Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
2801 |
DAR-DIA-5ff57136-18_1
|
|
c1ccc2c(c1)cncc2N(C(=O)[C@@H]3CCOc4c3cc(cc4)Cl)NC=S |
−9.6
± 0.1
|
6.97
± 0.09
|
2802 |
EN300-66764_1_4
|
|
COC(=O)[C@H]1C[C@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.3
|
7.0
± 0.2
|
2803 |
EN300-312450_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc(n5)N6CCOCC6 |
−9.6
± 0.3
|
7.0
± 0.2
|
2804 |
EN300-366278_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(=O)NCC56COC6 |
−9.6
± 0.3
|
7.0
± 0.2
|
2805 |
EN300-33478_3_1
|
|
CCN1C[C@@H](CC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.3
|
7.0
± 0.3
|
2806 |
EN300-1588613_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CC[N@@H+]6[C@@H]5COCC6 |
−9.6
± 0.3
|
7.0
± 0.2
|
2807 |
EN300-253462_3_1
|
|
CN(C)C(=O)[C@@H]1C[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.4
|
7.0
± 0.3
|
2808 |
MAT-POS-de59a476-5
|
|
c1ccc2c(c1)cncc2NC(=O)C(c3ccc(c(c3)Cl)Cl)OCCO |
−9.6
± 0.2
|
7.0
± 0.2
|
2809 |
EN300-7432302_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@]56CC[C@H](C5)[C@@H]([C@@H]6O)O |
−9.6
± 0.3
|
7.0
± 0.2
|
2810 |
EN300-65839_2_2
|
|
CC[C@H](C(=O)N)OC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.6
± 0.2
|
7.0
± 0.2
|
2811 |
EN300-66082_3_1
|
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C5CCC5 |
−9.6
± 0.3
|
7.0
± 0.3
|
2812 |
DAR-DIA-0d514e7d-30_1
|
|
C[C@@]1(c2cc(ccc2OCC1(C)C)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.6
± 0.3
|
7.0
± 0.2
|
2813 |
EN300-148421_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@]5(CCOC5)O |
−9.6
± 0.3
|
7.0
± 0.2
|
2814 |
EDG-MED-90036822-39
|
|
CC(CO)NCC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(F)F |
−9.6
± 0.3
|
7.0
± 0.2
|
2815 |
EN300-101197_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCc5[nH]ncn5 |
−9.6
± 0.3
|
7.0
± 0.2
|
2816 |
EN300-78368_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCCCC5)NC(=O)N |
−9.6
± 0.3
|
7.0
± 0.2
|
2817 |
EN300-51961_1_1
|
|
CC[C@@H](C)C(=O)NCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.6
± 0.3
|
7.0
± 0.2
|
2818 |
EN300-2923949_1_3
|
|
c1ccc(cc1)[C@@H]([C@H](C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O)O |
−9.6
± 0.3
|
7.0
± 0.2
|
2819 |
EN300-220194_1_3
|
|
C[C@@H]([C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)OC |
−9.6
± 0.3
|
7.0
± 0.2
|
2820 |
EDG-MED-4c68219f-6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N |
−9.6
± 0.2
|
7.0
± 0.1
|
2821 |
EN300-360157_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[C@]5(CCOC5)O |
−9.6
± 0.3
|
7.0
± 0.2
|
2822 |
EN300-25572_3_1
|
|
C[C@@H]1CN(CCO1)C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.3
|
7.0
± 0.2
|
2823 |
EN300-128715_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC(=O)NCC(F)(F)F |
−9.6
± 0.3
|
7.0
± 0.2
|
2824 |
EN300-157776_1_4
|
|
C[C@H]1CN(C[C@H](O1)CO)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.4
|
7.0
± 0.3
|
2825 |
EN300-367589_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(=O)NCC56COC6 |
−9.6
± 0.3
|
7.0
± 0.2
|
2826 |
EN300-203293_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@H]5CNC(=O)O5 |
−9.5
± 0.3
|
7.0
± 0.2
|
2827 |
EDJ-MED-7320d5d2-1
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)OC4CC(=O)N4 |
−9.5
± 0.4
|
7.0
± 0.3
|
2828 |
EN300-1425608_1_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@H](C5)CO)CCO |
−9.5
± 0.3
|
7.0
± 0.2
|
2829 |
EN300-01527_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NC[C@H]5CCCO5 |
−9.5
± 0.3
|
7.0
± 0.2
|
2830 |
EDG-MED-90036822-28
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.5
± 0.2
|
7.0
± 0.2
|
2831 |
EN300-195756_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@@H]5CCC(=O)N5 |
−9.5
± 0.2
|
7.0
± 0.2
|
2832 |
EN300-25572_3_2
|
|
C[C@H]1CN(CCO1)C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
7.0
± 0.2
|
2833 |
EN300-97300_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@@H]5F |
