Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
3501 |
EN300-77885_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H](CO)C5CC5 |
−9.1
± 0.3
|
6.7
± 0.2
|
3502 |
EN300-1915260_1_1
|
|
COC[C@@H](CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.1
± 0.4
|
6.7
± 0.3
|
3503 |
MAT-POS-e9e99895-13
|
|
CC(c1ccc(c(c1)Cl)Cl)(C(=O)Nc2cncc3c2cccc3)NC(=O)C4CCN(C4)C |
−9.1
± 0.2
|
6.7
± 0.2
|
3504 |
EDJ-MED-9e38fd34-4
|
|
CC1(c2cc(c(cc2NC1=O)Cl)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
6.7
± 0.2
|
3505 |
EN300-250593_4_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C[C@H]5CC(=O)N5 |
−9.1
± 0.3
|
6.7
± 0.2
|
3506 |
EN300-48886_1_2
|
|
CC(=O)N[C@H]1CCCN(C1)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.7
± 0.2
|
3507 |
EN300-208236_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CCCc6c5n[nH]n6 |
−9.1
± 0.4
|
6.7
± 0.3
|
3508 |
EN300-1721883_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CC5)n6ccnn6 |
−9.1
± 0.3
|
6.7
± 0.2
|
3509 |
EN300-250593_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5CC(=O)N5 |
−9.1
± 0.2
|
6.7
± 0.2
|
3510 |
ED_-GRI-5b13fbe2-50
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5CC5(C#N)C(=O)O |
−9.1
± 0.2
|
6.7
± 0.1
|
3511 |
EN300-7457160_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5C[C@@H](ON5)CC6(COC6)O |
−9.1
± 0.2
|
6.7
± 0.2
|
3512 |
EN300-6503811_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H](Cc5cnc[nH]5)O |
−9.1
± 0.2
|
6.7
± 0.2
|
3513 |
DAR-DIA-0d514e7d-14
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)c5cccc(c5F)F |
−9.1
± 0.2
|
6.7
± 0.2
|
3514 |
EN300-29387_2_2
|
|
C[C@H](CO)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
6.7
± 0.2
|
3515 |
EN300-11195_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)N5CCC5 |
−9.1
± 0.3
|
6.7
± 0.2
|
3516 |
EDJ-MED-ee07cf00-5
|
|
c1ccc2c(c1)cncc2NC(=O)C(c3cccc(c3)Cl)NC(=O)CNC(=O)c4ccc(cc4)C#N |
−9.1
± 0.6
|
6.7
± 0.4
|
3517 |
EN300-1273172_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnc(cn5)C(=O)N |
−9.1
± 0.2
|
6.7
± 0.2
|
3518 |
DAR-DIA-23e5a6a0-9
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4CC5CC6(CC6)CN5)Cl |
−9.1
± 0.3
|
6.7
± 0.2
|
3519 |
EN300-1072874_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCNC(=O)CC5 |
−9.1
± 0.4
|
6.7
± 0.3
|
3520 |
EN300-178876_2_1
|
|
C[C@@]1(CCCNC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.4
|
6.7
± 0.3
|
3521 |
EN300-6491697_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCc5cccc(=O)[nH]5 |
−9.1
± 0.2
|
6.7
± 0.2
|
3522 |
EN300-31147_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCNC(=O)C5CC5 |
−9.1
± 0.3
|
6.7
± 0.2
|
3523 |
BEN-DND-f2e727cd-3
|
|
CN1CCN(c2c1ccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
6.7
± 0.2
|
3524 |
EN300-1425608_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]([C@@H](C5)CO)CCO |
−9.1
± 0.3
|
6.6
± 0.2
|
3525 |
EN300-52768_1_2
|
|
CCCS(=O)(=O)[C@H](C)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.4
|
6.6
± 0.3
|
3526 |
EN300-7456499_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCS(=O)(=O)CCCO |
−9.1
± 0.3
|
6.6
± 0.2
|
3527 |
EN300-217107_3_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CC[C@H]5C(=O)N |
−9.1
± 0.3
|
6.6
± 0.2
|
3528 |
EN300-21409_2_1
|
|
C#CCNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.1
|
6.6
± 0.1
|
3529 |
EN300-220194_1_2
|
|
C[C@H]([C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)OC |
−9.1
± 0.2
|
6.6
± 0.2
|
3530 |
EN300-299248_1_1
|
|
Cn1cnc(cc1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
6.6
± 0.2
|
3531 |
EN300-105482_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5(COC5)CO |
−9.1
± 0.2
|
6.6
± 0.2
|
3532 |
ALF-EVA-5b152d2f-1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCCOc4c3cc(cc4)Cl |
−9.1
± 0.2
|
6.6
± 0.1
|
3533 |
EN300-198633_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[C@H]5CCCCNC5=O |
−9.1
± 0.3
|
6.6
± 0.2
|
3534 |
