Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
101 |
EN300-195924_3_1
|
|
C[C@@]1(CCC(=O)NC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.5
± 0.3
|
9.1
± 0.2
|
102 |
ALP-UNI-44c99a80-2_1
|
|
c1ccc2c(c1)cncc2N(Cc3cnc[nH]3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−12.5
± 0.2
|
9.1
± 0.1
|
103 |
EN300-200426_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6n(n5)CCNC6=O |
−12.5
± 0.2
|
9.1
± 0.2
|
104 |
EN300-7352736_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[C@@H]([C@@H](CO5)O)O |
−12.5
± 0.3
|
9.1
± 0.2
|
105 |
DAR-DIA-5ff57136-10_1
|
|
c1ccc2c(c1)cncc2N(C#CC#N)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−12.5
± 0.1
|
9.10
± 0.10
|
106 |
EN300-298552_3_4
|
|
CO[C@H]([C@H]1CCOC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.5
± 0.2
|
9.1
± 0.2
|
107 |
EN300-1273362_3_2
|
|
C[C@]1(CN(C1=O)C)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.5
± 0.4
|
9.1
± 0.3
|
108 |
EN300-364679_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCn5cnnn5 |
−12.5
± 0.3
|
9.1
± 0.2
|
109 |
EN300-106432_1_1
|
|
C#CCOCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−12.4
± 0.2
|
9.1
± 0.1
|
110 |
EN300-2908024_1_2
|
|
CC[C@](C)(C(=O)N)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−12.4
± 0.3
|
9.1
± 0.2
|
111 |
EN300-1719160_1_1
|
|
CCn1cnc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.4
± 0.2
|
9.1
± 0.2
|
112 |
PET-UNK-12d8d43f-2
|
|
COC(=O)N(c1cncc2c1cccc2)C(=O)Cc3cccc(c3)Cl |
−12.4
± 0.3
|
9.0
± 0.2
|
113 |
EN300-332002_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCc6n5c(=O)ccc6 |
−12.4
± 0.3
|
9.0
± 0.2
|
114 |
EDG-MED-90036822-19
|
|
Cn1ccnc1C(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)F |
−12.4
± 0.2
|
9.0
± 0.2
|
115 |
EN300-6487755_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[C@H]6C[C@@H](C5)[C@@H]([C@@H](C6)O)O |
−12.4
± 0.3
|
9.0
± 0.2
|
116 |
EN300-246248_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5CCNC5=O |
−12.4
± 0.2
|
9.0
± 0.2
|
117 |
EDJ-MED-6864a934-6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCc6c5n[nH]n6 |
−12.4
± 0.3
|
9.0
± 0.2
|
118 |
EN300-6744029_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccsc5n6cnnn6 |
−12.4
± 0.3
|
9.0
± 0.2
|
119 |
EN300-261859_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(=O)[nH]sn5 |
−12.4
± 0.2
|
9.0
± 0.1
|
120 |
DAR-DIA-5ff57136-17
|
|
c1ccc2c(c1)cncc2N(CC#CBr)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−12.4
± 0.2
|
9.0
± 0.1
|
121 |
EN300-124652_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H]5CC(=O)N |
−12.4
± 0.2
|
9.0
± 0.1
|
122 |
VLA-UCB-551c2366-1_1
|
|
CN(C)c1ccc(cc1)[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.4
± 0.2
|
9.0
± 0.2
|
123 |
MIC-UNK-50cce87d-9
|
|
c1cc(cc(c1)Cl)C2CCCN(C2=O)c3cncc4c3c(ccc4)F |
−12.4
± 0.2
|
9.0
± 0.2
|
124 |
EDJ-MED-6864a934-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6nccn6ccn5 |
−12.4
± 0.2
|
9.0
± 0.2
|
125 |
EN300-304135_1_1
|
|
CC[C@@]1(CCNC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.3
± 0.3
|
9.0
± 0.2
|
126 |
EN300-24297_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5csnn5 |
−12.3
± 0.2
|
9.0
± 0.1
|
127 |
EN300-61140_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCc5nc(no5)c6[nH]ncn6 |
−12.3
± 0.3
|
9.0
± 0.2
|
128 |
EN300-365398_3_1
|
|
Cn1c(nnn1)CCOCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.3
± 0.2
|
9.0
± 0.2
|
129 |
EDJ-MED-6864a934-2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6n(n5)CCO6 |
−12.3
± 0.2
|
9.0
± 0.1
|
130 |
EN300-1248064_3_1
|
|
CC(C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnnn5 |
−12.3
± 0.3
|
9.0
± 0.2
|
131 |
EN300-149296_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ncc(cn5)F |
−12.3
± 0.2
|
9.0
± 0.1
|
132 |
EN300-133058_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6c(n5)n[nH]n6 |
−12.3
± 0.2
|
9.0
± 0.2
|
133 |
EN300-173006_3_1
|
|
C[C@@H](c1nnnn1C)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.3
± 0.2
|
9.0
± 0.2
