Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
2101 |
EN300-300217_1_2
|
|
C/C=C/[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2102 |
EN300-256053_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H](C5)CO |
−10.0
± 0.3
|
7.3
± 0.2
|
2103 |
EN300-124301_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCn5ccnn5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2104 |
EN300-244403_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CNC(=O)O5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2105 |
EN300-68747_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCC5)C(=O)N |
−10.0
± 0.2
|
7.3
± 0.2
|
2106 |
EN300-48902_3_2
|
|
CNC(=O)[C@H]1CCCN1C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.4
|
7.3
± 0.3
|
2107 |
EN300-6494606_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cc(c(=O)[nH]c5=O)Cl |
−10.0
± 0.4
|
7.3
± 0.3
|
2108 |
EN300-137191_1_1
|
|
Cc1cc(n(c(=O)n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−10.0
± 0.3
|
7.3
± 0.2
|
2109 |
EN300-91401_1_1
|
|
C[C@@H]1CCNC(=O)[C@@H]1NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2110 |
EN300-25572_1_1
|
|
C[C@@H]1CN(CCO1)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2111 |
EN300-1258964_3_1
|
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)NC |
−10.0
± 0.3
|
7.3
± 0.2
|
2112 |
EN300-246992_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5CCC(=O)NC5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2113 |
EN300-259849_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCCC[C@H](C5=O)O |
−10.0
± 0.5
|
7.3
± 0.4
|
2114 |
EN300-25446_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnco5 |
−10.0
± 0.2
|
7.3
± 0.1
|
2115 |
EN300-1725538_1_2
|
|
Cn1cc(nc1)C[C@H](C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2116 |
EN300-66845_3_2
|
|
COC(=O)N1CCC[C@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.3
|
2117 |
EN300-181938_1_1
|
|
C[C@@](CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C=C)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2118 |
EN300-178288_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6C[C@@]6(C5)O |
−10.0
± 0.3
|
7.2
± 0.2
|
2119 |
EN300-258702_3_1
|
|
Cn1ccc(n1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.2
|
7.2
± 0.1
|
2120 |
EN300-123489_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CO)(F)F |
−10.0
± 0.2
|
7.2
± 0.2
|
2121 |
EN300-393148_1_1
|
|
C[N@]1[C@@H](CCS1(=O)=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.2
± 0.2
|
2122 |
EN300-127487_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H]5CC(=O)NC5 |
−10.0
± 0.2
|
7.2
± 0.2
|
2123 |
EN300-45049_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCS(=O)(=O)N5 |
−10.0
± 0.3
|
7.2
± 0.2
|
2124 |
EN300-69162_1_1
|
|
C[C@@H](COC)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.2
|
7.2
± 0.2
|
2125 |
EN300-116885_1_1
|
|
Cc1c(nc(c(=O)[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.9
± 0.3
|
7.2
± 0.2
|
2126 |
EN300-181938_1_2
|
|
C[C@](CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C=C)O |
−9.9
± 0.3
|
7.2
± 0.2
|
2127 |
EN300-10170_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H](CO)NC(=O)N |
−9.9
± 0.4
|
7.2
± 0.3
|
2128 |
EN300-342226_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnc[nH]5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2129 |
EN300-651665_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6[C@H]5CCO6 |
−9.9
± 0.3
|
7.2
± 0.2
|
2130 |
EN300-93573_3_1
|
|
CN(C)C(=O)CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.9
± 0.3
|
7.2
± 0.2
|
2131 |
EN300-66082_1_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C5CCC5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2132 |
MIC-UNK-d36ab305-2
|
|
CC(=O)Nc1ccc(cc1)N(c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.9
± 0.3
|
7.2
± 0.2
|
2133 |
EN300-246747_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5CC(=O)NC5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2134 |
EN300-91401_1_2
|
|
