Rank |
Microstate |
SMILES |
ΔG / kcal M-1 |
101 |
PET-UNK-ac320b15-6_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)NC(=O)[C@H]4CC[C@@H](O4)C(=O)N5CCCC5 |
−8.1
± 0.3
|
102 |
MAT-POS-29385cc1-4_1
|
|
Cc1cc(cc2c1c(cnc2)NC(=O)Cc3cccc(c3)Cl)F |
−8.10
± 0.10
|
103 |
MIC-UNK-5a93dd5f-3_11
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[N@H+]4CC[C@@H]5CCCC[C@H]5C4 |
−8.1
± 0.2
|
104 |
PET-UNK-8df914d1-1_1
|
|
COc1ccc2cncc(c2c1)NC(=O)Cc3cccc(c3)Cl |
−8.1
± 0.1
|
105 |
PET-UNK-12d8d43f-1_1
|
|
c1ccc2c(c1)cncc2N(C=O)C(=O)Cc3cccc(c3)Cl |
−8.0
± 0.1
|
106 |
MIC-UNK-5a93dd5f-3_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[N@H+]4CC[C@@H]5CCCC[C@@H]5C4 |
−8.0
± 0.2
|
107 |
SAM-UNK-2684b532-3_1
|
|
Cc1ccncc1NC(=O)[C@@H](c2cccc(c2)Cl)c3nnc(s3)C |
−8.0
± 0.2
|
108 |
JIN-POS-6dc588a4-11_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2ccc(c3)F |
−7.99
± 0.07
|
109 |
TRY-UNI-9f475305-3_1
|
|
Cc1ccncc1NC(=O)[C@@H](c2cccc(c2)Cl)c3nnc(s3)C |
−8.0
± 0.1
|
110 |
EDJ-MED-cf4b0d25-3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)NC(=O)[C@@H]4CCCO4 |
−7.97
± 0.09
|
111 |
PET-UNK-1320d94d-27_1
|
|
CN([C@H](c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3)C(=O)[C@@H]4C[C@@H](O4)C(=O)N5CCCC5 |
−8.0
± 0.2
|
112 |
MAT-POS-8293a91a-2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)NC(=O)[C@H]4CC[C@@H](O4)C(=O)N5CCCC5 |
−7.96
± 0.09
|
113 |
MIC-UNK-5a93dd5f-12_5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[N@@]4CC[C@H](C4)[NH+]5CCCCC5 |
−8.0
± 0.2
|
114 |
PET-UNK-1320d94d-2_1
|
|
CN(C)C(=O)[C@H]1CC[C@H](O1)C(=O)N[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.0
± 0.2
|
115 |
ALP-POS-3fc1724e-8_2
|
|
c1ccc2c(c1)[nH]c(n2)NC(=O)[C@H](CCC3CCCCC3)c4cccc(c4)Cl |
−7.9
± 0.3
|
116 |
VLA-UCB-05e51b3f-15_1
|
|
c1ccc2c(c1)cncc2N(C(=O)Cc3cccc(c3)Cl)C(=O)CCl |
−7.9
± 0.2
|
117 |
MIC-UNK-50cce87d-2_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2c(ccc3)Cl |
−7.9
± 0.1
|
118 |
RUB-POS-1325a9ea-4_1
|
|
Cc1ccc2cncc(c2c1)NC(=O)Cc3cccc(c3)Cl |
−7.91
± 0.07
|
119 |
SAM-UNK-2684b532-1_2
|
|
Cc1ccncc1NC(=O)[C@H](c2ccccc2)c3cccc(c3)Cl |
−7.9
± 0.2
|
120 |
PET-UNK-1320d94d-26_1
|
|
CN([C@@H](c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3)C(=O)[C@@H]4CC[C@@H](O4)C(=O)N5CCC5 |
−7.9
± 0.2
|
121 |
MAT-POS-d8472c4f-2_2
|
|
COC(=O)[C@H]1CC[C@H](O1)C[NH2+][C@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.89
± 0.09
|
122 |
MAK-UNK-ffc90da7-4_5
|
|
C[C@@H](C[NH2+]C[C@@H]1CCCO1)[C@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.9
± 0.3
|
123 |
MIC-UNK-5a93dd5f-12_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[N@]4CC[C@@H](C4)[NH+]5CCCCC5 |
−7.9
± 0.2
|
124 |
PET-UNK-a692de38-1_1
|
|
c1ccc2c(c1)cncc2N(C(=O)Cc3cccc(c3)Cl)NC#N |
−7.9
± 0.2
|
