Rank |
Microstate |
SMILES |
ΔG / kcal M-1 |
101 |
JOH-UNI-a38a7bdd-1_1
|
|
c1ccc2c(c1)cncc2N(C(=O)Cc3cccc(c3)Cl)C(=O)C(F)(F)F |
−7.9
± 0.2
|
102 |
RUB-POS-1325a9ea-4_1
|
|
Cc1ccc2cncc(c2c1)NC(=O)Cc3cccc(c3)Cl |
−7.92
± 0.07
|
103 |
MAT-POS-d8472c4f-2_2
|
|
COC(=O)[C@H]1CC[C@H](O1)C[NH2+][C@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.91
± 0.09
|
104 |
EDJ-MED-ee07cf00-12_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)NC(=O)COc4ccc(cc4)C(=O)N |
−7.91
± 0.09
|
105 |
MIC-UNK-5a93dd5f-3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[N@@H+]4CC[C@@H]5CCCC[C@@H]5C4 |
−7.9
± 0.2
|
106 |
NAU-LAT-4ce8bf23-2_1
|
|
c1ccc2c(c1)cncc2N(CCC(=O)N)C(=O)Cc3cccc(c3)Cl |
−7.9
± 0.2
|
107 |
PET-UNK-1320d94d-10_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)NC(=O)[C@@H]4CCC[C@@H](O4)C(=O)N5CCCC5 |
−7.9
± 0.3
|
108 |
PET-UNK-ac320b15-10_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)NC(=O)[C@H]4CC[C@H](O4)C(=O)N5CCCC5 |
−7.9
± 0.2
|
109 |
ROB-UNI-daaf9793-3_1
|
|
c1ccc2c(c1)cc(cc2O)NC(=O)Cc3cccc(c3)Cl |
−7.9
± 0.1
|
110 |
MAK-UNK-ffc90da7-6_1
|
|
C[C@@H](C[NH2+]CCCO)c1ccc2cncc(c2c1)NC(=O)Cc3cccc(c3)Cl |
−7.8
± 0.2
|
111 |
JOH-UNI-a38a7bdd-5_3
|
|
c1ccc2c(c1)cncc2N(C(=O)Cc3cccc(c3)Cl)C(=O)[C@@H]4C[C@H]4F |
−7.8
± 0.2
|
112 |
DAR-DIA-076fb6ea-9_2
|
|
c1ccc2c(c1)cncc2N(C#C[C@H]3CCC[NH2+]3)C(=O)Cc4cccc(c4)Cl |
−7.8
± 0.4
|
113 |
PET-UNK-e8c7a26f-2_1
|
|
C=CC(=O)N(c1cccnc1)C(=O)Cc2cccc(c2)Cl |
−7.8
± 0.2
|
114 |
PET-UNK-bbe8d7ff-1_1
|
|
Cc1ccncc1N(CC=O)C(=O)Cc2cccc(c2)Cl |
−7.8
± 0.2
|
115 |
DAR-DIA-076fb6ea-10_2
|
|
Cc1ccncc1N(C#C[C@H]2CCC[NH2+]2)C(=O)Cc3cccc(c3)Cl |
−7.8
± 0.2
|
116 |
NAU-LAT-a5c7d7cb-6_2
|
|
CC(=O)N1CC[NH+](CC1)[C@H](c2cccc(c2)Cl)C(=O)Nc3cc[nH]c(=O)c3 |
−7.8
± 0.3
|
117 |
MAT-POS-8293a91a-2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)NC(=O)[C@H]4CC[C@@H](O4)C(=O)N5CCCC5 |
−7.77
± 0.09
|
118 |
MIC-UNK-5a93dd5f-3_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[N@H+]4CC[C@@H]5CCCC[C@@H]5C4 |
−7.8
± 0.2
|
119 |
PET-UNK-1320d94d-22_1
|
|
CN(C)C(=O)[C@H]1CC[C@H](O1)C(=O)N(C)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.8
± 0.2
|
120 |
JAN-GHE-5a013bed-6_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cnns2 |
−7.8
± 0.1
|
121 |
RUB-POS-1325a9ea-14_1
|
|
Cn1c2c(cncc2NC(=O)Cc3cccc(c3)Cl)cn1 |
−7.72
± 0.08
|
122 |
MIC-UNK-5a93dd5f-3_13
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[N@@H+]4CC[C@H]5CCCC[C@H]5C4 |
−7.7
± 0.2
|
123 |
NAU-LAT-2fed8305-1_1
|
|
CC(C)(c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3 |
−7.71
± 0.05
|
124 |
EDJ-MED-cf4b0d25-2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[NH2+]C[C@@H]4CC[C@@H](O4)C(=O)N5CCCC5 |
−7.69
± 0.10
|
125 |
JAN-GHE-f4ca5a00-18_1
|
|
CCCC[C@@H](c1cccc(c1)Cl)C(=O)Nn2cncc2C3CC3 |
