Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
301 |
EN300-246248_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]5CCNC5=O |
−11.7
± 0.3
|
8.5
± 0.2
|
302 |
EN300-62574_3_1
|
|
Cn1c(nnn1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
8.5
± 0.2
|
303 |
EN300-80522_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COC[C@@H]5CCOC5 |
−11.7
± 0.2
|
8.5
± 0.2
|
304 |
EN300-7433864_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c[nH]c(=O)n(c5=O)C6CC6 |
−11.7
± 0.3
|
8.5
± 0.2
|
305 |
EN300-1267109_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(cn[nH]5)C#N |
−11.7
± 0.2
|
8.5
± 0.1
|
306 |
EN300-179091_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COC(F)F |
−11.7
± 0.2
|
8.5
± 0.1
|
307 |
VLA-UCB-34f3ed0c-3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)C(=O)NCc5ccn[nH]5 |
−11.7
± 0.3
|
8.5
± 0.2
|
308 |
EN300-373552_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cncc(n5)F |
−11.7
± 0.2
|
8.5
± 0.1
|
309 |
EN300-12067_1_1
|
|
Cc1csc(=O)n1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
8.5
± 0.2
|
310 |
EN300-64193_3_1
|
|
Cc1nnc(o1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
8.5
± 0.2
|
311 |
EN300-220228_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc6cc[nH]n6c5=O |
−11.7
± 0.3
|
8.5
± 0.2
|
312 |
EN300-186929_1_1
|
|
Cc1c(nc[nH]1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|
8.5
± 0.2
|
313 |
EN300-211777_1_1
|
|
CC(=O)N1CCC[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
8.5
± 0.2
|
314 |
EN300-98648_3_2
|
|
CN1CC[C@H](C1=O)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|
8.5
± 0.1
|
315 |
EN300-09325_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccccc5n6cnnn6 |
−11.7
± 0.3
|
8.5
± 0.2
|
316 |
EN300-805037_1_1
|
|
Cn1c2cc(c(=O)[nH]c2cn1)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.7
± 0.3
|
8.5
± 0.2
|
317 |
CHO-MSK-5891c1ff-3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCN5CCOC5=O |
−11.7
± 0.2
|
8.5
± 0.2
|
318 |
EN300-79022_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccnn5 |
−11.7
± 0.2
|
8.5
± 0.1
|
319 |
EN300-6494158_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5C[C@@H](CO5)CO |
−11.7
± 0.3
|
8.5
± 0.2
|
320 |
EN300-247428_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CC6CC6 |
−11.7
± 0.2
|
8.5
± 0.2
|
321 |
EN300-7443878_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](C5CCOCC5)O |
−11.7
± 0.2
|
8.5
± 0.2
|
322 |
EN300-7461217_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@H]([C@@H](C5)F)O |
−11.7
± 0.3
|
8.5
± 0.2
|
323 |
EN300-00271_3_1
|
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−11.7
± 0.3
|
8.5
± 0.2
|
324 |
EN300-6277108_3_2
|
|
CO[C@H]([C@@H]1CCCO1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.4
|
8.5
± 0.3
|
325 |
EN300-188174_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6c(n5)[nH]c(=O)o6 |
−11.7
± 0.2
|
8.5
± 0.2
|
326 |
GIA-UNK-80c9bc96-1
|
|
c1ccc2c(c1)cncc2N3CCC(C3=O)c4cccc(c4)Cl |
−11.7
± 0.3
|
8.5
± 0.2
|
327 |
EN300-85853_1_1
|
|
Cc1cc(=O)c(c[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
8.5
± 0.2
|
328 |
EN300-373476_1_1
|
|
C[C@@]1(CCCS1(=O)=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
8.5
± 0.2
|
329 |
EDJ-MED-6864a934-5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnn5CC#N |
−11.6
± 0.2
|
8.5
± 0.2
|
330 |
EN300-322400_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@H](OCCO5)C(F)(F)F |
−11.6
± 0.2
|
8.5
± 0.2
|
331 |
EN300-304695_1_2
|
|
CN1CCCC[C@H](C1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.3
|
8.5
± 0.2
|
332 |
EN300-120119_1_1
|
|
CN([C@@H]1CCNC1=O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.2
|
8.5
± 0.2
|
333 |
EN300-185378_3_1
|
|
C[C@@H](COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.6
± 0.3
|
8.5
± 0.2
|
334 |
MIC-UNK-50cce87d-12
|
|
COc1cccc2c1c(cnc2)N3CCCC(C3=O)c4cccc(c4)Cl |
