Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
1101 |
EN300-14437_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCS(=O)(=O)C5 |
−10.6
± 0.3
|
7.8
± 0.2
|
1102 |
EN300-1589101_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5c[nH]nc5 |
−10.6
± 0.2
|
7.8
± 0.2
|
1103 |
EN300-149224_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc(cn5)C#N |
−10.6
± 0.2
|
7.8
± 0.2
|
1104 |
EN300-370967_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCN5CCOC5=O |
−10.6
± 0.2
|
7.8
± 0.1
|
1105 |
EN300-36158_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5COCCO5 |
−10.6
± 0.2
|
7.8
± 0.2
|
1106 |
EN300-10895_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCCC#N |
−10.6
± 0.2
|
7.8
± 0.2
|
1107 |
EN300-103435_2_1
|
|
Cc1cc(cc(=O)n1CCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.6
± 0.3
|
7.7
± 0.2
|
1108 |
EN300-6729572_1_4
|
|
C[C@H]([C@H]1C[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.6
± 0.2
|
7.7
± 0.2
|
1109 |
EN300-6255179_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCn5cncn5 |
−10.6
± 0.1
|
7.7
± 0.1
|
1110 |
EN300-211203_3_2
|
|
CC(C)[C@]1(CC(=O)NC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.4
|
7.7
± 0.3
|
1111 |
EN300-113234_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CC(=O)OC5 |
−10.6
± 0.4
|
7.7
± 0.3
|
1112 |
EN300-6487134_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC56CC(C5)C(=O)NC6 |
−10.6
± 0.3
|
7.7
± 0.2
|
1113 |
EN300-754584_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CS(=O)(=O)CC(=O)N5 |
−10.6
± 0.2
|
7.7
± 0.2
|
1114 |
EN300-195590_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5CCCNC(=O)C5 |
−10.6
± 0.4
|
7.7
± 0.3
|
1115 |
EN300-175186_4_1
|
|
C[C@@H](CO)OCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.3
|
7.7
± 0.2
|
1116 |
EDG-MED-90036822-85
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5C[C@H]([C@@H](C5)F)O |
−10.6
± 0.2
|
7.7
± 0.1
|
1117 |
EDG-MED-90036822-88
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC(CCF)CN |
−10.6
± 0.2
|
7.7
± 0.1
|
1118 |
EN300-125769_1_1
|
|
COCCCOCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.3
|
7.7
± 0.2
|
1119 |
EN300-02067_1_1
|
|
C[C@@H](COC)NC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.3
|
7.7
± 0.2
|
1120 |
EN300-269453_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCc6nnnn6C5 |
−10.6
± 0.2
|
7.7
± 0.2
|
1121 |
EDJ-MED-40433386-3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@]5(CCSC5)O |
−10.6
± 0.4
|
7.7
± 0.3
|
1122 |
EN300-1600517_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H](CO)F |
−10.6
± 0.3
|
7.7
± 0.2
|
1123 |
EN300-7355519_3_5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[C@@H]5C[C@@H]6[C@H](O5)CCO6 |
−10.6
± 0.3
|
7.7
± 0.2
|
1124 |
EN300-90142_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCC[C@@H](C5)C(=O)N |
−10.6
± 0.3
|
7.7
± 0.2
|
1125 |
EN300-173006_2_1
|
|
C[C@@H](c1nnnn1C)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1126 |
EN300-62074_1_2
|
|
CC(=O)N[C@H](CCOC)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.3
|
7.7
± 0.2
|
1127 |
EN300-717276_1_1
|
|
CCn1cc(nn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.2
|
7.7
± 0.2
|
1128 |
EN300-78368_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCCCC5)NC(=O)N |
−10.6
± 0.4
|
7.7
± 0.3
|
1129 |
EN300-20233_1_1
|
|
COCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.2
|
7.7
± 0.2
|
1130 |
EDG-MED-90036822-71
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CN5CCNC5=O)(F)F |
−10.6
± 0.3
|
7.7
± 0.2
|
1131 |
EN300-23318_3_4
|
|
C[C@H](C(=O)N[C@H]1CCS(=O)(=O)C1)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1132 |
EN300-74448_1_1
|
|
CCN(CCO)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.2
|
7.7
± 0.2
|
1133 |
EN300-7355519_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5C[C@@H]6[C@@H](O5)CCO6 |
−10.6
± 0.3
|
7.7
± 0.2
|
1134 |
EN300-7436306_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5[C@H]6COC[C@H]6ON5 |
