Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
1301 |
EN300-2011576_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5Cc6c(nccn6)C5 |
−10.5
± 0.2
|
7.6
± 0.2
|
1302 |
EN300-7355519_1_8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5C[C@H]6[C@H](O5)CCO6 |
−10.5
± 0.2
|
7.6
± 0.2
|
1303 |
EN300-7352812_3_1
|
|
Cn1cc(cn1)OC2(CC2)C(=O)NCC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.5
± 0.3
|
7.6
± 0.2
|
1304 |
EN300-211203_1_2
|
|
CC(C)[C@]1(CC(=O)NC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.2
|
7.6
± 0.2
|
1305 |
EN300-17184_1_1
|
|
C=CCNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.2
|
7.6
± 0.1
|
1306 |
EN300-182725_3_2
|
|
C[C@H]([C@@H](C)S(=O)(=O)C)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.4
|
7.6
± 0.3
|
1307 |
EDG-MED-90036822-31
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5[nH]ccn5 |
−10.5
± 0.2
|
7.6
± 0.2
|
1308 |
EN300-1644723_1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5[C@H]6[C@@H]5COCC6 |
−10.5
± 0.3
|
7.6
± 0.2
|
1309 |
EN300-134855_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H](c5cccnc5)O |
−10.5
± 0.3
|
7.6
± 0.2
|
1310 |
EN300-1644723_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@@H]6[C@@H]5COCC6 |
−10.5
± 0.2
|
7.6
± 0.2
|
1311 |
EN300-19900_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnccn5 |
−10.5
± 0.2
|
7.6
± 0.1
|
1312 |
EN300-198540_3_1
|
|
Cn1cc(cn1)[C@@H](C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.5
± 0.3
|
7.6
± 0.2
|
1313 |
EN300-118760_3_1
|
|
C[C@@](C1CC1)(C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.5
± 0.4
|
7.6
± 0.3
|
1314 |
EN300-18928_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CSCN5C(=O)C6CC6 |
−10.5
± 0.3
|
7.6
± 0.2
|
1315 |
EN300-133915_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5csc(=O)[nH]5 |
−10.5
± 0.2
|
7.6
± 0.2
|
1316 |
EN300-64297_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cncnc5 |
−10.5
± 0.2
|
7.6
± 0.1
|
1317 |
EN300-300217_3_4
|
|
C/C=C/[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.5
± 0.4
|
7.6
± 0.3
|
1318 |
EN300-219020_1_1
|
|
Cn1ncc(n1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.1
|
7.6
± 0.1
|
1319 |
EN300-263669_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@]56C[C@H]5COC6 |
−10.5
± 0.2
|
7.6
± 0.2
|
1320 |
EN300-6474341_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCn6cnnc6C5 |
−10.5
± 0.2
|
7.6
± 0.2
|
1321 |
EN300-116313_3_1
|
|
CC(=O)N1CCOC[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1322 |
EN300-178876_3_1
|
|
C[C@@]1(CCCNC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.4
|
7.6
± 0.3
|
1323 |
EN300-96933_3_1
|
|
CC(C)c1nnnn1CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.4
|
7.6
± 0.3
|
1324 |
EN300-189672_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5ccc(=O)[nH]c5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1325 |
EDG-MED-90036822-33
|
|
COC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)F |
−10.5
± 0.1
|
7.63
± 0.10
|
1326 |
ALP-POS-477dc5b7-3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC5CC5 |
−10.5
± 0.2
|
7.6
± 0.2
|
1327 |
EN300-301925_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@]5(CCCOC5)C#N |
−10.5
± 0.3
|
7.6
± 0.2
|
1328 |
EN300-223187_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c6c(nn5)CCCC6 |
−10.5
± 0.3
|
7.6
± 0.2
|
1329 |
EN300-113234_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CC(=O)OC5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1330 |
EN300-67267_1_1
|
|
Cc1[nH]c(=O)c(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1331 |
EN300-12440_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CC(=O)N(C5)C6CC6 |
−10.5
± 0.4
|
7.6
± 0.3
|
1332 |
EN300-360158_1_2
|
|
CC1(C[C@](CO1)(CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O)C |
−10.5
± 0.3
|
7.6
± 0.2
|
1333 |
EDG-MED-90036822-101
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C5CC(C5)(F)F)O |
