Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
2001 |
EN300-173903_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC[C@H]5CO |
−10.0
± 0.4
|
7.3
± 0.3
|
2002 |
EN300-219437_1_1
|
|
Cc1c(cnn1C)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2003 |
EN300-6491682_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5CCc6c(n[nH]n6)C5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2004 |
EN300-1726340_2_1
|
|
Cn1ccc(n1)n2cc(nc2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.0
± 0.4
|
7.3
± 0.3
|
2005 |
EN300-46832_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NC[C@@H]5CCOC5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2006 |
EN300-14395_1_1
|
|
Cn1cc(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2007 |
EN300-249899_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6ncccn6cn5 |
−10.0
± 0.2
|
7.3
± 0.1
|
2008 |
EDG-MED-90036822-15
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CO)F |
−10.0
± 0.2
|
7.3
± 0.1
|
2009 |
EN300-246248_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@H]5CCNC5=O |
−10.0
± 0.2
|
7.3
± 0.2
|
2010 |
EDG-MED-90036822-66
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn[nH]c5F |
−10.0
± 0.2
|
7.3
± 0.1
|
2011 |
EN300-101505_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CC(=O)N5 |
−10.0
± 0.2
|
7.3
± 0.1
|
2012 |
EN300-20496_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCO[C@@H]5CCOC5=O |
−10.0
± 0.3
|
7.3
± 0.2
|
2013 |
EN300-70522_1_1
|
|
CS(=O)(=O)CCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.4
|
7.3
± 0.3
|
2014 |
EN300-10414_1_1
|
|
C[C@@]1(CCS(=O)(=O)C1)NC(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.4
|
7.3
± 0.3
|
2015 |
EN300-51350_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCc6nncn6C5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2016 |
EN300-4287199_1_1
|
|
Cc1cc(cc(=O)n1C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2017 |
EN300-67302_1_1
|
|
Cc1c(c(n[nH]1)C(=O)N)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2018 |
EN300-304662_3_1
|
|
CC1NNC(O1)CCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.2
|
7.3
± 0.1
|
2019 |
EN300-151423_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5(CCOCC5)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2020 |
EN300-1932780_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](C(F)F)O |
−10.0
± 0.2
|
7.3
± 0.1
|
2021 |
EN300-316216_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCn5cncn5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2022 |
EN300-16582_1_2
|
|
CC(C)[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−10.0
± 0.3
|
7.3
± 0.2
|
2023 |
EN300-174668_1_2
|
|
CO[C@]1(CCOC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.4
|
7.3
± 0.3
|
2024 |
EN300-6491795_1_1
|
|
C[C@@H]1C2(CC(C2)(O1)CO)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2025 |
EN300-246178_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn(c5)C[C@@H](CO)O |
−10.0
± 0.3
|
7.3
± 0.3
|
2026 |
EN300-364679_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCn5cnnn5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2027 |
EN300-201180_1_4
|
|
C[C@H]1CC[C@H](C(=O)N1)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2028 |
EN300-18064_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCC5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2029 |
EN300-88656_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCS5(=O)=O |
−10.0
± 0.3
|
7.3
± 0.2
|
2030 |
EN300-254121_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](c5cnc[nH]5)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2031 |
EN300-307084_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6C[C@H]5C[C@H]6O |
−10.0
± 0.3
|
7.3
± 0.2
|
2032 |
ADA-UCB-dc2b944c-6
|
|
c1ccc2c(c1)cncc2NC(=O)N(CCC34CCC(O3)CC4)c5cccc(c5)Cl |
−10.0
± 0.4
|
7.3
± 0.3
|
2033 |
EDG-MED-90036822-77