−7.7
± 0.2
|
126 |
MIC-UNK-67d4a29a-4_1
|
|
CN(c1cncc2c1c(ccc2)OC)C(=O)Cc3cccc(c3)Cl |
−7.7
± 0.3
|
127 |
MAT-POS-29385cc1-1_1
|
|
COc1cc2c(cc1F)cncc2NC(=O)Cc3cccc(c3)Cl |
−7.7
± 0.1
|
128 |
EDJ-MED-cf4b0d25-5_2
|
|
CN(C)C(=O)COCC(=O)N[C@H](c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3 |
−7.66
± 0.09
|
129 |
MIC-UNK-5a93dd5f-3_14
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)[N@@H+]4CC[C@H]5CCCC[C@H]5C4 |
−7.7
± 0.3
|
130 |
MAT-POS-8293a91a-6_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)NC(=O)[C@@H]4CC[C@H](O4)C(=O)N5CCCC5 |
−7.64
± 0.09
|
131 |
PET-UNK-1320d94d-4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)NC(=O)[C@@H]4CC[C@@H](O4)C(=O)N5CCOCC5 |
−7.6
± 0.3
|
132 |
JOH-UNI-3fc3434e-3_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2c(ccc3)CC(F)(F)F |
−7.6
± 0.1
|
133 |
MAK-UNK-ffc90da7-5_1
|
|
C[C@@](CO)(c1ccc2c(c1)cncc2NC(=O)Cc3cccc(c3)Cl)[NH2+]C4CC4 |
−7.6
± 0.2
|
134 |
MAT-POS-c0609ef7-1_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2ccc(c3)C(F)F |
−7.6
± 0.1
|
135 |
PET-UNK-158bee2a-2_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2ccns2 |
−7.6
± 0.1
|
136 |
MIC-UNK-50cce87d-2_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2c(ccc3)Cl |
−7.6
± 0.1
|
137 |
EDJ-MED-ee07cf00-2_1
|
|
Cc1c(c(=O)n2c(n1)cc[nH]2)CC(=O)N[C@@H](c3cccc(c3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.2
|
138 |
PET-UNK-8df914d1-1_1
|
|
COc1ccc2cncc(c2c1)NC(=O)Cc3cccc(c3)Cl |
−7.6
± 0.1
|
139 |
SAM-UNK-2684b532-3_1
|
|
Cc1ccncc1NC(=O)[C@@H](c2cccc(c2)Cl)c3nnc(s3)C |
−7.6
± 0.1
|
140 |
PET-UNK-e274cad4-1_1
|
|
Cn1c2c(cncc2NC(=O)Cc3cccc(c3)Cl)cn1 |
−7.6
± 0.1
|
141 |
EDJ-MED-ee07cf00-18_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)NC(=O)CN4CCN(C4=O)C5CC5 |
−7.60
± 0.09
|
142 |
PET-UNK-b1ef24dc-2_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2snc3 |
−7.6
± 0.1
|
143 |
PET-UNK-ac320b15-3_1
|
|
c1cc(cc(c1)Cl)[C@H](C(=O)Nc2cccnc2)NC(=O)[C@@H]3CC[C@@H](O3)C(=O)N4CCCC4 |
−7.6
± 0.3
|
144 |
MAT-POS-29385cc1-2_1
|
|
COc1cc2cncc(c2cc1F)NC(=O)Cc3cccc(c3)Cl |
−7.6
± 0.1
|
145 |
MIC-UNK-5a93dd5f-1_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[NH+]4C[C@H]5CCC[C@@H]5C4 |
−7.6
± 0.2
|
146 |
MAT-POS-f7918075-5_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2cncc3 |
−7.58
± 0.02
|
147 |
MAT-POS-29385cc1-4_1
|
|
Cc1cc(cc2c1c(cnc2)NC(=O)Cc3cccc(c3)Cl)F |
−7.6
± 0.1
|
148 |
MAT-POS-f7918075-7_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2CC(=O)N3 |
−7.6
± 0.1
|
149 |
EDJ-MED-ee07cf00-13_1
|
|
Cc1nc2n(n1)C[C@@H](CC2)C(=O)N[C@@H](c3cccc(c3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.6
± 0.2
|
150 |
JIN-POS-6dc588a4-22_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2ccs3 |
−7.56
± 0.07
|
151 |