−10.5
± 0.3
|
7.6
± 0.2
|
1334 |
EN300-95698_3_4
|
|
C[C@H]1CC(=O)NC[C@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1335 |
EN300-27261_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(nc5)n6cncn6 |
−10.5
± 0.2
|
7.6
± 0.2
|
1336 |
EN300-120282_3_1
|
|
Cn1cc(nn1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1337 |
EDJ-MED-e4b030d8-4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OC5COC5)Cl |
−10.5
± 0.2
|
7.6
± 0.1
|
1338 |
EN300-6477475_1_1
|
|
COCc1cc(no1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.2
|
7.6
± 0.2
|
1339 |
EN300-264744_1_2
|
|
CC(C)([C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)F)O |
−10.5
± 0.2
|
7.6
± 0.2
|
1340 |
EN300-1932013_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](CC(F)(F)F)O |
−10.5
± 0.3
|
7.6
± 0.2
|
1341 |
EN300-77464_1_1
|
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.5
± 0.2
|
7.6
± 0.1
|
1342 |
EN300-08065_1_1
|
|
c1ccc(cc1)c2nnn(n2)CC(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.5
± 0.3
|
7.6
± 0.2
|
1343 |
EN300-05512_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N[C@@H]5CCS(=O)(=O)C5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1344 |
EDG-MED-90036822-32
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(c[nH]n5)F |
−10.5
± 0.2
|
7.6
± 0.2
|
1345 |
EDJ-MED-d203f206-26
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H](C5)O |
−10.5
± 0.3
|
7.6
± 0.2
|
1346 |
EN300-331941_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5C[C@H]5C(=O)N |
−10.5
± 0.3
|
7.6
± 0.2
|
1347 |
EN300-123205_3_1
|
|
CNS(=O)(=O)CCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.3
|
7.6
± 0.2
|
1348 |
EN300-1387104_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CCS5(=O)=O |
−10.5
± 0.3
|
7.6
± 0.2
|
1349 |
EN300-05512_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N[C@H]5CCS(=O)(=O)C5 |
−10.5
± 0.3
|
7.6
± 0.2
|
1350 |
EN300-1654957_2_1
|
|
CN(CC(CO)CO)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.3
|
7.6
± 0.2
|
1351 |
EN300-304695_3_2
|
|
CN1CCCC[C@H](C1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.5
± 0.4
|
7.6
± 0.3
|
1352 |
EN300-317272_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)C[C@@H]6CCOC6 |
−10.5
± 0.3
|
7.6
± 0.2
|
1353 |
EN300-19507_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(F)F |
−10.5
± 0.2
|
7.6
± 0.2
|
1354 |
EN300-31186_3_1
|
|
CCC(=O)NCCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.5
± 0.3
|
7.6
± 0.2
|
1355 |
JOH-SUS-a69c159d-7_1
|
|
c1cc2c(cc1F)c(c(nc2F)F)NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−10.5
± 0.1
|
7.61
± 0.08
|
1356 |
EDJ-MED-e4b030d8-6_1
|
|
CCC[C@H]1COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−10.45
± 0.10
|
7.61
± 0.07
|
1357 |
EN300-23417_1_1
|
|
COCCn1c(=O)ccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
1358 |
EN300-133128_1_1
|
|
CN(C)S(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.3
|
7.6
± 0.2
|
1359 |
EN300-7473032_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCNC(=O)[C@@H]5C(=O)N |
−10.4
± 0.3
|
7.6
± 0.2
|
1360 |
EN300-305282_1_2
|
|
COC[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−10.4
± 0.3
|
7.6
± 0.2
|
1361 |
EN300-170463_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CCOC5 |
−10.4
± 0.3
|
7.6
± 0.2
|
1362 |
EN300-185398_1_1
|
|
C[C@@H](C(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(F)F)O |
−10.4
± 0.2
|
7.6
± 0.1
|
1363 |
EN300-259004_1_1
|
|
CC(=O)N1CC(C1)OCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
1364 |
EN300-48760_3_1
|
|
CC(C)(C)NC(=O)CNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.3
|
7.6
± 0.2
|
1365 |
EN300-6766359_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@H]6C[C@H]6C(=O)N5 |
−10.4
± 0.2
|
7.6
± 0.2
|
1366 |
EN300-268198_3_1
|
|
C[C@@H](CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−10.4
± 0.3
|
7.6
± 0.2
|
1367 |
EN300-302058_2_2
|
|
