3
|
3645 |
ALP-UNI-dbbfd3db-10
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(c(=O)[nH]c5=O)Cl |
−9.0
± 0.3
|
6.6
± 0.2
|
3646 |
EN300-7444316_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@@H](C5)C(=O)N)C(=O)N |
−9.0
± 0.4
|
6.6
± 0.3
|
3647 |
EN300-10397_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CNC(=O)N |
−9.0
± 0.2
|
6.6
± 0.2
|
3648 |
EN300-55744_1_1
|
|
CCCC[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−9.0
± 0.3
|
6.6
± 0.2
|
3649 |
EN300-314274_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cncc6c5CCNC6=O |
−9.0
± 0.3
|
6.6
± 0.3
|
3650 |
EN300-861925_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CO[C@@H](CO)F |
−9.0
± 0.2
|
6.6
± 0.2
|
3651 |
EN300-35789_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cccnc5=O |
−9.0
± 0.3
|
6.6
± 0.2
|
3652 |
MAT-POS-f9802937-4
|
|
CN(C)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.2
|
6.6
± 0.2
|
3653 |
EN300-62074_1_1
|
|
CC(=O)N[C@@H](CCOC)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.3
|
6.6
± 0.2
|
3654 |
EN300-103187_1_1
|
|
CCOCCNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.2
|
6.6
± 0.2
|
3655 |
EN300-14458_4_2
|
|
C[C@H](C(=O)N(C)C)OCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.3
|
6.6
± 0.2
|
3656 |
EN300-7375395_2_1
|
|
CC[C@@H](C(=O)N)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.3
|
6.6
± 0.2
|
3657 |
EN300-651177_1_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)Cn5cnnn5 |
−9.0
± 0.4
|
6.6
± 0.3
|
3658 |
EN300-6745081_1_2
|
|
C[C@]1(CCCCNC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
3659 |
EN300-39305_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[NH+]5CCS(=O)(=O)CC5 |
−9.0
± 0.3
|
6.6
± 0.2
|
3660 |
EN300-175186_1_2
|
|
C[C@H](CO)O[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.3
|
6.6
± 0.2
|
3661 |
EN300-252683_1_1
|
|
CO[C@@H]1COC[C@@H]1NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
3662 |
ALP-POS-d3acb8cc-1_1
|
|
C[C@H]1C[C@H](c2cc(ccc2O1)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.05
± 0.09
|
6.59
± 0.07
|
3663 |
EN300-130644_1_1
|
|
CNC(=O)[C@@H]1CN(CCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
3664 |
EN300-102347_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5(COC5)CO |
−9.0
± 0.2
|
6.6
± 0.2
|
3665 |
VLA-UCB-05e51b3f-14
|
|
c1ccc2c(c1)cncc2NC(=O)N(CCC3CCCCC3)c4cccc(c4)Cl |
−9.0
± 0.3
|
6.6
± 0.2
|
3666 |
EN300-4293814_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CS(=O)(=O)CCO |
−9.0
± 0.5
|
6.6
± 0.4
|
3667 |
EN300-1605566_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[NH+]6CC[NH+]5CC6 |
−9.0
± 0.3
|
6.6
± 0.2
|
3668 |
EN300-52325_3_1
|
|
CCCS(=O)(=O)CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.5
|
6.6
± 0.3
|
3669 |
EN300-1387145_3_1
|
|
CS(=O)(=O)[C@@H]1CCC[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
3670 |
DAR-DIA-076fb6ea-12
|
|
c1ccc2c(c1)cncc2N(C(=O)Cc3cccc(c3)Cl)C(=O)/C=C/CN4CCCCC4 |
−9.0
± 0.6
|
6.6
± 0.5
|
3671 |
EN300-312662_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5[nH]nc(n5)CO |
−9.0
± 0.4
|
6.6
± 0.3
|
3672 |
EN300-46832_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NC[C@@H]5CCOC5 |
−9.0
± 0.3
|
6.6
± 0.2
|
3673 |