−9.5
± 0.2
|
7.0
± 0.1
|
2834 |
EN300-20980_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5cnnn5 |
−9.5
± 0.3
|
7.0
± 0.2
|
2835 |
EN300-22880_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N5CCC[C@@H](C5)C(=O)N |
−9.5
± 0.4
|
7.0
± 0.3
|
2836 |
EN300-118869_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H](C5)NC(=O)N |
−9.5
± 0.3
|
7.0
± 0.2
|
2837 |
EN300-122340_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCSCC5)O |
−9.5
± 0.3
|
7.0
± 0.3
|
2838 |
EN300-58433_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc(c5)n6cncn6 |
−9.5
± 0.4
|
7.0
± 0.3
|
2839 |
EN300-195756_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@H]5CCC(=O)N5 |
−9.5
± 0.3
|
7.0
± 0.2
|
2840 |
EN300-211482_4_1
|
|
C[C@@H](C(=O)NC)OCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.5
|
7.0
± 0.3
|
2841 |
EN300-6763507_1_1
|
|
CO[C@@H]1C[C@@H](CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.5
± 0.3
|
6.9
± 0.2
|
2842 |
EN300-785910_1_1
|
|
COCc1c(n[nH]n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
2843 |
VLA-UNK-f702bf1c-5
|
|
c1ccc2c(c1)cncc2N3C(=O)[C@@]4(CCOc5c4cc(cc5)Cl)N(C3=O)CC6CCC(=O)NC6 |
−9.5
± 0.3
|
6.9
± 0.2
|
2844 |
EN300-217494_4_2
|
|
C[C@]([C@@H]1CCOC1)(C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.5
± 0.4
|
6.9
± 0.3
|
2845 |
JOH-UNI-6fede743-5
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2c3cc(ccc3cnc2C(F)F)F |
−9.5
± 0.4
|
6.9
± 0.3
|
2846 |
EN300-244713_1_1
|
|
CO[C@H]1C[C@H](N(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−9.5
± 0.3
|
6.9
± 0.2
|
2847 |
EN300-53423_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCOC5 |
−9.5
± 0.3
|
6.9
± 0.2
|
2848 |
ALP-POS-2da19ca7-7
|
|
CC1CN(CCC1NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)C |
−9.5
± 0.2
|
6.9
± 0.2
|
2849 |
EN300-107493_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CCNC(=O)C5 |
−9.5
± 0.3
|
6.9
± 0.2
|
2850 |
EN300-783124_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]([C@@H]5CCOC5)F |
−9.5
± 0.2
|
6.9
± 0.1
|
2851 |
EN300-54304_4_1
|
|
CCOCCOCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.4
|
6.9
± 0.3
|
2852 |
EN300-6478631_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCCc6n5cnn6 |
−9.5
± 0.3
|
6.9
± 0.2
|
2853 |
EN300-1699871_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]5CCS(=O)(=O)N5 |
−9.5
± 0.3
|
6.9
± 0.2
|
2854 |
EN300-107823_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCn5ncnn5 |
−9.5
± 0.2
|
6.9
± 0.2
|
2855 |
EN300-18610_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@H](C5)C(=O)N |
−9.5
± 0.5
|
6.9
± 0.3
|
2856 |
MAK-UNK-8be7dca9-5_1
|
|
c1cc2c(cc1C[NH3+])cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−9.5
± 0.1
|
6.94
± 0.08
|
2857 |
EN300-7102031_1_1
|
|
COCC(CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)COC |
−9.5
± 0.3
|
6.9
± 0.2
|
2858 |
EN300-120119_2_2
|
|
CN([C@H]1CCNC1=O)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
6.9
± 0.2
|
2859 |
EN300-6746918_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CC(C5)(CO)F |
−9.5
± 0.4
|
6.9
± 0.3
|
2860 |
EN300-97300_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@H]5F |
−9.5
± 0.2
|
6.9
± 0.1
|
2861 |
KAD-UNI-8a629cb0-32
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5[C@@H]6[C@@H]5CS(=O)(=O)C6 |
−9.5
± 0.3
|
6.9
± 0.2
|
2862 |
EN300-14752_1_2
|
|
CC(=O)N1CCC[C@H](C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
2863 |
JOH-UNI-3fc3434e-8
|
|
c1ccc2c(c1)cnc(c2NC(=O)Cc3cccc(c3)Cl)C#N |
−9.5
± 0.3
|
6.9
± 0.2
|
2864 |
VLA-UNK-56836b69-1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CC(=O)Nc4c3cc(c(c4)Cl)Cl |
−9.5
± 0.4
|
6.9
± 0.3
|
2865 |
EN300-114805_1_1
|
|
Cn1c(ccn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
6.9
± 0.1
|
2866 |
EN300-103187_2_1
|
|
CCOCCNC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.3
|
6.9
± 0.2
|