CON1CC[C@H](C1=O)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
1368 |
EN300-1644723_1_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@H]6[C@@H]5COCC6 |
−10.4
± 0.2
|
7.6
± 0.2
|
1369 |
EDG-MED-90036822-67
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(c5cnc[nH]5)(F)F |
−10.4
± 0.3
|
7.6
± 0.2
|
1370 |
EN300-5253939_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5COC(=O)O5 |
−10.4
± 0.2
|
7.6
± 0.1
|
1371 |
EN300-31145_1_1
|
|
CC(C)C(=O)N(C)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.2
|
7.6
± 0.2
|
1372 |
EN300-1253178_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NC5CC5 |
−10.4
± 0.2
|
7.6
± 0.1
|
1373 |
EN300-1725529_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CCCO)C5COC5 |
−10.4
± 0.3
|
7.6
± 0.2
|
1374 |
EN300-195855_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(cn5)n6cncn6 |
−10.4
± 0.2
|
7.6
± 0.2
|
1375 |
CHO-MSK-5891c1ff-11
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCCC#N |
−10.4
± 0.3
|
7.6
± 0.2
|
1376 |
ALP-UNI-dbbfd3db-13
|
|
Cn1cc(cn1)C2=NOC(C2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.4
± 0.2
|
7.6
± 0.1
|
1377 |
EN300-100741_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5[nH]ncn5 |
−10.4
± 0.2
|
7.6
± 0.1
|
1378 |
EN300-1653482_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCn6c(nnn6)C5 |
−10.4
± 0.2
|
7.6
± 0.2
|
1379 |
EDG-MED-90036822-76
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)NC(=O)[C@H]5C[C@@](C5)(F)CO)cc1 |
−10.4
± 0.2
|
7.6
± 0.2
|
1380 |
CHO-MSK-5891c1ff-9
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCC(F)F |
−10.4
± 0.2
|
7.6
± 0.2
|
1381 |
EN300-97699_3_1
|
|
C[C@@H](CS(=O)(=O)C)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.3
|
7.6
± 0.2
|
1382 |
EN300-731622_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[C@@H]5COCCO5 |
−10.4
± 0.3
|
7.6
± 0.2
|
1383 |
EN300-7461023_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)N(=O)=O |
−10.4
± 0.3
|
7.6
± 0.2
|
1384 |
EDG-MED-ba1ac7b9-24
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)CC(=O)N(CC(F)(F)F)C5COC5 |
−10.4
± 0.3
|
7.6
± 0.2
|
1385 |
EN300-12440_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CC(=O)N(C5)C6CC6 |
−10.4
± 0.3
|
7.6
± 0.2
|
1386 |
EN300-16248_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(cc5)S(=O)(=O)N |
−10.4
± 0.3
|
7.6
± 0.2
|
1387 |
EN300-304135_3_2
|
|
CC[C@]1(CCNC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
1388 |
EN300-119126_3_1
|
|
Cc1[nH]nc(n1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
1389 |
EDJ-MED-28ec730d-1
|
|
COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.4
± 0.2
|
7.6
± 0.2
|
1390 |
EN300-158260_3_1
|
|
CC(=O)N1C[C@@H](C[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.4
± 0.3
|
7.6
± 0.2
|
1391 |
EDJ-MED-28ec730d-4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5c[nH]nc5 |
−10.4
± 0.2
|
7.6
± 0.2
|
1392 |
JOH-SUS-a69c159d-7
|
|
c1cc2c(cc1F)c(c(nc2F)F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−10.43
± 0.06
|
7.60
± 0.05
|
1393 |
ED_-GRI-5b13fbe2-18
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H](c5cn(nn5)CC6CC6)N |
−10.4
± 0.4
|
7.6
± 0.3
|
1394 |
EN300-96933_1_1
|
|
CC(C)c1nnnn1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
1395 |
EN300-1258964_1_2
|
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)NC |
−10.4
± 0.2
|
7.6
± 0.2
|
1396 |
ALP-UNI-dbbfd3db-18
|
|
Cn1c(=O)ccn(c1=O)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.4
± 0.3
|
7.6
± 0.2
|
1397 |
EN300-178829_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC(=O)NCC5CC5 |
−10.4
± 0.3
|
7.6
± 0.2
|
1398 |
EN300-305294_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6C[C@@H]([C@@H]6C5)O |
−10.4
± 0.3
|
7.6
± 0.2
|
1399 |
EN300-343474_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5CCNC5=O |
−10.4
± 0.3
|
7.6
± 0.2
|
1400 |
EN300-37195_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N[C@H]5CCCCNC5=O |
−10.4
± 0.3
|
7.6
± 0.2
|