Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
2501 |
EN300-316679_3_1
|
|
CCC[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.7
± 0.4
|
7.1
± 0.3
|
2502 |
EN300-14628_3_2
|
|
C[N@@H+](CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)[C@H]5CCS(=O)(=O)C5 |
−9.7
± 0.5
|
7.1
± 0.3
|
2503 |
EN300-00904_1_1
|
|
Cc1cc([n+]2c(n1)NC(N2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)C |
−9.7
± 0.3
|
7.1
± 0.2
|
2504 |
EN300-249804_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CCOC(=O)N5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2505 |
EN300-220536_1_1
|
|
CS(=O)(=O)C1(CCOCC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2506 |
EN300-74876_1_1
|
|
CC(=O)N1CC(C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2507 |
DAR-DIA-e7614d05-2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC(F)(F)F |
−9.7
± 0.2
|
7.1
± 0.1
|
2508 |
EDG-MED-ba1ac7b9-8
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)CC(=O)N(CC#N)C5CC5 |
−9.7
± 0.2
|
7.1
± 0.2
|
2509 |
EN300-217494_3_2
|
|
C[C@]([C@@H]1CCOC1)(C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2510 |
EN300-201346_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5COC(=O)N5 |
−9.7
± 0.2
|
7.1
± 0.1
|
2511 |
EN300-38979_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5ccnc5 |
−9.7
± 0.2
|
7.1
± 0.1
|
2512 |
EDG-MED-4c68219f-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5cn(nn5)CCN6CCOCC6 |
−9.7
± 0.4
|
7.1
± 0.3
|
2513 |
EN300-2924757_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(cc5)CC(=O)N |
−9.7
± 0.3
|
7.1
± 0.2
|
2514 |
EN300-1724086_1_2
|
|
C[C@H]1C[C@@H](CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−9.7
± 0.3
|
7.1
± 0.2
|
2515 |
EN300-6489696_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(Cc6ccn[nH]6)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2516 |
EN300-104746_2_2
|
|
CC[C@](C)(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2517 |
EN300-127629_1_1
|
|
C[C@@]1(COCCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−9.7
± 0.3
|
7.1
± 0.2
|
2518 |
EN300-48760_1_1
|
|
CC(C)(C)NC(=O)CNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.4
|
7.1
± 0.3
|
2519 |
EN300-1932780_4_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H](C(F)F)O |
−9.7
± 0.2
|
7.1
± 0.1
|
2520 |
EN300-199359_3_1
|
|
CC(C)[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2521 |
EN300-19515_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCC(=O)N5 |
−9.7
± 0.2
|
7.1
± 0.1
|
2522 |
EN300-115421_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)c5c(cccn5)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2523 |
EN300-100180_3_1
|
|
CC(=O)N1CC[C@@H](C1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.5
|
7.1
± 0.3
|
2524 |
DAR-DIA-0d514e7d-25_1
|
|
C[C@H]1COc2c(cc(cc2OC)Cl)[C@]1(C)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.1
|
7.08
± 0.10
|
2525 |
DAR-DIA-6a508060-5
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4CC5CC(=O)N5)Cl |
−9.7
± 0.1
|
7.1
± 0.1
|
2526 |
EN300-7457160_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5C[C@H](ON5)CC6(COC6)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2527 |
EN300-102901_1_1
|
|
CCC[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−9.7
± 0.2
|
7.1
± 0.2
|
2528 |
EN300-182758_1_1
|
|
Cc1nc(no1)Cn2cc(nn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.7
± 0.3
|
7.1
± 0.2
|
2529 |
EN300-113633_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CCC(=O)NC5=O |
−9.7
± 0.2
|
7.1
± 0.2
|
2530 |
EN300-37077_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5ccn[nH]5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2531 |
EN300-1091444_1_1
|
|
CN(C1COC1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2532 |
EN300-113112_2_1
|
|
Cn1cnnc1COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.2
|
7.1
± 0.2
|
2533 |
EN300-1387243_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCO[C@H]6[C@H]5COCC6 |