2867 |
EN300-360157_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@]5(CCOC5)O |
−9.5
± 0.3
|
6.9
± 0.2
|
2868 |
EN300-248888_1_1
|
|
C[C@@](C=C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.5
± 0.3
|
6.9
± 0.2
|
2869 |
EN300-7444950_1_1
|
|
COc1cc(ncn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
2870 |
EN300-21258_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCO |
−9.5
± 0.2
|
6.9
± 0.1
|
2871 |
EN300-1268016_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@H]6[C@@H]5C[C@@H](C6)C(=O)N |
−9.5
± 0.3
|
6.9
± 0.2
|
2872 |
EN300-43206_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[N@]5CCCS5(=O)=O |
−9.5
± 0.3
|
6.9
± 0.3
|
2873 |
EN300-05754_3_1
|
|
C[C@@H](C(=O)N1CCOCC1)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.4
|
6.9
± 0.3
|
2874 |
EN300-53918_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCN5CCOC5=O |
−9.5
± 0.2
|
6.9
± 0.2
|
2875 |
MAT-POS-53907a1c-3
|
|
c1ccc2c(c1)cncc2NC(=O)N(CCC3CCCCC3)c4cc(cc(c4)Cl)OC5CC(=O)N5 |
−9.52
± 0.07
|
6.93
± 0.05
|
2876 |
VLA-UCB-34f3ed0c-10
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCc5cc[nH]n5 |
−9.5
± 0.3
|
6.9
± 0.2
|
2877 |
EN300-173562_1_1
|
|
C[C@@H]1C[C@@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.5
± 0.3
|
6.9
± 0.2
|
2878 |
EN300-1664603_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCc5ccn[nH]5 |
−9.5
± 0.2
|
6.9
± 0.2
|
2879 |
EN300-122656_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@]5(CCSC5)O |
−9.5
± 0.4
|
6.9
± 0.3
|
2880 |
EN300-244744_1_1
|
|
Cn1ncc(n1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
2881 |
EN300-196320_1_1
|
|
CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
6.9
± 0.2
|
2882 |
DAR-DIA-0d514e7d-14_1
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)c5cccc(c5F)F |
−9.5
± 0.2
|
6.9
± 0.1
|
2883 |
EN300-188217_3_1
|
|
CC(C)(CS(=O)(=O)C)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.5
|
6.9
± 0.3
|
2884 |
EN300-110423_3_1
|
|
Cc1c(c(=O)[nH]o1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
2885 |
EDJ-MED-d203f206-11
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5nnnn5C6CC6 |
−9.5
± 0.3
|
6.9
± 0.2
|
2886 |
EN300-30480_1_1
|
|
Cn1ccc(cc1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
6.9
± 0.2
|
2887 |
EN300-1262640_4_1
|
|
CC(C)NC(=O)C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.3
|
6.9
± 0.2
|
2888 |
EN300-7444533_1_4
|
|
C[C@H]1C[C@H](C(=O)O1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
6.9
± 0.2
|
2889 |
EN300-743350_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC6(C5)CCNC6=O |
−9.5
± 0.3
|
6.9
± 0.2
|
2890 |
EDG-MED-90036822-38
|
|
CC(CNCC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(F)F)O |
−9.5
± 0.3
|
6.9
± 0.2
|
2891 |
EN300-2908024_1_1
|
|
CC[C@@](C)(C(=O)N)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.3
|
6.9
± 0.2
|
2892 |
EN300-1627945_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CO[C@@H]5CCCOC5 |
−9.5
± 0.2
|
6.9
± 0.2
|
2893 |
EN300-19542_2_2
|
|
C[C@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.5
± 0.3
|
6.9
± 0.2
|
2894 |
EN300-296237_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H](CO)C(F)(F)F |
−9.5
± 0.5
|
6.9
± 0.4
|
2895 |
EN300-1911992_3_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]([C@H]5CCOC5)O |
−9.5
± 0.4
|
6.9
± 0.3
|
2896 |
MIC-UNK-cdc2493e-4
|
|
c1ccc2c(c1)cncc2NC(=O)N(c3cccc(c3)Cl)C4CC5CCCC5C4 |
−9.5
± 0.3
|
6.9
± 0.2
|
2897 |
JOH-UNI-f51e3bbc-4_1
|
|
COc1c(c2ccccc2cn1)NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−9.5
± 0.1
|
6.92
± 0.09
|
2898 |
MAT-POS-fce787c2-2
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)Cl |
−9.5
± 0.2
|
6.9
± 0.2
|
2899 |
EN300-41473_1_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)[NH+]5CCOCC5 |
−9.5
± 0.4
|
6.9
± 0.3
|
2900 |
EN300-6736515_2_1
|
|
C[C@@H]([C@@H]1COCCO1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|