−10.6
± 0.2
|
7.7
± 0.2
|
1135 |
EN300-155498_1_1
|
|
CC([CH2-])[C@H](CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.6
± 0.2
|
7.7
± 0.2
|
1136 |
KAD-UNI-8a629cb0-1
|
|
CS(=O)(=O)N1CC[C@H](C1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1137 |
EN300-71405_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5ccn[nH]5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1138 |
EN300-46832_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NC[C@@H]5CCOC5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1139 |
EN300-120282_1_1
|
|
Cn1cc(nn1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.2
|
7.7
± 0.1
|
1140 |
EN300-4726186_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[N@]5CCCNS5(=O)=O |
−10.6
± 0.4
|
7.7
± 0.3
|
1141 |
DAR-DIA-6a508060-5_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4C[C@H]5CC(=O)N5)Cl |
−10.6
± 0.2
|
7.7
± 0.1
|
1142 |
EN300-250126_1_1
|
|
CC(C)C[C@@H](C(=O)N)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.3
|
7.7
± 0.2
|
1143 |
EN300-1717596_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(C5)n6cnnc6 |
−10.6
± 0.3
|
7.7
± 0.3
|
1144 |
EN300-94945_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CCNC5=O |
−10.6
± 0.2
|
7.7
± 0.1
|
1145 |
EN300-358956_1_1
|
|
Cc1cc(c(=O)[nH]c1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C#N |
−10.6
± 0.4
|
7.7
± 0.3
|
1146 |
EN300-6479181_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CC[C@@H]6N5C(=O)CC6 |
−10.6
± 0.3
|
7.7
± 0.2
|
1147 |
EN300-52009_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCC5)O |
−10.6
± 0.3
|
7.7
± 0.2
|
1148 |
EN300-1072972_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5CCOC5=O |
−10.6
± 0.2
|
7.7
± 0.2
|
1149 |
EN300-219330_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCN5CCOCC5=O |
−10.6
± 0.2
|
7.7
± 0.2
|
1150 |
EN300-321789_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]6C[C@@H]5CO6 |
−10.6
± 0.2
|
7.7
± 0.2
|
1151 |
EN300-6356960_1_1
|
|
Cn1cnnc1CCCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1152 |
EN300-96362_3_2
|
|
C[C@H]([C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C5CC5)O |
−10.6
± 0.4
|
7.7
± 0.3
|
1153 |
EN300-6745453_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5Cc6nncn6C5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1154 |
EN300-103144_3_1
|
|
CSCC[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.6
± 0.4
|
7.7
± 0.3
|
1155 |
EDJ-MED-fcba3f31-8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CO[C@H]5CCOC5=O |
−10.6
± 0.2
|
7.7
± 0.1
|
1156 |
EN300-189563_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCC5CS(=O)(=O)C5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1157 |
VLA-UCB-34f3ed0c-8_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)C(=O)CCc5ccn[nH]5 |
−10.6
± 0.2
|
7.7
± 0.2
|
1158 |
EN300-7430501_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCn6c(cnn6)C5 |
−10.6
± 0.2
|
7.7
± 0.1
|
1159 |
EN300-1271924_1_1
|
|
Cc1cc(=O)c(cn1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−10.6
± 0.3
|
7.7
± 0.2
|
1160 |
EN300-217494_1_1
|
|
C[C@@]([C@@H]1CCOC1)(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.6
± 0.3
|
7.7
± 0.2
|
1161 |
DAR-DIA-0d514e7d-18_1
|
|
C[C@H]1COc2c(cc(cc2OC(F)(F)F)Cl)[C@@H]1C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.2
|
7.7
± 0.1
|
1162 |
EN300-198633_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5CCCCNC5=O |
−10.6
± 0.3
|
7.7
± 0.2
|
1163 |
EN300-120920_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCO[C@@H]5CCC(=O)NC5=O |
−10.6
± 0.2
|
7.7
± 0.2
|
1164 |
EN300-121144_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5ccccc5C(=O)N |
−10.6
± 0.3
|
7.7
± 0.2
|
1165 |
EN300-73772_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5[nH]c(=O)[nH]n5 |
−10.6
± 0.2
|
7.7
± 0.2
|
1166 |
EN300-185751_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cncnc5 |
−10.6
± 0.2
|
7.7
± 0.1
|
1167 |
EN300-31099_3_1
|
|