|
134 |
EN300-2007627_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H](C[C@@H](C5)CO)CO |
−12.3
± 0.3
|
8.9
± 0.2
|
135 |
EN300-210110_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)C6CC6 |
−12.3
± 0.2
|
8.9
± 0.2
|
136 |
EN300-7494324_1_2
|
|
Cc1c(nc[nH]1)C[C@H](C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−12.3
± 0.3
|
8.9
± 0.2
|
137 |
EN300-149013_2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c(n[nH]n5)Cl |
−12.3
± 0.2
|
8.9
± 0.2
|
138 |
EN300-176023_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6n(nn5)CCNC6=O |
−12.3
± 0.2
|
8.9
± 0.2
|
139 |
EN300-20496_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCO[C@@H]5CCOC5=O |
−12.3
± 0.2
|
8.9
± 0.2
|
140 |
EN300-245264_3_1
|
|
CC[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnc(n5)C#N |
−12.3
± 0.3
|
8.9
± 0.3
|
141 |
EN300-1251424_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccn(n5)CC#N |
−12.3
± 0.3
|
8.9
± 0.2
|
142 |
VLA-UCB-05e51b3f-10
|
|
C=CC(=O)N(c1cncc2c1cccc2)C(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−12.3
± 0.3
|
8.9
± 0.2
|
143 |
EN300-86878_1_1
|
|
C#CCSCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−12.2
± 0.2
|
8.9
± 0.2
|
144 |
VLA-UCB-50c39ae8-6
|
|
c1ccc2c(c1)cncc2N(C(=O)CCl)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−12.2
± 0.2
|
8.9
± 0.2
|
145 |
EN300-245264_1_2
|
|
CC[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnc(n5)C#N |
−12.2
± 0.3
|
8.9
± 0.2
|
146 |
EN300-123614_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)NC(=O)N |
−12.2
± 0.3
|
8.9
± 0.2
|
147 |
EN300-09239_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc(c5)n6cnnn6 |
−12.2
± 0.3
|
8.9
± 0.2
|
148 |
EN300-378044_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CC=CCO5 |
−12.2
± 0.2
|
8.9
± 0.2
|
149 |
EN300-10334_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@]56CCC(=O)N5CCS6 |
−12.2
± 0.3
|
8.9
± 0.3
|
150 |
EN300-7549555_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5coc(n5)CO |
−12.2
± 0.2
|
8.9
± 0.1
|
151 |
EN300-1703711_1_1
|
|
COc1c(cnc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)F |
−12.2
± 0.2
|
8.9
± 0.2
|
152 |
EN300-173006_3_2
|
|
C[C@H](c1nnnn1C)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.2
± 0.3
|
8.9
± 0.2
|
153 |
EN300-315238_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CC[C@H](O5)C(=O)N |
−12.2
± 0.3
|
8.9
± 0.2
|
154 |
EN300-250112_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5csc(n5)CO |
−12.2
± 0.2
|
8.9
± 0.2
|
155 |
EN300-6744028_1_5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@@H]6C[C@H]5[C@@H]([C@H]6O)O |
−12.2
± 0.3
|
8.9
± 0.2
|
156 |
EN300-862094_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H]5C(=O)N |
−12.2
± 0.3
|
8.9
± 0.2
|
157 |
EN300-217499_3_2
|
|
C[C@](C1CCOCC1)(C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−12.2
± 0.4
|
8.9
± 0.3
|
158 |
EN300-302058_3_2
|
|
CON1CC[C@H](C1=O)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.1
± 0.3
|
8.8
± 0.2
|
159 |
EN300-86357_1_1
|
|
Cn1cc(nn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.1
± 0.2
|
8.8
± 0.2
|
160 |
EN300-58864_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(nc5)C(=O)N |
−12.1
± 0.3
|
8.8
± 0.2
|
161 |
VLA-UCB-34f3ed0c-21
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)C(=O)CCC5CC(=O)NC5 |
−12.1
± 0.3
|
8.8
± 0.2
|
162 |
EN300-373791_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnn5CC#N |
−12.1
± 0.3
|
8.8
± 0.2
|
163 |
EN300-69811_1_1
|
|
Cn1cccc(c1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.1
± 0.3
|
8.8
± 0.2
|
164 |
EN300-147499_1_1
|
|
Cc1cc(c(=O)[nH]n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.1
± 0.3
|
8.8
± 0.2
|
165 |
EN300-3031933_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC[C@@]6(O5)CCOC6 |
−12.1
± 0.3
|
8.8
± 0.2
|
166 |
EN300-1627945_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CO[C@H]5CCCOC5 |
−12.1
± 0.2
|
8.8
± 0.1
|
167 |
EN300-6740329_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5[C@H]6CCC[C@@H]5C(=O)NC6 |