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)NC(=O)[C@H]5C[C@](C5)(F)CO)cc1 |
−10.0
± 0.3
|
7.3
± 0.2
|
2034 |
EN300-783124_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]([C@@H]5CCOC5)F |
−10.0
± 0.2
|
7.3
± 0.2
|
2035 |
EDG-MED-90036822-53
|
|
CCn1cc(nc1)C(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)F |
−10.0
± 0.2
|
7.3
± 0.1
|
2036 |
EN300-39826_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5nc6ncccn6n5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2037 |
EN300-23223_3_1
|
|
CNC(=O)CNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.3
|
7.3
± 0.2
|
2038 |
EN300-6494474_3_1
|
|
Cn1cnnc1CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2039 |
EN300-749499_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H](C5(CCOCC5)O)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2040 |
EN300-132624_2_1
|
|
CCC(=O)CNC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.4
|
7.3
± 0.3
|
2041 |
EN300-245061_3_1
|
|
Cc1c(cn(n1)C)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2042 |
EN300-651307_3_2
|
|
CC[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cncn5 |
−10.0
± 0.4
|
7.3
± 0.3
|
2043 |
EN300-180875_3_1
|
|
CN(C)C(=O)C1(CC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.3
|
2044 |
EN300-1932013_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H](CC(F)(F)F)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2045 |
EN300-72730_1_2
|
|
C[C@H](C#N)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.2
|
7.3
± 0.1
|
2046 |
EN300-1710153_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H](C(C5)(F)F)O |
−10.0
± 0.2
|
7.3
± 0.2
|
2047 |
EN300-6082676_1_1
|
|
C[C@@H]1C[C@@H](CCS1(=O)=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2048 |
EN300-55109_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@H]5CO |
−10.0
± 0.2
|
7.3
± 0.2
|
2049 |
EN300-05512_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)N[C@@H]5CCS(=O)(=O)C5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2050 |
EN300-174603_1_1
|
|
CN(C(=O)CCO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−10.0
± 0.3
|
7.3
± 0.2
|
2051 |
EN300-1932780_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H](C(F)F)O |
−10.0
± 0.2
|
7.3
± 0.2
|
2052 |
EN300-6356960_3_1
|
|
Cn1cnnc1CCCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2053 |
EN300-94945_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCNC5=O |
−10.0
± 0.3
|
7.3
± 0.2
|
2054 |
EN300-7494324_1_1
|
|
Cc1c(nc[nH]1)C[C@@H](C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2055 |
EN300-2011083_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCC(=O)OCC5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2056 |
EN300-175425_1_1
|
|
CC[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)OC |
−10.0
± 0.2
|
7.3
± 0.2
|
2057 |
EN300-47500_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NCCCn5cccn5 |
−10.0
± 0.4
|
7.3
± 0.3
|
2058 |
EN300-128463_3_1
|
|
CNC(=O)CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.3
|
7.3
± 0.2
|
2059 |
EN300-55109_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC[C@@H]5CO |
−10.0
± 0.3
|
7.3
± 0.2
|
2060 |
EN300-244148_1_1
|
|
Cn1cc(c(n1)COC)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2061 |
EN300-1630093_1_2
|
|
CC(C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)[C@]5(CCOC5)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2062 |
EN300-135530_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccnc5C(=O)N |
−10.0
± 0.3
|
7.3
± 0.2
|
2063 |
EN300-61636_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)C(=O)NC6CC6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2064 |
MIC-UNK-cdc2493e-5
|
|
c1ccc2c(c1)cncc2NC(=O)N(c3cccc(c3)Cl)C4CC5CCCCC5C4 |
−10.0
± 0.2
|
7.3
± 0.2
|
2065 |
EN300-72896_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCC(=O)N5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2066 |
