Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
1901 |
EN300-103219_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC(=O)N5 |
−10.1
± 0.2
|
7.3
± 0.2
|
1902 |
EN300-173562_1_2
|
|
C[C@H]1C[C@@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.1
± 0.2
|
7.3
± 0.1
|
1903 |
EDG-MED-90036822-56
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC#N |
−10.1
± 0.1
|
7.3
± 0.1
|
1904 |
EN300-368758_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)C[C@@H]6CCCO6 |
−10.1
± 0.3
|
7.3
± 0.2
|
1905 |
EN300-1697763_2_1
|
|
C[C@]1(CCCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−10.1
± 0.3
|
7.3
± 0.3
|
1906 |
EN300-24014_3_2
|
|
CS(=O)(=O)[N@]1CCCC[C@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.5
|
7.3
± 0.4
|
1907 |
EN300-6477207_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6COC[C@H](C5)NC6=O |
−10.1
± 0.5
|
7.3
± 0.3
|
1908 |
VLA-UCB-50c39ae8-6_1
|
|
c1ccc2c(c1)cncc2N(C(=O)CCl)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−10.1
± 0.2
|
7.3
± 0.2
|
1909 |
EN300-107267_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CO[C@@H]5CCCNC5=O |
−10.1
± 0.2
|
7.3
± 0.2
|
1910 |
EN300-27476_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c(=O)[n+]6ccccc6[nH]5 |
−10.1
± 0.3
|
7.3
± 0.2
|
1911 |
EN300-219437_3_1
|
|
Cc1c(cnn1C)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.3
± 0.2
|
1912 |
EN300-113112_1_1
|
|
Cn1cnnc1CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.2
|
7.3
± 0.2
|
1913 |
EN300-650518_2_1
|
|
CO[C@@H]1C[C@H]1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.2
|
7.3
± 0.2
|
1914 |
EN300-318058_1_1
|
|
C[C@@]1(CN(C[C@@]1(C)CO)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−10.1
± 0.3
|
7.3
± 0.2
|
1915 |
EN300-6482296_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CO[C@@H]6[C@@H]5COC6 |
−10.1
± 0.3
|
7.3
± 0.2
|
1916 |
EN300-304135_1_2
|
|
CC[C@]1(CCNC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.3
± 0.2
|
1917 |
EN300-154942_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5OCCO5 |
−10.1
± 0.3
|
7.3
± 0.2
|
1918 |
EN300-6729572_3_1
|
|
C[C@@H]([C@@H]1C[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.1
± 0.3
|
7.3
± 0.2
|
1919 |
EN300-173023_1_1
|
|
CC(=O)OC1(CC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.3
± 0.2
|
1920 |
EN300-345656_1_1
|
|
C[C@@H]1C[C@@H](NC(=O)C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.3
± 0.2
|
1921 |
EN300-1072199_1_1
|
|
CO[C@@]1(CCCOC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.3
± 0.2
|
1922 |
EN300-1215738_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC[C@@H]5CCC(=O)NC5 |
−10.1
± 0.3
|
7.3
± 0.2
|
1923 |
EN300-246992_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5CCC(=O)NC5 |
−10.1
± 0.3
|
7.3
± 0.2
|
1924 |
EN300-649743_2_1
|
|
C[C@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)Cn5cnnn5 |
−10.1
± 0.4
|
7.3
± 0.3
|
1925 |
EN300-373476_3_1
|
|
C[C@@]1(CCCS1(=O)=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.4
|
7.3
± 0.3
|
1926 |
EN300-62857_3_1
|
|
COCCS(=O)(=O)CCCOCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.6
|
7.3
± 0.4
|
1927 |
EN300-122579_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCSC[C@H]5CO |
−10.1
± 0.3
|
7.3
± 0.2
|
1928 |
EDJ-MED-40433386-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCC5)CO |
−10.1
± 0.3
|
7.3
± 0.2
|
1929 |
EN300-90142_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCC[C@@H](C5)C(=O)N |
−10.1
± 0.4
|
7.3
± 0.3
|
1930 |
EN300-211422_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC5 |
−10.1
± 0.2
|
7.3
± 0.2
|
1931 |
EN300-1988306_3_1
|
|
CS(=O)(=O)CCC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.4
|
7.3
± 0.3
|
1932 |
EN300-6494158_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]5C[C@@H](CO5)CO |
−10.1
± 0.3
|
7.3
± 0.2
|
1933 |
EN300-783124_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]([C@@H]5CCOC5)F |