CCC(=O)NCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.3
|
7.7
± 0.2
|
1168 |
EN300-1708882_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5COC[C@H]5O |
−10.6
± 0.2
|
7.7
± 0.2
|
1169 |
EN300-99391_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CO[C@H]5CCOC5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1170 |
EN300-109535_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5CC(=O)OC5 |
−10.6
± 0.2
|
7.7
± 0.2
|
1171 |
EN300-301925_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@]5(CCCOC5)C#N |
−10.6
± 0.2
|
7.7
± 0.2
|
1172 |
EN300-50514_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COc5ccc(cc5)CC(=O)N |
−10.6
± 0.4
|
7.7
± 0.3
|
1173 |
DAR-DIA-5ff57136-11_1
|
|
[CH2-]C=CC(=O)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−10.6
± 0.2
|
7.7
± 0.2
|
1174 |
EN300-109535_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5CC(=O)OC5 |
−10.6
± 0.2
|
7.7
± 0.2
|
1175 |
MAK-UNK-c749d764-22
|
|
CC(CNCC1CCCO1)C(c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.4
|
7.7
± 0.3
|
1176 |
EN300-731622_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5COCCO5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1177 |
EN300-263153_3_1
|
|
Cn1cc(nn1)C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1178 |
EN300-159633_3_2
|
|
C[C@](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C(F)(F)F)O |
−10.6
± 0.3
|
7.7
± 0.2
|
1179 |
FRA-DIA-b66f7109-3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCOc4c3cc(cc4Cl)O[C@H]5C[C@H](N5)O |
−10.6
± 0.5
|
7.7
± 0.4
|
1180 |
EN300-109540_3_1
|
|
C[C@@H](c1cn(nn1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.6
± 0.3
|
7.7
± 0.2
|
1181 |
EN300-42243_1_1
|
|
CC(C)CS(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.3
|
7.7
± 0.2
|
1182 |
EN300-1425677_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@]5(CCCO5)CO |
−10.6
± 0.4
|
7.7
± 0.3
|
1183 |
EN300-245265_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCn5cnc(n5)C#N |
−10.6
± 0.3
|
7.7
± 0.2
|
1184 |
EN300-299215_1_1
|
|
C[C@H]1[C@H](OCCO1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1185 |
KAD-UNI-8a629cb0-17
|
|
CN(C1CCN(CC1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)C |
−10.6
± 0.3
|
7.7
± 0.2
|
1186 |
EN300-30768_1_2
|
|
C[C@H]1C[C@@H]1C(=O)NCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1187 |
DAR-DIA-5ff57136-14_1
|
|
CC(C)(C#C)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−10.6
± 0.2
|
7.7
± 0.1
|
1188 |
EN300-268198_3_2
|
|
C[C@H](CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−10.6
± 0.3
|
7.7
± 0.2
|
1189 |
EN300-249764_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](C5CCC5)O |
−10.6
± 0.2
|
7.7
± 0.2
|
1190 |
EN300-705386_1_1
|
|
COC[C@@H]1C[C@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.2
|
7.7
± 0.1
|
1191 |
EN300-62074_3_2
|
|
CC(=O)N[C@H](CCOC)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.6
± 0.3
|
7.7
± 0.2
|
1192 |
EN300-56202_3_1
|
|
CC(=O)N1CSC[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1193 |
CHO-MSK-a31cca77-4
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5ncon5 |
−10.6
± 0.2
|
7.7
± 0.2
|
1194 |
EN300-16582_3_1
|
|
CC(C)[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−10.6
± 0.4
|
7.7
± 0.3
|
1195 |
EN300-101443_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(COC5)O |
−10.6
± 0.2
|
7.7
± 0.2
|
1196 |
EDJ-MED-d203f206-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@H]6[C@@H]5C[C@H](C6)C(=O)N |
−10.6
± 0.3
|
7.7
± 0.2
|
1197 |
EN300-92605_1_2
|
|
Cn1cc(cn1)C2C[C@@H](ON2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.6
± 0.2
|
7.7
± 0.2
|
1198 |
ALF-EVA-0b412456-8
|
|
c1cc2cncc(c2cc1C3CNC3)NC(=O)Cc4cc(cc(c4)Cl)OC5CC(=O)N5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1199 |
EN300-100467_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5ccnn5 |
−10.6
± 0.3
|
7.7
± 0.2
|
1200 |
EN300-31146_1_1
|
|
CN(CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)C5CC5 |
−10.6
± 0.2
|
7.7
± 0.2
|