Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
2401 |
EN300-53677_3_1
|
|
CS(=O)(=O)CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.3
|
7.1
± 0.2
|
2402 |
EN300-35781_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c[nH]c6cccc[n+]6c5=O |
−9.8
± 0.3
|
7.1
± 0.2
|
2403 |
EN300-1721328_1_1
|
|
Cc1nnc(n1C)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2404 |
EN300-78121_1_1
|
|
CS(=O)(=O)c1cnn(c1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2405 |
EN300-185751_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5cncnc5 |
−9.8
± 0.2
|
7.1
± 0.1
|
2406 |
EN300-22879_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N5CCCC[C@H]5C(=O)N |
−9.8
± 0.4
|
7.1
± 0.3
|
2407 |
EN300-6745453_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5Cc6nncn6C5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2408 |
EN300-59285_1_1
|
|
CC(C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.8
± 0.3
|
7.1
± 0.2
|
2409 |
EDJ-MED-d203f206-30
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC[C@@H]5C(=O)N |
−9.8
± 0.3
|
7.1
± 0.2
|
2410 |
EN300-1704723_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CCCF |
−9.8
± 0.3
|
7.1
± 0.2
|
2411 |
EN300-2855057_3_2
|
|
C[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)N5CCOCC5 |
−9.8
± 0.4
|
7.1
± 0.3
|
2412 |
EN300-1299691_1_2
|
|
CC(C)OC[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−9.8
± 0.3
|
7.1
± 0.2
|
2413 |
EN300-66432_3_1
|
|
CN(C)S(=O)(=O)CCCOCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.3
|
7.1
± 0.3
|
2414 |
EN300-21258_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCO |
−9.8
± 0.2
|
7.1
± 0.1
|
2415 |
EN300-6494158_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@@H]5C[C@@H](CO5)CO |
−9.8
± 0.3
|
7.1
± 0.2
|
2416 |
ED_-GRI-5b13fbe2-9
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(CN)c5[nH]nnn5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2417 |
EN300-206282_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)C#N |
−9.8
± 0.2
|
7.1
± 0.2
|
2418 |
EN300-61860_1_1
|
|
Cc1cc2[nH+]c(=O)c(cn2[nH]1)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.8
± 0.3
|
7.1
± 0.2
|
2419 |
EN300-247343_2_1
|
|
CC1(CC(C1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.8
± 0.2
|
7.1
± 0.2
|
2420 |
EN300-6473273_3_1
|
|
Cn1c(ccn1)[C@@H](C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.8
± 0.3
|
7.1
± 0.2
|
2421 |
EN300-1703852_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5COC(=O)N5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2422 |
EN300-203293_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@@H]5CNC(=O)O5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2423 |
EN300-182725_1_4
|
|
C[C@H]([C@H](C)S(=O)(=O)C)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.3
|
7.1
± 0.2
|
2424 |
EN300-1709410_1_1
|
|
C[C@@H]1C[C@@H](N1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−9.8
± 0.3
|
7.1
± 0.2
|
2425 |
EN300-134855_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H](c5cccnc5)O |
−9.8
± 0.3
|
7.1
± 0.2
|
2426 |
ED_-GRI-5b13fbe2-72
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCO |
−9.8
± 0.2
|
7.1
± 0.1
|
2427 |
EN300-6492197_1_1
|
|
CNC(=O)[C@H]1CCCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2428 |
EN300-169955_3_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5[C@H](CC(=O)N5)C(F)(F)F |
−9.8
± 0.4
|
7.1
± 0.3
|
2429 |
MAT-POS-8a69d52e-4_2
|
|
C[C@H]1COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−9.79
± 0.06
|
7.13
± 0.04
|
2430 |
EN300-18569_3_1
|
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−9.8
± 0.3
|
7.1
± 0.2
|
2431 |
EN300-52768_3_2
|
|
CCCS(=O)(=O)[C@H](C)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.5
|
7.1
± 0.3
|
2432 |
EN300-249804_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCOC(=O)N5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2433 |