−9.7
± 0.3
|
7.1
± 0.2
|
2534 |
EN300-184355_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@H](C(=O)N)O |
−9.7
± 0.4
|
7.1
± 0.3
|
2535 |
EN300-706065_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(C5(CCOCC5)O)(F)F |
−9.7
± 0.3
|
7.1
± 0.3
|
2536 |
EDJ-MED-40433386-8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@]5(CCOC5)C#N |
−9.7
± 0.3
|
7.1
± 0.2
|
2537 |
EN300-1601684_3_1
|
|
CC1([C@@H](OCCO1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.7
± 0.4
|
7.1
± 0.3
|
2538 |
EN300-154332_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H]5CO |
−9.7
± 0.3
|
7.1
± 0.2
|
2539 |
EN300-7471076_1_2
|
|
C[C@H]1[C@@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2540 |
EN300-6473273_1_2
|
|
Cn1c(ccn1)[C@H](C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.7
± 0.2
|
7.1
± 0.1
|
2541 |
EDG-MED-90036822-84
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C#N)(F)F |
−9.7
± 0.2
|
7.1
± 0.2
|
2542 |
EN300-6481287_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)O[C@H]5[C@@H](C[C@H]6[C@@H]5CC6=O)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2543 |
EN300-1710153_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H](C(C5)(F)F)O |
−9.7
± 0.2
|
7.1
± 0.2
|
2544 |
EN300-649743_1_1
|
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)Cn5cnnn5 |
−9.7
± 0.4
|
7.1
± 0.3
|
2545 |
EN300-36390_1_1
|
|
CCOC(=O)NCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.2
|
7.1
± 0.2
|
2546 |
ALP-UNI-dbbfd3db-6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCC(O5)C(=O)N6CCCC6 |
−9.7
± 0.2
|
7.1
± 0.2
|
2547 |
EN300-48902_3_1
|
|
CNC(=O)[C@@H]1CCCN1C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.4
|
7.1
± 0.3
|
2548 |
EN300-248526_2_2
|
|
c1ccc(cc1)[C@](COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(C(=O)N)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2549 |
EN300-107267_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)O[C@@H]5CCCNC5=O |
−9.7
± 0.3
|
7.1
± 0.2
|
2550 |
EN300-148421_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@]5(CCOC5)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2551 |
EN300-98018_3_2
|
|
CC(=O)N1CC[C@](C1)(C)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.4
|
7.1
± 0.3
|
2552 |
EN300-202922_1_4
|
|
C[C@H]([C@](C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2553 |
EN300-1915260_3_2
|
|
COC[C@H](COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2554 |
EN300-30458_3_2
|
|
CN1CC[C@H](CC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2555 |
EN300-198540_3_2
|
|
Cn1cc([cH+][nH]1)[C@H](C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.7
± 0.5
|
7.1
± 0.3
|
2556 |
EN300-6238494_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC([C@H]5COCCO5)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2557 |
EN300-298552_1_1
|
|
CO[C@@H]([C@@H]1CCOC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.2
|
7.1
± 0.1
|
2558 |
EN300-196962_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@H]5CO |
−9.7
± 0.2
|
7.1
± 0.2
|
2559 |
EN300-65063_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCN(CC5)C(=O)N |
−9.7
± 0.3
|
7.1
± 0.2
|
2560 |
EN300-261365_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CS(=O)(=O)C5 |
−9.7
± 0.2
|
7.1
± 0.2
|
2561 |
EN300-155362_1_2
|
|
C[C@H]1CC(=O)N[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.2
|
7.1
± 0.2
|
2562 |
EN300-52768_1_1
|
|
CCCS(=O)(=O)[C@@H](C)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.4
|
7.1
± 0.3
|
2563 |
EN300-1265946_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(CC5)C(=O)N |
−9.7
± 0.3
|
7.1
± 0.2
|
2564 |
EN300-215799_1_1
|
|
Cc1c(c(no1)CO)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2565 |
EN300-266117_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H](C5)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2566 |
EDG-MED-4c68219f-1
|
|
CC(CN1C(=O)C(CO1)N)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2567 |