JOH-UNI-ee5ed7c8-3_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2c(ccc3)CC(F)(F)F |
−7.6
± 0.2
|
152 |
PET-UNK-f4e47ebd-2_1
|
|
COc1cc2cncc(c2cn1)NC(=O)Cc3cccc(c3)Cl |
−7.5
± 0.1
|
153 |
EDJ-MED-ee07cf00-14_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)NC(=O)Cn4c(=O)c(=O)n5c(n4)CCC5 |
−7.53
± 0.09
|
154 |
MAT-POS-199e2e7c-2_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2c3cn[nH]c3ccn2 |
−7.5
± 0.1
|
155 |
RUB-POS-1325a9ea-12_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2[nH]nc3 |
−7.53
± 0.07
|
156 |
JOH-UNI-a38a7bdd-3_1
|
|
Cc1ccncc1N(C(=O)Cc2cccc(c2)Cl)C(=O)C(F)(F)F |
−7.5
± 0.1
|
157 |
JAG-UCB-a3ef7265-10_1
|
|
Cc1nnc(s1)NC(=O)Cc2cccc(c2F)Cl |
−7.5
± 0.1
|
158 |
JAN-GHE-f4ca5a00-14_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nn2cncc2C3CC3 |
−7.5
± 0.1
|
159 |
EDJ-MED-ee07cf00-11_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)NC(=O)[C@H]4CC[C@@H](O4)C(=O)N5CCCC5 |
−7.5
± 0.2
|
160 |
MIC-UNK-7574fcc6-1_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2c(cc(c3)F)F |
−7.5
± 0.1
|
161 |
EDJ-MED-ee07cf00-16_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)NC(=O)Cn4cc(c(=O)[nH]c4=O)Cl |
−7.44
± 0.09
|
162 |
DAR-DIA-56cf811e-3_1
|
|
c1ccc2c(c1)cncc2N(C(=O)Cc3cccc(c3)Cl)C(=O)/C=C/C#N |
−7.4
± 0.3
|
163 |
EDJ-MED-ee07cf00-11_8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)NC(=O)[C@H]4CC[C@H](O4)C(=O)N5CCCC5 |
−7.4
± 0.2
|
164 |
MAT-POS-a13804f0-1_3
|
|
Cc1nc2n(n1)C[C@@H](CC2)C(=O)N[C@H](c3cccc(c3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.42
± 0.09
|
165 |
EDJ-MED-ee07cf00-18_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)NC(=O)CN4CCN(C4=O)C5CC5 |
−7.42
± 0.09
|
166 |
ADA-UCB-6c2cb422-1_1
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cccc(c3)Cl |
−7.41
± 0.02
|
167 |
MAT-POS-f7918075-3_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2cccn3 |
−7.41
± 0.04
|
168 |
MIC-UNK-13557a72-1_2
|
|
c1cc(cc(c1)Cl)CC(=O)N[C@H]2C[NH+]3CCC2CC3 |
−7.4
± 0.2
|
169 |
MIC-UNK-50cce87d-1_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2c(ccc3)F |
−7.41
± 0.02
|
170 |
EDJ-MED-ee07cf00-4_4
|
|
C[C@H](C(=O)N[C@H](c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3)NC(=O)C4CCC4 |
−7.40
± 0.09
|
171 |
RUB-POS-1325a9ea-1_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2CC(=O)N3 |
−7.4
± 0.1
|
172 |
MAT-POS-bb423b95-1_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2ccnc3 |
−7.38
± 0.03
|
173 |
MIC-UNK-5a93dd5f-2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[NH+]4C[C@H]5CCCC[C@H]5C4 |
−7.4
± 0.2
|
174 |
RUB-POS-1325a9ea-3_1
|
|
Cc1cccc2c1c(cnc2)NC(=O)Cc3cccc(c3)Cl |
−7.36
± 0.09
|
175 |
MIC-UNK-5a93dd5f-3_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)[N@@H+]4CC[C@@H]5CCCC[C@@H]5C4 |
−7.4
± 0.2
|
176 |