EN300-366687_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCc6nncn6CC5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3535 |
EN300-295515_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H](C5)O |
−9.1
± 0.3
|
6.6
± 0.2
|
3536 |
EN300-137255_2_2
|
|
CO[C@]1(CCOC1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3537 |
EN300-1452069_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H](CC5CCOCC5)O |
−9.1
± 0.4
|
6.6
± 0.3
|
3538 |
EN300-80940_1_1
|
|
C[C@@H]1[C@@H](S(=O)(=O)CCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.1
± 0.3
|
6.6
± 0.2
|
3539 |
CHO-MSK-a31cca77-3
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5nccnn5 |
−9.1
± 0.2
|
6.6
± 0.2
|
3540 |
DAR-DIA-0d514e7d-33
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3c4cc(ccc4OC5C3C5)Cl |
−9.1
± 0.1
|
6.6
± 0.1
|
3541 |
ED_-GRI-5b13fbe2-19
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCOCCNCCOCCO |
−9.1
± 0.9
|
6.6
± 0.7
|
3542 |
EN300-2008102_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]5CN6C[C@@H](O5)CCC6=O |
−9.1
± 0.4
|
6.6
± 0.3
|
3543 |
EN300-7355477_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]6C[C@H]([C@@H](C[C@H]6C5)O)O |
−9.1
± 0.3
|
6.6
± 0.2
|
3544 |
EN300-105267_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)Nc5cnccn5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3545 |
EN300-6505003_3_4
|
|
C[C@H]1CC[C@H](C(=O)N1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.4
|
6.6
± 0.3
|
3546 |
EN300-69312_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H](C5)O |
−9.1
± 0.2
|
6.6
± 0.2
|
3547 |
EN300-95698_1_3
|
|
C[C@@H]1CC(=O)NC[C@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
6.6
± 0.2
|
3548 |
EN300-69368_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCOCC5)O |
−9.1
± 0.3
|
6.6
± 0.2
|
3549 |
DAR-DIA-0d514e7d-3_1
|
|
CC1(COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)C |
−9.1
± 0.2
|
6.6
± 0.2
|
3550 |
EN300-54541_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H]5CCC(=O)N5 |
−9.1
± 0.3
|
6.6
± 0.3
|
3551 |
EN300-127156_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(no5)C(=O)N |
−9.1
± 0.3
|
6.6
± 0.2
|
3552 |
EN300-30768_3_3
|
|
C[C@@H]1C[C@H]1C(=O)NCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3553 |
EN300-315854_3_2
|
|
C[C@]1(CCNC(=O)C1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3554 |
EN300-7436306_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5[C@H]6COC[C@H]6ON5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3555 |
EN300-299920_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H](C([C@H](C5)O)O)O |
−9.1
± 0.5
|
6.6
± 0.3
|
3556 |
EN300-299215_3_1
|
|
C[C@H]1[C@H](OCCO1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3557 |
EN300-1654606_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5C[C@@H]5F |
−9.1
± 0.1
|
6.6
± 0.1
|
3558 |
EN300-249764_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H](C5CCC5)O |
−9.1
± 0.3
|
6.6
± 0.2
|
3559 |
EDG-MED-ba1ac7b9-15
|
|
CC1CN(CCN1C(=O)CC2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.1
± 0.3
|
6.6
± 0.2
|
3560 |
EDG-MED-90036822-64
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CN(C5)CC(F)F |
−9.1
± 0.3
|
6.6
± 0.2
|
3561 |
DAR-DIA-0cde14eb-53
|
|
c1ccc2c(c1)cncc2NC(=O)Nc3cccc(c3)C4(CC4)I |
−9.1
± 0.3
|
6.6
± 0.2
|
3562 |
EN300-92031_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5nc(no5)c6[nH]ncn6 |
−9.1
± 0.3
|
6.6
± 0.2
|
3563 |
EN300-103144_1_1
|
|
CSCC[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.1
± 0.3
|
6.6
± 0.2
|
3564 |
VLA-UCB-34f3ed0c-21_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)C(=O)CC[C@H]5CC(=O)NC5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3565 |
EN300-117931_2_1
|
|
CC(C)(CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.1
± 0.3
|
6.6
± 0.2
|
3566 |
EN300-717276_3_1
|
|
CCn1cc(nn1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3567 |
EN300-174668_4_2
|
|