EN300-21009_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5CCCO5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2568 |
EN300-260816_2_1
|
|
CN1CC[C@@H](C1=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.2
|
7.1
± 0.2
|
2569 |
EN300-87334_2_1
|
|
Cn1c(ncn1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2570 |
MAK-UNK-83e0a0b4-3_1
|
|
c1ccc2c(c1)cncc2N(CCNC3C[NH2+]C3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−9.7
± 0.5
|
7.1
± 0.3
|
2571 |
EN300-6739414_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5Cc6ccnn6C[C@H](C5)CO |
−9.7
± 0.3
|
7.1
± 0.2
|
2572 |
EN300-54922_1_1
|
|
CS(=O)(=O)[N@]1CCC[C@@H](C1)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.2
|
7.1
± 0.2
|
2573 |
EDG-MED-971238d3-8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCO |
−9.7
± 0.2
|
7.1
± 0.1
|
2574 |
EN300-124052_1_2
|
|
C[C@H]1CN(C[C@@H]1O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2575 |
EN300-25986_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5cccn5 |
−9.7
± 0.2
|
7.1
± 0.2
|
2576 |
CHO-MSK-a31cca77-1
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5nnco5 |
−9.7
± 0.2
|
7.1
± 0.2
|
2577 |
EN300-7459540_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC[C@@H]5[C@@H](CO)O |
−9.7
± 0.4
|
7.1
± 0.3
|
2578 |
EDJ-MED-e4b030d8-11
|
|
C[C@H]1COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−9.70
± 0.05
|
7.06
± 0.04
|
2579 |
EN300-01527_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NC[C@@H]5CCCO5 |
−9.7
± 0.4
|
7.1
± 0.3
|
2580 |
EN300-68794_4_1
|
|
CS(=O)(=O)CCCOCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.4
|
7.1
± 0.3
|
2581 |
EN300-1073320_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H](C5(CCC5)O)O |
−9.7
± 0.4
|
7.1
± 0.3
|
2582 |
ALP-UNI-0676e700-23
|
|
Cn1cc(nn1)c2cc(no2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.7
± 0.3
|
7.1
± 0.3
|
2583 |
DAR-DIA-0d514e7d-25
|
|
C[C@H]1COc2c(cc(cc2OC)Cl)[C@]1(C)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.1
|
7.06
± 0.09
|
2584 |
EN300-218116_1_1
|
|
CC(CO)(CO)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.4
|
7.1
± 0.3
|
2585 |
EN300-6478433_1_1
|
|
CCn1c(nn(c1=O)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.7
± 0.3
|
7.1
± 0.3
|
2586 |
EN300-07936_1_1
|
|
CCN(CC(=O)NC(C)C)C(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.4
|
7.1
± 0.3
|
2587 |
EN300-201164_1_2
|
|
CC(C)(C)[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−9.7
± 0.3
|
7.1
± 0.2
|
2588 |
EN300-131943_2_1
|
|
COc1cc(ncn1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2589 |
EN300-2007564_3_2
|
|
CC1([C@H](CCS1(=O)=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.7
± 0.4
|
7.1
± 0.3
|
2590 |
EN300-41507_1_1
|
|
Cc1nccn1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2591 |
EN300-305294_1_6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]6C[C@@H]([C@H]6C5)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2592 |
EN300-23317_4_1
|
|
C[C@@H](C(=O)NCCOC)OCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.4
|
7.1
± 0.3
|
2593 |
EN300-175425_1_2
|
|
CC[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)OC |
−9.7
± 0.2
|
7.1
± 0.2
|
2594 |
EN300-132157_1_1
|
|
C[C@@]1(CC(=O)NC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2595 |
EN300-185729_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCc6c(n[nH]n6)C5 |
−9.7
± 0.2
|
7.1
± 0.2
|
2596 |
EN300-1915260_1_2
|
|
COC[C@H](CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2597 |
KAD-UNI-8a629cb0-4
|
|
Cn1cc(cc1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−9.7
± 0.3
|
7.1
± 0.2
|
2598 |
EN300-41507_3_1
|
|
Cc1nccn1CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2599 |
EN300-198515_1_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnc(n5)C#N |
−9.7
± 0.2
|
7.1
± 0.2
|
2600 |
EN300-97300_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[C@@H]5F |
−9.7
± 0.2
|
7.1
± 0.1
|