−10.1
± 0.2
|
7.3
± 0.1
|
1934 |
EN300-211482_3_1
|
|
C[C@@H](C(=O)NC)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.2
|
7.3
± 0.1
|
1935 |
EN300-13890_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CS[C@@H]5CCS(=O)(=O)C5 |
−10.1
± 0.4
|
7.3
± 0.3
|
1936 |
EN300-6478526_1_1
|
|
CNC(=O)N1CCC(CC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.3
± 0.2
|
1937 |
EN300-1273016_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CCCc6n5ncn6 |
−10.1
± 0.3
|
7.3
± 0.2
|
1938 |
EN300-114894_1_1
|
|
CC1(OCCO1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.3
± 0.2
|
1939 |
EN300-3044054_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CCC(=O)N5C6CC6 |
−10.1
± 0.4
|
7.3
± 0.3
|
1940 |
EN300-62166_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC[C@H]5CNC(=O)N |
−10.1
± 0.3
|
7.3
± 0.2
|
1941 |
EN300-182124_1_1
|
|
COC1(CC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.2
|
7.3
± 0.2
|
1942 |
EN300-65050_2_1
|
|
CC(C)(CO)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.3
|
7.3
± 0.2
|
1943 |
VLA-UCB-34f3ed0c-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cc[nH]n5 |
−10.1
± 0.2
|
7.3
± 0.1
|
1944 |
EN300-248888_1_2
|
|
C[C@](C=C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.1
± 0.3
|
7.3
± 0.2
|
1945 |
EN300-92684_1_2
|
|
Cc1c([cH+]n([nH]1)C)C2C[C@@H](ON2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.1
± 0.3
|
7.3
± 0.2
|
1946 |
EN300-378044_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CC=CCO5 |
−10.1
± 0.3
|
7.3
± 0.2
|
1947 |
EN300-261986_3_1
|
|
CS(=O)(=O)[N@]1CC[C@@H](C1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.3
± 0.2
|
1948 |
EN300-1692359_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@]5(CC[C@@H]5CO)CO |
−10.1
± 0.3
|
7.3
± 0.2
|
1949 |
EN300-53677_1_1
|
|
CS(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.2
|
7.3
± 0.2
|
1950 |
EN300-101443_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(COC5)O |
−10.1
± 0.2
|
7.3
± 0.2
|
1951 |
EN300-114805_3_1
|
|
Cn1c(ccn1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.2
|
7.3
± 0.1
|
1952 |
EN300-202922_3_1
|
|
C[C@@H]([C@@](C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−10.1
± 0.4
|
7.3
± 0.3
|
1953 |
EN300-6746890_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(C5)(CO)F |
−10.1
± 0.2
|
7.3
± 0.2
|
1954 |
EN300-72211_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H](C5CC5)O |
−10.1
± 0.3
|
7.3
± 0.2
|
1955 |
EN300-65839_3_1
|
|
CC[C@@H](C(=O)N)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.3
|
7.3
± 0.2
|
1956 |
EN300-1258964_3_2
|
|
C[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)NC |
−10.1
± 0.3
|
7.3
± 0.2
|
1957 |
EN300-262409_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(cn5)n6cnnn6 |
−10.1
± 0.2
|
7.3
± 0.2
|
1958 |
EN300-1241327_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCOCC5 |
−10.1
± 0.2
|
7.3
± 0.1
|
1959 |
EN300-17184_3_1
|
|
C=CCNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.3
|
7.3
± 0.2
|
1960 |
ED_-GRI-5b13fbe2-71
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5C[C@H]5N |
−10.1
± 0.3
|
7.3
± 0.2
|
1961 |
EN300-6473108_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6cccnn6n5 |
−10.1
± 0.2
|
7.3
± 0.2
|
1962 |
EN300-94945_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCNC5=O |
−10.0
± 0.2
|
7.3
± 0.2
|
1963 |
EN300-39961_1_1
|
|
CCN1CCN(C(=O)C1=O)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.4
|
7.3
± 0.3
|
1964 |
EN300-158274_3_1
|
|
CC(=O)N1C[C@H](C[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.0
± 0.4
|
7.3
± 0.3
|
1965 |
EN300-227055_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5CC(=O)NC5=O |
−10.0
± 0.2
|
7.3
± 0.2
|
1966 |
EN300-18561_3_1
|
|
CC(=O)NCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.3
|
7.3
± 0.2
|
1967 |
EN300-25702_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)O |