125 |
MAT-POS-8293a91a-6_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)NC(=O)[C@@H]4CC[C@H](O4)C(=O)N5CCCC5 |
−7.84
± 0.09
|
126 |
RUB-POS-1325a9ea-15_1
|
|
Cn1c2cncc(c2cn1)NC(=O)Cc3cccc(c3)Cl |
−7.8
± 0.1
|
127 |
MIC-UNK-5a93dd5f-2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[NH+]4C[C@H]5CCCC[C@H]5C4 |
−7.8
± 0.2
|
128 |
ALP-POS-ddb41b15-9_2
|
|
COc1cccc(c1)[C@H](c2[nH]c3ccccc3n2)NC(=O)Cc4cccc(c4)Cl |
−7.8
± 0.3
|
129 |
EDG-MED-0da5ad92-18_1
|
|
Cc1ccnc(c1NC(=O)Cc2cccc(c2)Cl)N |
−7.81
± 0.08
|
130 |
MIC-UNK-5a93dd5f-1_5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[NH+]4C[C@@H]5CCC[C@H]5C4 |
−7.8
± 0.2
|
131 |
MAT-POS-29385cc1-2_1
|
|
COc1cc2cncc(c2cc1F)NC(=O)Cc3cccc(c3)Cl |
−7.8
± 0.1
|
132 |
JIN-POS-6dc588a4-22_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2ccs3 |
−7.80
± 0.07
|
133 |
ALP-POS-95b75b4d-6_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2c[nH]ccc2=O |
−7.8
± 0.1
|
134 |
MIC-UNK-5a93dd5f-5_7
|
|
CC(=O)N[C@@H]1CC[N@H+](C1)[C@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.8
± 0.2
|
135 |
RAL-THA-2d450e86-22_1
|
|
COc1c(cccc1Cl)CC(=O)Nc2cncc3c2cccc3 |
−7.8
± 0.1
|
136 |
PET-UNK-b1ef24dc-2_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2snc3 |
−7.8
± 0.1
|
137 |
MAT-POS-f7918075-5_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2cncc3 |
−7.77
± 0.02
|
138 |
PET-UNK-f4e47ebd-2_1
|
|
COc1cc2cncc(c2cn1)NC(=O)Cc3cccc(c3)Cl |
−7.8
± 0.2
|
139 |
PET-UNK-f4e47ebd-1_1
|
|
COc1cc2c(cncc2NC(=O)Cc3cccc(c3)Cl)cn1 |
−7.8
± 0.1
|
140 |
DAR-DIA-076fb6ea-8_1
|
|
C=C=CC(=O)N(c1cncc2c1cccc2)C(=O)Cc3cccc(c3)Cl |
−7.8
± 0.2
|
141 |
EDJ-MED-ee07cf00-18_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)NC(=O)CN4CCN(C4=O)C5CC5 |
−7.75
± 0.09
|
142 |
RUB-POS-1325a9ea-14_1
|
|
Cn1c2c(cncc2NC(=O)Cc3cccc(c3)Cl)cn1 |
−7.74
± 0.08
|
143 |
NAU-LAT-2fed8305-1_1
|
|
CC(C)(c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3 |
−7.73
± 0.05
|
144 |
EDJ-MED-ee07cf00-12_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)NC(=O)COc4ccc(cc4)C(=O)N |
−7.72
± 0.09
|
145 |
EDJ-MED-ee07cf00-14_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)NC(=O)Cn4c(=O)c(=O)n5c(n4)CCC5 |
−7.72
± 0.09
|
146 |
JOH-UNI-a38a7bdd-2_1
|
|
c1ccc2c(c1)cncc2N(CC(F)(F)F)C(=O)Cc3cccc(c3)Cl |
−7.7
± 0.3
|
147 |
MAT-POS-c0609ef7-1_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2ccc(c3)C(F)F |
−7.7
± 0.1
|
148 |
MAT-POS-a13804f0-1_3
|
|
Cc1nc2n(n1)C[C@@H](CC2)C(=O)N[C@H](c3cccc(c3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.70
± 0.09
|
149 |
MIC-UNK-5a93dd5f-2_5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[NH+]4C[C@@H]5CCCC[C@H]5C4 |
−7.7
± 0.2
|
150 |
JOH-UNI-3fc3434e-12_1
|
|
CN(c1cncc2c1N(CCO2)C(=O)C#C)C(=O)Cc3cccc(c3)Cl |
−7.7
± 0.1
|
