Rank |
Microstate |
SMILES |
ΔG / kcal M-1 |
701 |
MAK-UNK-c749d764-22_3
|
|
C[C@@H](C[NH2+]C[C@H]1CCCO1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−2.8
± 0.3
|
702 |
JIN-POS-6dc588a4-5_1
|
|
c1ccc2c(c1)c(c[nH]2)NC(=O)Cc3cccc(c3)Cl |
−2.8
± 0.1
|
703 |
NAU-LAT-a5c7d7cb-13_2
|
|
c1ccc2c(c1)[C@H](C(=O)N2)NC(=O)Cc3cccc(c3)Cl |
−2.8
± 0.1
|
704 |
JOH-UNI-ee5ed7c8-11_1
|
|
c1ccc2c(c1)cnc(c2NC(=O)Cc3cccc(c3)Cl)CC(F)(F)F |
−2.7
± 0.2
|
705 |
MIC-UNK-8373f97b-4_5
|
|
c1cc(cc(c1)Cl)CC(=O)N[C@@H]2[C@@H]3CCCC[C@H]3NC2=O |
−2.7
± 0.1
|
706 |
EDJ-MED-c8e7a002-10_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2c3ccc(cc3[nH]n2)F |
−2.6
± 0.1
|
707 |
EDJ-MED-cf4b0d25-2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)[NH2+]C[C@@H]4CC[C@@H](O4)C(=O)N5CCCC5 |
−2.63
± 0.10
|
708 |
EDJ-MED-6e43a462-11_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2c[nH+]c3n2CCCC3 |
−2.6
± 0.2
|
709 |
BAR-COM-ebf5acce-9_1
|
|
Cc1ccncc1N(C[C@@]2(C[C@@]2(C)[NH3+])C)C(=O)Cc3cccc(c3)Cl |
−2.6
± 0.2
|
710 |
JAN-GHE-83b26c96-9_2
|
|
Cc1ccncc1NC(=O)[C@H](c2cccc(c2)Cl)C(C)C |
−2.6
± 0.2
|
711 |
MIC-UNK-5a93dd5f-6_2
|
|
CC(=O)N(C)C1CC[NH+](CC1)[C@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−2.6
± 0.2
|
712 |
EDJ-MED-b24713dc-4_1
|
|
Cc1cccn2c1[nH+]cc2NC(=O)Cc3cccc(c3)Cl |
−2.5
± 0.2
|
713 |
MAK-UNK-f203cb68-20_1
|
|
Cc1ccncc1NC(=O)c2c(c(ccn2)C)NC(=O)[C@@H](C)c3cccc(c3)Cl |
−2.5
± 0.2
|
714 |
RUB-POS-1325a9ea-24_1
|
|
CC1([C@@H](c2ccccc2N1)NC(=O)Cc3cccc(c3)Cl)C |
−2.5
± 0.2
|
715 |
ALP-POS-90e38439-1_2
|
|
c1ccc2c(c1)[C@H](C(=O)N2)NC(=O)Cc3cccc(c3)Cl |
−2.4
± 0.1
|
716 |
MAK-UNK-ffc90da7-4_1
|
|
C[C@@H](C[NH2+]C[C@@H]1CCCO1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−2.4
± 0.2
|
717 |
JAN-GHE-83b26c96-2_1
|
|
C[C@@H](c1cccc(c1)Cl)C(=O)Nc2cnccc2NC(=O)C |
−2.4
± 0.1
|
718 |
ADA-UCB-6c2cb422-10_1
|
|
COc1ccccc1C[NH2+][C@@H](c2cccc(c2)Cl)C(=O)Nc3cc(=O)[nH]c4c3cccc4 |
−2.4
± 0.2
|
719 |
MAK-UNK-f203cb68-2_2
|
|
C[C@H](c1cccc(c1)Cl)C(=O)Nc2cnccc2Cc3ccncc3NC(=O)C |
−2.4
± 0.2
|
720 |
RUB-POS-1325a9ea-24_2
|
|
CC1([C@H](c2ccccc2N1)NC(=O)Cc3cccc(c3)Cl)C |
−2.4
± 0.2
|
721 |
EDJ-MED-b24713dc-3_1
|
|
Cc1ccc2[nH+]cc(n2c1)NC(=O)Cc3cccc(c3)Cl |
−2.3
± 0.2
|
722 |
JOH-UNI-3fc3434e-11_1
|
|
c1ccc2c(c1)cnc(c2NC(=O)Cc3cccc(c3)Cl)CC(F)(F)F |
−2.3
± 0.2
|
723 |
BEN-DND-1e24cf73-2_1
|
|
Cc1ccccc1n2cncc2NC(=O)Cc3cccc(c3)Cl |
−2.3
± 0.2
|
724 |
EDJ-MED-6e43a462-13_1
|
|
CN(C)c1ccc2[nH+]cc(n2c1)NC(=O)Cc3cccc(c3)Cl |
−2.2
± 0.2
|
725 |
MIC-UNK-5a93dd5f-4_1
|
|
CC(=O)NC1CC[NH+](CC1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−2.1
± 0.2
|
726 |
