Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
201 |
EN300-1627945_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CO[C@@H]5CCCOC5 |
−11.9
± 0.2
|
8.7
± 0.2
|
202 |
DAR-DIA-5ff57136-12_1
|
|
c1ccc2c(c1)cncc2N(C#C[C@@H]3CCC[NH2+]3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−11.9
± 0.2
|
8.7
± 0.1
|
203 |
EN300-7444533_1_1
|
|
C[C@@H]1C[C@@H](C(=O)O1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.3
|
8.7
± 0.2
|
204 |
EN300-18928_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CSCN5C(=O)C6CC6 |
−11.9
± 0.4
|
8.7
± 0.3
|
205 |
EN300-48902_1_2
|
|
CNC(=O)[C@H]1CCCN1C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.3
|
8.7
± 0.3
|
206 |
EN300-6481287_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCO[C@H]5[C@@H](C[C@H]6[C@@H]5CC6=O)O |
−11.9
± 0.3
|
8.7
± 0.2
|
207 |
EN300-36158_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5COCCO5 |
−11.9
± 0.2
|
8.7
± 0.2
|
208 |
EN300-303519_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5OCC6 |
−11.9
± 0.2
|
8.7
± 0.1
|
209 |
VLA-UCB-50c39ae8-10
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC5CCCCC5 |
−11.9
± 0.3
|
8.7
± 0.2
|
210 |
EN300-12587_1_1
|
|
CC(=O)N1CCC[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.3
|
8.7
± 0.2
|
211 |
EN300-331828_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCO[C@@H]5COC[C@H]5O |
−11.9
± 0.3
|
8.7
± 0.2
|
212 |
EN300-51350_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCc6nncn6C5 |
−11.9
± 0.3
|
8.7
± 0.2
|
213 |
EN300-90142_1_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCC[C@H](C5)C(=O)N |
−11.9
± 0.2
|
8.7
± 0.2
|
214 |
EN300-113218_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CS[C@@H]5CCOC5=O |
−11.9
± 0.4
|
8.7
± 0.3
|
215 |
EN300-132157_3_2
|
|
C[C@]1(CC(=O)NC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.3
|
8.7
± 0.2
|
216 |
EN300-83529_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5nc6ncccn6n5 |
−11.9
± 0.2
|
8.7
± 0.2
|
217 |
EN300-140837_1_1
|
|
Cn1c(c(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C#N |
−11.9
± 0.2
|
8.7
± 0.2
|
218 |
EN300-100916_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5nccn5 |
−11.9
± 0.2
|
8.7
± 0.2
|
219 |
EN300-300519_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5csnn5 |
−11.9
± 0.2
|
8.7
± 0.1
|
220 |
DAR-DIA-9e4459de-15
|
|
c1cc2c(cc1NC(=O)CCC(=O)NC3=CC=CC4C3C(=O)N(C4=O)C5CCC(=O)NC5=O)cncc2NC(=O)C6CCOc7c6cc(cc7)Cl |
−11.9
± 0.2
|
8.7
± 0.1
|
221 |
EN300-6503702_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@]56CC[C@@H](C5)S(=O)(=O)CC6 |
−11.9
± 0.3
|
8.6
± 0.2
|
222 |
ALF-EVA-0b412456-5
|
|
c1cc2cncc(c2cc1CN)NC(=O)Cc3cc(cc(c3)Cl)OC4CC(=O)N4 |
−11.9
± 0.6
|
8.6
± 0.4
|
223 |
EDG-MED-90036822-26
|
|
Cn1cncc1C(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)F |
−11.9
± 0.2
|
8.6
± 0.2
|
224 |
EN300-72730_3_1
|
|
C[C@@H](C#N)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.9
± 0.2
|
8.6
± 0.2
|
225 |
EN300-102853_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6nn[nH][n+]6c5 |
−11.9
± 0.2
|
8.6
± 0.2
|
226 |
EN300-104395_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCO5 |
−11.9
± 0.2
|
8.6
± 0.2
|
227 |
EN300-65050_3_1
|
|
CC(C)(CO)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.9
± 0.3
|
8.6
± 0.2
|
228 |
EN300-749499_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](C5(CCOCC5)O)O |
−11.9
± 0.2
|
8.6
± 0.2
|
229 |
EN300-6764836_1_5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@H]6[C@@H]([C@H]([C@@H]5O6)O)O |
−11.9
± 0.3
|
8.6
± 0.2
|
230 |
EDG-MED-90036822-41
|
|
Cn1ccnc1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.2
|
8.6
± 0.2
|
231 |
EN300-181688_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6n(n5)CCO6 |
−11.8
± 0.2
|
8.6
± 0.2
|
232 |
EN300-315963_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnoc5 |
−11.8
± 0.2
|
8.6
± 0.2
|
233 |
EN300-37123_1_1