MIC-UNK-5a93dd5f-1_5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[NH+]4C[C@@H]5CCC[C@H]5C4 |
−7.3
± 0.2
|
177 |
PET-UNK-b1ef24dc-1_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2onc3 |
−7.35
± 0.08
|
178 |
MIC-UNK-5a93dd5f-7_5
|
|
CC(=O)N(C)[C@@H]1CC[N@@H+](C1)[C@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.3
± 0.2
|
179 |
ADA-UCB-6c2cb422-8_1
|
|
COc1ccccc1OC[C@@H](c2cccc(c2)Cl)C(=O)Nc3cc(=O)[nH]c4c3cccc4 |
−7.3
± 0.3
|
180 |
PET-UNK-b38839dc-1_1
|
|
COc1cc2c(cc1F)cncc2NC(=O)Cc3cccc(c3)Cl |
−7.3
± 0.1
|
181 |
EDJ-MED-cf4b0d25-3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)NC(=O)[C@@H]4CCCO4 |
−7.31
± 0.08
|
182 |
JIN-POS-6dc588a4-13_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2cccc3F |
−7.31
± 0.04
|
183 |
JAN-GHE-f4ca5a00-19_2
|
|
CCCC[C@H](c1cccc(c1)Cl)C(=O)Nn2cnnc2C3CC3 |
−7.3
± 0.2
|
184 |
DAR-DIA-076fb6ea-7_1
|
|
Cc1ccncc1N(C(=O)Cc2cccc(c2)Cl)C(=O)C=C=C |
−7.3
± 0.2
|
185 |
JAN-GHE-5a013bed-1_1
|
|
Cc1c(n(nn1)NC(=O)Cc2cccc(c2)Cl)C |
−7.29
± 0.07
|
186 |
EDJ-MED-cf4b0d25-4_2
|
|
CC(=O)N[C@H](c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3 |
−7.27
± 0.08
|
187 |
MIC-UNK-5a93dd5f-9_7
|
|
CN(C)[C@@H]1CC[N@H+](C1)[C@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.3
± 0.2
|
188 |
RUB-POS-1325a9ea-2_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2c(ccc3)F |
−7.25
± 0.03
|
189 |
MIC-UNK-5a93dd5f-3_9
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[N@@H+]4CC[C@@H]5CCCC[C@H]5C4 |
−7.2
± 0.2
|
190 |
JAN-GHE-83b26c96-6_2
|
|
C[C@H](c1cccc(c1)Cl)C(=O)Nc2cncnc2C(C)C |
−7.2
± 0.1
|
191 |
MIC-UNK-5a93dd5f-2_5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[NH+]4C[C@@H]5CCCC[C@H]5C4 |
−7.2
± 0.2
|
192 |
PET-UNK-1320d94d-8_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)NC(=O)[C@@H]4C[C@@H](O4)C(=O)N5CCCC5 |
−7.2
± 0.2
|
193 |
BAR-COM-ebf5acce-14_1
|
|
Cc1ccncc1N(CCn2cccn2)C(=O)Cc3cccc(c3)Cl |
−7.2
± 0.2
|
194 |
MIC-UNK-5a93dd5f-7_7
|
|
CC(=O)N(C)[C@@H]1CC[N@H+](C1)[C@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.2
± 0.2
|
195 |
MAK-UNK-ffc90da7-6_2
|
|
C[C@H](C[NH2+]CCCO)c1ccc2cncc(c2c1)NC(=O)Cc3cccc(c3)Cl |
−7.2
± 0.2
|
196 |
MIC-UNK-8971c93c-1_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2[nH]c(=O)[nH]3 |
−7.2
± 0.1
|
197 |
EDJ-MED-ee07cf00-1_2
|
|
Cn1c(=O)ccn(c1=O)CC(=O)N[C@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.22
± 0.08
|
198 |
PET-UNK-1320d94d-28_1
|
|
CN([C@@H](c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3)C(=O)[C@@H]4C[C@@H](O4)C(=O)N5CCCC5 |
−7.2
± 0.2
|
199 |
MIC-UNK-5a93dd5f-1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[NH+]4C[C@H]5CCC[C@H]5C4 |
−7.2
± 0.2
|
200 |
RUB-POS-1325a9ea-8_1
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncn3c2ncc3 |
−7.2
± 0.1
|