MIC-UNK-5a93dd5f-12_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)[N@@]4CC[C@@H](C4)[NH+]5CCCCC5 |
−2.1
± 0.2
|
727 |
MAK-UNK-f203cb68-22_1
|
|
Cc1ccncc1NC(=O)c2cncc(c2C)NC(=O)[C@@H](C)c3cccc(c3)Cl |
−2.1
± 0.2
|
728 |
MIC-UNK-5a93dd5f-9_1
|
|
CN(C)[C@@H]1CC[N@@H+](C1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−2.0
± 0.2
|
729 |
EDJ-MED-c8e7a002-11_1
|
|
c1ccc2c(c1)c(n[nH]2)NC(=O)Cc3cccc(c3)Cl |
−2.0
± 0.1
|
730 |
MAT-POS-8293a91a-2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)NC(=O)[C@H]4CC[C@@H](O4)C(=O)N5CCCC5 |
−1.92
± 0.09
|
731 |
MAK-UNK-ffc90da7-4_4
|
|
C[C@H](C[NH2+]C[C@H]1CCCO1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−1.9
± 0.3
|
732 |
MAK-UNK-ffc90da7-1_1
|
|
C[C@@H](C[NH2+]CCCO)[C@@H](c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3 |
−1.9
± 0.2
|
733 |
MAK-UNK-ffc90da7-4_2
|
|
C[C@H](C[NH2+]C[C@@H]1CCCO1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−1.7
± 0.2
|
734 |
EDJ-MED-6e43a462-3_1
|
|
COc1cccc2n1c(c[nH+]2)NC(=O)Cc3cccc(c3)Cl |
−1.6
± 0.2
|
735 |
MAK-UNK-c749d764-22_1
|
|
C[C@@H](C[NH2+]C[C@@H]1CCCO1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−1.5
± 0.3
|
736 |
MIC-UNK-5a93dd5f-2_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)[NH+]4C[C@H]5CCCC[C@@H]5C4 |
−1.5
± 0.2
|
737 |
ADA-UNI-f8e79267-11_1
|
|
C[NH2+]CC[C@@H](c1cccc(c1)Cl)C(=O)Nc2cccnc2 |
−1.5
± 0.2
|
738 |
MIC-UNK-5a93dd5f-9_4
|
|
CN(C)[C@H]1CC[N@H+](C1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−1.5
± 0.2
|
739 |
MAK-UNK-c749d764-22_2
|
|
C[C@H](C[NH2+]C[C@@H]1CCCO1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−1.4
± 0.2
|
740 |
MAK-UNK-f203cb68-21_1
|
|
Cc1ccncc1NC(=O)c2cc(c(cn2)NC(=O)[C@@H](C)c3cccc(c3)Cl)C |
−1.3
± 0.2
|
741 |
MIC-UNK-5a93dd5f-11_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[NH+]4CCC(CC4)[NH+]5CCCCC5 |
−1.3
± 0.3
|
742 |
EDJ-MED-c8e7a002-15_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2c3c(ccnc3Br)[nH]n2 |
−1.3
± 0.1
|
743 |
BAR-COM-ebf5acce-6_1
|
|
Cc1ccncc1N(C[C@@H](C(C)(C)O)[NH3+])C(=O)Cc2cccc(c2)Cl |
−1.3
± 0.3
|
744 |
NAU-LAT-a5c7d7cb-10_1
|
|
c1ccc2c(c1)c(n[nH]2)NC(=O)Cc3cccc(c3)Cl |
−1.0
± 0.1
|
745 |
MIC-UNK-5a93dd5f-7_3
|
|
CC(=O)N(C)[C@@H]1CC[N@H+](C1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−0.9
± 0.2
|
746 |
EDJ-MED-b24713dc-2_1
|
|
Cc1cccc2n1c(c[nH+]2)NC(=O)Cc3cccc(c3)Cl |
−0.8
± 0.1
|
747 |
MIC-UNK-5a93dd5f-9_3
|
|
CN(C)[C@@H]1CC[N@H+](C1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−0.7
± 0.2
|
748 |
MAK-UNK-f203cb68-5_1
|
|
Cc1ccncc1NC(=O)[C@@H](C)c2cccc(c2c3ccncc3NC(=O)C)Cl |
−0.6
± 0.3
|
749 |
MIC-UNK-5a93dd5f-10_1
|
|
CC(=O)N1CC[NH+](CC1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−0.5