EN300-72730_1_1
|
|
C[C@@H](C#N)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.2
|
7.3
± 0.2
|
2067 |
EN300-103144_1_2
|
|
CSCC[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2068 |
EN300-211203_1_1
|
|
CC(C)[C@@]1(CC(=O)NC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2069 |
EN300-7473354_1_1
|
|
Cc1ncn(n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2070 |
EN300-6486855_3_1
|
|
Cn1c(cnn1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2071 |
EN300-1718364_1_1
|
|
CC1(CS(=O)(=O)C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2072 |
EN300-1301381_1_1
|
|
COC[C@@]1(CCCO1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2073 |
EN300-1605226_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(C5)CNC(=O)N6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2074 |
EN300-123614_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)NC(=O)N |
−10.0
± 0.3
|
7.3
± 0.2
|
2075 |
EN300-54837_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5C(=O)CCCC5=O |
−10.0
± 0.3
|
7.3
± 0.2
|
2076 |
EN300-1138792_1_1
|
|
Cn1cnnc1CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2077 |
EN300-7003350_1_1
|
|
CCNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.1
|
7.27
± 0.08
|
2078 |
EN300-109920_1_1
|
|
C[C@@H]1CO[C@@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−10.0
± 0.5
|
7.3
± 0.4
|
2079 |
EN300-7494115_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6c(=O)[nH]cnc6nc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2080 |
EN300-373476_1_2
|
|
C[C@]1(CCCS1(=O)=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
2081 |
EN300-158260_1_1
|
|
CC(=O)N1C[C@@H](C[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2082 |
EDJ-MED-d203f206-34
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@H]5CO |
−10.0
± 0.3
|
7.3
± 0.2
|
2083 |
EN300-188356_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@]5(CCOC5)F |
−10.0
± 0.3
|
7.3
± 0.2
|
2084 |
EN300-79588_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCCS(=O)(=O)N |
−10.0
± 0.2
|
7.3
± 0.2
|
2085 |
MAK-UNK-8be7dca9-5
|
|
c1cc2c(cc1CN)cncc2NC(=O)C3CCOc4c3cc(cc4)Cl |
−10.0
± 0.1
|
7.26
± 0.09
|
2086 |
EN300-71560_1_1
|
|
COC(=O)NCCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.3
|
7.3
± 0.2
|
2087 |
EN300-1709410_1_2
|
|
C[C@H]1C[C@@H](N1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−10.0
± 0.3
|
7.3
± 0.2
|
2088 |
EN300-90225_2_1
|
|
Cn1nc(nn1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2089 |
ED_-GRI-5b13fbe2-24
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5cn(nn5)CC6CNC6 |
−10.0
± 0.4
|
7.3
± 0.3
|
2090 |
BEN-BAS-c2bc0d80-1
|
|
c1ccc2c(c1)cncc2NC(=O)C3CC=Nc4c3cc(cc4)Cl |
−10.0
± 0.3
|
7.3
± 0.2
|
2091 |
EN300-97300_1_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[C@H]5F |
−10.0
± 0.2
|
7.3
± 0.1
|
2092 |
EN300-1718194_1_2
|
|
CO[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)OC |
−10.0
± 0.2
|
7.3
± 0.2
|
2093 |
EN300-7444533_3_4
|
|
C[C@H]1C[C@H](C(=O)O1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.4
|
7.3
± 0.3
|
2094 |
EN300-722418_1_1
|
|
C[C@H](CN(C[C@H](C)O)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.0
± 0.4
|
7.3
± 0.3
|
2095 |
EN300-748981_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCCn6c5nnc6 |
−10.0
± 0.3
|
7.3
± 0.2
|
2096 |
EN300-259694_1_2
|
|
CCO[C@]1(CCOC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.3
|
2097 |
EN300-74314_1_1
|
|
CCn1c(=O)ccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.2
|
7.3
± 0.2
|
2098 |
EN300-6762327_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H](Cc5ccccn5)O |
−10.0
± 0.3
|
7.3
± 0.2
|
2099 |
EN300-306026_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(C5)O |
−10.0
± 0.2
|
7.3
± 0.2
|
2100 |
EN300-7493296_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6[C@H]5COC6 |
−10.0
± 0.2
|
7.3
± 0.2
|