−11.6
± 0.2
|
8.5
± 0.2
|
335 |
EN300-1244816_1_1
|
|
Cc1nnnn1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.2
|
8.5
± 0.2
|
336 |
EN300-6744028_1_7
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@@H]6C[C@H]5[C@H]([C@H]6O)O |
−11.6
± 0.3
|
8.5
± 0.2
|
337 |
EN300-244909_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCOCC5)CO |
−11.6
± 0.3
|
8.5
± 0.2
|
338 |
EN300-209316_1_1
|
|
Cn1c(ncn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.2
|
8.5
± 0.2
|
339 |
EN300-77520_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COC5CCOCC5 |
−11.6
± 0.2
|
8.5
± 0.2
|
340 |
EN300-373435_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5C[C@H]6CC[C@@H](C5)S6(=O)=O |
−11.6
± 0.3
|
8.5
± 0.2
|
341 |
DAR-DIA-23e5a6a0-3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4O[C@@H]5CC6([NH2+]5)COC6)Cl |
−11.6
± 0.3
|
8.5
± 0.2
|
342 |
EN300-254854_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@H]5N(=O)=O |
−11.6
± 0.2
|
8.5
± 0.1
|
343 |
EN300-191904_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCn5cnnn5 |
−11.6
± 0.3
|
8.5
± 0.3
|
344 |
EN300-105693_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(COC5)CO |
−11.6
± 0.3
|
8.5
± 0.2
|
345 |
EN300-80083_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCCC(=O)N5 |
−11.6
± 0.3
|
8.5
± 0.2
|
346 |
EN300-79497_1_1
|
|
Cn1cc(c(=O)n(c1=O)C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.4
|
8.5
± 0.3
|
347 |
EN300-56202_1_1
|
|
CC(=O)N1CSC[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.4
|
8.5
± 0.3
|
348 |
EN300-185378_3_2
|
|
C[C@H](COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.6
± 0.3
|
8.5
± 0.2
|
349 |
EN300-6736413_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCO[C@@H]5CCNC5=O |
−11.6
± 0.2
|
8.5
± 0.1
|
350 |
EN300-300217_1_1
|
|
C/C=C\[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.6
± 0.3
|
8.5
± 0.2
|
351 |
CHO-MSK-5891c1ff-1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5C[C@H](CO5)CO |
−11.6
± 0.3
|
8.4
± 0.2
|
352 |
EN300-178876_1_2
|
|
C[C@]1(CCCNC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.4
|
8.4
± 0.3
|
353 |
EN300-341337_1_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@]56CCO[C@H]5CCOC6 |
−11.6
± 0.3
|
8.4
± 0.2
|
354 |
EN300-6494158_3_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]5C[C@H](CO5)CO |
−11.6
± 0.3
|
8.4
± 0.2
|
355 |
EN300-6737762_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCCNC5=O |
−11.6
± 0.2
|
8.4
± 0.2
|
356 |
EN300-171766_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5n[nH]c(=O)s5 |
−11.6
± 0.2
|
8.4
± 0.2
|
357 |
EN300-702756_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CS(=O)(=O)CC(=O)N5 |
−11.6
± 0.3
|
8.4
± 0.2
|
358 |
EN300-1248064_1_1
|
|
CC(C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnnn5 |
−11.6
± 0.2
|
8.4
± 0.2
|
359 |
EN300-04520_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc(c5)S(=O)(=O)N |
−11.6
± 0.3
|
8.4
± 0.2
|
360 |
EN300-126104_1_1
|
|
Cc1cccn(c1=O)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.3
|
8.4
± 0.2
|
361 |
EN300-6479181_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC[C@@H]6N5C(=O)CC6 |
−11.6
± 0.4
|
8.4
± 0.3
|
362 |
EDG-MED-ba1ac7b9-6
|
|
CC(C)N(CC#N)C(=O)CC1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.6
± 0.3
|
8.4
± 0.2
|
363 |
EN300-6736394_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@]56C[C@@H](CCO5)OC6 |
−11.6
± 0.3
|
8.4
± 0.2
|
364 |
EN300-1608590_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5[NH2+][C@@H](ON5)[NH+]6CCOCC6 |
−11.6
± 0.4
|
8.4
± 0.3
|
365 |
EN300-315963_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5cnoc5 |
−11.6
± 0.3
|
8.4
± 0.2
|
366 |
EN300-220194_1_4
|
|
C[C@H]([C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)OC |
−11.6
± 0.3
|
8.4
± 0.2
|
367 |
EN300-1073264_1_1
|
|
Cn1cc(nn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.2