MAK-UNK-c749d764-2
|
|
CCC1CCCC(C1O)CC(=O)Nc2cncc3c2cccc3 |
−9.0
± 0.2
|
6.6
± 0.2
|
3674 |
EN300-104395_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5CCCO5 |
−9.0
± 0.3
|
6.6
± 0.2
|
3675 |
DAR-DIA-6a508060-3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4)C#N |
−9.04
± 0.05
|
6.59
± 0.04
|
3676 |
EN300-2007648_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C56CC(C5)CO6 |
−9.0
± 0.3
|
6.6
± 0.2
|
3677 |
EN300-194442_1_2
|
|
C[C@]1(CCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−9.0
± 0.4
|
6.6
± 0.3
|
3678 |
EN300-110423_2_1
|
|
Cc1c(c(=O)[nH]o1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.2
|
6.6
± 0.1
|
3679 |
EN300-212814_1_2
|
|
C[C@H]1CN(C[C@@H](O1)CCO)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.4
|
6.6
± 0.3
|
3680 |
EN300-37195_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N[C@@H]5CCCCNC5=O |
−9.0
± 0.3
|
6.6
± 0.2
|
3681 |
EN300-19542_4_2
|
|
C[C@H](C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.0
± 0.3
|
6.6
± 0.2
|
3682 |
EDG-MED-90036822-107
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(c[nH]5)F |
−9.0
± 0.2
|
6.6
± 0.2
|
3683 |
EN300-366468_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCNC(=O)C5 |
−9.0
± 0.3
|
6.6
± 0.2
|
3684 |
EDG-MED-90036822-52
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CNCCCO)(F)F |
−9.0
± 0.3
|
6.6
± 0.2
|
3685 |
EN300-310254_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H]5C(=O)NCC56CCOCC6 |
−9.0
± 0.5
|
6.6
± 0.3
|
3686 |
EN300-01527_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)NC[C@@H]5CCCO5 |
−9.0
± 0.3
|
6.6
± 0.3
|
3687 |
EN300-7353973_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@@H](CO)F |
−9.0
± 0.3
|
6.6
± 0.2
|
3688 |
EN300-761220_3_1
|
|
CC(=O)N1CSC[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
3689 |
ED_-GRI-5b13fbe2-8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCOCCNCCN |
−9.0
± 0.7
|
6.6
± 0.5
|
3690 |
BEN-DND-c852c98b-4
|
|
c1cc2cncc(c2cc1O)NC(=O)C3CCOc4c3cc(cc4)Cl |
−9.04
± 0.05
|
6.58
± 0.04
|
3691 |
EN300-7471076_1_4
|
|
C[C@H]1[C@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.0
± 0.2
|
6.6
± 0.2
|
3692 |
EDJ-MED-c314995a-1
|
|
c1ccc2c(c1)cncc2NC(=O)N(CCC3CCCCC3)c4cccc(c4)Cl |
−9.03
± 0.10
|
6.58
± 0.07
|
3693 |
EN300-321597_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5CC[C@H](C5)O |
−9.0
± 0.4
|
6.6
± 0.3
|
3694 |
EN300-51257_2_1
|
|
C[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−9.0
± 0.3
|
6.6
± 0.2
|
3695 |
EN300-1215738_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC[C@@H]5CCC(=O)NC5 |
−9.0
± 0.2
|
6.6
± 0.2
|
3696 |
EN300-141480_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H]5CCCN(C5=O)CCO |
−9.0
± 0.3
|
6.6
± 0.2
|
3697 |
BEN-BAS-5c03e89e-1_1
|
|
CC(C)([C@@H]1COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)O |
−9.0
± 0.2
|
6.6
± 0.2
|
3698 |
MAT-POS-0c8fa4a7-1
|
|
c1ccc2c(c1)cncc2NC(=O)C3=CCCc4c3cc(cc4)Cl |
−9.03
± 0.09
|
6.58
± 0.07
|
3699 |
RAL-THA-c9f97604-2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3c4cc(ccc4[C@@H]5OC[C@H]3O5)Cl |
−9.0
± 0.2
|
6.6
± 0.2
|
3700 |
EN300-7493939_1_1
|
|
CC1(CN(CC(=O)N1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.0
± 0.2
|
6.6
± 0.1
|