C[C@H]1CCNC(=O)[C@@H]1NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2135 |
EN300-7494324_3_2
|
|
Cc1c(nc[nH]1)C[C@H](C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.9
± 0.3
|
7.2
± 0.2
|
2136 |
EN300-317272_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)C[C@H]6CCOC6 |
−9.9
± 0.3
|
7.2
± 0.2
|
2137 |
EN300-148515_1_1
|
|
Cn1c(nnn1)CN(C)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.2
|
7.2
± 0.2
|
2138 |
EN300-95698_2_2
|
|
C[C@H]1CC(=O)NC[C@@H]1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.4
|
7.2
± 0.3
|
2139 |
ED_-GRI-5b13fbe2-61
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5cn(nn5)C6CCNC6 |
−9.9
± 0.2
|
7.2
± 0.2
|
2140 |
EN300-1265071_1_1
|
|
CN(Cc1cn[nH]n1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2141 |
EN300-222969_1_1
|
|
CN1C[C@@H](OC1=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2142 |
DAR-DIA-0d514e7d-8_1
|
|
C[C@H]1COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)C#N |
−9.94
± 0.07
|
7.24
± 0.05
|
2143 |
EDJ-MED-fcba3f31-9
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@H]5CCC(=O)N5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2144 |
EN300-47500_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NCCCn5cccn5 |
−9.9
± 0.4
|
7.2
± 0.3
|
2145 |
EN300-341337_2_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@]56CCO[C@H]5CCOC6 |
−9.9
± 0.3
|
7.2
± 0.2
|
2146 |
MIC-UNK-16ccb665-1
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)OC(F)F |
−9.9
± 0.3
|
7.2
± 0.2
|
2147 |
EN300-249421_3_2
|
|
C[C@H]([C@@H]1CCC(=O)N1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.3
|
7.2
± 0.3
|
2148 |
EN300-95698_1_2
|
|
C[C@H]1CC(=O)NC[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2149 |
EN300-54304_3_1
|
|
CCOCCOCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.9
± 0.3
|
7.2
± 0.2
|
2150 |
EN300-05754_4_1
|
|
C[C@@H](C(=O)N1CCOCC1)OCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.4
|
7.2
± 0.3
|
2151 |
EN300-332601_3_2
|
|
CC[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−9.9
± 0.3
|
7.2
± 0.2
|
2152 |
ALP-POS-ce760d3f-6
|
|
COc1ccc2cncc(c2c1)NC(=O)C3=CCOc4c3cc(cc4)Cl |
−9.9
± 0.3
|
7.2
± 0.2
|
2153 |
EDJ-MED-fcba3f31-6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@H]5CCNC5=O |
−9.9
± 0.3
|
7.2
± 0.2
|
2154 |
EN300-36855_3_1
|
|
CN(CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)c5cnccn5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2155 |
EN300-50228_1_2
|
|
c1ccc(cc1)C(=O)N[C@H](CO)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2156 |
EN300-146174_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)CO |
−9.9
± 0.2
|
7.2
± 0.2
|
2157 |
DAR-DIA-0d514e7d-4_1
|
|
C[C@H]1COc2c(cc(cc2OC3CCCC3)Cl)[C@@H]1C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.2
|
7.2
± 0.2
|
2158 |
EN300-7355519_1_5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5C[C@@H]6[C@H](O5)CCO6 |
−9.9
± 0.3
|
7.2
± 0.2
|
2159 |
EN300-1448603_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]5CCS(=O)(=O)C5 |
−9.9
± 0.2
|
7.2
± 0.2
|
2160 |
EN300-208959_1_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CNC(=O)C[C@H]5C(F)(F)F |
−9.9
± 0.3
|
7.2
± 0.2
|
2161 |
ED_-GRI-5b13fbe2-26
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5cn(nn5)CC6CC(C6)N |
−9.9
± 0.3
|
7.2
± 0.2
|
2162 |
EN300-202922_3_2
|
|
C[C@H]([C@@](C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−9.9
± 0.3
|
7.2
± 0.2
|
2163 |
EN300-219531_1_2
|
|
CCC[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.9
± 0.3
|
7.2
± 0.2
|
2164 |
EN300-1708882_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[C@@H]5COC[C@H]5O |
−9.9
± 0.3
|
7.2
± 0.2
|
2165 |
EN300-6238494_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)[C@@H]5COCCO5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2166 |
EN300-210084_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[C@@H]5CCCC(=O)N5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2167 |
EN300-222620_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5cc(cnc5)O |
