Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
2601 |
EDG-MED-90036822-69
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CC[C@@](C5)(CN)F |
−9.7
± 0.4
|
7.1
± 0.3
|
2602 |
EN300-301690_1_1
|
|
CS(=O)(=O)[N@]1CC[C@@H](C1)O[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2603 |
EN300-120562_1_1
|
|
C[C@@H]1C[N@@H+]2CC[N@H+]1[C@@H](C2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.7
± 0.4
|
7.1
± 0.3
|
2604 |
EN300-41366_1_1
|
|
Cc1nc(n(n1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.7
± 0.3
|
7.1
± 0.2
|
2605 |
EN300-201346_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5COC(=O)N5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2606 |
EN300-151423_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CCOCC5)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2607 |
EN300-722418_1_2
|
|
C[C@H](CN(C[C@@H](C)O)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.7
± 0.4
|
7.1
± 0.3
|
2608 |
EN300-219531_1_1
|
|
CCC[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.7
± 0.3
|
7.1
± 0.3
|
2609 |
EN300-317082_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC5COC5 |
−9.7
± 0.2
|
7.0
± 0.1
|
2610 |
EN300-10895_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NCCC#N |
−9.7
± 0.3
|
7.0
± 0.2
|
2611 |
EN300-17381_1_2
|
|
C[C@H](C(=O)N)O[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.1
|
7.05
± 0.09
|
2612 |
EN300-210553_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@](C5)(C(=O)N)O |
−9.7
± 0.4
|
7.0
± 0.3
|
2613 |
EN300-50561_1_1
|
|
Cc1nnc2n1C[C@@H](CC2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.7
± 0.3
|
7.0
± 0.2
|
2614 |
EDJ-MED-e4b030d8-11_1
|
|
C[C@H]1COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−9.67
± 0.06
|
7.05
± 0.04
|
2615 |
EN300-218116_2_1
|
|
CC(CO)(CO)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.4
|
7.0
± 0.3
|
2616 |
DAR-DIA-5ff57136-9_1
|
|
COC(=O)/C=C/C(=O)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−9.7
± 0.3
|
7.0
± 0.2
|
2617 |
EN300-1605226_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)CNC(=O)N6 |
−9.7
± 0.2
|
7.0
± 0.2
|
2618 |
EN300-90142_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CCC[C@@H](C5)C(=O)N |
−9.7
± 0.3
|
7.0
± 0.2
|
2619 |
EN300-143564_1_2
|
|
CN1C(SCC1=O)[CH-]C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.2
|
7.0
± 0.1
|
2620 |
EN300-100689_1_2
|
|
CC(=O)N1CCO[C@H](C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.0
± 0.2
|
2621 |
EN300-6744028_2_7
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5C[C@@H]6C[C@H]5[C@H]([C@H]6O)O |
−9.7
± 0.3
|
7.0
± 0.2
|
2622 |
EN300-64247_3_1
|
|
CC(C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)[NH+]5CCOCC5 |
−9.7
± 0.5
|
7.0
± 0.3
|
2623 |
EN300-1694056_1_1
|
|
CC1([C@@H](CC(=O)N1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.7
± 0.3
|
7.0
± 0.2
|
2624 |
EN300-118647_2_1
|
|
CN(C)C(=O)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.2
|
7.0
± 0.2
|
2625 |
EN300-332002_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCc6n5c(=O)ccc6 |
−9.7
± 0.4
|
7.0
± 0.3
|
2626 |
EN300-142412_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCCC(=O)N |
−9.7
± 0.3
|
7.0
± 0.2
|
2627 |
EN300-19542_1_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.7
± 0.2
|
7.0
± 0.2
|
2628 |
EN300-261986_1_1
|
|
CS(=O)(=O)[N@]1CC[C@@H](C1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.0
± 0.2
|
2629 |
EN300-98648_1_1
|
|
CN1CC[C@@H](C1=O)O[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.1
|
7.0
± 0.1
|
2630 |
ED_-GRI-5b13fbe2-22
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5CNC[C@H](O5)CO |
−9.7
± 0.4
|
7.0
± 0.3
|
2631 |
EN300-221518_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCCO |
−9.7
± 0.1
|
7.04
± 0.08
|
2632 |
EN300-182913_1_1
|
|
CC(C)(C(=O)N)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.2
|
7.0
± 0.2
|
2633 |