EN300-62448_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CNC(=O)C5CCC5 |
−9.8
± 0.3
|
7.1
± 0.3
|
2434 |
EN300-1703718_1_1
|
|
CC(=O)N1C[C@@H](C[C@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.8
± 0.4
|
7.1
± 0.3
|
2435 |
EN300-1387104_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCS5(=O)=O |
−9.8
± 0.2
|
7.1
± 0.2
|
2436 |
EN300-6792206_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H](C5CCOCC5)O |
−9.8
± 0.3
|
7.1
± 0.2
|
2437 |
EN300-107435_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CCCCS5(=O)=O |
−9.8
± 0.3
|
7.1
± 0.2
|
2438 |
EN300-123416_1_1
|
|
CCCn1cc(nn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2439 |
EN300-2008102_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5CN6C[C@H](O5)CCC6=O |
−9.8
± 0.3
|
7.1
± 0.2
|
2440 |
EN300-55109_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC[C@H]5CO |
−9.8
± 0.3
|
7.1
± 0.2
|
2441 |
EN300-175251_1_1
|
|
COCCCNC(=O)CCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.4
|
7.1
± 0.3
|
2442 |
EN300-307336_1_3
|
|
C[C@@]1(C[C@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O)CO |
−9.8
± 0.3
|
7.1
± 0.2
|
2443 |
EN300-1071940_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@]5(CCCOC5)O |
−9.8
± 0.3
|
7.1
± 0.2
|
2444 |
EN300-1715993_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCn5ccnn5 |
−9.8
± 0.2
|
7.1
± 0.2
|
2445 |
EN300-1911992_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]([C@@H]5CCOC5)O |
−9.8
± 0.3
|
7.1
± 0.2
|
2446 |
EN300-245061_1_1
|
|
Cc1c(cn(n1)C)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
2447 |
EN300-315453_1_1
|
|
Cc1cncn1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
2448 |
EN300-22884_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N5CCNC(=O)C5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2449 |
EN300-94900_1_1
|
|
CS(=O)(=O)Cc1nc(on1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.4
|
7.1
± 0.3
|
2450 |
EN300-186943_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCOCC5=O |
−9.8
± 0.3
|
7.1
± 0.2
|
2451 |
EDG-MED-4c68219f-9
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)Nc5ccnn5C6CNC6 |
−9.8
± 0.4
|
7.1
± 0.3
|
2452 |
EN300-7456948_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5cccnn5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2453 |
EDG-MED-90036822-65
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CN(C5)CCF |
−9.8
± 0.3
|
7.1
± 0.2
|
2454 |
EN300-6953121_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[C@H]5F |
−9.8
± 0.2
|
7.1
± 0.1
|
2455 |
EN300-28871_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCn5ccnn5 |
−9.8
± 0.2
|
7.1
± 0.2
|
2456 |
EN300-7442332_3_1
|
|
Cc1c(n(cn1)OC)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2457 |
MIC-UNK-08fa0751-1
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4C(CO)(F)F)Cl |
−9.8
± 0.2
|
7.1
± 0.1
|
2458 |
EN300-395954_1_1
|
|
C[C@@]12CN(CCN1C(=O)OC2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.8
± 0.3
|
7.1
± 0.2
|
2459 |
EN300-22879_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCCC[C@@H]5C(=O)N |
−9.8
± 0.2
|
7.1
± 0.2
|
2460 |
EN300-107493_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCNC(=O)C5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2461 |
ED_-GRI-5b13fbe2-27
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCn5cc(cn5)CN6CCNCC6 |
−9.8
± 0.4
|
7.1
± 0.3
|
2462 |
EN300-55072_1_1
|
|
C[C@@H](CO)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.3
|
7.1
± 0.2
|
2463 |
EN300-39439_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCCC(=O)N |
−9.8
± 0.3
|
7.1
± 0.2
|
2464 |
EN300-6738887_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5[C@@H]6CC[C@H]5[C@@H](CC[C@@H]6O)O |
−9.8
± 0.3
|
7.1
± 0.2
|
2465 |
EN300-113234_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC(=O)OC5 |
−9.8
± 0.2
|
7.1
± 0.2
|
2466 |
EN300-182084_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)c5cscn5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2467 |