−9.9
± 0.4
|
7.2
± 0.3
|
2168 |
EN300-1706036_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5C(=O)NCCO5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2169 |
EN300-261986_1_2
|
|
CS(=O)(=O)[N@]1CC[C@H](C1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2170 |
EN300-1911992_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@H]([C@@H]5CCOC5)O |
−9.9
± 0.4
|
7.2
± 0.3
|
2171 |
EN300-113112_4_1
|
|
Cn1cnnc1COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.4
|
7.2
± 0.3
|
2172 |
MIC-UNK-cdc2493e-8
|
|
c1ccc2c(c1)cncc2NC(=O)N(c3cccc(c3)Cl)C4CCC5CCCCC5C4 |
−9.9
± 0.2
|
7.2
± 0.1
|
2173 |
EN300-126389_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5COC(=O)N5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2174 |
EN300-101373_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCO[C@@H](C5)CO |
−9.9
± 0.4
|
7.2
± 0.3
|
2175 |
EN300-299532_1_2
|
|
CC(C)([C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−9.9
± 0.2
|
7.2
± 0.2
|
2176 |
EN300-04492_1_1
|
|
COCCCNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.9
± 0.2
|
7.2
± 0.2
|
2177 |
EN300-265285_2_1
|
|
C[C@@H]1Cn2c(cc(n2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)C(=O)N1 |
−9.9
± 0.4
|
7.2
± 0.3
|
2178 |
EN300-99391_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CO[C@@H]5CCOC5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2179 |
EN300-1700143_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)c6ncon6 |
−9.9
± 0.3
|
7.2
± 0.2
|
2180 |
EN300-6729572_1_7
|
|
C[C@@H]([C@H]1C[C@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.9
± 0.3
|
7.2
± 0.2
|
2181 |
EN300-131093_3_2
|
|
C[C@H](C(=O)NCC(=O)C)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.9
± 0.3
|
7.2
± 0.2
|
2182 |
EN300-101197_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCc5[nH]ncn5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2183 |
KAD-UNI-8a629cb0-42
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6C[C@H]5CN6C(=O)N |
−9.9
± 0.3
|
7.2
± 0.2
|
2184 |
EN300-158272_1_1
|
|
CC(=O)N1C[C@H](C[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−9.9
± 0.3
|
7.2
± 0.2
|
2185 |
EN300-7433125_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@]56C[C@@H]5[C@@H](C6)O |
−9.9
± 0.2
|
7.2
± 0.2
|
2186 |
EN300-197715_2_1
|
|
Cc1nnnn1CCCOC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2187 |
EN300-39151_1_1
|
|
Cc1ccc(c(=O)[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2188 |
EN300-2855057_1_2
|
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)N5CCOCC5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2189 |
EN300-246248_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5CCNC5=O |
−9.9
± 0.2
|
7.2
± 0.2
|
2190 |
EN300-51736_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COc5cccc(c5)C(=O)N |
−9.9
± 0.3
|
7.2
± 0.2
|
2191 |
EN300-31553_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCS(=O)(=O)N |
−9.9
± 0.3
|
7.2
± 0.2
|
2192 |
EN300-114082_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)C#N |
−9.9
± 0.2
|
7.2
± 0.2
|
2193 |
EN300-175186_2_2
|
|
C[C@H](CO)OC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.9
± 0.2
|
7.2
± 0.2
|
2194 |
EN300-169955_1_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@H](CC(=O)N5)C(F)(F)F |
−9.9
± 0.3
|
7.2
± 0.2
|
2195 |
JAG-UCB-706446eb-5
|
|
COCCN(C1CCCOC1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.3
|
7.2
± 0.2
|
2196 |
EN300-50009_3_1
|
|
COC(=O)NCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.9
± 0.3
|
7.2
± 0.2
|
2197 |
EN300-640503_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@H](C56CCOCC6)O |
−9.9
± 0.4
|
7.2
± 0.3
|
2198 |
EN300-188356_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@]5(CCOC5)F |
−9.9
± 0.3
|
7.2
± 0.2
|
2199 |
EN300-6481287_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CO[C@H]5[C@@H](C[C@H]6[C@@H]5CC6=O)O |
−9.9
± 0.3
|
7.2
± 0.2
|
2200 |
EN300-19507_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(F)F |
−9.9
± 0.2
|
7.2
± 0.1
|