CO[C@]1(CCOC1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.4
|
6.6
± 0.3
|
3568 |
EN300-203293_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC[C@@H]5CNC(=O)O5 |
−9.1
± 0.4
|
6.6
± 0.3
|
3569 |
EN300-220194_3_4
|
|
C[C@H]([C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)OC |
−9.1
± 0.3
|
6.6
± 0.3
|
3570 |
EN300-251396_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@](C5)(CO)O |
−9.1
± 0.5
|
6.6
± 0.4
|
3571 |
EN300-300088_2_1
|
|
CCn1cc(nn1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
6.6
± 0.2
|
3572 |
EN300-220194_4_2
|
|
C[C@H]([C@@H](C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)OC |
−9.1
± 0.3
|
6.6
± 0.2
|
3573 |
EN300-1588907_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5[C@H]6CCO[C@H]6C[C@H]5CO |
−9.1
± 0.3
|
6.6
± 0.2
|
3574 |
EN300-45049_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5CCS(=O)(=O)N5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3575 |
MAT-POS-8a69d52e-4
|
|
CC1COc2ccc(cc2C1C(=O)Nc3cncc4c3cccc4)Cl |
−9.09
± 0.06
|
6.62
± 0.04
|
3576 |
EN300-43972_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5[nH]ncn5 |
−9.1
± 0.2
|
6.6
± 0.1
|
3577 |
EN300-65414_3_1
|
|
CC(=O)NC(C)(C)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
6.6
± 0.2
|
3578 |
EN300-205616_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC[C@@H]5c6[nH]ncn6 |
−9.1
± 0.3
|
6.6
± 0.2
|
3579 |
EN300-268198_4_2
|
|
C[C@H](CC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−9.1
± 0.3
|
6.6
± 0.3
|
3580 |
EN300-6953121_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5C[C@H]5F |
−9.1
± 0.2
|
6.6
± 0.1
|
3581 |
EN300-62192_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CC(=O)NC(=O)C5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3582 |
EN300-124918_2_1
|
|
CN1C(=O)NC(N1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3583 |
EN300-30458_3_1
|
|
CN1CC[C@@H](CC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3584 |
EDG-MED-ba1ac7b9-4
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)N6CCC(C6)O |
−9.1
± 0.2
|
6.6
± 0.1
|
3585 |
EN300-1709745_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5cn(nn5)C6COC6 |
−9.1
± 0.2
|
6.6
± 0.2
|
3586 |
EN300-253187_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@@H]5COCO5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3587 |
EN300-52467_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCOCCO |
−9.1
± 0.1
|
6.6
± 0.1
|
3588 |
EN300-85760_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CCO5 |
−9.1
± 0.2
|
6.6
± 0.1
|
3589 |
EN300-332601_1_1
|
|
CC[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−9.1
± 0.2
|
6.6
± 0.2
|
3590 |
EN300-305294_1_7
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6C[C@H]([C@H]6C5)O |
−9.1
± 0.3
|
6.6
± 0.2
|
3591 |
FRA-DIA-13af2da5-2
|
|
CN(C)c1ccc(cc1)[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
6.6
± 0.1
|
3592 |
EN300-204935_2_1
|
|
Cn1ncc(n1)C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3593 |
EN300-311920_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@]5(CCS(=O)(=O)C5)F |
−9.1
± 0.3
|
6.6
± 0.2
|
3594 |
EN300-103219_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CC(=O)N5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3595 |
EN300-60033_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)COC[C@H]5CCCO5 |
−9.1
± 0.3
|
6.6
± 0.2
|
3596 |
EDJ-MED-d203f206-28
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCN(CC5)c6[nH]ncn6 |
−9.1
± 0.3
|
6.6
± 0.2
|
3597 |
CHO-MSK-5891c1ff-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCC[C@@H](C5)C(=O)N |
−9.1
± 0.3
|
6.6
± 0.2
|
3598 |
EN300-7434114_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(C5)[C@@H](CCCO6)O |
−9.1
± 0.2
|
6.6
± 0.2
|
3599 |
EN300-7445396_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5Cc6c[nH]cc6S5(=O)=O |
−9.1
± 0.5
|
6.6
± 0.4
|
3600 |
EDJ-MED-d203f206-18
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5nccnn5 |
−9.1
± 0.3
|
6.6
± 0.2
|