|
|
Cn1cc(c(=O)[nH]c1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
8.6
± 0.2
|
234 |
EN300-6737762_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCCNC5=O |
−11.8
± 0.3
|
8.6
± 0.2
|
235 |
EN300-52380_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CC(=O)N |
−11.8
± 0.3
|
8.6
± 0.2
|
236 |
EN300-197715_3_1
|
|
Cc1nnnn1CCCOCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
8.6
± 0.2
|
237 |
EN300-304627_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@H](CCO5)Cn6cccn6 |
−11.8
± 0.3
|
8.6
± 0.2
|
238 |
EN300-1301381_1_2
|
|
COC[C@]1(CCCO1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
8.6
± 0.2
|
239 |
EN300-341337_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@]56CCO[C@@H]5CCOC6 |
−11.8
± 0.4
|
8.6
± 0.3
|
240 |
EN300-150212_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc([nH]n5)F |
−11.8
± 0.2
|
8.6
± 0.1
|
241 |
EN300-82616_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCNC5=O |
−11.8
± 0.3
|
8.6
± 0.2
|
242 |
DAR-DIA-5ff57136-16_2
|
|
C[C@H](C#C)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−11.8
± 0.1
|
8.6
± 0.1
|
243 |
EN300-1726277_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](n5cccn5)F |
−11.8
± 0.2
|
8.6
± 0.1
|
244 |
DAR-DIA-5ff57136-13_1
|
|
C#CCN(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−11.8
± 0.1
|
8.61
± 0.10
|
245 |
EN300-41425_1_1
|
|
Cc1cc(n[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.2
|
8.6
± 0.1
|
246 |
EN300-66976_1_1
|
|
Cn1ccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.2
|
8.6
± 0.2
|
247 |
EN300-1178005_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(on5)C#N |
−11.8
± 0.2
|
8.6
± 0.2
|
248 |
EN300-82037_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5C=CON5 |
−11.8
± 0.2
|
8.6
± 0.1
|
249 |
EN300-748981_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCn6c5nnc6 |
−11.8
± 0.3
|
8.6
± 0.2
|
250 |
EN300-246747_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]5CC(=O)NC5 |
−11.8
± 0.3
|
8.6
± 0.2
|
251 |
EN300-6489289_1_2
|
|
Cc1nnc2n1[C@H](CC2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.8
± 0.3
|
8.6
± 0.2
|
252 |
EN300-872798_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c(nnn5)C6CC6 |
−11.8
± 0.3
|
8.6
± 0.2
|
253 |
EN300-143449_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCN(=O)=O |
−11.8
± 0.2
|
8.6
± 0.2
|
254 |
EN300-7465954_1_1
|
|
COc1c(=O)ccoc1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.2
|
8.6
± 0.2
|
255 |
EN300-208236_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCc6c5n[nH]n6 |
−11.8
± 0.2
|
8.6
± 0.2
|
256 |
EN300-189901_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc6c5[nH]c(=O)[nH]6 |
−11.8
± 0.2
|
8.6
± 0.2
|
257 |
EN300-141695_1_1
|
|
CN1CC[C@@H](C1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
8.6
± 0.2
|
258 |
EN300-65839_3_2
|
|
CC[C@H](C(=O)N)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.8
± 0.3
|
8.6
± 0.2
|
259 |
EN300-651307_3_1
|
|
CC[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cncn5 |
−11.8
± 0.3
|
8.6
± 0.2
|
260 |
EN300-6731334_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C56CCN(CC5)S(=O)(=O)C6 |
−11.8
± 0.4
|
8.6
± 0.3
|
261 |
EN300-304695_1_1
|
|
CN1CCCC[C@@H](C1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.2
|
8.6
± 0.2
|
262 |
EN300-33478_3_2
|
|
CCN1C[C@H](CC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.4
|
8.6
± 0.3
|
263 |
EN300-216673_2_1
|
|
Cn1c(cnn1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
8.6
± 0.2
|
264 |
EDG-MED-90036822-99
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C(C5CCC5)O)F |
−11.8
± 0.2
|
8.6
± 0.2
|
265 |
EN300-2983057_1_1
|
|
Cn1c(c(cn1)C#N)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.2
|
8.6
± 0.2
|
266 |
EN300-132157_3_1
|
|
C[C@@]1(CC(=O)NC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
8.6
± 0.2
|
267 |