−10.0
± 0.2
|
7.3
± 0.2
|
1968 |
EN300-131093_4_1
|
|
C[C@@H](C(=O)NCC(=O)C)OCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.4
|
7.3
± 0.3
|
1969 |
MIC-UNK-cdc2493e-24
|
|
c1ccc2c(c1)cncc2NC(=O)N(CCn3cncn3)c4cccc(c4)Cl |
−10.0
± 0.3
|
7.3
± 0.3
|
1970 |
EN300-250836_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCc5c[nH]nc5 |
−10.0
± 0.2
|
7.3
± 0.2
|
1971 |
EN300-6494158_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5C[C@@H](CO5)CO |
−10.0
± 0.3
|
7.3
± 0.2
|
1972 |
VLA-UCB-34f3ed0c-5
|
|
c1ccc2c(c1)cncc2NC(=O)N(c3cccc(c3)Cl)C(=O)CCc4cc[nH]n4 |
−10.0
± 0.4
|
7.3
± 0.3
|
1973 |
EN300-5309123_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc(c5)Cn6cnnc6 |
−10.0
± 0.3
|
7.3
± 0.2
|
1974 |
EDJ-MED-d203f206-40
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H]([C@@H](C5)CO)O |
−10.0
± 0.3
|
7.3
± 0.2
|
1975 |
KAD-UNI-80f122c8-2
|
|
CC(=O)N1CC2CC1CN2C(=O)CC3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.0
± 0.3
|
7.3
± 0.2
|
1976 |
EN300-46832_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NC[C@H]5CCOC5 |
−10.0
± 0.3
|
7.3
± 0.3
|
1977 |
EN300-316216_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCn5cncn5 |
−10.0
± 0.2
|
7.3
± 0.1
|
1978 |
EN300-14458_3_1
|
|
C[C@@H](C(=O)N(C)C)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.2
|
7.3
± 0.2
|
1979 |
EN300-1693852_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@@H](C5)F)CO |
−10.0
± 0.3
|
7.3
± 0.2
|
1980 |
EN300-302290_4_1
|
|
CS(=O)(=O)N1CC(C1)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.4
|
7.3
± 0.3
|
1981 |
VLA-UCB-34f3ed0c-6
|
|
c1ccc2c(c1)cncc2NC(=O)N(c3cccc(c3)Cl)C(=O)CC4CCCCC4 |
−10.0
± 0.5
|
7.3
± 0.3
|
1982 |
EN300-2977549_1_1
|
|
CNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.04
± 0.10
|
7.31
± 0.07
|
1983 |
EDJ-MED-28ec730d-2
|
|
COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.1
|
7.3
± 0.1
|
1984 |
EN300-53423_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCOC5 |
−10.0
± 0.3
|
7.3
± 0.2
|
1985 |
EN300-193679_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@@]5(CCCOC5)O |
−10.0
± 0.3
|
7.3
± 0.2
|
1986 |
VLA-UCB-34f3ed0c-15
|
|
c1ccc2c(c1)cncc2N3C(=O)[C@@]4(CCOc5c4cc(cc5)Cl)N(C3=O)CN6CCNCC6 |
−10.0
± 0.5
|
7.3
± 0.3
|
1987 |
EN300-217107_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC[C@H]5C(=O)N |
−10.0
± 0.2
|
7.3
± 0.2
|
1988 |
EN300-263085_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CC5)n6cnnn6 |
−10.0
± 0.3
|
7.3
± 0.2
|
1989 |
EN300-1662365_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCc6ncnn6C5 |
−10.0
± 0.3
|
7.3
± 0.2
|
1990 |
EN300-1722017_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)n6nccn6 |
−10.0
± 0.3
|
7.3
± 0.2
|
1991 |
DAR-DIA-0d514e7d-30
|
|
C[C@@]1(c2cc(ccc2OCC1(C)C)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.2
|
7.3
± 0.2
|
1992 |
EN300-19542_2_1
|
|
C[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.0
± 0.3
|
7.3
± 0.2
|
1993 |
EN300-7439284_1_1
|
|
COc1cn[nH]c1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.0
± 0.3
|
7.3
± 0.2
|
1994 |
EN300-316679_1_1
|
|
CCC[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.0
± 0.3
|
7.3
± 0.2
|
1995 |
EN300-154332_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H]5CO |
−10.0
± 0.3
|
7.3
± 0.2
|
1996 |
EN300-6482967_1_1
|
|
CNS(=O)(=O)CCO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.3
|
7.3
± 0.2
|
1997 |
EN300-224741_3_1
|
|
CC[C@@H](CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.0
± 0.3
|
7.3
± 0.2
|
1998 |
EN300-226314_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)[C@@H]5CCS(=O)(=O)C5 |
−10.0
± 0.4
|
7.3
± 0.3
|
1999 |
EN300-04492_4_1
|
|
COCCCNC(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.0
± 0.3
|
7.3
± 0.3
|
2000 |
EN300-59487_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CC(=O)NC5 |
−10.0
± 0.3
|
7.3
± 0.2
|