EN300-23942_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cccn5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2468 |
EN300-69313_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H](C5)O |
−9.8
± 0.2
|
7.1
± 0.2
|
2469 |
EN300-159953_2_1
|
|
CN([C@@H]1CC[N@@H+]2CCO[C@H]1C2)C(=O)CC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.8
± 0.3
|
7.1
± 0.3
|
2470 |
EN300-198515_3_1
|
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnc(n5)C#N |
−9.8
± 0.3
|
7.1
± 0.2
|
2471 |
EN300-7493922_3_1
|
|
Cn1cnc(n1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2472 |
EN300-122340_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCSCC5)O |
−9.8
± 0.3
|
7.1
± 0.2
|
2473 |
EN300-125769_3_1
|
|
COCCCOCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.3
|
7.1
± 0.2
|
2474 |
EN300-317085_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@@H](C5)F)O |
−9.8
± 0.2
|
7.1
± 0.2
|
2475 |
EN300-393148_3_1
|
|
C[N@]1[C@@H](CCS1(=O)=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2476 |
ALP-UNI-dbbfd3db-17
|
|
Cc1c(c(=O)n2c(n1)cc[nH]2)CC(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.8
± 0.3
|
7.1
± 0.2
|
2477 |
EN300-31148_1_1
|
|
CCC(=O)N[C@@H](C)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.3
|
7.1
± 0.2
|
2478 |
MIC-UNK-91acba05-2
|
|
CN1CC(c2cc(ccc2C1=O)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.2
|
7.1
± 0.2
|
2479 |
EN300-74089_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOCC5)C#N |
−9.8
± 0.2
|
7.1
± 0.2
|
2480 |
EN300-264184_1_1
|
|
CCn1c(c[nH]c1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
2481 |
EN300-98018_1_2
|
|
CC(=O)N1CC[C@](C1)(C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2482 |
EN300-332002_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCc6n5c(=O)ccc6 |
−9.8
± 0.3
|
7.1
± 0.2
|
2483 |
EN300-378722_1_2
|
|
CN1CC[C@H](C1=O)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
2484 |
EN300-148515_2_1
|
|
Cn1c(nnn1)CN(C)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
2485 |
EN300-05754_3_2
|
|
C[C@H](C(=O)N1CCOCC1)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.3
|
2486 |
EN300-6494859_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@H](OC5)Cn6cccn6 |
−9.8
± 0.3
|
7.1
± 0.2
|
2487 |
EN300-7444533_1_3
|
|
C[C@@H]1C[C@H](C(=O)O1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
2488 |
EN300-321703_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCOC5COC5 |
−9.8
± 0.2
|
7.1
± 0.2
|
2489 |
EN300-341337_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@]56CCO[C@H]5CCOC6 |
−9.7
± 0.3
|
7.1
± 0.2
|
2490 |
EN300-36111_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCCCC5=O |
−9.7
± 0.3
|
7.1
± 0.2
|
2491 |
VLA-UCB-05e51b3f-13
|
|
c1ccc2c(c1)cncc2NC(=O)[C@]3(CCOc4c3cc(cc4)Cl)CCC5CCCCC5 |
−9.7
± 0.4
|
7.1
± 0.3
|
2492 |
EN300-1911992_1_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@H]([C@H]5CCOC5)O |
−9.7
± 0.3
|
7.1
± 0.2
|
2493 |
EN300-85707_1_2
|
|
COC[C@H]1CN(CCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2494 |
EN300-23792_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(sc5)S(=O)(=O)N |
−9.7
± 0.2
|
7.1
± 0.2
|
2495 |
EN300-195590_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[C@H]5CCCNC(=O)C5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2496 |
EN300-2617222_3_1
|
|
CNC(=O)c1cn(nn1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2497 |
EN300-22880_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N5CCC[C@H](C5)C(=O)N |
−9.7
± 0.3
|
7.1
± 0.2
|
2498 |
ED_-GRI-5b13fbe2-55
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5(CNCC5CO)F |
−9.7
± 0.2
|
7.1
± 0.1
|
2499 |
EN300-33398_1_2
|
|
CC(C)N1C[C@H](CC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
2500 |
EN300-174763_1_1
|
|
CCN(CC(=O)N)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.3
|
7.1
± 0.2
|