|
8.4
± 0.2
|
368 |
EN300-207765_3_2
|
|
CN1[C@H](CCC1=O)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.2
|
8.4
± 0.2
|
369 |
EN300-7355981_1_1
|
|
Cn1c2c(c(n1)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)nc[nH]c2=O |
−11.6
± 0.3
|
8.4
± 0.2
|
370 |
EN300-317082_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC5COC5 |
−11.6
± 0.2
|
8.4
± 0.2
|
371 |
EN300-14767_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCN(C5)C(=O)N |
−11.6
± 0.4
|
8.4
± 0.3
|
372 |
EN300-203293_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5CNC(=O)O5 |
−11.6
± 0.3
|
8.4
± 0.2
|
373 |
EN300-90142_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCC[C@H](C5)C(=O)N |
−11.6
± 0.3
|
8.4
± 0.2
|
374 |
EN300-1644723_3_6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5[C@@H]6[C@H]5COCC6 |
−11.5
± 0.3
|
8.4
± 0.2
|
375 |
EN300-83280_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CNC(=O)c5ccccn5 |
−11.5
± 0.3
|
8.4
± 0.2
|
376 |
EN300-205635_1_1
|
|
COC(=O)COCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.5
± 0.2
|
8.4
± 0.2
|
377 |
EN300-315854_1_1
|
|
C[C@@]1(CCNC(=O)C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.3
|
8.4
± 0.2
|
378 |
EN300-33513_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CSCC(=O)N |
−11.5
± 0.2
|
8.4
± 0.2
|
379 |
EDJ-MED-d203f206-29
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CCNC5=O |
−11.5
± 0.3
|
8.4
± 0.2
|
380 |
EN300-128464_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC(=O)NC5CC5 |
−11.5
± 0.4
|
8.4
± 0.3
|
381 |
MAT-POS-9db1e783-3
|
|
COC(=O)/C=C/C(=O)N(c1cncc2c1cccc2)C(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−11.5
± 0.4
|
8.4
± 0.3
|
382 |
EN300-13890_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CS[C@H]5CCS(=O)(=O)C5 |
−11.5
± 0.3
|
8.4
± 0.2
|
383 |
EN300-148421_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@]5(CCOC5)O |
−11.5
± 0.4
|
8.4
± 0.3
|
384 |
EN300-1696043_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)C6COC6 |
−11.5
± 0.2
|
8.4
± 0.2
|
385 |
EN300-190283_1_2
|
|
Cn1cncc1[C@H](C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−11.5
± 0.3
|
8.4
± 0.3
|
386 |
EN300-80522_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COC[C@H]5CCOC5 |
−11.5
± 0.2
|
8.4
± 0.2
|
387 |
EN300-107435_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCCS5(=O)=O |
−11.5
± 0.3
|
8.4
± 0.2
|
388 |
EN300-191915_3_1
|
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnnn5 |
−11.5
± 0.3
|
8.4
± 0.2
|
389 |
EN300-6744028_1_8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[C@@H]6C[C@H]5[C@H]([C@H]6O)O |
−11.5
± 0.3
|
8.4
± 0.2
|
390 |
EN300-1590388_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(cn5)C#N |
−11.5
± 0.2
|
8.4
± 0.2
|
391 |
EN300-10334_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@]56CCC(=O)N5CCS6 |
−11.5
± 0.4
|
8.4
± 0.3
|
392 |
EN300-6487680_1_1
|
|
Cc1nnn(n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.2
|
8.4
± 0.2
|
393 |
EDJ-MED-d203f206-5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CCO)c5ccncn5 |
−11.5
± 0.4
|
8.4
± 0.3
|
394 |
EN300-55072_3_2
|
|
C[C@H](CO)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.5
± 0.3
|
8.4
± 0.2
|
395 |
EN300-373476_3_2
|
|
C[C@]1(CCCS1(=O)=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.4
|
8.4
± 0.3
|
396 |
EN300-114082_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)C#N |
−11.5
± 0.3
|
8.4
± 0.2
|
397 |
EN300-72211_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](C5CC5)O |
−11.5
± 0.2
|
8.4
± 0.2
|
398 |
EN300-1726277_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H](n5cccn5)F |
−11.5
± 0.2
|
8.4
± 0.2
|
399 |
EN300-253571_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCc6nnnn6CC5 |
−11.5
± 0.2
|
8.4
± 0.2
|
400 |
MIC-UNK-50cce87d-10
|
|
c1cc(cc(c1)Cl)C2CCCN(C2=O)c3cncc4c3c(ccc4)Cl |
−11.5
± 0.2
|
8.4
± 0.2
|