± 0.2
|
750 |
JOH-UNI-ee5ed7c8-7_1
|
|
CN(c1cncc2c1cccc2)C(=O)[C@@H](CC#N)c3cccc(c3)Cl |
−0.5
± 0.2
|
751 |
BEN-DND-02317c5c-9_1
|
|
c1ccn2c(c1)c[nH+]c2NC(=O)Cc3cccc(c3)Cl |
−0.5
± 0.1
|
752 |
MIC-UNK-5a93dd5f-5_4
|
|
CC(=O)N[C@H]1CC[N@H+](C1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−0.4
± 0.2
|
753 |
JOH-UNI-3fc3434e-7_1
|
|
CN(c1cncc2c1cccc2)C(=O)[C@@H](CC#N)c3cccc(c3)Cl |
−0.3
± 0.2
|
754 |
MIC-UNK-5a93dd5f-5_3
|
|
CC(=O)N[C@@H]1CC[N@H+](C1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−0.3
± 0.2
|
755 |
MIC-UNK-6ab519a7-1_1
|
|
CC(=O)N1CC[NH+](CC1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−0.3
± 0.2
|
756 |
NIR-THE-590dedc7-1_1
|
|
CC(=O)N1CC[NH+](CC1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−0.2
± 0.2
|
757 |
MIC-UNK-5a93dd5f-6_1
|
|
CC(=O)N(C)C1CC[NH+](CC1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
0.2
± 0.2
|
758 |
MIC-UNK-5a93dd5f-7_4
|
|
CC(=O)N(C)[C@H]1CC[N@H+](C1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
0.2
± 0.2
|
759 |
MIC-UNK-5a93dd5f-7_2
|
|
CC(=O)N(C)[C@H]1CC[N@@H+](C1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
0.3
± 0.2
|
760 |
MIC-UNK-5a93dd5f-5_2
|
|
CC(=O)N[C@H]1CC[N@@H+](C1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
0.3
± 0.2
|
761 |
MIC-UNK-5a93dd5f-8_1
|
|
C[NH+](C)C1CC[NH+](CC1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
0.4
± 0.2
|
762 |
MIC-UNK-5a93dd5f-5_1
|
|
CC(=O)N[C@@H]1CC[N@@H+](C1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
0.6
± 0.2
|
763 |
MAT-POS-d8472c4f-2_1
|
|
COC(=O)[C@H]1CC[C@H](O1)C[NH2+][C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
0.68
± 0.09
|
764 |
MIC-UNK-5a93dd5f-2_6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)[NH+]4C[C@@H]5CCCC[C@H]5C4 |
0.9
± 0.2
|
765 |
MAK-UNK-ffc90da7-7_2
|
|
CC(C)OC[C@H]([C@@H](c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3)[NH2+]C |
1.4
± 0.4
|
766 |
MIC-UNK-5a93dd5f-1_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)[NH+]4C[C@H]5CCC[C@@H]5C4 |
1.6
± 0.2
|
767 |
NAU-LAT-a5c7d7cb-2_1
|
|
CC(=O)N1CC[NH+](CC1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
1.6
± 0.2
|
768 |
MAK-UNK-ffc90da7-7_1
|
|
CC(C)OC[C@@H]([C@@H](c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3)[NH2+]C |
2.2
± 0.5
|
769 |
MIC-UNK-5a93dd5f-9_2
|
|
CN(C)[C@H]1CC[N@@H+](C1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
2.4
± 0.2
|
770 |
MIC-UNK-5a93dd5f-11_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)[NH+]4CCC(CC4)[NH+]5CCCCC5 |
2.5
± 0.2
|
771 |
MIC-UNK-5a93dd5f-7_1
|
|
CC(=O)N(C)[C@@H]1CC[N@@H+](C1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
5.2
± 0.2
|