EN300-3710141_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@]5(CCCO5)C#N |
−9.7
± 0.2
|
7.0
± 0.1
|
2634 |
EN300-1706036_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@H]5C(=O)NCCO5 |
−9.7
± 0.2
|
7.0
± 0.2
|
2635 |
ED_-GRI-5b13fbe2-3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(c5[nH]nnn5)N |
−9.7
± 0.3
|
7.0
± 0.2
|
2636 |
EN300-256583_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CS(=O)(=O)C5 |
−9.7
± 0.3
|
7.0
± 0.2
|
2637 |
EN300-6504697_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5CC6(CC6)S(=O)(=O)N5 |
−9.7
± 0.3
|
7.0
± 0.2
|
2638 |
EN300-72896_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCC(=O)N5 |
−9.7
± 0.2
|
7.0
± 0.2
|
2639 |
EN300-259060_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@](C5)(CC(=O)N)O |
−9.7
± 0.4
|
7.0
± 0.3
|
2640 |
EN300-73772_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5NC(=O)NN5 |
−9.7
± 0.3
|
7.0
± 0.2
|
2641 |
MIC-UNK-cdc2493e-19
|
|
CC(C)CCCN(c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3 |
−9.7
± 0.4
|
7.0
± 0.3
|
2642 |
EN300-697519_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCOC5 |
−9.7
± 0.2
|
7.0
± 0.2
|
2643 |
PET-UNK-cf04cb02-1
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)OC4CCN4 |
−9.7
± 0.3
|
7.0
± 0.2
|
2644 |
EDG-MED-90036822-22
|
|
CC(CCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(CN)OCCO |
−9.7
± 0.5
|
7.0
± 0.4
|
2645 |
EN300-103144_3_2
|
|
CSCC[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.7
± 0.3
|
7.0
± 0.3
|
2646 |
MIC-UNK-67d4a29a-4
|
|
CN(c1cncc2c1c(ccc2)OC)C(=O)Cc3cccc(c3)Cl |
−9.7
± 0.3
|
7.0
± 0.2
|
2647 |
DAR-DIA-23e5a6a0-10
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4CC5CC6(N5)CC6)Cl |
−9.7
± 0.2
|
7.0
± 0.2
|
2648 |
EDJ-MED-d08626de-2
|
|
CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.1
|
7.04
± 0.09
|
2649 |
EN300-157776_1_2
|
|
C[C@H]1CN(C[C@@H](O1)CO)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.4
|
7.0
± 0.3
|
2650 |
EN300-237224_1_1
|
|
C[NH+]1CCC(CC1)OCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.0
± 0.2
|
2651 |
EN300-19700_2_1
|
|
COC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.1
|
7.03
± 0.08
|
2652 |
EN300-7436306_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@@H]5[C@H]6COC[C@H]6ON5 |
−9.7
± 0.3
|
7.0
± 0.2
|
2653 |
EN300-33657_1_1
|
|
CC(=O)N(C)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.3
|
7.0
± 0.2
|
2654 |
EN300-11441_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cc(=O)[nH]c(=O)[nH]5 |
−9.7
± 0.3
|
7.0
± 0.2
|
2655 |
EN300-152337_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCC(=O)NCC5 |
−9.7
± 0.3
|
7.0
± 0.2
|
2656 |
EN300-19926_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC#N |
−9.7
± 0.3
|
7.0
± 0.2
|
2657 |
EN300-59478_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCC(=O)N |
−9.7
± 0.4
|
7.0
± 0.3
|
2658 |
EN300-6479181_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CC[C@@H]6N5C(=O)CC6 |
−9.7
± 0.4
|
7.0
± 0.3
|
2659 |
VLA-UNK-56836b69-3
|
|
CN1C(=O)N(C(=O)[C@@]12CCOc3c2cc(c(c3)Cl)Cl)c4cncc5c4cccc5 |
−9.7
± 0.2
|
7.0
± 0.2
|
2660 |
EN300-250501_2_1
|
|
COC[C@@]1(CCOC1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.0
± 0.2
|
2661 |
EN300-195756_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@H]5CCC(=O)N5 |
−9.7
± 0.3
|
7.0
± 0.2
|
2662 |
EN300-1273016_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCc6n5ncn6 |
−9.7
± 0.2
|
7.0
± 0.2
|
2663 |
EN300-18569_1_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−9.7
± 0.2
|
7.0
± 0.2
|
2664 |
EN300-95639_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H]([C@@H](C5)O)CO |
−9.7
± 0.3
|
7.0
± 0.2
|
2665 |
EN300-126555_1_1
|
|
CC(=O)NCCOCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.3
|
7.0
± 0.2
|
2666 |
VLA-UNK-f702bf1c-3
|
|
c1ccc2c(c1)cncc2N3C(=O)[C@@]4(CCOc5c4cc(cc5)Cl)N(C3=O)Cc6nc[nH]n6 |
−9.6
± 0.3
|
7.0
± 0.2
|
2667 |
EN300-20233_2_1
|
|
COCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.6
± 0.2
|
7.0
± 0.2
|
2668 |
CHO-MSK-5891c1ff-5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)[C@@H]5CCS(=O)(=O)C5 |
−9.6
± 0.3
|
7.0
± 0.2
|
2669 |
EN300-195590_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[C@@H]5CCCNC(=O)C5 |
−9.6
± 0.3
|
7.0
± 0.3
|
2670 |
VLA-UCB-05e51b3f-6
|
|
c1ccc2c(c1)cncc2N3C(=O)CC[C@]4(C3=O)CCOc5c4cc(cc5)Cl |
−9.6
± 0.2
|
7.0
± 0.2
|
2671 |
EDG-MED-90036822-13
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CO |
−9.6
± 0.2
|
7.0
± 0.1
|
2672 |
EN300-1723511_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CCC5)CO |
−9.6
± 0.3
|
7.0
± 0.2
|
2673 |
EN300-66845_3_1
|
|
COC(=O)N1CCC[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.3
|
7.0
± 0.2
|
2674 |
EN300-36690_1_1
|
|
Cn1c(=O)ccn(c1=O)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.3
|
7.0
± 0.2
|
2675 |
ED_-GRI-5b13fbe2-53
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5c[nH]nc5 |
−9.6
± 0.2
|
7.0
± 0.2
|
2676 |
EN300-185378_2_1
|
|
C[C@@H](COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.6
± 0.2
|
7.0
± 0.2
|
2677 |
EN300-202757_1_2
|
|
C[C@H](CC(=O)N)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.6
± 0.3
|
7.0
± 0.2
|
2678 |
EN300-108507_1_1
|
|
CO[C@@H]1CN(CCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.3
|
7.0
± 0.2
|
2679 |
EN300-68635_1_1
|
|
CCNC(=O)CCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.6
± 0.3
|
7.0
± 0.2
|
2680 |
EN300-2977549_2_1
|
|
CNC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.6
± 0.1
|
7.02
± 0.09
|
2681 |
EN300-1662365_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCc6ncnn6C5 |
−9.6
± 0.2
|
7.0
± 0.2
|
2682 |
EN300-255496_3_2
|
|
C[N@]1CC[C@H](S1(=O)=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.4
|
7.0
± 0.3
|
2683 |
EN300-261365_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CS(=O)(=O)C5 |
−9.6
± 0.2
|
7.0
± 0.2
|
2684 |
DAR-DIA-23e5a6a0-2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OC5CC6(N5)CCC6)Cl |
−9.6
± 0.2
|
7.0
± 0.2
|
2685 |
EN300-157897_2_1
|
|
CC[C@@H](CO)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.6
± 0.4
|
7.0
± 0.3
|
2686 |
EN300-6473273_3_2
|
|
Cn1c(ccn1)[C@H](C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.6
± 0.3
|
7.0
± 0.2
|
2687 |
EN300-249421_1_4
|
|
C[C@H]([C@H]1CCC(=O)N1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.3
|
7.0
± 0.2
|
2688 |
EN300-214800_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCN5CCNC5=O |
−9.6
± 0.2
|
7.0
± 0.2
|
2689 |
MAK-UNK-c749d764-28
|
|
c1ccc2c(c1)cncc2N(C=O)C(=O)CC3CCCC(C3O)C(F)F |
−9.6
± 0.2
|
7.0
± 0.2
|
2690 |
EN300-17381_4_1
|
|
C[C@@H](C(=O)N)OCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.6
± 0.2
|
7.0
± 0.2
|
2691 |
EN300-304135_3_1
|
|
CC[C@@]1(CCNC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.4
|
7.0
± 0.3
|
2692 |
EN300-1600517_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC[C@@H](CO)F |
−9.6
± 0.5
|
7.0
± 0.4
|
2693 |
DAR-DIA-6a508060-5_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4C[C@@H]5C[C@@H](N5)O)Cl |
−9.6
± 0.3
|
7.0
± 0.2
|
2694 |
JAG-UCB-706446eb-6_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5ccn[nH]5 |
−9.6
± 0.2
|
7.0
± 0.2
|
2695 |
EN300-331993_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)Nc5[nH]ccn5 |
−9.6
± 0.2
|
7.0
± 0.2
|
2696 |
EN300-26147_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCn5cncn5 |
−9.6
± 0.4
|
7.0
± 0.3
|
2697 |
EN300-6478631_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCc6n5cnn6 |
−9.6
± 0.2
|
7.0
± 0.2
|
2698 |
EN300-128750_3_1
|
|
CC(=O)N(C)CCCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.6
± 0.3
|
7.0
± 0.2
|
2699 |
EN300-207959_3_2
|
|
C[C@]1(CCNC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.4
|
7.0
± 0.3
|
2700 |
EN300-1267093_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H]6C[C@@]6(C5)O |
−9.6
± 0.3
|
7.0
± 0.2
|