EN300-42819_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCC(=O)NC5 |
−11.8
± 0.2
|
8.6
± 0.2
|
268 |
EN300-60033_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COC[C@H]5CCCO5 |
−11.8
± 0.3
|
8.6
± 0.2
|
269 |
EN300-379219_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)C[C@@H]6CNC(=O)O6 |
−11.8
± 0.3
|
8.6
± 0.2
|
270 |
EN300-97847_1_1
|
|
Cn1cc(nc1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.2
|
8.6
± 0.2
|
271 |
EN300-1932780_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H](C(F)F)O |
−11.8
± 0.3
|
8.6
± 0.2
|
272 |
EN300-237561_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c(=O)cccn5 |
−11.7
± 0.3
|
8.6
± 0.2
|
273 |
EN300-76387_2_2
|
|
C[C@H](CC1NNNN1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|
8.6
± 0.2
|
274 |
EN300-3710141_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@]5(CCCO5)C#N |
−11.7
± 0.3
|
8.6
± 0.2
|
275 |
EN300-7437385_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[N@H+]6CCC[C@H]6CO5 |
−11.7
± 0.4
|
8.6
± 0.3
|
276 |
EN300-53918_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCN5CCOC5=O |
−11.7
± 0.3
|
8.6
± 0.2
|
277 |
EN300-12929_1_1
|
|
Cc1cc(no1)OCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
8.6
± 0.2
|
278 |
EN300-23318_3_2
|
|
C[C@H](C(=O)N[C@@H]1CCS(=O)(=O)C1)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.4
|
8.6
± 0.3
|
279 |
EN300-261210_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@]5(CCOC5)C#N |
−11.7
± 0.2
|
8.6
± 0.2
|
280 |
EN300-1273016_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCc6n5ncn6 |
−11.7
± 0.3
|
8.6
± 0.2
|
281 |
EN300-321703_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCOC5COC5 |
−11.7
± 0.3
|
8.5
± 0.2
|
282 |
EN300-92447_1_2
|
|
CC1C[C@@H](ON1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|
8.5
± 0.2
|
283 |
VLA-UCB-551c2366-1
|
|
CN(C)c1ccc(cc1)[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|
8.5
± 0.1
|
284 |
EN300-269453_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCc6nnnn6C5 |
−11.7
± 0.3
|
8.5
± 0.2
|
285 |
EN300-6482296_1_5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CO[C@@H]6[C@H]5COC6 |
−11.7
± 0.3
|
8.5
± 0.2
|
286 |
EN300-332838_3_2
|
|
CN1[C@H](COC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
8.5
± 0.2
|
287 |
EN300-301925_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@]5(CCCOC5)C#N |
−11.7
± 0.3
|
8.5
± 0.2
|
288 |
DAR-DIA-6a508060-9_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC5CCCCC5 |
−11.7
± 0.3
|
8.5
± 0.2
|
289 |
EN300-305567_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc[n+]6c(c5)[nH]nn6 |
−11.7
± 0.3
|
8.5
± 0.2
|
290 |
EN300-1601684_1_2
|
|
CC1([C@H](OCCO1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−11.7
± 0.3
|
8.5
± 0.2
|
291 |
EN300-640698_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc([nH]c5=O)C#N |
−11.7
± 0.2
|
8.5
± 0.2
|
292 |
EN300-262745_1_1
|
|
CCn1cc(nn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|
8.5
± 0.2
|
293 |
EN300-218116_3_1
|
|
CC(CO)(CO)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.7
± 0.4
|
8.5
± 0.3
|
294 |
EN300-83558_1_1
|
|
Cc1ccnn1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|
8.5
± 0.2
|
295 |
EN300-30768_1_1
|
|
C[C@@H]1C[C@@H]1C(=O)NCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
8.5
± 0.2
|
296 |
EN300-65352_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CCO)c5ncccn5 |
−11.7
± 0.3
|
8.5
± 0.2
|
297 |
EN300-142240_1_1
|
|
Cn1c(cc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−11.7
± 0.3
|
8.5
± 0.2
|
298 |
EN300-2007648_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C56CC(C5)CO6 |
−11.7
± 0.2
|
8.5
± 0.2
|
299 |
MAK-UNK-3875bbc8-2_1
|
|
CN(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−11.70
± 0.09
|
8.52
± 0.07
|
300 |
EN300-107267_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCO[C@@H]5CCCNC5=O |
−11.7
± 0.2
|
8.5
± 0.2
|