Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
1801 |
EN300-19507_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(F)F |
−10.1
± 0.3
|
7.4
± 0.2
|
1802 |
EN300-36911_3_1
|
|
CNC(=O)NCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.3
|
7.4
± 0.2
|
1803 |
EN300-2958082_3_1
|
|
C[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)NC |
−10.1
± 0.3
|
7.4
± 0.2
|
1804 |
MAK-UNK-8be7dca9-4
|
|
c1cc2cncc(c2cc1N3CCNCC3)NC(=O)C4CCOc5c4cc(cc5)Cl |
−10.14
± 0.10
|
7.39
± 0.07
|
1805 |
EN300-6486793_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCCC5)S(=O)(=O)N |
−10.1
± 0.4
|
7.4
± 0.3
|
1806 |
EN300-188356_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@]5(CCOC5)F |
−10.1
± 0.3
|
7.4
± 0.2
|
1807 |
EN300-6482296_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CO[C@H]6[C@@H]5COC6 |
−10.1
± 0.3
|
7.4
± 0.2
|
1808 |
EN300-131093_3_1
|
|
C[C@@H](C(=O)NCC(=O)C)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.4
|
7.4
± 0.3
|
1809 |
EN300-50009_1_1
|
|
COC(=O)NCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.2
|
7.4
± 0.2
|
1810 |
EN300-59487_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC(=O)NC5 |
−10.1
± 0.2
|
7.4
± 0.2
|
1811 |
EN300-157502_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5OCCCO5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1812 |
EN300-127197_1_1
|
|
COc1cc(on1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1813 |
EN300-1703143_1_1
|
|
CC(C)(C)c1nnn(n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.3
|
1814 |
EN300-248521_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]([C@H](C5)O)CO |
−10.1
± 0.3
|
7.4
± 0.2
|
1815 |
EN300-31015_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCSCC(=O)N |
−10.1
± 0.2
|
7.4
± 0.2
|
1816 |
EDG-MED-90036822-105
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CNC5CC5)(F)F |
−10.1
± 0.3
|
7.4
± 0.2
|
1817 |
EN300-84785_2_1
|
|
C[C@@H](CC(=O)N)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.2
|
7.4
± 0.1
|
1818 |
EDG-MED-90036822-44
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(=O)CCF |
−10.1
± 0.2
|
7.4
± 0.1
|
1819 |
EN300-72109_1_2
|
|
CC(C)(C)OC(=O)N[C@H](CO)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.3
|
7.4
± 0.2
|
1820 |
EN300-55498_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COc5ccc(cc5)C(=O)N |
−10.1
± 0.3
|
7.4
± 0.2
|
1821 |
EN300-97661_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc[nH]c(=O)c5 |
−10.1
± 0.2
|
7.4
± 0.2
|
1822 |
EN300-72211_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H](C5CC5)O |
−10.1
± 0.3
|
7.4
± 0.2
|
1823 |
ALP-POS-5bb456a5-1
|
|
CC1CN(CCC1NC(=O)CC2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)C |
−10.1
± 0.3
|
7.4
± 0.2
|
1824 |
EN300-1702864_2_1
|
|
CS(=O)(=O)C[C@@H]1C[C@@H](CN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)F |
−10.1
± 0.3
|
7.4
± 0.2
|
1825 |
EN300-177118_3_2
|
|
C[C@]1(CCC(=O)N1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1826 |
EN300-295905_1_1
|
|
C[C@@H]1CN(C[C@@H](O1)C(=O)N)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1827 |
EN300-1968342_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@@H](CF)O |
−10.1
± 0.2
|
7.4
± 0.1
|
1828 |
EN300-7003350_3_1
|
|
CCNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.1
|
7.38
± 0.09
|
1829 |
EN300-171766_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCc5n[nH]c(=O)s5 |
−10.1
± 0.4
|
7.4
± 0.3
|
1830 |
EN300-6736413_2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CO[C@H]5CCNC5=O |
−10.1
± 0.1
|
7.4
± 0.1
|
1831 |
EN300-109540_1_1
|
|
C[C@@H](c1cn(nn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.1
± 0.3
|
7.4
± 0.2
|
1832 |
VLA-UNK-cf7facf1-1
|
|
c1ccc2c(c1)cncc2N3C(=O)[C@]4(CCOc5c4cc(cc5)Cl)NC3=O |
−10.1
± 0.2
|
7.4
± 0.2
|
1833 |
EN300-1601684_3_2
|
|
CC1([C@H](OCCO1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−10.1
± 0.3
|
7.4
± 0.2
|
1834 |