−12.1
± 0.4
|
8.8
± 0.3
|
168 |
ALP-UNI-44c99a80-2
|
|
c1ccc2c(c1)cncc2N(Cc3cnc[nH]3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−12.1
± 0.2
|
8.8
± 0.1
|
169 |
EN300-198515_3_2
|
|
C[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnc(n5)C#N |
−12.1
± 0.3
|
8.8
± 0.2
|
170 |
EN300-122340_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCSCC5)O |
−12.1
± 0.3
|
8.8
± 0.2
|
171 |
EN300-66845_1_1
|
|
COC(=O)N1CCC[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.1
± 0.3
|
8.8
± 0.2
|
172 |
EN300-378828_3_1
|
|
C[C@@H]1[C@H]([C@H](C(=O)N1C)O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.1
± 0.5
|
8.8
± 0.3
|
173 |
EDJ-MED-28ec730d-5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCc5c[nH]nc5 |
−12.1
± 0.2
|
8.8
± 0.2
|
174 |
EN300-26973_1_1
|
|
Cc1nc(nn1c2[nH]ncn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−12.1
± 0.2
|
8.8
± 0.2
|
175 |
EN300-123712_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc(n5)n6cncn6 |
−12.1
± 0.2
|
8.8
± 0.2
|
176 |
VLA-UCB-34f3ed0c-21_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)C(=O)CC[C@@H]5CC(=O)NC5 |
−12.1
± 0.3
|
8.8
± 0.2
|
177 |
EN300-151461_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)[C@@H]6CCOC6 |
−12.1
± 0.2
|
8.8
± 0.2
|
178 |
EN300-6738732_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@]56COC[C@H]5C6(F)F |
−12.1
± 0.2
|
8.8
± 0.2
|
179 |
EN300-6735902_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@@H]6CC[C@@H]6C(=O)N5 |
−12.1
± 0.3
|
8.8
± 0.2
|
180 |
EN300-21009_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCO5 |
−12.0
± 0.2
|
8.8
± 0.2
|
181 |
EN300-298552_1_4
|
|
CO[C@H]([C@H]1CCOC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.3
|
8.8
± 0.2
|
182 |
BEN-BAS-c2bc0d80-7
|
|
CN1C(=O)N(C(=O)C12CCOc3c2cc(cc3)Cl)c4cncc5c4cccc5 |
−12.0
± 0.3
|
8.8
± 0.2
|
183 |
EN300-39501_1_1
|
|
COCCS(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−12.0
± 0.4
|
8.8
± 0.3
|
184 |
DAR-DIA-5ff57136-10
|
|
c1ccc2c(c1)cncc2N(C#CC#N)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−12.0
± 0.1
|
8.8
± 0.1
|
185 |
EN300-7437779_1_1
|
|
Cn1c(=O)c(c[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.2
|
8.8
± 0.1
|
186 |
EN300-199991_1_1
|
|
Cc1cc(=O)c(cn1C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.3
|
8.8
± 0.2
|
187 |
EN300-27341_2_2
|
|
CS(=O)(=O)[N@@]1CCC[C@H](C1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.3
|
8.8
± 0.2
|
188 |
EN300-6494158_3_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5C[C@H](CO5)CO |
−12.0
± 0.3
|
8.8
± 0.2
|
189 |
EN300-37102_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CCO)C5CC5 |
−12.0
± 0.4
|
8.7
± 0.3
|
190 |
VLA-UCB-34f3ed0c-14
|
|
c1ccc2c(c1)cncc2N3C(=O)[C@@]4(CCOc5c4cc(cc5)Cl)N(C3=O)CC6CCCCC6 |
−12.0
± 0.3
|
8.7
± 0.3
|
191 |
CHO-MSK-5891c1ff-12
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCc5c[nH]nc5 |
−12.0
± 0.2
|
8.7
± 0.2
|
192 |
EN300-2908024_3_2
|
|
CC[C@](C)(C(=O)N)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−12.0
± 0.3
|
8.7
± 0.2
|
193 |
EN300-7435929_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ncc6c(n5)CCOC6 |
−12.0
± 0.3
|
8.7
± 0.2
|
194 |
EN300-248883_3_2
|
|
COC[C@]1(CCOC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.3
|
8.7
± 0.3
|
195 |
EN300-244278_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5C=C6COCCN6N5 |
−12.0
± 0.3
|
8.7
± 0.2
|
196 |
EN300-172179_1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCOC5=O |
−12.0
± 0.3
|
8.7
± 0.2
|
197 |
EN300-42819_1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCC(=O)NC5 |
−12.0
± 0.2
|
8.7
± 0.2
|
198 |
EN300-261210_3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@]5(CCOC5)C#N |
−12.0
± 0.3
|
8.7
± 0.2
|
199 |
EN300-1715993_3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCn5ccnn5 |
−12.0
± 0.2
|
8.7
± 0.2
|
200 |
DAR-DIA-5ff57136-13
|
|
C#CCN(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−12.0
± 0.1
|
8.71
± 0.09
|