151 |
PET-UNK-1320d94d-6_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)NC(=O)[C@@H]4CC[C@@H](O4)C(=O)N5CCC5 |
−7.7
± 0.2
|
152 |
EDJ-MED-cf4b0d25-3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)NC(=O)[C@@H]4CCCO4 |
−7.67
± 0.09
|
153 |
MAT-POS-199e2e7c-2_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2c3cn[nH]c3ccn2 |
−7.7
± 0.1
|
154 |
MIC-UNK-5a93dd5f-9_8
|
|
CN(C)[C@H]1CC[N@H+](C1)[C@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.7
± 0.2
|
155 |
PET-UNK-ac320b15-8_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)NC(=O)[C@@H]4CC[C@H](O4)C(=O)N5CCCC5 |
−7.7
± 0.2
|
156 |
MAT-POS-29385cc1-1_1
|
|
COc1cc2c(cc1F)cncc2NC(=O)Cc3cccc(c3)Cl |
−7.7
± 0.1
|
157 |
JAN-GHE-f4ca5a00-14_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nn2cncc2C3CC3 |
−7.6
± 0.1
|
158 |
MIC-UNK-5a93dd5f-1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[NH+]4C[C@H]5CCC[C@@H]5C4 |
−7.6
± 0.2
|
159 |
DAR-DIA-076fb6ea-10_2
|
|
Cc1ccncc1N(C#C[C@H]2CCC[NH2+]2)C(=O)Cc3cccc(c3)Cl |
−7.6
± 0.2
|
160 |
EDJ-MED-cf4b0d25-2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[NH2+]C[C@@H]4CC[C@@H](O4)C(=O)N5CCCC5 |
−7.63
± 0.10
|
161 |
EDG-MED-0da5ad92-1_1
|
|
Cc1ccncc1N(C)C(=O)Cc2cccc(c2)Cl |
−7.6
± 0.1
|
162 |
PET-UNK-b38839dc-1_1
|
|
COc1cc2c(cc1F)cncc2NC(=O)Cc3cccc(c3)Cl |
−7.6
± 0.1
|
163 |
EDJ-MED-ee07cf00-2_1
|
|
Cc1c(c(=O)n2c(n1)cc[nH]2)CC(=O)N[C@@H](c3cccc(c3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.2
|
164 |
MAT-POS-bb423b95-1_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2ccnc3 |
−7.60
± 0.03
|
165 |
JOH-UNI-3fc3434e-1_1
|
|
C#CC(=O)c1cccc2c1c(cnc2)NC(=O)Cc3cccc(c3)Cl |
−7.6
± 0.2
|
166 |
JOH-UNI-50ce7ec3-4_1
|
|
c1ccc2c(c1)c(cnc2C(F)F)N(C(=O)Cc3cccc(c3)Cl)S(=O)(=O)F |
−7.6
± 0.4
|
167 |
EDJ-MED-cf4b0d25-5_2
|
|
CN(C)C(=O)COCC(=O)N[C@H](c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3 |
−7.57
± 0.09
|
168 |
ABI-SAT-4d06482b-2_1
|
|
Cc1c(cncn1)NC(=O)Cc2cccc(c2)Cl |
−7.6
± 0.1
|
169 |
ADA-UCB-6c2cb422-1_1
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cccc(c3)Cl |
−7.56
± 0.02
|
170 |
MAK-UNK-ffc90da7-5_1
|
|
C[C@@](CO)(c1ccc2c(c1)cncc2NC(=O)Cc3cccc(c3)Cl)[NH2+]C4CC4 |
−7.5
± 0.2
|
171 |
RUB-POS-1325a9ea-2_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2c(ccc3)F |
−7.54
± 0.02
|
172 |
MAK-UNK-ffc90da7-6_2
|
|
C[C@H](C[NH2+]CCCO)c1ccc2cncc(c2c1)NC(=O)Cc3cccc(c3)Cl |
−7.5
± 0.2
|
173 |
MIC-UNK-50cce87d-1_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2c(ccc3)F |
−7.53
± 0.02
|
174 |
JOH-UNI-a38a7bdd-4_1
|
|
Cc1ccncc1N(CC(F)(F)F)C(=O)Cc2cccc(c2)Cl |
−7.5
± 0.2
|
175 |
JIN-POS-6dc588a4-13_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2cccc3F |
−7.52
± 0.03
|
176 |
SAM-UNK-2684b532-1_1
|
|
Cc1ccncc1NC(=O)[C@@H](c2ccccc2)c3cccc(c3)Cl |