PET-UNK-29afea89-1_1
|
|
C#C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.1
|
7.38
± 0.08
|
1835 |
EN300-266736_2_1
|
|
Cc1c(nc[nH]1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1836 |
EN300-30397_3_1
|
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cncn5 |
−10.1
± 0.2
|
7.4
± 0.2
|
1837 |
EN300-23214_3_1
|
|
CCCNC(=O)[C@@H](C)NC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.5
|
7.4
± 0.4
|
1838 |
EN300-18569_3_2
|
|
C[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−10.1
± 0.3
|
7.4
± 0.2
|
1839 |
EN300-297927_1_1
|
|
CC(C)(C)n1nc(nn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1840 |
EN300-31969_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC(=O)N(C5)CC6CC6 |
−10.1
± 0.3
|
7.4
± 0.2
|
1841 |
EN300-51257_1_2
|
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−10.1
± 0.2
|
7.4
± 0.1
|
1842 |
EN300-202757_3_2
|
|
C[C@H](CC(=O)N)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.3
|
7.4
± 0.2
|
1843 |
EN300-395654_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H](C6(C5)COC6)CO |
−10.1
± 0.3
|
7.4
± 0.2
|
1844 |
EN300-248526_3_1
|
|
c1ccc(cc1)[C@@](COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(C(=O)N)O |
−10.1
± 0.4
|
7.4
± 0.3
|
1845 |
EN300-188356_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@]5(CCOC5)F |
−10.1
± 0.3
|
7.4
± 0.2
|
1846 |
EN300-47500_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCCCn5cccn5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1847 |
EN300-19700_3_1
|
|
COC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.1
|
7.37
± 0.09
|
1848 |
EN300-1724086_1_4
|
|
C[C@H]1C[C@H](CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−10.1
± 0.3
|
7.4
± 0.2
|
1849 |
EN300-211403_1_1
|
|
CN(C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C5(CC5)CO |
−10.1
± 0.3
|
7.4
± 0.2
|
1850 |
EN300-12587_3_2
|
|
CC(=O)N1CCC[C@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1851 |
RAL-THA-1d44ff04-2
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)OCc4[nH]ncn4 |
−10.1
± 0.3
|
7.4
± 0.2
|
1852 |
EN300-863933_1_2
|
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N(C)C(=O)C |
−10.1
± 0.3
|
7.4
± 0.2
|
1853 |
EN300-249421_1_1
|
|
C[C@@H]([C@@H]1CCC(=O)N1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1854 |
EN300-124052_1_3
|
|
C[C@@H]1CN(C[C@H]1O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1855 |
EN300-143449_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCN(=O)=O |
−10.1
± 0.3
|
7.4
± 0.2
|
1856 |
EN300-310022_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@H](C[N@]5c6ccncn6)O |
−10.1
± 0.4
|
7.4
± 0.3
|
1857 |
EN300-203293_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@H]5CNC(=O)O5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1858 |
EN300-6729572_3_2
|
|
C[C@H]([C@@H]1C[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.1
± 0.3
|
7.4
± 0.2
|
1859 |
EDJ-MED-28ec730d-2_1
|
|
COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.2
|
7.4
± 0.1
|
1860 |
EN300-30768_3_4
|
|
C[C@H]1C[C@H]1C(=O)NCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1861 |
EN300-30397_1_2
|
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cncn5 |
−10.1
± 0.2
|
7.4
± 0.1
|
1862 |
EN300-11934_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCCC5=O |
−10.1
± 0.3
|
7.4
± 0.2
|
1863 |
MIC-UNK-50cce87d-7
|
|
Cc1cccc2c1c(cnc2)N3CCC(C3=O)c4cccc(c4)Cl |
−10.1
± 0.2
|
7.4
± 0.2
|
1864 |
EN300-173562_1_4
|
|
C[C@H]1C[C@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.1
± 0.3
|
7.4
± 0.2
|
1865 |
EN300-305282_3_2
|
|
COC[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−10.1
± 0.4
|
7.4
± 0.3
|
1866 |
EN300-82616_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CCCNC5=O |
−10.1
± 0.2
|
7.4
± 0.2
|
1867 |
EN300-31146_3_1
|
|
CN(CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)C5CC5 |
−10.1
± 0.4
|
7.4
± 0.3
|
1868 |
MIC-UNK-16ccb665-2
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)SC(F)F |
−10.1
± 0.3
|
7.4
± 0.2
|
1869 |
EN300-48861_1_1
|
|
CNC(=O)Cn1[cH+]c(c[nH]1)NC(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1870 |
EN300-133058_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc6c(n5)n[nH]n6 |
−10.1
± 0.3
|
7.4
± 0.2
|
1871 |
EDJ-MED-fcba3f31-11
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@@H]5C[C@@H](CO5)CO |
−10.1
± 0.3
|
7.4
± 0.2
|
1872 |
VLA-UCB-34f3ed0c-8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)C(=O)CCc5cc[nH]n5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1873 |
EN300-1723663_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCN(C(=O)C5)CCO |
−10.1
± 0.3
|
7.4
± 0.2
|
1874 |
EN300-7538678_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(=O)n6c5COCC6 |
−10.1
± 0.3
|
7.4
± 0.2
|
1875 |
EN300-318344_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ncco5 |
−10.1
± 0.1
|
7.4
± 0.1
|
1876 |
EN300-1265949_3_2
|
|
C[C@H](C(=O)N1CCS(=O)(=O)CC1)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.3
|
1877 |
EN300-12247_3_1
|
|
CC(C)(C)C(=O)NCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.3
|
7.4
± 0.2
|
1878 |
EN300-1915260_3_1
|
|
COC[C@@H](COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.1
± 0.4
|
7.4
± 0.3
|
1879 |
EN300-207873_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5(CC5)O |
−10.1
± 0.3
|
7.4
± 0.2
|
1880 |
EN300-19542_1_2
|
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.1
± 0.2
|
7.4
± 0.1
|
1881 |
EN300-6493060_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]6[C@@H]([C@@H]5CO6)O |
−10.1
± 0.3
|
7.4
± 0.2
|
1882 |
EN300-6498856_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC[C@H]5C(=O)NC(=O)N5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1883 |
EN300-315792_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)COCC(F)F |
−10.1
± 0.3
|
7.4
± 0.2
|
1884 |
EN300-10729_4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCNC(=O)N |
−10.1
± 0.3
|
7.4
± 0.2
|
1885 |
EN300-226314_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)[C@H]5CCS(=O)(=O)C5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1886 |
EN300-706065_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C5(CCOCC5)O)(F)F |
−10.1
± 0.3
|
7.4
± 0.2
|
1887 |
ED_-GRI-5b13fbe2-69
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5CC5N |
−10.1
± 0.2
|
7.4
± 0.1
|
1888 |
EN300-263153_4_1
|
|
Cn1cc(nn1)C(=O)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1889 |
EN300-315854_1_2
|
|
C[C@]1(CCNC(=O)C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1890 |
ED_-GRI-5b13fbe2-41
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H](CN)F |
−10.1
± 0.4
|
7.4
± 0.3
|
1891 |
EN300-6729747_1_2
|
|
CC1NN[C@H]2[N@@H+]1C[C@H](C2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.1
± 0.4
|
7.4
± 0.3
|
1892 |
EN300-6742996_1_1
|
|
COC[C@@H]1CN(CCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.3
|
7.4
± 0.2
|
1893 |
EN300-47657_1_2
|
|
C[C@H](C(=O)N(C)C)NC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.1
± 0.3
|
7.4
± 0.2
|
1894 |
EN300-47606_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NC[C@H]5CCS(=O)(=O)C5 |
−10.1
± 0.4
|
7.4
± 0.3
|
1895 |
EN300-18569_1_2
|
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−10.1
± 0.2
|
7.4
± 0.2
|
1896 |
EN300-383906_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)N5CCCC5 |
−10.1
± 0.3
|
7.3
± 0.2
|
1897 |
EN300-138787_1_1
|
|
COC(=O)C1(CC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.1
± 0.2
|
7.3
± 0.2
|
1898 |
EDG-MED-90036822-36
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(n5ccnc5)F |
−10.1
± 0.2
|
7.3
± 0.2
|
1899 |
EN300-7464289_1_2
|
|
C[C@](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C(=O)OC)F |
−10.1
± 0.2
|
7.3
± 0.2
|
1900 |
EN300-135310_1_1
|
|
Cc1nc(on1)Cn2cc(cn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.1
± 0.3
|
7.3
± 0.2
|