−7.5
± 0.1
|
177 |
RUB-POS-1325a9ea-16_1
|
|
c1ccc2c(c1)[C@@H](CC2=O)NC(=O)Cc3cccc(c3)Cl |
−7.5
± 0.1
|
178 |
RUB-POS-1325a9ea-17_1
|
|
c1ccc2c(c1)c(cnc2F)NC(=O)Cc3cccc(c3)Cl |
−7.48
± 0.03
|
179 |
MIC-UNK-7574fcc6-1_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2c(cc(c3)F)F |
−7.5
± 0.1
|
180 |
EDJ-MED-cf4b0d25-1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)NC(=O)COCC(=O)N4CCCC4 |
−7.45
± 0.09
|
181 |
DAR-DIA-076fb6ea-16_1
|
|
Cc1ccncc1N(C(=O)Cc2cccc(c2)Cl)N=C=S |
−7.4
± 0.1
|
182 |
MIC-UNK-5a93dd5f-7_8
|
|
CC(=O)N(C)[C@H]1CC[N@H+](C1)[C@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.4
± 0.2
|
183 |
EDJ-MED-ee07cf00-6_3
|
|
Cn1cc(cn1)C2=NO[C@@H](C2)C(=O)N[C@H](c3cccc(c3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.42
± 0.09
|
184 |
MAK-UNK-c749d764-22_5
|
|
C[C@@H](C[NH2+]C[C@@H]1CCCO1)[C@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.4
± 0.3
|
185 |
MIC-UNK-5a93dd5f-1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[NH+]4C[C@H]5CCC[C@H]5C4 |
−7.4
± 0.2
|
186 |
MAK-UNK-ffc90da7-6_1
|
|
C[C@@H](C[NH2+]CCCO)c1ccc2cncc(c2c1)NC(=O)Cc3cccc(c3)Cl |
−7.4
± 0.2
|
187 |
MIC-UNK-13557a72-1_2
|
|
c1cc(cc(c1)Cl)CC(=O)N[C@H]2C[NH+]3CCC2CC3 |
−7.4
± 0.2
|
188 |
MIC-UNK-5a93dd5f-9_5
|
|
CN(C)[C@@H]1CC[N@@H+](C1)[C@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.4
± 0.2
|
189 |
MAT-POS-29385cc1-3_1
|
|
Cc1ccc2c(c1)cncc2NC(=O)Cc3cccc(c3)Cl |
−7.3
± 0.1
|
190 |
EDJ-MED-ee07cf00-4_4
|
|
C[C@H](C(=O)N[C@H](c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3)NC(=O)C4CCC4 |
−7.32
± 0.09
|
191 |
MIC-UNK-d36ab305-1_1
|
|
CC(=O)Nc1ccc(cc1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.3
± 0.2
|
192 |
DAR-DIA-56cf811e-3_1
|
|
c1ccc2c(c1)cncc2N(C(=O)Cc3cccc(c3)Cl)C(=O)/C=C/C#N |
−7.3
± 0.3
|
193 |
ALP-POS-a9ad2217-2_1
|
|
CN([C@@H](c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3)C(=O)[C@@H]4CC[C@@H](O4)C(=O)N5CCCC5 |
−7.3
± 0.2
|
194 |
MAK-UNK-c749d764-6_3
|
|
C[C@@H](C[NH2+]CCCO)[C@H](c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3 |
−7.3
± 0.2
|
195 |
MIC-UNK-5a93dd5f-3_7
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[N@H+]4CC[C@H]5CCCC[C@@H]5C4 |
−7.3
± 0.3
|
196 |
MAK-UNK-ffc90da7-9_2
|
|
C[C@H]1[C@@H](CCO1)SC[C@@H](C)c2ccc3c(c2)cncc3NC(=O)Cc4cccc(c4)Cl |
−7.3
± 0.2
|
197 |
PET-UNK-d899bab6-3_1
|
|
CN(C)c1cc2c(cncc2NC(=O)Cc3cccc(c3)Cl)cn1 |
−7.3
± 0.2
|
198 |
EDJ-MED-ee07cf00-15_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)NC(=O)Cc4ccc(cc4)n5cnnn5 |
−7.29
± 0.09
|
199 |
EDJ-MED-cf4b0d25-4_2
|
|
CC(=O)N[C@H](c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3 |
−7.28
± 0.08
|
200 |
RUB-POS-1325a9ea-12_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2[nH]nc3 |
−7.28
± 0.07
|